AR035816A1 - Compuestos derivados de dihidro-benzo[b][1,4]diazepin-2-ona, su uso, un proceso para prepararlos y medicamentos que los contienen. - Google Patents
Compuestos derivados de dihidro-benzo[b][1,4]diazepin-2-ona, su uso, un proceso para prepararlos y medicamentos que los contienen.Info
- Publication number
- AR035816A1 AR035816A1 ARP020101290A ARP020101290A AR035816A1 AR 035816 A1 AR035816 A1 AR 035816A1 AR P020101290 A ARP020101290 A AR P020101290A AR P020101290 A ARP020101290 A AR P020101290A AR 035816 A1 AR035816 A1 AR 035816A1
- Authority
- AR
- Argentina
- Prior art keywords
- fluoro
- lower alkyl
- alkoxy
- substituted
- cyano
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Compuestos derivados de dihidro-benzo[b][1,4] diazepin-2-ona de la fórmula general (1) en donde X es un enlace simple o un grupo etinodiilo; en donde en el caso X es un enlace simple, R1 es ciano, halógeno, alquilo inferior, C3-6-cicloalquilo, alcoxilo inferior, fluoro-alcoxilo inferior, fluoro-alquilo inferior, o es pirrol-1-ilo, que no está sustituido o está sustituido por uno a tres sustituyentes seleccionados del grupo consistente en fluoro, cloro, ciano, -(CH2)1-4-hidroxilo, fluoro-alquilo inferior, alquilo inferior, -(CH2)n-alcoxilo inferior, -(CH2)n-C(O)O-R", -(CH2)1-4NR'R'', hidroxi-alcoxilo inferior, y -(CH2)n-CONR'R'', o es fenilo que no está sustituido o está sustituido por uno o dos sustituyentes seleccionados del grupo consistente en halógeno, alquilo inferior, fluoro-alquilo inferior, alcoxilo inferior, fluoro-alcoxilo inferior y ciano; en el caso X es un grupo etinodiilo, R1 es fenilo, que no está sustituido o está sustituido por uno a tres sustituyentes seleccionados del grupo consistente en halógeno, alquilo inferior, fluoro-alquilo inferior, C3-6-cicloalquilo, alcoxilo inferior y fluoro-alcoxilo inferior; R2 es -NR'R'', fluoro-alcoxilo inferior o 3-oxo-piperazin-1-ilo, pirrolidin-1-ilo o piperidin-1-ilo, cuyos anillos están opcionalmente sustituidos por R'; R' es hidrógeno, alquilo inferior, C3-6-cicloalquilo, fluoro-alquilo inferior o 2-alcoxilo inferior alquilo inferior; R" es hidrógeno, alquilo inferior, C3-6-cicloalquilo, fluoro-alquilo inferior, 2-alcoxilo inferior alquilo inferior, -(CH2)2-4-di-alquilamino inferior, -(CH2)2-4-morfolinilo, -(CH2)2-4-pirrolidinilo, -(CH2)2-4-piperidinilo o 3-hidroxi-alquilo inferior; Y es -CH= o =N-; R3 es halógeno, alquilo inferior, fluoro-alquilo inferior, alcoxilo inferior, ciano, -(CH2)nC(O)-OR", -(CH2)n-C(O)-NR'R", o es un heterociclo aromático de cinco miembros opcionalmente sustituido que puede estar sustituido por halógeno, fluoro-alquilo inferior, fluoro-alcoxilo inferior, ciano, -(CH2)n-NR'R",-(CH2)n-C(O)-OR", -(CH2)n-C(O)-NR'R", -(CH2)n-SO2-NR'R", -(CH2)n-C(NH2)=NR'', hidroxilo, alcoxilo inferior, alquiltio inferior, o por alquilo inferior, que está opcionalmente sustituido por fluoro, hidroxilo, alcoxilo inferior, ciano o carbamoiloxilo; n es 0, 1, 2, 3 o 4; y sus sales de adición farmacéuticamente aceptables. Medicamentos que contienen estos compuestos, un proceso para su preparación y su uso para la preparación de medicamentos para el tratamiento o prevención de trastornos neurológicos agudos y/o crónicos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01109125 | 2001-04-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR035816A1 true AR035816A1 (es) | 2004-07-14 |
Family
ID=8177126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020101290A AR035816A1 (es) | 2001-04-12 | 2002-04-09 | Compuestos derivados de dihidro-benzo[b][1,4]diazepin-2-ona, su uso, un proceso para prepararlos y medicamentos que los contienen. |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US6544985B2 (es) |
| EP (1) | EP1379511B1 (es) |
| JP (1) | JP4071115B2 (es) |
| KR (1) | KR100566171B1 (es) |
| CN (1) | CN1264825C (es) |
| AR (1) | AR035816A1 (es) |
| AT (1) | ATE299868T1 (es) |
| AU (1) | AU2002312788B2 (es) |
| BG (1) | BG108254A (es) |
| BR (1) | BR0208891A (es) |
| CA (1) | CA2442557C (es) |
| CZ (1) | CZ20033003A3 (es) |
| DE (1) | DE60205100T2 (es) |
| DK (1) | DK1379511T3 (es) |
| EC (1) | ECSP034797A (es) |
| ES (1) | ES2246012T3 (es) |
| GT (1) | GT200200073A (es) |
| HK (1) | HK1068888A1 (es) |
| HR (1) | HRP20030792A2 (es) |
| HU (1) | HUP0400851A3 (es) |
| IL (2) | IL157873A0 (es) |
| JO (1) | JO2285B1 (es) |
| MA (1) | MA27012A1 (es) |
| MX (1) | MXPA03009311A (es) |
| MY (1) | MY140271A (es) |
| NO (1) | NO20034576L (es) |
| NZ (1) | NZ528315A (es) |
| PA (1) | PA8543301A1 (es) |
| PE (1) | PE20021041A1 (es) |
| PL (1) | PL367064A1 (es) |
| PT (1) | PT1379511E (es) |
| RU (1) | RU2263112C2 (es) |
| SI (1) | SI1379511T1 (es) |
| SK (1) | SK13682003A3 (es) |
| UY (1) | UY27258A1 (es) |
| WO (1) | WO2002083652A1 (es) |
| YU (1) | YU79003A (es) |
| ZA (1) | ZA200307243B (es) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE261945T1 (de) | 1999-10-15 | 2004-04-15 | Hoffmann La Roche | Benzodiazepinderivate und deren verwendung als metabotrope glutamatrezeptor antagonisten |
| AU2002359923B2 (en) * | 2001-12-27 | 2007-12-20 | Taisho Pharmaceutical Co., Ltd. | 6-fluorobicyclo[3.1.0]hexane derivatives |
| EP1925614A1 (en) * | 2002-03-28 | 2008-05-28 | Wisys Technology Foundation, Inc. | Anxiolytic agents with reduced sedative and ataxic effects |
| JP2005525392A (ja) | 2002-03-28 | 2005-08-25 | ウィシス テクノロジー ファウンデーション，インコーポレイティド | 減少された鎮静及び失調効果を有する抗不安薬剤 |
| DK1651234T3 (da) * | 2003-07-25 | 2008-01-28 | Hoffmann La Roche | Kombination af en mglur2-antagonist og ache-inhibitor til behandling af akutte og/eller kroniske neurologiske lidelser |
| US7329662B2 (en) | 2003-10-03 | 2008-02-12 | Hoffmann-La Roche Inc. | Pyrazolo-pyridine |
| US20060160823A1 (en) * | 2004-05-28 | 2006-07-20 | Leonore Witchey-Lakshmanan | Particulate-stabilized injectable pharmaceutical compositions of Posaconazole |
| ES2365406T3 (es) | 2005-02-11 | 2011-10-04 | F. Hoffmann-La Roche Ag | Derivados de pirazolo-pirimidina como antagonistas de mglur2. |
| CN101180299B (zh) | 2005-03-23 | 2010-12-15 | 弗·哈夫曼-拉罗切有限公司 | 作为mglur2拮抗剂的乙炔基-吡唑并嘧啶衍生物 |
| CN101248060B (zh) * | 2005-06-23 | 2014-09-10 | 阵列生物制药公司 | 用于制备苯并咪唑化合物的方法 |
| ES2340321T3 (es) | 2005-09-27 | 2010-06-01 | F.Hoffmann-La Roche Ag | Oxadiazolilpirazolo-pirimidinas, como antagonistas de mglur2. |
| GB0600228D0 (en) * | 2006-01-06 | 2006-02-15 | Fermentas Uab | Inactivation method |
| TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途 |
| TW200808751A (en) * | 2006-04-13 | 2008-02-16 | Astrazeneca Ab | New compounds |
| WO2008034735A2 (en) * | 2006-09-20 | 2008-03-27 | F. Hoffmann-La Roche Ag | 4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine derivatives |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| EP2137167B1 (en) | 2007-04-19 | 2011-08-10 | F. Hoffmann-La Roche AG | Dihydro-benzo[b][1,4]diazepin-2-one sulfonamide derivatives |
| CA2698929C (en) * | 2007-09-14 | 2016-01-19 | Addex Pharma S.A. | 1,3-disubstituted-4-phenyl-1h-pyridin-2-ones |
| ATE496906T1 (de) | 2007-09-14 | 2011-02-15 | Ortho Mcneil Janssen Pharm | 1',3'-disubstituierte 4-phenyl-3,4,5,6-tetrahydro-2h,1'h-ä1,4'übipyri inyl-2'-one |
| AU2008297876B2 (en) | 2007-09-14 | 2011-07-07 | Addex Pharma S.A. | 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones |
| CN101861316B (zh) | 2007-11-14 | 2013-08-21 | 奥梅-杨森制药有限公司 | 咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| CA2735764C (en) | 2008-09-02 | 2016-06-14 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
| AU2009304293B2 (en) | 2008-10-16 | 2012-04-26 | Addex Pharma S.A. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| US8691813B2 (en) | 2008-11-28 | 2014-04-08 | Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
| RS53075B (en) | 2009-05-12 | 2014-04-30 | Janssen Pharmaceuticals Inc. | 1,2,4-TRIAZOLO [4,3-A] PYRIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| CA2760259C (en) | 2009-05-12 | 2018-05-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| CN104086528A (zh) | 2010-07-15 | 2014-10-08 | 拜耳知识产权有限责任公司 | 作为杀虫剂的新杂环化合物 |
| WO2012059431A1 (en) | 2010-11-01 | 2012-05-10 | Abbott Gmbh & Co. Kg | Benzenesulfonyl or sulfonamide compounds suitable for treating disorders that respond to the modulation of the serotonin 5-ht6 receptor |
| WO2012059432A1 (en) | 2010-11-01 | 2012-05-10 | Abbott Gmbh & Co. Kg | N-phenyl-(homo)piperazinyl-benzenesulfonyl or benzenesulfonamide compounds suitable for treating disorders that respond to the modulation of the 5-ht6 receptor |
| EP2643320B1 (en) | 2010-11-08 | 2015-03-04 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
| EP2661435B1 (en) | 2010-11-08 | 2015-08-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
| PL2649069T3 (pl) | 2010-11-08 | 2016-01-29 | Janssen Pharmaceuticals Inc | Pochodne 1,2,4-triazolo[4,3-a]pirydyny i ich zastosowanie jako dodatnich allosterycznych modulatorów receptorów mGluR2 |
| JP6240063B2 (ja) | 2011-04-28 | 2017-11-29 | ザ ブロード インスティテュート， インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
| JP5790195B2 (ja) * | 2011-06-22 | 2015-10-07 | セントラル硝子株式会社 | ピラゾール化合物の製造方法 |
| CA2847247C (en) | 2011-08-29 | 2019-10-15 | Sanford-Burnham Medical Research Institute | Benzodiazepinones as modulators of metabotropic glutamate receptor functions and neurological uses thereof |
| CA2880117C (en) | 2012-07-27 | 2021-04-06 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
| MX2015004604A (es) | 2012-10-23 | 2015-10-08 | Hoffmann La Roche | Antagonistas de los receptores metabotropicos de glutamato 2/3 (mglu2/3) para el tratamiento de los trastornos autistas. |
| WO2014100438A1 (en) | 2012-12-20 | 2014-06-26 | The Broad Institute, Inc. | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors |
| MX2015008396A (es) * | 2012-12-28 | 2016-04-15 | Crystalgenomics Inc | Derivados de la 2,3-dihidro-isoindol-1-ona, como inhibidores de la btk quinasa y composiciones farmacéuticas que los incluyen. |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| KR20200126026A (ko) | 2014-01-21 | 2020-11-05 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
| CN109999033B (zh) | 2014-01-21 | 2022-12-23 | 詹森药业有限公司 | 包括代谢型谷氨酸能受体亚型2的正别构调节物或正位激动剂的组合及其用途 |
| DK3828173T3 (da) | 2014-03-07 | 2022-11-07 | Biocryst Pharm Inc | Substituerede pyrazoler som humant plasma-kallikreininhibitorer |
| CN106132966A (zh) | 2014-04-23 | 2016-11-16 | 豪夫迈·罗氏有限公司 | 用于治疗智力残疾的mglu2/3拮抗剂 |
| US9969726B2 (en) | 2014-06-10 | 2018-05-15 | Sanford-Burnham Medical Research Institute | Metabotropic glutamate receptor negative allosteric modulators (NAMS) and uses thereof |
| CN108727345B (zh) * | 2017-04-25 | 2023-06-27 | 广东东阳光药业有限公司 | 一种咪唑环中间体的制备方法 |
| CN108586447B (zh) * | 2018-01-19 | 2021-01-29 | 中国人民解放军第四军医大学 | 一种苯二氮杂卓化合物及其制备方法和应用 |
| JP2022534561A (ja) * | 2019-06-06 | 2022-08-02 | アーカス バイオサイエンシズ インコーポレイティド | アミノピリミジン化合物の調製方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA02001340A (es) * | 1999-08-05 | 2004-07-16 | Prescient Neuropharma Inc | Compuestos novedosos 1,4-benzodiazepina y derivados de los mismos. |
| ATE261945T1 (de) * | 1999-10-15 | 2004-04-15 | Hoffmann La Roche | Benzodiazepinderivate und deren verwendung als metabotrope glutamatrezeptor antagonisten |
| BR0014859A (pt) * | 1999-10-15 | 2002-07-16 | Hoffmann La Roche | Derivados de benzodiazepina |
-
2002
- 2002-04-02 NZ NZ528315A patent/NZ528315A/en unknown
- 2002-04-02 EP EP02737911A patent/EP1379511B1/en not_active Expired - Lifetime
- 2002-04-02 PL PL02367064A patent/PL367064A1/xx not_active Application Discontinuation
- 2002-04-02 DE DE60205100T patent/DE60205100T2/de not_active Expired - Lifetime
- 2002-04-02 CZ CZ20033003A patent/CZ20033003A3/cs unknown
- 2002-04-02 JP JP2002581408A patent/JP4071115B2/ja not_active Expired - Fee Related
- 2002-04-02 WO PCT/EP2002/003644 patent/WO2002083652A1/en active IP Right Grant
- 2002-04-02 PT PT02737911T patent/PT1379511E/pt unknown
- 2002-04-02 SI SI200230163T patent/SI1379511T1/xx unknown
- 2002-04-02 MX MXPA03009311A patent/MXPA03009311A/es active IP Right Grant
- 2002-04-02 IL IL15787302A patent/IL157873A0/xx active IP Right Grant
- 2002-04-02 DK DK02737911T patent/DK1379511T3/da active
- 2002-04-02 RU RU2003130637/04A patent/RU2263112C2/ru not_active IP Right Cessation
- 2002-04-02 ES ES02737911T patent/ES2246012T3/es not_active Expired - Lifetime
- 2002-04-02 YU YU79003A patent/YU79003A/sh unknown
- 2002-04-02 CN CNB028081811A patent/CN1264825C/zh not_active Expired - Fee Related
- 2002-04-02 HU HU0400851A patent/HUP0400851A3/hu unknown
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2005
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