MA27012A1 - Derives de dihydro-benzo [b] [1,4] diazepin-2-one en tant qu'antagonistes ii de mglur2 - Google Patents
Derives de dihydro-benzo [b] [1,4] diazepin-2-one en tant qu'antagonistes ii de mglur2Info
- Publication number
- MA27012A1 MA27012A1 MA27346A MA27346A MA27012A1 MA 27012 A1 MA27012 A1 MA 27012A1 MA 27346 A MA27346 A MA 27346A MA 27346 A MA27346 A MA 27346A MA 27012 A1 MA27012 A1 MA 27012A1
- Authority
- MA
- Morocco
- Prior art keywords
- mglur2
- diazepin
- agonists
- benzo
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01109125 | 2001-04-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA27012A1 true MA27012A1 (fr) | 2004-12-20 |
Family
ID=8177126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA27346A MA27012A1 (fr) | 2001-04-12 | 2003-10-08 | Derives de dihydro-benzo [b] [1,4] diazepin-2-one en tant qu'antagonistes ii de mglur2 |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US6544985B2 (fr) |
| EP (1) | EP1379511B1 (fr) |
| JP (1) | JP4071115B2 (fr) |
| KR (1) | KR100566171B1 (fr) |
| CN (1) | CN1264825C (fr) |
| AR (1) | AR035816A1 (fr) |
| AT (1) | ATE299868T1 (fr) |
| AU (1) | AU2002312788B2 (fr) |
| BG (1) | BG108254A (fr) |
| BR (1) | BR0208891A (fr) |
| CA (1) | CA2442557C (fr) |
| CZ (1) | CZ20033003A3 (fr) |
| DE (1) | DE60205100T2 (fr) |
| DK (1) | DK1379511T3 (fr) |
| EC (1) | ECSP034797A (fr) |
| ES (1) | ES2246012T3 (fr) |
| GT (1) | GT200200073A (fr) |
| HK (1) | HK1068888A1 (fr) |
| HR (1) | HRP20030792A2 (fr) |
| HU (1) | HUP0400851A3 (fr) |
| IL (2) | IL157873A0 (fr) |
| JO (1) | JO2285B1 (fr) |
| MA (1) | MA27012A1 (fr) |
| MX (1) | MXPA03009311A (fr) |
| MY (1) | MY140271A (fr) |
| NO (1) | NO20034576L (fr) |
| NZ (1) | NZ528315A (fr) |
| PA (1) | PA8543301A1 (fr) |
| PE (1) | PE20021041A1 (fr) |
| PL (1) | PL367064A1 (fr) |
| PT (1) | PT1379511E (fr) |
| RU (1) | RU2263112C2 (fr) |
| SI (1) | SI1379511T1 (fr) |
| SK (1) | SK13682003A3 (fr) |
| UY (1) | UY27258A1 (fr) |
| WO (1) | WO2002083652A1 (fr) |
| YU (1) | YU79003A (fr) |
| ZA (1) | ZA200307243B (fr) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1224175T3 (da) * | 1999-10-15 | 2004-07-12 | Hoffmann La Roche | Benzodiazepinderivater som metabotropiske glutamatreceptorantagonister |
| NZ533699A (en) * | 2001-12-27 | 2006-05-26 | Taisho Pharmaceutical Co Ltd | 6-fluorobicyclo[3.1.0]hexane derivatives |
| EP1925614A1 (fr) * | 2002-03-28 | 2008-05-28 | Wisys Technology Foundation, Inc. | Agents anxiolytiques avec effets ataxiques et sédatifs réduits |
| DE60319812T2 (de) * | 2002-03-28 | 2009-04-23 | Wisys Technology Foundation, Inc., Madison | Angstlösende wirkstoffe mit verminderten beruhigenden und ataktischen nebenwirkungen |
| JP5005343B2 (ja) * | 2003-07-25 | 2012-08-22 | エフ．ホフマン−ラ ロシュ アーゲー | 急性及び／又は慢性神経障害の治療のためのｍＧｌｕＲ２アンタゴニストとＡＣｈＥインヒビターの併用 |
| US7329662B2 (en) | 2003-10-03 | 2008-02-12 | Hoffmann-La Roche Inc. | Pyrazolo-pyridine |
| US20060160823A1 (en) * | 2004-05-28 | 2006-07-20 | Leonore Witchey-Lakshmanan | Particulate-stabilized injectable pharmaceutical compositions of Posaconazole |
| ES2365406T3 (es) * | 2005-02-11 | 2011-10-04 | F. Hoffmann-La Roche Ag | Derivados de pirazolo-pirimidina como antagonistas de mglur2. |
| MX2007011483A (es) | 2005-03-23 | 2007-10-12 | Hoffmann La Roche | Derivados de acetilenil-pirazolo-pirimidina como antagonistas de glutamato metabotropico 2. |
| KR20140000721A (ko) * | 2005-06-23 | 2014-01-03 | 어레이 바이오파마 인크. | 벤즈이미다졸 화합물의 제조 방법 |
| CA2623721C (fr) | 2005-09-27 | 2014-05-13 | F. Hoffmann-La Roche Ag | Oxadiazolylpyrazolopyrimidines en tant qu'antagonistes de mglur2 |
| GB0600228D0 (en) * | 2006-01-06 | 2006-02-15 | Fermentas Uab | Inactivation method |
| AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
| TW200808751A (en) * | 2006-04-13 | 2008-02-16 | Astrazeneca Ab | New compounds |
| CA2663240A1 (fr) | 2006-09-20 | 2008-03-27 | F. Hoffmann-La Roche Ag | Derives 4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| CA2684760A1 (fr) | 2007-04-19 | 2008-10-30 | F. Hoffmann-La Roche Ag | Derives du dihydro-benzo[b][1,4]diazepine-2-one sulfamide |
| EA019085B1 (ru) | 2007-09-14 | 2014-01-30 | Янссен Фармасьютикалз, Инк. | 1',3-двузамещенные 4-(арил-х-фенил)-1н-пиридин-2-оны |
| EP2205565B1 (fr) * | 2007-09-14 | 2013-04-17 | Janssen Pharmaceuticals, Inc. | 4-phényl-1h-pyridin-2-ones 1,3-di-substituées |
| NZ584145A (en) | 2007-09-14 | 2012-03-30 | Ortho Mcneil Janssen Pharm | 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-[1,4'] bipyridinyl-2'-ones |
| MX2010005110A (es) | 2007-11-14 | 2010-09-09 | Ortho Mcneil Janssen Pharm | Derivados de imidazo[1,2-a]piridina y su uso como moduladores alostericos positivos de los receptores de glutamato metabotropico 2. |
| ES2439291T3 (es) | 2008-09-02 | 2014-01-22 | Janssen Pharmaceuticals, Inc. | Derivados de 3-azabiciclo[3.1.0]hexilo como moduladores de receptores de glutamato metabotrópicos |
| US8697689B2 (en) | 2008-10-16 | 2014-04-15 | Janssen Pharmaceuticals, Inc. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| MX2011005242A (es) | 2008-11-28 | 2011-09-06 | Ortho Mcneil Janssen Pharm | Derivados de indol y benzoxazina como moduladores de los receptores de glutamato metabotropicos. |
| CA2760259C (fr) | 2009-05-12 | 2018-05-01 | Janssen Pharmaceuticals, Inc. | Derives de la 1,2,4-triazolo [4,3-a] pyridine et leur utilisation en tant que modulateurs allosteriques positifs des recepteurs mglur2 |
| MY161325A (en) | 2009-05-12 | 2017-04-14 | Janssen Pharmaceuticals Inc | 1, 2, 4-triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| JP5996532B2 (ja) | 2010-07-15 | 2016-09-21 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 有害生物防除剤としての新規複素環式化合物 |
| WO2012059431A1 (fr) | 2010-11-01 | 2012-05-10 | Abbott Gmbh & Co. Kg | Composés de type benzènesulfonyle ou sulfonamide appropriés pour le traitement de troubles qui répondent à la modulation du récepteur 5-ht6 de la sérotonine |
| WO2012059432A1 (fr) | 2010-11-01 | 2012-05-10 | Abbott Gmbh & Co. Kg | Composés de type n-phényl-(homo)pipérazinyl-benzènesulfonyle ou benzènesulfonamide appropriés pour le traitement de troubles qui répondent à la modulation du récepteur 5-ht6 |
| ES2536433T3 (es) | 2010-11-08 | 2015-05-25 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
| CN103298809B (zh) | 2010-11-08 | 2016-08-31 | 杨森制药公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| JP5852664B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
| JP6240063B2 (ja) | 2011-04-28 | 2017-11-29 | ザ ブロード インスティテュート， インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
| JP5790195B2 (ja) * | 2011-06-22 | 2015-10-07 | セントラル硝子株式会社 | ピラゾール化合物の製造方法 |
| WO2013033246A2 (fr) | 2011-08-29 | 2013-03-07 | Braincells, Inc. | Nouveaux benzodiazépinones en tant que modulateurs de fonctions d'un récepteur métabotropique du glutamate, et utilisations neurologiques de ceux-ci |
| US9790184B2 (en) | 2012-07-27 | 2017-10-17 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
| AU2013336863A1 (en) | 2012-10-23 | 2015-03-19 | F. Hoffmann-La Roche Ag | MGlu2/3 antagonists for the treatment of autistic disorders |
| WO2014100438A1 (fr) | 2012-12-20 | 2014-06-26 | The Broad Institute, Inc. | Dérivés d'acide hydroxamique cycloalcényle et leurs utilisations en tant qu'inhibiteurs de l'histone désacétylase |
| ES2696700T3 (es) * | 2012-12-28 | 2019-01-17 | Crystalgenomics Inc | Derivado de 2,3-dihidro-isoindol-1-on como supresor de quinasa BTK y composición farmacéutica que incluye el mismo |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| WO2015110435A1 (fr) | 2014-01-21 | 2015-07-30 | Janssen Pharmaceutica Nv | Combinaisons comprenant des modulateurs allostériques positifs ou des agonistes orthostériques de sous-type 2 de récepteur glutamatergique métabotrope, et leur utilisation |
| ME03518B (fr) | 2014-01-21 | 2020-04-20 | Janssen Pharmaceutica Nv | Combinaisons comprenant des modulateurs allostériques positifs de sous-type 2 de récepteurs glutamatergiques métabotropes et leur utilisation |
| EP3828173B1 (fr) | 2014-03-07 | 2022-08-31 | BioCryst Pharmaceuticals, Inc. | Pyrazoles substitués en tant qu`inhibiteurs de la kallicréine plasmatique humaine |
| KR20160143853A (ko) * | 2014-04-23 | 2016-12-14 | 에프. 호프만-라 로슈 아게 | 지적 장애의 치료를 위한 mglu2/3 길항제 |
| WO2015191630A1 (fr) | 2014-06-10 | 2015-12-17 | Sanford-Burnham Medical Research Institute | Modulateurs allostériques négatifs (nam) du récepteur métabotropique du glutamate et utilisations de ceux-ci |
| CN108727345B (zh) * | 2017-04-25 | 2023-06-27 | 广东东阳光药业有限公司 | 一种咪唑环中间体的制备方法 |
| CN108586447B (zh) * | 2018-01-19 | 2021-01-29 | 中国人民解放军第四军医大学 | 一种苯二氮杂卓化合物及其制备方法和应用 |
| AU2020289465A1 (en) * | 2019-06-06 | 2021-12-09 | Arcus Biosciences, Inc. | Processes for preparing aminopyrimidine compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1210338A2 (fr) * | 1999-08-05 | 2002-06-05 | IGT Pharma Inc. | Derives de 1,4 benzodiazepine utiles dans le traitement de maladies liees au systeme nerveux central |
| RU2259360C2 (ru) * | 1999-10-15 | 2005-08-27 | Ф.Хоффманн-Ля Рош Аг | Производные бензодиазепина и лекарственное средство, их содержащее |
| DK1224175T3 (da) * | 1999-10-15 | 2004-07-12 | Hoffmann La Roche | Benzodiazepinderivater som metabotropiske glutamatreceptorantagonister |
-
2002
- 2002-04-02 AU AU2002312788A patent/AU2002312788B2/en not_active Ceased
- 2002-04-02 EP EP02737911A patent/EP1379511B1/fr not_active Expired - Lifetime
- 2002-04-02 WO PCT/EP2002/003644 patent/WO2002083652A1/fr active IP Right Grant
- 2002-04-02 BR BR0208891-6A patent/BR0208891A/pt not_active Application Discontinuation
- 2002-04-02 YU YU79003A patent/YU79003A/sh unknown
- 2002-04-02 ES ES02737911T patent/ES2246012T3/es not_active Expired - Lifetime
- 2002-04-02 HU HU0400851A patent/HUP0400851A3/hu unknown
- 2002-04-02 NZ NZ528315A patent/NZ528315A/en unknown
- 2002-04-02 CN CNB028081811A patent/CN1264825C/zh not_active Expired - Fee Related
- 2002-04-02 AT AT02737911T patent/ATE299868T1/de not_active IP Right Cessation
- 2002-04-02 DE DE60205100T patent/DE60205100T2/de not_active Expired - Lifetime
- 2002-04-02 SK SK1368-2003A patent/SK13682003A3/sk unknown
- 2002-04-02 MX MXPA03009311A patent/MXPA03009311A/es active IP Right Grant
- 2002-04-02 DK DK02737911T patent/DK1379511T3/da active
- 2002-04-02 JP JP2002581408A patent/JP4071115B2/ja not_active Expired - Fee Related
- 2002-04-02 SI SI200230163T patent/SI1379511T1/xx unknown
- 2002-04-02 KR KR1020037013300A patent/KR100566171B1/ko not_active IP Right Cessation
- 2002-04-02 IL IL15787302A patent/IL157873A0/xx active IP Right Grant
- 2002-04-02 PT PT02737911T patent/PT1379511E/pt unknown
- 2002-04-02 CZ CZ20033003A patent/CZ20033003A3/cs unknown
- 2002-04-02 CA CA002442557A patent/CA2442557C/fr not_active Expired - Fee Related
- 2002-04-02 RU RU2003130637/04A patent/RU2263112C2/ru not_active IP Right Cessation
- 2002-04-02 PL PL02367064A patent/PL367064A1/xx not_active Application Discontinuation
- 2002-04-03 US US10/115,826 patent/US6544985B2/en not_active Expired - Fee Related
- 2002-04-09 PA PA20028543301A patent/PA8543301A1/es unknown
- 2002-04-09 AR ARP020101290A patent/AR035816A1/es not_active Application Discontinuation
- 2002-04-10 PE PE2002000291A patent/PE20021041A1/es not_active Application Discontinuation
- 2002-04-10 JO JO200232A patent/JO2285B1/en active
- 2002-04-11 UY UY27258A patent/UY27258A1/es not_active Application Discontinuation
- 2002-04-11 GT GT200200073A patent/GT200200073A/es unknown
- 2002-04-11 MY MYPI20021345A patent/MY140271A/en unknown
-
2003
- 2003-09-11 IL IL157873A patent/IL157873A/en not_active IP Right Cessation
- 2003-09-16 ZA ZA200307243A patent/ZA200307243B/en unknown
- 2003-10-01 HR HR20030792A patent/HRP20030792A2/hr not_active Application Discontinuation
- 2003-10-08 EC EC2003004797A patent/ECSP034797A/es unknown
- 2003-10-08 MA MA27346A patent/MA27012A1/fr unknown
- 2003-10-10 NO NO20034576A patent/NO20034576L/no not_active Application Discontinuation
- 2003-10-10 BG BG108254A patent/BG108254A/bg unknown
-
2005
- 2005-02-24 HK HK05101555A patent/HK1068888A1/xx not_active IP Right Cessation
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| MA26782A1 (fr) | Pyrazolobenzodiazepines en tant qu'inhibiteurs de cdk2. | |
| DZ3443A1 (fr) | Derives de 3-aroylindole et leur utilisation en tant qu'agonistes des recepteurs cb2 | |
| MA26932A1 (fr) | Derives d'imidazole. | |
| MA26936A1 (fr) | Derives de 3-indolyl-4 phenyl-1h-pyrrole-2,5-dione en tant qu'inhibiteurs de glycogene synthase kinase-3 beta | |
| MA26831A1 (fr) | Derives de benzodiazepine." | |
| FR07C0057I2 (fr) | Derives de pleuromutiline utilises comme agents antimicrobiens | |
| DZ3439A1 (fr) | Derives de 2-aminocarbonyl-9h-purine | |
| AR028596A1 (es) | Nuevos derivados de fenilglicina | |
| MA26958A1 (fr) | Derives de 2-phenylaminoimidazoline phenyl cetone substituee en tant qu'antagonistes ip | |
| MA27046A1 (fr) | Nouveaux derives d'oxazolidinones en tant qu'agents antibacteriens. | |
| BR0014775B1 (pt) | misturas antimicrobianas de 1,3-bis (hidroximetil) -5,5-dimetilidantoina e 1,2-benzisotiazolin-3-ona. | |
| FR2810318B1 (fr) | Derives de diamano-phenothiazine | |
| AR028607A1 (es) | Derivados de 1,4-diazepan-2,5-diona | |
| PT1322592E (pt) | Derivados substituidos de 1-aminobutan-3-ol | |
| PT1246793E (pt) | Derivados substituidos de aminometilfenilciclo-hexano | |
| MA27240A1 (fr) | Derives d'imidazoquinoleine | |
| PT1178984E (pt) | Derivados de 1-trifluorometil-4-hidroxi-7-piperidinilamimometilcromano | |
| ES1045112Y (es) | Pieza base para la fabricacion de gafas. | |
| FR2806909B3 (fr) | Composition detergente pour l'hygiene personnelle, a haute teneur en vitamine e ou en derives de cette derniere | |
| ES1048243Y (es) | Maquina para la prepoda de arboles. | |
| ITRM20000434A0 (it) | Procedimento per la preparazione di 9,10-diidro-pirrolo [2,1-b] [1,3]benzotiazepine 9-ammino sostituite. |