LV11283B - Improved tangential filtration process and apparatus - Google Patents
Improved tangential filtration process and apparatus Download PDFInfo
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- LV11283B LV11283B LVP-96-59A LV960059A LV11283B LV 11283 B LV11283 B LV 11283B LV 960059 A LV960059 A LV 960059A LV 11283 B LV11283 B LV 11283B
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- filtration
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
- B01D61/146—Ultrafiltration comprising multiple ultrafiltration steps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/147—Microfiltration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/58—Reaction vessels connected in series or in parallel
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/10—Separation or concentration of fermentation products
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- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Water Supply & Treatment (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Cyclones (AREA)
- Combined Means For Separation Of Solids (AREA)
Claims (25)
- LV 11283 IZGUDROJUMA FORMULA 1. Process interesējošo daļiņu, kuru molekulārā masa ir no 1 līdz 1000 kDa, atdalīšanai no maisījuma, kas atšķiras ar to, ka šo daļiņu molekulārā masa ir mazāk kā desmit reizes lielāka vai mazāka par citu maisījuma daļiņu molekulāro masu un šajā procesā ietilpst maisījuma filtrēšana ar tangenciālās plūsmas metodi caur filtrējošo membrānu ar tādu poru izmēriem, kas nepieciešami, lai atdalītu interesējošās daļiņas no maisījuma un uzturētu filtrācijas plūsmas līmeni 5 līdz 100% diapazonā no plūsmas pārejas punktā, līknes apgabalā, kurā transmembrālais spiediens ir atkarīgs no plūsmas, tādējādi panākot vajadzīgo daļiņu selektīvu izdalīšanu no maisījuma.
- 2. Process saskaņā ar 1. punktu, kas atšķiras ar to, ka transmembrālo spiedienu uztur pēc būtības nemainīgu gar membrānu uz līmeņa, kas nav lielāks par transmembrālo spiedienu filtrācijas pārejas punktā.
- 3. Process saskaņā ar 1. punktu, kas atšķiras ar to, ka plūsmas lielums ir no 50 līdz 100% no plūsmas vērtības pārejas punktā.
- 4. Process saskaņā ar 1. punktu, kas atšķiras ar to, ka plūsmas lielums ir no 75 līdz 100% no plūsmas vērtības pārejas punktā.
- 5. Process saskaņā ar 1. punktu, kas atšķiras ar to, ka maisījums nav atšķaidīts. I
- 6. Process saskaņā ar 1. punktu, kas atšķiras ar to, ka filtrācijā izdalītos paraugus atgriež atpakaļ rezervuārā, kurā atrodas sadalāmais maisījums, un procesu atkārto.
- 7. Process saskaņā ar 1. punktu, kas ir daudzpakāpju process, kurā papildus ietilpst filtrāta filtrēšana otrajā tangenciālās plūsmas filtrācijas stadijā caur membrānu, kurai ir mazāks poru izmērs nekā membrānai, kura tiek izmantota pirmajā riltrēšanas stadijā, un otrās stadijas filtrāta atgriešana atpakaļ pirmajā filtrēšanas stadijā, sakarā ar ko šis process tiek atkārtots.
- 8. Process saskaņā ar 7. punktu, kas atšķiras ar to, ka plūsmas lielums otrajā filtrācijas stadijā ir lielāks par 100% plūsmas vērtību pārejas punktā. 2
- 9. Process saskaņā ar 8. punktu, kas atšķiras ar to, ka abas filtrēšanas stadijas ir ultrafiltrēšanas stadijas.
- 10. Process saskaņā ar 7. punktu, kurā papildus ietilpst otras filtrēšanas stadijas filtrēta filtrēšana trešajā tangenciālās plūsmas filtrēšanas stadijā caur filtrēšanas membrānu, kurai ir mazāks poru izmērs nekā tas ir otrai membrānai, un trešās filtrēšanas stadijas filtrēta atgriešana atpakaļ uz pirmo filtrēšanas stadiju, sakarā ar ko šis process tiek atkārtots.
- 11. Process saskaņā ar 10. punktu, kas atšķiras ar to, ka plūsmas lielums trešajā filtrēšanas stadijā ir lielāks par 100% plūsmas vērtību pārejas punktā.
- 12. Process saskaņā ar 11. punktu, kas atšķiras ar to, ka visas trīs filtrēšanas stadijas ir ultrafiltrēšanas stadijas.
- 13. Process saskaņā ar 1. punktu, kas atšķiras ar to, ka transmembrālais spiediens pazeminās filtrēšanas procesam virzoties uz priekšu.
- 14. Process saskaņā ar 1. punktu, kas atšķiras ar to, ka transmembrālais spiediens paliek aptuveni nemainīgs, filtrēšanas procesam virzoties uz priekšu.
- 15. Process saskaņā ar 1. punktu, kas atšķiras ar to, ka interesējošās daļiņas ir bioloģiski objekti, ko izvēlas no grupām, sastāvošām no proteīniem, polipeptīdiem, aminoskābēm, koloīdiem, mikoplazmām, endotoksīniem, vīrusiem, ogļhidrātiem, RNS un DNS.
- 16. Process saskaņā ar 15. punktu, kas atšķiras ar to, ka interesējošās daļiņas ir proteīni vai polipeptīdi.
- 17. Tangenciālās plūsmas filtrācijas aparatūra procesa realizācijai saskaņā ar vienu no 1.-16. punktiem, kurā ietilpst filtrēšanas komplekts (97), kuram ir liels daudzums slāņainu filtrēšanas un filtrēta kameru (95a), (96b), (95c), (95d), visām filtrācijas kamerām, izņemot pēdējo kameru noslāņošanas kameru rindā (virknē) (95d), ir ieplūdes ierīces (93), (107), (117) un izplūdes ierīces (101), (111), (121) šķidruma komunikācijai caur recirkulācijas līnijām, kuras savieno visas ieplūdes un izplūdes ierīces, izņemot pēdējo filtrēta kameru (95d), ar attiecīgiem atsevišķiem rezervuāriem (91), (105), (115), lai savāktu filtrētu katras filtrēta kameras izplūdes vietā, un pēdējai filtrēta kamerai (95d) ir izplūdes ierīce (125) filtrēta cirkulācijai uz 3 LV 11283 rezervuāru (91), kurš pēc šķidruma komunikācijas caur recirkulācijas līniju savieno izplūdes ierīci ar pirmo filtrācijas kameru (95a) noslāņošanās kameru rindā; katrai kamerai ir ierīces (99), (109), (119) šķidruma pārsūknēšanai no attiecīgā rezervuāra uz kameras ieplūdes ierīci, un katra kamera ir atdalīta no tai blakus esošās kameras ar filtrēšanas membrānu (103), (113), (123) palīdzību; aparatūra ir tāda, ka šķidruma plūsma no ieplūdes uz izplūdes ierīci visās kamerās ir paralēla un ar to pašu virzienu; pirmajai filtrēšanas membrānai noslāņošanās kameru rindā (103) ir tāds poru izmērs, kas aiztur vislielākās interesējošās daļiņas; pēdējai filtrēšanas membrānai noslāņošanās kameru rindā (123) ir tāds poru izmērs, kas aiztur interesējošās daļiņas ar vismazāko izmēru; vidējai(-ām) filtrēšanas membrānai(-ām) noslāņošanās kameru rindā (113) ir tāds poru izmērs, kas aiztur interesējošās daļiņas ar izmēriem, kuri ir starp pirmās un pēdējās membrānas poru izmēriem to samazināšanās kārtībā.
- 18. Aparatūra saskaņā ar 17. punktu, kas atšķiras ar to, ka katra filtrēšanas membrāna sastāv no daudzām paralēlām blakus esošām membrānām ar to pašu poru izmēru.
- 19. Aparatūra saskaņā ar 18. punktu, kas atšķiras ar to, ka katra membrāna sastāv no divām paralēlām blakus esošām membrānām ar to pašu poru izmēru.
- 20. Aparatūra saskaņā ar 17. punktu, kas atšķiras ar to, ka filtrēšanas komplekts ietver trīs kameras un divus rezervuārus.
- 21. Aparatūra saskaņā ar 17. punktu, kas atšķiras ar to, ka filtrēšanas komplekts ietver četras kameras un trīs rezervuārus.
- 22. Tangenciālās plūsmas filtrācijas aparatūra procesa realizācijai saskaņā ar vienu no 1.-16. punktiem, kurā ietilpst: (a) pirmais rezervuārs (31) šķidruma savienošanai ar pirmo filtrēšanas komplektu (37), kuram ir pirmā filtrēšanas membrāna (43), kura sadala iepriekš minēto komplektu pirmajā filtrēšanas un filtrēta kamerā (35a), (35b), iepriekš minētai filtrēšanas un filtrēta kamerai ir ieplūdes (33) un izplūdes ierīces (47); (b) ierīce (33), kas pievieno visas pirmās filtrēšanas kameras ieplūdes ierīces pirmajam rezervuāram, kura satur ierīci (39) šķidruma pārsūknēšanai no pirmā rezervuāra uz pirmās filtrēšanas kameras ieplūdi; 4 (c) ierīce (49) filtrēta recīrkulācijai caur pirmo filtrēšanas kameru tajā pašā virzienā, kā arī paralēli šķidruma plūsmai pirmajā filtrēšanas kamerā; (d) otrais rezervuārs (51) šķidruma savienošanai ar otro filtrēšanas komplektu (57), kuram ir otra filtrēšanas membrāna (63), kura sadala iepriekš minēto komplektu otrajā filtrēšanas un filtrēta kamerā (55a), (55b), iepriekš minētai filtrēšanas un filtrēta kamerai ir ieplūdes (53) un izplūdes ierīces (67); (e) ierīce filtrēta cirkulācijai no pirmās filtrēšanas kameras izplūdes ierīces uz otro rezervuāru; (f) ierīce (53), kas savieno otrās filtrēšanas kameras ieplūdes ierīci ar otro rezervuāru, kura satur ierīci (59) šķidruma pārsūknēšanai no otrā rezervuāra uz otrās filtrēšanas kameras ieplūdes ierīci; (g) ierīce (69) filtrēta recirkulācijai caur otro filtrēta kameru tajā pašā virzienā, kā arī paralēli šķidruma plūsmai otrajā filtrēšanas kamerā; (h) trešais rezervuārs (71) šķidruma savienošanai ar trešo filtrēšanas elementu (77), kuram ir trešā filtrēšanas membrāna (83), kura sadala iepriekš minēto elementu trešajā filtrēšanas un filtrēta kamerā (75a), (75b), iepriekš minētai filtrēšanas un filtrēta kamerai ir ieplūdes (73) un izplūdes (87) ierīces; (i) ierīce filtrēta cirkulācijai no otrās filtrēta kameras izplūdes ierīces uz trešo rezervuāru; (j) ierīce (73), kas savieno trešās filtrēšanas kameras ieplūdes ierīces ar trešo rezervuāru, kura satur ierīci (79) šķidruma pārsūknēšanai no trešā rezervuāra uz trešās filtrēšanas kameras ieplūdes ierīci; un (k) ierīce (85) filtrēta recirkulācijai no trešās filtrēta kameras izplūdes ierīces uz pirmo rezervuāru filtrēta savākšanai, kur pirmai filtrēšanas membrānai (43) ir tāds poru izmērs, kas aiztur interesējošās daļiņas ar vislielāko izmēru; otra filtrēšanas kamera (63) aiztur interesējošās daļiņas ar izmēru, kas ir starp pirmo un trešo filtrēšanas membrānu poru izmēru un trešai filtrēšanas membrānai (73) ir poru izmērs, kas aiztur interesējošās daļiņas ar vismazāko izmēru.
- 23. Aparatūra saskaņā ar 22. punktu, kurā papildus ietilpst ierīce (89) filtrēta recirkulācijai caur trešo filtrēta kameru tajā pašā virzienā, kā arī paralēli šķidruma plūsmai trešajā filtrēšanas kamerā.
- 24. Aparatūra saskaņā ar 22. punktu, kas atšķiras ar to, ka recirkulācijas ierīce ir sūknis.
- 25. Aparatūra saskaņā ar 22. punktu, kas atšķiras ar to, ka membrānas ir ultrafiltrācijas membrānas, kurām samazinās poru izmēri kaskādē.
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| US07/583,886 US5256294A (en) | 1990-09-17 | 1990-09-17 | Tangential flow filtration process and apparatus |
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| LV11283A LV11283A (lv) | 1996-06-20 |
| LV11283B true LV11283B (en) | 1996-12-20 |
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| EP (1) | EP0552192B1 (lv) |
| JP (2) | JP3828143B2 (lv) |
| AT (1) | ATE119063T1 (lv) |
| CA (1) | CA2089663C (lv) |
| DE (1) | DE69107855T2 (lv) |
| DK (1) | DK0552192T3 (lv) |
| ES (1) | ES2072017T3 (lv) |
| LV (1) | LV11283B (lv) |
| WO (1) | WO1992004970A1 (lv) |
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| FR2380052A1 (fr) * | 1977-02-11 | 1978-09-08 | Akzo Nv | Membrane de dialyse pour l'hemodialyse |
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-
1990
- 1990-09-17 US US07/583,886 patent/US5256294A/en not_active Expired - Lifetime
-
1991
- 1991-09-11 EP EP91917291A patent/EP0552192B1/en not_active Expired - Lifetime
- 1991-09-11 CA CA002089663A patent/CA2089663C/en not_active Expired - Lifetime
- 1991-09-11 AT AT91917291T patent/ATE119063T1/de not_active IP Right Cessation
- 1991-09-11 ES ES91917291T patent/ES2072017T3/es not_active Expired - Lifetime
- 1991-09-11 JP JP51568391A patent/JP3828143B2/ja not_active Expired - Lifetime
- 1991-09-11 DE DE69107855T patent/DE69107855T2/de not_active Expired - Lifetime
- 1991-09-11 DK DK91917291.6T patent/DK0552192T3/da active
- 1991-09-11 WO PCT/US1991/006553 patent/WO1992004970A1/en active IP Right Grant
-
1994
- 1994-07-06 US US08/271,223 patent/US5490937A/en not_active Expired - Lifetime
-
1996
- 1996-02-28 LV LVP-96-59A patent/LV11283B/en unknown
-
2003
- 2003-05-30 JP JP2003156060A patent/JP2003334425A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003334425A (ja) | 2003-11-25 |
| JPH06500730A (ja) | 1994-01-27 |
| EP0552192B1 (en) | 1995-03-01 |
| ES2072017T3 (es) | 1995-07-01 |
| US5490937A (en) | 1996-02-13 |
| ATE119063T1 (de) | 1995-03-15 |
| CA2089663C (en) | 2002-05-28 |
| DK0552192T3 (da) | 1995-07-17 |
| WO1992004970A1 (en) | 1992-04-02 |
| JP3828143B2 (ja) | 2006-10-04 |
| DE69107855D1 (de) | 1995-04-06 |
| CA2089663A1 (en) | 1992-03-18 |
| LV11283A (lv) | 1996-06-20 |
| EP0552192A1 (en) | 1993-07-28 |
| US5256294A (en) | 1993-10-26 |
| DE69107855T2 (de) | 1995-09-07 |
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