|
US8183344B2
(en)
*
|
1996-04-24 |
2012-05-22 |
University Of Michigan |
Inactivation resistant factor VIII
|
|
US7173003B2
(en)
|
2001-10-10 |
2007-02-06 |
Neose Technologies, Inc. |
Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
|
|
US7214660B2
(en)
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
|
US8791070B2
(en)
|
2003-04-09 |
2014-07-29 |
Novo Nordisk A/S |
Glycopegylated factor IX
|
|
EP2055189A1
(en)
|
2003-04-09 |
2009-05-06 |
Neose Technologies, Inc. |
Glycopegylation methods and proteins/peptides produced by the methods
|
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
|
US9005625B2
(en)
|
2003-07-25 |
2015-04-14 |
Novo Nordisk A/S |
Antibody toxin conjugates
|
|
US8633157B2
(en)
|
2003-11-24 |
2014-01-21 |
Novo Nordisk A/S |
Glycopegylated erythropoietin
|
|
US20080305992A1
(en)
|
2003-11-24 |
2008-12-11 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin
|
|
AU2004296768B2
(en)
*
|
2003-12-03 |
2010-06-24 |
University Of Rochester |
Recombinant factor VIII having increased specific activity
|
|
US20060040856A1
(en)
|
2003-12-03 |
2006-02-23 |
Neose Technologies, Inc. |
Glycopegylated factor IX
|
|
JP5743368B2
(ja)
|
2004-01-08 |
2015-07-01 |
ラショファーム ゲーエムベーハー |
ペプチドのo結合型グリコシル化
|
|
US20080300173A1
(en)
|
2004-07-13 |
2008-12-04 |
Defrees Shawn |
Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1]
|
|
EP2586456B1
(en)
|
2004-10-29 |
2016-01-20 |
ratiopharm GmbH |
Remodeling and glycopegylation of fibroblast growth factor (FGF)
|
|
ES2449195T3
(es)
|
2005-01-10 |
2014-03-18 |
Ratiopharm Gmbh |
Factor estimulante de colonias de granulocitos glicopegilado
|
|
EP1871795A4
(en)
|
2005-04-08 |
2010-03-31 |
Biogenerix Ag |
COMPOSITIONS AND METHOD FOR PRODUCING GLYCOSYLATION MUTANTS OF A PROTEASE-RESISTANT HUMAN GROWTH HORMONE
|
|
KR20080007226A
(ko)
*
|
2005-04-14 |
2008-01-17 |
체에스엘 베링 게엠베하 |
증가된 안정성을 가진 변형된 응고 인자 ⅷ 및 이의 유도체
|
|
EP1891231A4
(en)
|
2005-05-25 |
2011-06-22 |
Novo Nordisk As |
GLYCOPEGYLATED FACTOR IX
|
|
US20070105755A1
(en)
|
2005-10-26 |
2007-05-10 |
Neose Technologies, Inc. |
One pot desialylation and glycopegylation of therapeutic peptides
|
|
US20090048440A1
(en)
|
2005-11-03 |
2009-02-19 |
Neose Technologies, Inc. |
Nucleotide Sugar Purification Using Membranes
|
|
US20090215025A1
(en)
|
2005-12-07 |
2009-08-27 |
Technische Universitat Munchen |
Small peptidic and peptido-mimetic affinity ligands for factor viii and factor viii-like proteins
|
|
AU2007269233B2
(en)
*
|
2006-06-30 |
2011-06-09 |
Cnj Holdings, Inc. |
Method of producing Factor VIII proteins by recombinant methods
|
|
US20090203077A1
(en)
*
|
2006-06-30 |
2009-08-13 |
The Regents Of The University Of Michigan |
Method of producing factor viii proteins by recombinant methods
|
|
CN101516388B
(zh)
|
2006-07-21 |
2012-10-31 |
诺和诺德公司 |
通过o-联糖基化序列的肽的糖基化
|
|
JP2010505874A
(ja)
|
2006-10-03 |
2010-02-25 |
ノヴォ ノルディスク アー/エス |
ポリペプチドコンジュゲートの精製方法
|
|
HUE035243T2
(hu)
|
2007-02-23 |
2018-05-02 |
Sk Chemicals Co Ltd |
Eljárás VIII. faktor és származékainak elõállítására és tisztítására
|
|
NZ580030A
(en)
|
2007-04-03 |
2012-06-29 |
Biogenerix Ag |
Methods of treatment using glycopegylated g-csf
|
|
CA2690611C
(en)
|
2007-06-12 |
2015-12-08 |
Novo Nordisk A/S |
Improved process for the production of nucleotide sugars
|
|
CN104152489A
(zh)
|
2007-11-01 |
2014-11-19 |
罗切斯特大学 |
具有增加的稳定性的重组因子viii
|
|
JP5647899B2
(ja)
*
|
2008-01-08 |
2015-01-07 |
ラツィオファルム ゲーエムベーハーratiopharm GmbH |
オリゴサッカリルトランスフェラーゼを使用するポリペプチドの複合糖質化
|
|
CN103497246B
(zh)
|
2008-02-27 |
2016-08-10 |
诺沃—诺迪斯克有限公司 |
缀合的因子viii分子
|
|
US20110077202A1
(en)
*
|
2008-05-16 |
2011-03-31 |
Bayer Healthcare Llc |
Targeted Coagulation Factors and Method of Using the Same
|
|
NZ606427A
(en)
|
2009-02-03 |
2014-10-31 |
Amunix Operating Inc |
Extended recombinant polypeptides and compositions comprising same
|
|
EP2470670A4
(en)
|
2009-08-24 |
2013-07-10 |
Amunix Operating Inc |
COAGULATION FACTOR VII COMPOSITIONS AND METHODS OF PREPARATION AND USE THEREOF
|
|
AU2010300292B2
(en)
|
2009-10-02 |
2016-11-10 |
The Children's Hospital Of Philadelphia |
Compositions and methods for enhancing coagulation factor VIII function
|
|
WO2011069164A2
(en)
|
2009-12-06 |
2011-06-09 |
Biogen Idec Ma Inc. |
Factor viii-fc chimeric and hybrid polypeptides, and methods of use thereof
|
|
CA2804280A1
(en)
|
2010-07-09 |
2012-01-12 |
Biogen Idec Hemophilia Inc. |
Chimeric clotting factors
|
|
US9611310B2
(en)
|
2010-07-09 |
2017-04-04 |
Bioverativ Therapeutics Inc. |
Systems for factor VIII processing and methods thereof
|
|
BR112013011041B1
(pt)
*
|
2010-11-05 |
2021-05-25 |
Baxalta GmbH |
variante de fator viii, método para produzir uma variante de fviii, uso da variante de fator viii, e, composição farmacêutica
|
|
US9486507B2
(en)
|
2011-06-10 |
2016-11-08 |
Biogen Ma Inc. |
Pro-coagulant compounds and methods of use thereof
|
|
EP2729161B1
(en)
|
2011-07-08 |
2018-12-19 |
Bioverativ Therapeutics Inc. |
Factor viii chimeric and hybrid polypeptides, and methods of use thereof
|
|
WO2013016454A1
(en)
|
2011-07-25 |
2013-01-31 |
Biogen Idec Hemophilia Inc. |
Assays to monitor bleeding disorders
|
|
HK1198541A1
(en)
|
2011-10-18 |
2015-05-15 |
Csl Limited |
Method for improving the stability of purified factor viii after reconstitution
|
|
KR20140083036A
(ko)
|
2011-10-18 |
2014-07-03 |
체에스엘 베링 게엠베하 |
인자 viii의 생체이용률을 향상시키기 위한 황산화 글리코사미노글리칸의 용도
|
|
EP2768521B1
(en)
|
2011-10-18 |
2016-07-13 |
CSL Behring GmbH |
Combined use of a sulfated glycosaminoglycan and a hyaluronidase for improving the bioavailability of factor viii
|
|
EP2804623B1
(en)
|
2012-01-12 |
2019-08-07 |
Bioverativ Therapeutics Inc. |
Chimeric factor viii polypeptides and uses thereof
|
|
NZ627078A
(en)
|
2012-01-12 |
2016-07-29 |
Biogen Ma Inc |
Methods of reducing immunogenicity against factor viii in individuals undergoing factor viii therapy
|
|
ES2771208T3
(es)
|
2012-02-15 |
2020-07-06 |
Bioverativ Therapeutics Inc |
Composiciones de factor VIII y métodos de preparación y uso de las mismas
|
|
BR112014019901A8
(pt)
|
2012-02-15 |
2018-01-02 |
Biogen Idec Inc |
Proteínas de fator viii recombinante
|
|
CN104519897A
(zh)
|
2012-06-08 |
2015-04-15 |
比奥根艾迪克Ma公司 |
促凝血化合物
|
|
EP2863940A4
(en)
|
2012-06-08 |
2016-08-10 |
Biogen Ma Inc |
Chimeric clotting factors
|
|
EP2870250B2
(en)
|
2012-07-06 |
2022-06-29 |
Bioverativ Therapeutics Inc. |
Cell line expressing single chain factor viii polypeptides and uses thereof
|
|
KR101395736B1
(ko)
*
|
2012-07-10 |
2014-05-16 |
아주대학교산학협력단 |
인간 혈액응고인자 ⅷ 도메인 특이적 항체 및 이의 제조방법
|
|
US10138291B2
(en)
|
2012-07-11 |
2018-11-27 |
Bioverativ Therapeutics Inc. |
Factor VIII complex with XTEN and von Willebrand Factor protein, and uses thereof
|
|
US10001495B2
(en)
|
2012-07-25 |
2018-06-19 |
Bioverativ Therapeutics Inc. |
Blood factor monitoring assay and uses thereof
|
|
HK1213767A1
(zh)
|
2012-10-18 |
2016-07-15 |
Bioverativ Therapeutics Inc. |
使用固定劑量凝血因子的方法
|
|
HK1214539A1
(zh)
|
2012-10-30 |
2016-07-29 |
Bioverativ Therapeutics Inc. |
應用viii因子多肽的方法
|
|
WO2014127215A1
(en)
*
|
2013-02-15 |
2014-08-21 |
Biogen Idec Ma Inc. |
Optimized factor viii gene
|
|
UY35462A
(es)
|
2013-03-15 |
2014-10-31 |
Biogen Idec Inc |
Formulación de un polipéptido del factor viii.
|
|
AU2014228938B2
(en)
|
2013-03-15 |
2019-05-02 |
Bioverativ Therapeutics Inc. |
Factor IX polypeptide formulations
|
|
EP2796145B1
(en)
|
2013-04-22 |
2017-11-01 |
CSL Ltd. |
A covalent complex of von willebrand factor and faktor viii linked by a disulphide bridge
|
|
HK1223302A1
(zh)
|
2013-06-28 |
2017-07-28 |
Bioverativ Therapeutics Inc. |
具有xten的凝血酶可裂解连接子和其用途
|
|
US10947269B2
(en)
|
2013-08-08 |
2021-03-16 |
Bioverativ Therapeutics Inc. |
Purification of chimeric FVIII molecules
|
|
EP3033097B1
(en)
|
2013-08-14 |
2021-03-10 |
Bioverativ Therapeutics Inc. |
Factor viii-xten fusions and uses thereof
|
|
EP3065769A4
(en)
|
2013-11-08 |
2017-05-31 |
Biogen MA Inc. |
Procoagulant fusion compound
|
|
US10325687B2
(en)
|
2013-12-06 |
2019-06-18 |
Bioverativ Therapeutics Inc. |
Population pharmacokinetics tools and uses thereof
|
|
PT3091997T
(pt)
|
2014-01-10 |
2022-09-29 |
Bioverativ Therapeutics Inc |
Proteínas quiméricas de fator viii e utilizações destas
|
|
EP3097118B1
(en)
*
|
2014-01-20 |
2018-07-18 |
Octapharma AG |
A process for manufacturing factor viii having an improved ratio of fviii:c/fviii:ag
|
|
EP3102589A1
(en)
|
2014-02-04 |
2016-12-14 |
Biogen MA Inc. |
Use of cation-exchange chromatography in the flow-through mode to enrich post-translational modifications
|
|
WO2016004113A1
(en)
|
2014-06-30 |
2016-01-07 |
Biogen Ma Inc. |
Optimized factor ix gene
|
|
JP6516829B2
(ja)
|
2014-08-04 |
2019-05-22 |
シーエスエル、リミテッド |
第viii因子製剤
|
|
MA40864A
(fr)
|
2014-10-31 |
2017-09-05 |
Biogen Ma Inc |
Hypotaurine, gaba, bêta-alanine et choline pour la régulation de l'accumulation de sous-produits résiduaires dans des procédés de culture de cellules mammifères
|
|
BR112017018468A2
(pt)
|
2015-03-06 |
2018-04-17 |
Csl Behring Recombinant Facility Ag |
fator de von willebrand modificado com meia-vida aumentada
|
|
RU2017145002A
(ru)
|
2015-05-22 |
2019-06-24 |
Цсл Беринг Ленгнау Аг |
Способы получения модифицированного фактора фон виллебранда
|
|
CA2986626A1
(en)
|
2015-05-22 |
2016-12-01 |
Csl Behring Recombinant Facility Ag |
Truncated von willebrand factor polypeptides for treating hemophilia
|
|
BR112018002150A2
(pt)
|
2015-08-03 |
2018-09-18 |
Bioverativ Therapeutics Inc |
proteínas de fusão do fator ix e métodos de fabricação e uso das mesmas
|
|
WO2017050820A1
(en)
*
|
2015-09-22 |
2017-03-30 |
Novo Nordisk A/S |
Fviii fusion proteins
|
|
EP3374388A1
(en)
|
2015-11-13 |
2018-09-19 |
Baxalta Incorporated |
Viral vectors encoding recombinant fviii variants with increased expression for gene therapy of hemophilia a
|
|
IL305526A
(en)
|
2015-11-13 |
2023-10-01 |
Takeda Pharmaceuticals Co |
Viral vectors encoding recombinant FVIII variants with increased expression for gene therapy in hemophilia A
|
|
US10806774B2
(en)
|
2016-01-07 |
2020-10-20 |
CSL Behring Lengnau AG |
Mutated truncated von Willebrand Factor
|
|
JP7217630B2
(ja)
|
2016-02-01 |
2023-02-03 |
バイオベラティブ セラピューティクス インコーポレイテッド |
最適化第viii因子遺伝子
|
|
JP6877469B2
(ja)
|
2016-06-24 |
2021-05-26 |
モガム・インスティテュート・フォー・バイオメディカル・リサーチMogam Institute For Biomedical Research |
Fviiiおよびvwf因子を含むキメラタンパク質、ならびにそれらの使用
|
|
WO2017222330A1
(ko)
|
2016-06-24 |
2017-12-28 |
재단법인 목암생명과학연구소 |
재조합 단쇄 fviii 및 그 화학 접합물
|
|
JP6351679B2
(ja)
*
|
2016-09-30 |
2018-07-04 |
エスケー ケミカルズ カンパニー リミテッド |
第viii因子とその誘導体の製造及び精製方法
|
|
CN110381986B
(zh)
|
2016-11-11 |
2023-08-18 |
康诺贝林伦瑙有限公司 |
用于血管外施予以治疗或预防凝血疾病的截短型冯维勒布兰德因子多肽
|
|
AU2017358861B2
(en)
|
2016-11-11 |
2022-02-17 |
CSL Behring Lengnau AG |
Truncated von Willebrand Factor polypeptides for treating hemophilia
|
|
US12257288B2
(en)
|
2016-12-02 |
2025-03-25 |
Bioverativ Therapeutics Inc. |
Methods of inducing immune tolerance to clotting factors
|
|
US12161696B2
(en)
|
2016-12-02 |
2024-12-10 |
Bioverativ Therapeutics Inc. |
Methods of treating hemophilic arthropathy using chimeric clotting factors
|
|
JP2020530436A
(ja)
|
2017-06-22 |
2020-10-22 |
ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト |
トランケート型vwfによるfviiiの免疫原性の調節
|
|
US12168776B2
(en)
|
2017-08-09 |
2024-12-17 |
Bioverativ Therapeutics Inc. |
Nucleic acid molecules and uses thereof
|
|
WO2019074886A1
(en)
|
2017-10-09 |
2019-04-18 |
Terumo Bct Biotechnologies, Llc |
LYOPHILIZATION CONTAINER AND METHOD OF USE
|
|
AU2019215063B2
(en)
|
2018-02-01 |
2025-10-16 |
Bioverativ Therapeutics, Inc. |
Use of lentiviral vectors expressing Factor VIII
|
|
CN112203646A
(zh)
|
2018-04-04 |
2021-01-08 |
西吉隆医疗股份有限公司 |
可植入颗粒和相关方法
|
|
DK3793588T3
(da)
|
2018-05-18 |
2025-06-16 |
Bioverativ Therapeutics Inc |
Fremgangsmåder til behandling af hæmofili a
|
|
MX2021000582A
(es)
|
2018-07-16 |
2021-04-12 |
Baxalta Inc |
Terapia genica de hemofilia a mediante el uso de vectores virales que codifican variantes del factor viii (fviii) recombinantes con mayor expresion.
|
|
CN113227385B
(zh)
|
2018-08-09 |
2024-12-24 |
比奥维拉迪维治疗股份有限公司 |
核酸分子及其用于非病毒基因疗法的用途
|
|
WO2020061281A1
(en)
*
|
2018-09-19 |
2020-03-26 |
Cell Machines, Inc. |
Methods and compositions related to improved factor viii long half-life coagulation complexes
|
|
UY38389A
(es)
|
2018-09-27 |
2020-04-30 |
Sigilon Therapeutics Inc |
Dispositivos implantables para terapia celular y métodos relacionados
|
|
TWI851647B
(zh)
|
2019-01-16 |
2024-08-11 |
日商武田藥品工業股份有限公司 |
用於a型血友病基因治療之編碼表現增加之重組fviii變異體的病毒載體
|
|
WO2020168362A1
(en)
*
|
2019-02-15 |
2020-08-20 |
Crispr Therapeutics Ag |
Gene editing for hemophilia a with improved factor viii expression
|
|
WO2020242552A1
(en)
|
2019-03-14 |
2020-12-03 |
Terumo Bct Biotechnologies, Llc |
Multi-part lyophilization container and method of use
|
|
EP3736286A1
(en)
|
2019-05-09 |
2020-11-11 |
Biotest AG |
Single chain factor viii molecule
|
|
CN113710284A
(zh)
*
|
2019-06-05 |
2021-11-26 |
克里斯珀医疗股份公司 |
具有改善的因子viii表达的血友病a基因编辑
|
|
CN114007637A
(zh)
|
2019-06-19 |
2022-02-01 |
比奥维拉迪维治疗股份有限公司 |
用于治疗血友病和低骨矿物质密度的重组因子viii-fc
|
|
JP7780341B2
(ja)
|
2019-07-04 |
2025-12-04 |
ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト |
第VIII凝固因子のin vitroでの安定性を向上させるための切断型フォン・ヴィレブランド因子(VWF)
|
|
KR20220097891A
(ko)
|
2019-09-30 |
2022-07-08 |
바이오버라티브 테라퓨틱스 인크. |
렌티바이러스 벡터 제형
|
|
WO2021094344A1
(en)
|
2019-11-11 |
2021-05-20 |
CSL Behring Lengnau AG |
Polypeptides for inducing tolerance to factor viii
|
|
CN114981299A
(zh)
|
2019-12-12 |
2022-08-30 |
武田药品工业株式会社 |
使用编码具有增加的表达的重组fviii变体的病毒载体的a型血友病的基因疗法
|
|
JP7681268B2
(ja)
*
|
2020-03-30 |
2025-05-22 |
シスメックス株式会社 |
血液凝固活性の測定方法
|
|
KR20230074703A
(ko)
|
2020-06-24 |
2023-05-31 |
바이오버라티브 테라퓨틱스 인크. |
유리 인자 viii을 상기 단백질이 발현되도록 변형된 렌티바이러스 벡터의 제제로부터 제거하는 방법
|
|
US20240269241A1
(en)
|
2021-06-14 |
2024-08-15 |
Takeda Pharmaceutical Company Limited |
Gene therapy of hemophilia a using viral vectors encoding recombinant fviii variants with increased expression
|
|
MX2024002334A
(es)
|
2021-08-23 |
2024-05-23 |
Bioverativ Therapeutics Inc |
Genes optimizados del factor viii.
|
|
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