ES2133544T3 - Derivados de indazol. - Google Patents

Derivados de indazol.

Info

Publication number
ES2133544T3
ES2133544T3 ES94909209T ES94909209T ES2133544T3 ES 2133544 T3 ES2133544 T3 ES 2133544T3 ES 94909209 T ES94909209 T ES 94909209T ES 94909209 T ES94909209 T ES 94909209T ES 2133544 T3 ES2133544 T3 ES 2133544T3
Authority
ES
Spain
Prior art keywords
dopam
formula
indazol
derivatives
indazol derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94909209T
Other languages
English (en)
Inventor
Raymond Baker
Janusz Jozef Kulagowski
Paul David Leeson
Adrian Leonard Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Application granted granted Critical
Publication of ES2133544T3 publication Critical patent/ES2133544T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

UNA CLASE DE COMPUESTOS QUIMICOS QUE CONTIENEN UNA MITAD DE 1HINDAZOLA Y UNA MITAD SUSTITUIDA HETEROCICLICA, ENLAZADAS POR LAS 3-POSICIONES DE LA MITAD DE INDAZOLA MEDIANTE UN GRUPO METILENO, QUE SON LIGANDOS PARA LOS SUBTIPOS RECEPTORES DE DOPAMINA EN EL CUERPO Y SON POR TANTO UTILES EN EL TRATAMIENTO Y/O PREVENCION DE DESORDENES DEL SISTEMA DE DOPAMINA, EN PARTICULAR LA ESQUIZOFRENIA. EN DICHA FORMULA (I), R REPRESENTA HIDROGENO O ALQUIL C{SUB,1-6}, Q REPRESENTA UNA MITAD DE LA FORMULA QA, QB O QC.
ES94909209T 1993-03-18 1994-03-14 Derivados de indazol. Expired - Lifetime ES2133544T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939305641A GB9305641D0 (en) 1993-03-18 1993-03-18 Therapeutic agents

Publications (1)

Publication Number Publication Date
ES2133544T3 true ES2133544T3 (es) 1999-09-16

Family

ID=10732323

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94909209T Expired - Lifetime ES2133544T3 (es) 1993-03-18 1994-03-14 Derivados de indazol.

Country Status (10)

Country Link
US (1) US5665732A (es)
EP (1) EP0701555B1 (es)
JP (1) JPH08507780A (es)
AT (1) ATE182891T1 (es)
AU (1) AU679214B2 (es)
CA (1) CA2156839A1 (es)
DE (1) DE69419917T2 (es)
ES (1) ES2133544T3 (es)
GB (1) GB9305641D0 (es)
WO (1) WO1994021626A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9305623D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
TW421649B (en) * 1995-01-31 2001-02-11 Janssen Pharmaceutica Nv 4-(1H-indol-1yl)-1-piperidinyl derivatives
GB9523462D0 (en) * 1995-11-16 1996-01-17 Merck Sharp & Dohme Therapeutic agents
US6187774B1 (en) * 1996-03-04 2001-02-13 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and pharmaceutical applications thereof
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
AU6246198A (en) * 1997-02-18 1998-09-08 American Home Products Corporation 4-aminoethoxyindazole derivatives
US5872144A (en) * 1997-02-18 1999-02-16 American Home Products Corporation 4-aminoethoxyindazole derivatives
BR9911843A (pt) 1998-06-19 2001-03-20 Lundbeck & Co As H 4 5 6 7-indol e derivados de indolina, preparação e utilização dos mesmos
HUP0101475A3 (en) * 1998-06-19 2003-01-28 Lundbeck & Co As H 4,5,6 and 7-indole and indoline derivatives, their preparation and use
KR100704710B1 (ko) * 1999-10-29 2007-04-09 주식회사 중외제약 간 섬유화 억제작용을 나타내는 벤조[3,4-ｄ]1,3-디옥솔란 유도체
US7094790B2 (en) 2003-05-07 2006-08-22 Abbott Laboratories Fused bicyclic-substituted amines as histamine-3 receptor ligands
DE102004005172A1 (de) * 2004-02-02 2005-08-18 Aventis Pharma Deutschland Gmbh Indazolderivate als Inhibitoren der Hormon Sensitiven Lipase
CA2743864A1 (en) * 2008-11-25 2010-06-10 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
WO2017178377A1 (en) * 2016-04-13 2017-10-19 Ucb Biopharma Sprl Tetrahydroisoquinoline derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3488353A (en) * 1967-05-29 1970-01-06 Sterling Drug Inc New 1-((2-azaindolyl)-lower-alkyl) 4-substituted-piperazines
US3678059A (en) * 1969-10-07 1972-07-18 Ciba Geigy Corp 3-aminoalkylidene-indazoles
US5116846A (en) * 1990-03-28 1992-05-26 Du Pont Merck Pharmaceutical Company N-aralkyl piperidine derivatives as psychotropic drugs
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
FR2692901B1 (fr) * 1992-06-26 1994-08-19 Cray Valley Sa Résines et compositions pour la fabrication de matériaux de haut module résistants à la chaleur et articles moulés obtenus à partir de ces matériaux.
HUT71799A (en) * 1993-03-01 1996-02-28 Merck Sharp & Dohme Pyrrolo-pyridine derivatives, pharmaceutical compositions containing the same, process for producing them

Also Published As

Publication number Publication date
WO1994021626A1 (en) 1994-09-29
CA2156839A1 (en) 1994-09-29
ATE182891T1 (de) 1999-08-15
EP0701555A1 (en) 1996-03-20
JPH08507780A (ja) 1996-08-20
AU6213994A (en) 1994-10-11
DE69419917D1 (de) 1999-09-09
DE69419917T2 (de) 2000-02-24
US5665732A (en) 1997-09-09
GB9305641D0 (en) 1993-05-05
AU679214B2 (en) 1997-06-26
EP0701555B1 (en) 1999-08-04

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