|
US8183344B2
(en)
*
|
1996-04-24 |
2012-05-22 |
University Of Michigan |
Inactivation resistant factor VIII
|
|
US7214660B2
(en)
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
|
US7173003B2
(en)
|
2001-10-10 |
2007-02-06 |
Neose Technologies, Inc. |
Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
|
|
WO2006127896A2
(en)
|
2005-05-25 |
2006-11-30 |
Neose Technologies, Inc. |
Glycopegylated factor ix
|
|
US8791070B2
(en)
|
2003-04-09 |
2014-07-29 |
Novo Nordisk A/S |
Glycopegylated factor IX
|
|
EP1615945B1
(en)
|
2003-04-09 |
2011-09-28 |
BioGeneriX AG |
Glycopegylation methods and proteins/peptides produced by the methods
|
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
|
WO2005012484A2
(en)
|
2003-07-25 |
2005-02-10 |
Neose Technologies, Inc. |
Antibody-toxin conjugates
|
|
US8633157B2
(en)
|
2003-11-24 |
2014-01-21 |
Novo Nordisk A/S |
Glycopegylated erythropoietin
|
|
US20080305992A1
(en)
|
2003-11-24 |
2008-12-11 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin
|
|
US20060040856A1
(en)
|
2003-12-03 |
2006-02-23 |
Neose Technologies, Inc. |
Glycopegylated factor IX
|
|
US7855274B2
(en)
*
|
2003-12-03 |
2010-12-21 |
University Of Rochester |
Recombinant factor VIII having increased specific activity
|
|
US8361961B2
(en)
|
2004-01-08 |
2013-01-29 |
Biogenerix Ag |
O-linked glycosylation of peptides
|
|
WO2006010143A2
(en)
|
2004-07-13 |
2006-01-26 |
Neose Technologies, Inc. |
Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
|
|
EP1814573B1
(en)
|
2004-10-29 |
2016-03-09 |
ratiopharm GmbH |
Remodeling and glycopegylation of fibroblast growth factor (fgf)
|
|
CA2593682C
(en)
|
2005-01-10 |
2016-03-22 |
Neose Technologies, Inc. |
Glycopegylated granulocyte colony stimulating factor
|
|
EP1871795A4
(en)
|
2005-04-08 |
2010-03-31 |
Biogenerix Ag |
COMPOSITIONS AND METHOD FOR PRODUCING GLYCOSYLATION MUTANTS OF A PROTEASE-RESISTANT HUMAN GROWTH HORMONE
|
|
US20110124565A1
(en)
*
|
2005-04-14 |
2011-05-26 |
Hans-Peter Hauser |
Modified Coagulation Factor VIII With Enhanced Stability and Its Derivatives
|
|
US20070105755A1
(en)
|
2005-10-26 |
2007-05-10 |
Neose Technologies, Inc. |
One pot desialylation and glycopegylation of therapeutic peptides
|
|
WO2007056191A2
(en)
|
2005-11-03 |
2007-05-18 |
Neose Technologies, Inc. |
Nucleotide sugar purification using membranes
|
|
CN101379077A
(zh)
|
2005-12-07 |
2009-03-04 |
夏洛特·豪泽 |
因子ⅷ和因子ⅷ-类似蛋白的小肽或者拟肽亲合性配体
|
|
US20090203077A1
(en)
*
|
2006-06-30 |
2009-08-13 |
The Regents Of The University Of Michigan |
Method of producing factor viii proteins by recombinant methods
|
|
US20080070251A1
(en)
*
|
2006-06-30 |
2008-03-20 |
Kaufman Randal J |
Method of Producing Factor VIII Proteins by Recombinant Methods
|
|
US9187532B2
(en)
|
2006-07-21 |
2015-11-17 |
Novo Nordisk A/S |
Glycosylation of peptides via O-linked glycosylation sequences
|
|
US20100075375A1
(en)
|
2006-10-03 |
2010-03-25 |
Novo Nordisk A/S |
Methods for the purification of polypeptide conjugates
|
|
PT2126106T
(pt)
|
2007-02-23 |
2017-12-12 |
Sk Chemicals Co Ltd |
Proceso para produzir e purificar o fator viii e seus derivados
|
|
CN101796063B
(zh)
|
2007-04-03 |
2017-03-22 |
拉蒂奥法姆有限责任公司 |
使用糖聚乙二醇化g‑csf的治疗方法
|
|
WO2008154639A2
(en)
|
2007-06-12 |
2008-12-18 |
Neose Technologies, Inc. |
Improved process for the production of nucleotide sugars
|
|
EP2209908B1
(en)
*
|
2007-11-01 |
2014-09-03 |
University Of Rochester |
Recombinant factor viii having increased stability
|
|
WO2009089396A2
(en)
*
|
2008-01-08 |
2009-07-16 |
Neose Technologies, Inc. |
Glycoconjugation of polypeptides using oligosaccharyltransferases
|
|
CN103497247A
(zh)
|
2008-02-27 |
2014-01-08 |
诺沃—诺迪斯克有限公司 |
缀合的因子viii分子
|
|
CA2724630A1
(en)
*
|
2008-05-16 |
2009-11-19 |
Bayer Healthcare Llc |
Targeted coagulation factors and method of using the same
|
|
SI2393828T1
(sl)
|
2009-02-03 |
2017-01-31 |
Amunix Operating Inc. |
Podaljšani rekombinantni polipetidi in sestavki, ki jih obsegajo
|
|
US20110046060A1
(en)
|
2009-08-24 |
2011-02-24 |
Amunix Operating, Inc., |
Coagulation factor IX compositions and methods of making and using same
|
|
DK2482841T4
(da)
|
2009-10-02 |
2022-10-24 |
Childrens Hospital Philadelphia |
Sammensætninger og fremgangsmåder til at forbedre koagulationsfaktor-viii-funktion
|
|
BR112012013502A2
(pt)
|
2009-12-06 |
2017-01-10 |
Biogen Idec Hemophilia Inc |
"polipeptídeos quiméricos e híbridos de fator viii-fc, e métodos de uso dos mesmos".
|
|
US9611310B2
(en)
|
2010-07-09 |
2017-04-04 |
Bioverativ Therapeutics Inc. |
Systems for factor VIII processing and methods thereof
|
|
ES2739503T3
(es)
|
2010-07-09 |
2020-01-31 |
Bioverativ Therapeutics Inc |
Moléculas de cadena simple procesables y polipéptidos producidos usándolas
|
|
CA2816575C
(en)
*
|
2010-11-05 |
2019-06-11 |
Baxter Healthcare S.A. |
A new variant of antihemophilic factor viii having increased specific activity
|
|
ES2724778T3
(es)
|
2011-06-10 |
2019-09-16 |
Bioverativ Therapeutics Inc |
Compuestos procoagulantes y procedimientos de uso de los mismos
|
|
DK2729161T3
(en)
|
2011-07-08 |
2019-04-08 |
Bioverativ Therapeutics Inc |
FACTOR VIII CHEMICAL AND HYBRID POLYPEPTIDES AND PROCEDURES FOR USE THEREOF
|
|
WO2013016454A1
(en)
|
2011-07-25 |
2013-01-31 |
Biogen Idec Hemophilia Inc. |
Assays to monitor bleeding disorders
|
|
KR20140083036A
(ko)
|
2011-10-18 |
2014-07-03 |
체에스엘 베링 게엠베하 |
인자 viii의 생체이용률을 향상시키기 위한 황산화 글리코사미노글리칸의 용도
|
|
AU2012318292B2
(en)
*
|
2011-10-18 |
2015-08-20 |
Csl Limited |
Method for improving the stability of purified Factor VIII after reconstitution
|
|
KR20140083035A
(ko)
|
2011-10-18 |
2014-07-03 |
체에스엘 베링 게엠베하 |
인자 viii의 생체이용률을 증가시키기 위한 황산화 글리코사미노글리칸과 하이알루로니다제의 병용 사용
|
|
CN111499761A
(zh)
|
2012-01-12 |
2020-08-07 |
比奥贝拉蒂治疗公司 |
嵌合因子viii多肽及其用途
|
|
BR112014017111A8
(pt)
|
2012-01-12 |
2018-05-15 |
Biogen Idec Inc |
métodos de redução de imunogenicidade contra o fator viii em indivíduos submetidos à terapia de fator viii
|
|
NZ628014A
(en)
|
2012-02-15 |
2016-09-30 |
Biogen Ma Inc |
Recombinant factor viii proteins
|
|
CN111548418A
(zh)
*
|
2012-02-15 |
2020-08-18 |
比奥贝拉蒂治疗公司 |
因子viii组合物及其制备和使用方法
|
|
US10202595B2
(en)
|
2012-06-08 |
2019-02-12 |
Bioverativ Therapeutics Inc. |
Chimeric clotting factors
|
|
EP2858659B1
(en)
|
2012-06-08 |
2019-12-25 |
Bioverativ Therapeutics Inc. |
Procoagulant compounds
|
|
WO2014008480A2
(en)
|
2012-07-06 |
2014-01-09 |
Biogen Idec Ma Inc. |
Cell line expressing single chain factor viii polypeptides and uses thereof
|
|
KR101395736B1
(ko)
*
|
2012-07-10 |
2014-05-16 |
아주대학교산학협력단 |
인간 혈액응고인자 ⅷ 도메인 특이적 항체 및 이의 제조방법
|
|
AU2013290173B2
(en)
|
2012-07-11 |
2018-02-15 |
Bioverativ Therapeutics Inc. |
Factor VIII complex with XTEN and von Willebrand Factor protein, and uses thereof
|
|
EP3970738A1
(en)
|
2012-07-25 |
2022-03-23 |
Bioverativ Therapeutics Inc. |
Blood factor monitoring assay and uses thereof
|
|
EP2908847B1
(en)
|
2012-10-18 |
2022-03-30 |
Bioverativ Therapeutics Inc. |
Methods of using a fixed dose of a clotting factor
|
|
EP2914293A4
(en)
|
2012-10-30 |
2016-04-20 |
Biogen Ma Inc |
METHOD OF USE OF FVIII POLYPEPTIDE
|
|
DK2956477T4
(da)
|
2013-02-15 |
2024-04-15 |
Bioverativ Therapeutics Inc |
Optimeret faktor viii-gen
|
|
EP3666283B1
(en)
|
2013-03-15 |
2022-06-08 |
Bioverativ Therapeutics Inc. |
Factor viii polypeptide formulations
|
|
EA037906B1
(ru)
|
2013-03-15 |
2021-06-04 |
Биовератив Терапьютикс Инк. |
Препараты полипептида фактора ix
|
|
ES2657291T3
(es)
|
2013-04-22 |
2018-03-02 |
Csl Ltd. |
Un complejo covalente de factor de von Willebrand y factor VIII asociado por un puente disulfuro
|
|
HK1223302A1
(zh)
|
2013-06-28 |
2017-07-28 |
Bioverativ Therapeutics Inc. |
具有xten的凝血酶可裂解连接子和其用途
|
|
EP3043813B1
(en)
|
2013-08-08 |
2021-01-13 |
Bioverativ Therapeutics Inc. |
Purification of chimeric fviii molecules
|
|
US10548953B2
(en)
|
2013-08-14 |
2020-02-04 |
Bioverativ Therapeutics Inc. |
Factor VIII-XTEN fusions and uses thereof
|
|
US10584147B2
(en)
|
2013-11-08 |
2020-03-10 |
Biovertiv Therapeutics Inc. |
Procoagulant fusion compound
|
|
US10325687B2
(en)
|
2013-12-06 |
2019-06-18 |
Bioverativ Therapeutics Inc. |
Population pharmacokinetics tools and uses thereof
|
|
PH12016501323B1
(en)
|
2014-01-10 |
2022-04-29 |
Bioverativ Therapeutics Inc |
Factor viii chimeric proteins and uses thereof
|
|
CA2934705C
(en)
*
|
2014-01-20 |
2020-03-31 |
Octapharma Ag |
A process for manufacturing factor viii having an improved ratio of fviii:c/fviii:ag
|
|
KR102382402B1
(ko)
|
2014-02-04 |
2022-04-01 |
바이오젠 엠에이 인코포레이티드 |
번역 후 변형을 강화시키기 위한 통류 방식 양이온 교환 크로마토그래피의 용도
|
|
US11008561B2
(en)
|
2014-06-30 |
2021-05-18 |
Bioverativ Therapeutics Inc. |
Optimized factor IX gene
|
|
NZ729629A
(en)
|
2014-08-04 |
2021-12-24 |
Csl Ltd |
Factor viii formulation
|
|
MA40864A
(fr)
|
2014-10-31 |
2017-09-05 |
Biogen Ma Inc |
Hypotaurine, gaba, bêta-alanine et choline pour la régulation de l'accumulation de sous-produits résiduaires dans des procédés de culture de cellules mammifères
|
|
KR20170125941A
(ko)
|
2015-03-06 |
2017-11-15 |
체에스엘 베링 리컴비넌트 퍼실리티 아게 |
개선된 반감기를 갖는 변형된 폰 빌레브란트 인자
|
|
EP4089109A3
(en)
|
2015-05-22 |
2023-03-01 |
CSL Behring Lengnau AG |
Methods for preparing modified von willebrand factor
|
|
BR112017023785A2
(pt)
|
2015-05-22 |
2018-07-17 |
Csl Behring Recombinant Facility Ag |
polipeptídeos do fator de von willebrand truncados para tratar hemofilia
|
|
AU2016301303B2
(en)
|
2015-08-03 |
2021-10-07 |
Bioverativ Therapeutics Inc. |
Factor IX fusion proteins and methods of making and using same
|
|
WO2017050820A1
(en)
*
|
2015-09-22 |
2017-03-30 |
Novo Nordisk A/S |
Fviii fusion proteins
|
|
SG11201804070XA
(en)
|
2015-11-13 |
2018-06-28 |
Baxalta Inc |
Viral vectors encoding recombinant fviii variants with increased expression for gene therapy of hemophilia a
|
|
EP3374388A1
(en)
|
2015-11-13 |
2018-09-19 |
Baxalta Incorporated |
Viral vectors encoding recombinant fviii variants with increased expression for gene therapy of hemophilia a
|
|
RU2018128582A
(ru)
|
2016-01-07 |
2020-02-11 |
Цсл Беринг Ленгнау Аг |
Мутированный укороченный фактор фон виллебранда
|
|
KR20180118659A
(ko)
|
2016-02-01 |
2018-10-31 |
바이오버라티브 테라퓨틱스 인크. |
최적화된 viii 인자 유전자
|
|
EP3476937A4
(en)
|
2016-06-24 |
2019-12-04 |
Mogam Institute for Biomedical Research |
CHIMERIC PROTEIN WITH FVIII AND VWF FACTORS AND USE THEREOF
|
|
EP3476860A4
(en)
|
2016-06-24 |
2020-01-22 |
Mogam Institute for Biomedical Research |
Recombinant single-chain fviii and chemical conjugate thereof
|
|
JP6351679B2
(ja)
*
|
2016-09-30 |
2018-07-04 |
エスケー ケミカルズ カンパニー リミテッド |
第viii因子とその誘導体の製造及び精製方法
|
|
US11814421B2
(en)
|
2016-11-11 |
2023-11-14 |
CSL Behring Lengnau AG |
Truncated von Willebrand Factor polypeptides for treating hemophilia
|
|
SG11201903954WA
(en)
|
2016-11-11 |
2019-05-30 |
CSL Behring Lengnau AG |
Truncated von willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder
|
|
CN110520149A
(zh)
|
2016-12-02 |
2019-11-29 |
比奥维拉迪维治疗股份有限公司 |
诱导对凝血因子的免疫耐受性的方法
|
|
WO2018102743A1
(en)
|
2016-12-02 |
2018-06-07 |
Bioverativ Therapeutics Inc. |
Methods of treating hemophilic arthropathy using chimeric clotting factors
|
|
WO2018234518A1
(en)
|
2017-06-22 |
2018-12-27 |
CSL Behring Lengnau AG |
Modulation of fviii immunogenicity by truncated vwf
|
|
TWI904068B
(zh)
|
2017-08-09 |
2025-11-11 |
美商生物化學醫療公司 |
核酸分子及其用途
|
|
JP7110360B2
(ja)
|
2017-10-09 |
2022-08-01 |
テルモ ビーシーティー バイオテクノロジーズ,エルエルシー |
凍結乾燥方法
|
|
SG11202007114VA
(en)
|
2018-02-01 |
2020-08-28 |
Bioverativ Therapeutics Inc |
Use of lentiviral vectors expressing factor viii
|
|
MX2020010369A
(es)
|
2018-04-04 |
2020-10-22 |
Sigilon Therapeutics Inc |
Particulas implantables y metodos relacionados.
|
|
JP7763589B2
(ja)
|
2018-05-18 |
2025-11-04 |
バイオベラティブ セラピューティクス インコーポレイテッド |
血友病aを処置する方法
|
|
AU2019306194A1
(en)
|
2018-07-16 |
2021-02-04 |
Baxalta GmbH |
Gene therapy of hemophilia A using viral vectors encoding recombinant FVIII variants with increased expression
|
|
WO2020033863A1
(en)
|
2018-08-09 |
2020-02-13 |
Bioverativ Therapeutics Inc. |
Nucleic acid molecules and uses thereof for non-viral gene therapy
|
|
JP2022501373A
(ja)
*
|
2018-09-19 |
2022-01-06 |
セル マシン,インコーポレイテッド |
改善された第viii因子長期半減期凝固複合体に関連する方法および組成物
|
|
UY38389A
(es)
|
2018-09-27 |
2020-04-30 |
Sigilon Therapeutics Inc |
Dispositivos implantables para terapia celular y métodos relacionados
|
|
TWI851647B
(zh)
|
2019-01-16 |
2024-08-11 |
日商武田藥品工業股份有限公司 |
用於a型血友病基因治療之編碼表現增加之重組fviii變異體的病毒載體
|
|
WO2020168362A1
(en)
*
|
2019-02-15 |
2020-08-20 |
Crispr Therapeutics Ag |
Gene editing for hemophilia a with improved factor viii expression
|
|
JP7541993B2
(ja)
|
2019-03-14 |
2024-08-29 |
テルモ ビーシーティー バイオテクノロジーズ,エルエルシー |
凍結乾燥用ローディングトレイ組立体、凍結乾燥システム及び凍結乾燥方法
|
|
EP3736286A1
(en)
|
2019-05-09 |
2020-11-11 |
Biotest AG |
Single chain factor viii molecule
|
|
JP7585217B2
(ja)
*
|
2019-06-05 |
2024-11-18 |
クリスパー セラピューティクス アクチェンゲゼルシャフト |
改善された第viii因子発現による血友病aのための遺伝子編集
|
|
JP2022537200A
(ja)
|
2019-06-19 |
2022-08-24 |
バイオベラティブ セラピューティクス インコーポレイテッド |
血友病および低骨ミネラル密度を処置するための方法および組成物
|
|
KR20220029733A
(ko)
|
2019-07-04 |
2022-03-08 |
체에스엘 베링 렝나우 아게 |
응고 인자 viii의 시험관내 안정성을 증가시키기 위한 절단된 폰 빌레브란트 인자 (vwf)
|
|
TW202126284A
(zh)
|
2019-09-30 |
2021-07-16 |
美商百歐維拉提夫治療公司 |
慢病毒載體配製物
|
|
WO2021094344A1
(en)
|
2019-11-11 |
2021-05-20 |
CSL Behring Lengnau AG |
Polypeptides for inducing tolerance to factor viii
|
|
US20230023826A1
(en)
|
2019-12-12 |
2023-01-26 |
Takeda Pharmaceutical Company Limited |
Gene therapy of hemophilia a using viral vectors encoding recombinant fviii variants with increased expression
|
|
JP7681268B2
(ja)
*
|
2020-03-30 |
2025-05-22 |
シスメックス株式会社 |
血液凝固活性の測定方法
|
|
WO2021262963A1
(en)
|
2020-06-24 |
2021-12-30 |
Bioverativ Therapeutics Inc. |
Methods for the removal of free factor viii from preparations of lentiviral vectors modified to express said protein
|
|
JP2024527252A
(ja)
|
2021-06-14 |
2024-07-24 |
武田薬品工業株式会社 |
発現の増加した組み換えfviiiバリアントをコードするウイルスベクターを用いた、血友病aの遺伝子療法
|
|
KR20240049332A
(ko)
|
2021-08-23 |
2024-04-16 |
바이오버라티브 테라퓨틱스 인크. |
최적화된 인자 viii 유전자
|
|
EP4408874A1
(en)
|
2021-09-30 |
2024-08-07 |
Bioverativ Therapeutics Inc. |
Nucleic acids encoding factor viii polypeptides with reduced immunogenicity
|
|
WO2024081309A1
(en)
|
2022-10-11 |
2024-04-18 |
Sigilon Therapeutics, Inc. |
Engineered cells and implantable elements for treatment of disease
|
|
WO2025008774A1
(en)
|
2023-07-05 |
2025-01-09 |
Takeda Pharmaceutical Company Limited |
Viral vectors encoding recombinant fviii variants with increased expression for gene therapy of hemophilia a
|