MA20150350A1 - Dérivés isoxazolidine - Google Patents

Dérivés isoxazolidine

Info

Publication number
MA20150350A1
MA20150350A1 MA37927A MA37927A MA20150350A1 MA 20150350 A1 MA20150350 A1 MA 20150350A1 MA 37927 A MA37927 A MA 37927A MA 37927 A MA37927 A MA 37927A MA 20150350 A1 MA20150350 A1 MA 20150350A1
Authority
MA
Morocco
Prior art keywords
isoxazolidine
derivatives
relates
compounds
glucocorticosteroids
Prior art date
Application number
MA37927A
Other languages
English (en)
Other versions
MA37927B2 (fr
Inventor
Eleonora Ghidini
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47044778&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA20150350(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of MA20150350A1 publication Critical patent/MA20150350A1/fr
Publication of MA37927B2 publication Critical patent/MA37927B2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0057—Nitrogen and oxygen
    • C07J71/0068—Nitrogen and oxygen at position 16(17)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Otolaryngology (AREA)

Abstract

La présente invention concerne de nouveaux composés anti-inflammatoires et antiallergiques de la série des glucocorticostéroïdes, des méthodes de préparation de ces composés, des compositions pharmaceutiques les comprenant, des combinaisons et des usages thérapeutiques de ceux-ci. Plus particulièrement, l'invention porte sur des glucocorticostéroïdes qui sont des dérivés isoxazolidine.
MA37927A 2012-09-13 2013-08-23 Dérivés isoxazolidine MA37927B2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12184286 2012-09-13
PCT/EP2013/067509 WO2014040837A1 (fr) 2012-09-13 2013-08-23 Dérivés isoxazolidine

Publications (2)

Publication Number Publication Date
MA20150350A1 true MA20150350A1 (fr) 2015-10-30
MA37927B2 MA37927B2 (fr) 2021-08-31

Family

ID=47044778

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37927A MA37927B2 (fr) 2012-09-13 2013-08-23 Dérivés isoxazolidine

Country Status (28)

Country Link
US (2) US9155747B2 (fr)
EP (1) EP2895495B1 (fr)
JP (2) JP2015533801A (fr)
KR (1) KR101719524B1 (fr)
CN (2) CN104619714A (fr)
AR (1) AR092547A1 (fr)
AU (1) AU2013314539B2 (fr)
BR (1) BR112015005500B1 (fr)
CA (1) CA2884705C (fr)
CL (1) CL2015000610A1 (fr)
EA (1) EA027034B1 (fr)
ES (1) ES2672140T3 (fr)
GE (1) GEP201706708B (fr)
HK (1) HK1209756A1 (fr)
IL (1) IL237686A (fr)
MA (1) MA37927B2 (fr)
MX (1) MX364865B (fr)
MY (1) MY182523A (fr)
NZ (1) NZ705902A (fr)
PE (1) PE20150675A1 (fr)
PH (1) PH12015500534A1 (fr)
PL (1) PL2895495T3 (fr)
SA (1) SA515360134B1 (fr)
SG (1) SG11201501902RA (fr)
TN (1) TN2015000093A1 (fr)
UA (1) UA116545C2 (fr)
WO (1) WO2014040837A1 (fr)
ZA (1) ZA201501691B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI658047B (zh) 2011-03-15 2019-05-01 吉斯藥品公司 異唑啶衍生物
WO2019071147A1 (fr) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. Inhibiteurs de la kinase p38 réduisant l'expression du gène dux4 et des gènes aval pour le traitement de la fshd
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
CN115785188B (zh) * 2022-12-20 2024-06-07 湖南科益新生物医药有限公司 一种布地奈德的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL31997A (en) * 1968-05-03 1974-03-14 Lepetit Spa Process for the preparation of pregnano(17alpha,16alpha-d)oxazolines and 16alpha,21-dihydroxy-17alpha-aminopregnanes
SE378110B (fr) * 1972-05-19 1975-08-18 Bofors Ab
JPS617293A (ja) * 1984-06-20 1986-01-13 Mitsubishi Chem Ind Ltd 新規なコルチコイド誘導体およびその製法
US5888995A (en) * 1991-02-04 1999-03-30 Astra Aktiebolag Steroid esters
AU2003217535A1 (en) * 2002-02-20 2003-09-09 Sepracor Inc. Carbonate and carbamate modified forms of glucocorticoids
WO2005028495A1 (fr) * 2003-09-24 2005-03-31 Glaxo Group Limited Glucocorticoïdes anti-inflammatoires
NO331891B1 (no) * 2007-03-20 2012-04-30 Clavis Pharma Asa Kjemiske forbindelser, et farmasoytisk preparat inneholdende slike forbindelser, samt anvendelse derav for behandling av kreft, inflammasjon og KOLS
MX2010009022A (es) * 2008-02-27 2010-09-07 Astrazeneca Ab Derivados 16 alfa, 17 alfa-acetal glucocorticoesteroideos y su uso.
KR101451486B1 (ko) * 2009-09-11 2014-10-22 키에시 파르마슈티시 엣스. 피. 에이. N-치환된 이속사졸리딘 링과 함께 16, 17 위치 내에 응축된 항염증제로서의 프레그난 유도체
TW201139369A (en) 2010-02-05 2011-11-16 Chiesi Farma Spa Pyrrolidine derivatives
CA2829982A1 (fr) 2011-03-15 2012-09-20 Chiesi Farmaceutici S.P.A. Derives d'isoxazolidine
TWI658047B (zh) 2011-03-15 2019-05-01 吉斯藥品公司 異唑啶衍生物
CN103814043A (zh) * 2011-08-01 2014-05-21 奇斯药制品公司 在16，17位与吡咯烷环稠合的抗炎类固醇

Also Published As

Publication number Publication date
IL237686A (en) 2017-10-31
JP2015533801A (ja) 2015-11-26
EP2895495A1 (fr) 2015-07-22
KR101719524B1 (ko) 2017-03-24
PE20150675A1 (es) 2015-05-20
PH12015500534B1 (en) 2015-05-04
MA37927B2 (fr) 2021-08-31
AU2013314539A1 (en) 2015-04-02
JP2018162270A (ja) 2018-10-18
MX364865B (es) 2019-05-09
UA116545C2 (uk) 2018-04-10
US9155747B2 (en) 2015-10-13
WO2014040837A1 (fr) 2014-03-20
JP6736607B2 (ja) 2020-08-05
SA515360134B1 (ar) 2016-07-24
EA201590390A1 (ru) 2015-08-31
BR112015005500B1 (pt) 2022-11-22
GEP201706708B (en) 2017-07-25
EA027034B1 (ru) 2017-06-30
US20140069419A1 (en) 2014-03-13
CA2884705A1 (fr) 2014-03-20
CL2015000610A1 (es) 2015-12-04
US9469669B2 (en) 2016-10-18
ES2672140T3 (es) 2018-06-12
MX2015002898A (es) 2015-06-03
ZA201501691B (en) 2016-10-26
AR092547A1 (es) 2015-04-22
NZ705902A (en) 2018-04-27
US20150376226A1 (en) 2015-12-31
AU2013314539B2 (en) 2018-03-08
EP2895495B1 (fr) 2018-05-16
BR112015005500A2 (pt) 2018-05-22
CN104619714A (zh) 2015-05-13
SG11201501902RA (en) 2015-04-29
CN108440637A (zh) 2018-08-24
HK1209756A1 (en) 2016-04-08
CA2884705C (fr) 2021-04-13
TN2015000093A1 (en) 2016-06-29
PL2895495T3 (pl) 2018-10-31
KR20150042264A (ko) 2015-04-20
MY182523A (en) 2021-01-25
PH12015500534A1 (en) 2015-05-04

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