FR17C1024I2 - Polypeptide de facteur viii - Google Patents

Polypeptide de facteur viii

Info

Publication number
FR17C1024I2
FR17C1024I2 FR17C1024C FR17C1024C FR17C1024I2 FR 17C1024 I2 FR17C1024 I2 FR 17C1024I2 FR 17C1024 C FR17C1024 C FR 17C1024C FR 17C1024 C FR17C1024 C FR 17C1024C FR 17C1024 I2 FR17C1024 I2 FR 17C1024I2
Authority
FR
France
Prior art keywords
factor viii
viii polypeptide
polypeptide
factor
viii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR17C1024C
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SK Chemicals Co Ltd
Original Assignee
SK Chemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SK Chemicals Co Ltd filed Critical SK Chemicals Co Ltd
Publication of FR17C1024I1 publication Critical patent/FR17C1024I1/fr
Application granted granted Critical
Publication of FR17C1024I2 publication Critical patent/FR17C1024I2/fr
Active legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • C07K14/755Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/10Factor VIII, AHF; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FR17C1024C 2003-01-28 2017-07-03 Polypeptide de facteur viii Active FR17C1024I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/353,753 US7041635B2 (en) 2003-01-28 2003-01-28 Factor VIII polypeptide
PCT/KR2003/002277 WO2004067566A1 (fr) 2003-01-28 2003-10-27 Polypeptide de facteur viii

Publications (2)

Publication Number Publication Date
FR17C1024I1 FR17C1024I1 (fr) 2017-09-08
FR17C1024I2 true FR17C1024I2 (fr) 2019-07-19

Family

ID=32736253

Family Applications (1)

Application Number Title Priority Date Filing Date
FR17C1024C Active FR17C1024I2 (fr) 2003-01-28 2017-07-03 Polypeptide de facteur viii

Country Status (14)

Country Link
US (1) US7041635B2 (fr)
EP (2) EP2253645B1 (fr)
KR (1) KR100642293B1 (fr)
CN (1) CN100404552C (fr)
AU (1) AU2003274766B8 (fr)
BE (1) BE2017C021I2 (fr)
CA (1) CA2514646C (fr)
DK (2) DK1587832T3 (fr)
ES (1) ES2446041T3 (fr)
FR (1) FR17C1024I2 (fr)
HK (1) HK1150840A1 (fr)
LU (1) LUC00023I2 (fr)
NL (1) NL300878I2 (fr)
WO (1) WO2004067566A1 (fr)

Families Citing this family (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8183344B2 (en) * 1996-04-24 2012-05-22 University Of Michigan Inactivation resistant factor VIII
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
WO2004099231A2 (fr) 2003-04-09 2004-11-18 Neose Technologies, Inc. Methode de glycopegylation et proteines/peptides produits au moyen de ces methodes
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
WO2006127896A2 (fr) 2005-05-25 2006-11-30 Neose Technologies, Inc. Facteur ix glycopegyle
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
WO2005012484A2 (fr) 2003-07-25 2005-02-10 Neose Technologies, Inc. Conjugues anticorps-toxines
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
WO2005055930A2 (fr) * 2003-12-03 2005-06-23 University Of Rochester Facteur viii recombine presentant une activite specifique amelioree
US20060040856A1 (en) 2003-12-03 2006-02-23 Neose Technologies, Inc. Glycopegylated factor IX
CN101072789B (zh) 2004-01-08 2013-05-15 生物种属学股份公司 肽的o-连接的糖基化
WO2006010143A2 (fr) 2004-07-13 2006-01-26 Neose Technologies, Inc. Remodelage de peg ramifie et glycosylation de peptide-1 semblable a glucagon [glp-1]
US20080176790A1 (en) 2004-10-29 2008-07-24 Defrees Shawn Remodeling and Glycopegylation of Fibroblast Growth Factor (Fgf)
MX2007008229A (es) 2005-01-10 2007-09-11 Neose Technologies Inc Factor estimulador de colonias de granulocitos glicopegilado.
US9187546B2 (en) 2005-04-08 2015-11-17 Novo Nordisk A/S Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
KR20080007226A (ko) * 2005-04-14 2008-01-17 체에스엘 베링 게엠베하 증가된 안정성을 가진 변형된 응고 인자 ⅷ 및 이의 유도체
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
WO2007056191A2 (fr) 2005-11-03 2007-05-18 Neose Technologies, Inc. Purification de sucre de nucleotide en utilisant des membranes
EP1968999A2 (fr) 2005-12-07 2008-09-17 Technische Universität München Petits ligands d'affinite peptidiques et peptido-mimetiques pour le facteur viii et pour des proteines similaires au facteur viii
US20090203077A1 (en) * 2006-06-30 2009-08-13 The Regents Of The University Of Michigan Method of producing factor viii proteins by recombinant methods
WO2008005847A2 (fr) * 2006-06-30 2008-01-10 The Regents Of The University Of Michigan Procédé de production de protéines de type facteur viii par des procédés recombinants
EP2049144B8 (fr) 2006-07-21 2015-02-18 ratiopharm GmbH Glycosylation de peptides par l'intermédiaire de séquences de glycosylation à liaison o
EP2054521A4 (fr) 2006-10-03 2012-12-19 Novo Nordisk As Méthodes de purification de conjugués de polypeptides
ES2651028T3 (es) 2007-02-23 2018-01-23 Sk Chemicals Co., Ltd. Proceso para producir y purificar el factor VIII y sus derivados
JP2010523582A (ja) 2007-04-03 2010-07-15 バイオジェネリクス アクチェンゲゼルシャフト グリコpeg化g−csfを用いた治療方法
MX2009013259A (es) 2007-06-12 2010-01-25 Novo Nordisk As Proceso mejorado para la produccion de azucares de nucleotidos.
US8183345B2 (en) * 2007-11-01 2012-05-22 University Of Rochester Recombinant factor VIII having reduced inactivation by activated protein C
JP5647899B2 (ja) * 2008-01-08 2015-01-07 ラツィオファルム ゲーエムベーハーratiopharm GmbH オリゴサッカリルトランスフェラーゼを使用するポリペプチドの複合糖質化
CN103497247A (zh) 2008-02-27 2014-01-08 诺沃—诺迪斯克有限公司 缀合的因子viii分子
US20110077202A1 (en) * 2008-05-16 2011-03-31 Bayer Healthcare Llc Targeted Coagulation Factors and Method of Using the Same
CA2748314C (fr) 2009-02-03 2018-10-02 Amunix Operating Inc. Polypeptides recombinants etendus et compositions les comprenant
AU2010290131C1 (en) 2009-08-24 2015-12-03 Amunix Operating Inc. Coagulation factor VII compositions and methods of making and using same
EP2482841B2 (fr) 2009-10-02 2022-09-28 The Children's Hospital Of Philadelphia Compositions et procédés pour renforcer la fonction du facteur de coagulation viii
CA2782424C (fr) 2009-12-06 2021-07-27 Biogen Idec Hemophilia Inc. Polypeptides chimeriques et hybrides de facteur viii-fc, et procedes d'utilisation de ceux-ci
EP3508573A1 (fr) 2010-07-09 2019-07-10 Bioverativ Therapeutics Inc. Systèmes de traitement de facteur viii et procédés associés
PT2591006T (pt) 2010-07-09 2019-07-29 Bioverativ Therapeutics Inc Moléculas de cadeia simples processáveis e polipéptidos preparados utilizando as mesmas
KR101948337B1 (ko) 2010-11-05 2019-02-14 박스알타 인코퍼레이티드 증가된 특이 활성도를 갖는 항혈우병 인자 viii의 신규 변이체
PT2717898T (pt) 2011-06-10 2019-05-20 Bioverativ Therapeutics Inc Compostos pró-coagulantes e processos para a sua utilização
PT3513804T (pt) 2011-07-08 2022-06-02 Bioverativ Therapeutics Inc Polipéptidos fator viii híbridos e quiméricos, e métodos de utilização dos mesmos
EA028914B1 (ru) 2011-07-25 2018-01-31 Байоджен Хемофилия Инк. Исследования для мониторинга нарушений свертываемости крови
WO2013057219A1 (fr) * 2011-10-18 2013-04-25 Csl Behring Gmbh Procédé pour l'amélioration de la stabilité du facteur viii purifié après la reconstitution
WO2013057167A1 (fr) 2011-10-18 2013-04-25 Csl Behring Gmbh Utilisation de glycosaminoglycanes sulfates pour ameliorer la biodisponibilite du facteur viii
JP6029674B2 (ja) 2011-10-18 2016-11-24 ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー 第viii因子のバイオアベイラビリティを改善するための、硫酸化グリコサミノグリカン及びヒアルロニダーゼの組み合わせ使用
CN108465106B (zh) 2012-01-12 2022-05-27 普吉特海湾血液中心 降低经受因子viii疗法的个体中针对因子viii的免疫原性的方法
BR112014017165B1 (pt) 2012-01-12 2023-05-02 Bioverativ Therapeutics Inc Proteína quimérica compreendendo uma proteína de fator viii, composição farmacêutica, e seus usos
ES2771208T3 (es) 2012-02-15 2020-07-06 Bioverativ Therapeutics Inc Composiciones de factor VIII y métodos de preparación y uso de las mismas
DK2822577T3 (en) 2012-02-15 2019-04-01 Bioverativ Therapeutics Inc RECOMBINANT FACTOR VIII PROTEINS
US10202595B2 (en) 2012-06-08 2019-02-12 Bioverativ Therapeutics Inc. Chimeric clotting factors
EP3693000B1 (fr) 2012-06-08 2022-03-02 Bioverativ Therapeutics Inc. Composés procoagulants
US10023628B2 (en) 2012-07-06 2018-07-17 Bioverativ Therapeutics Inc. Cell line expressing single chain factor VIII polypeptides and uses thereof
KR101395736B1 (ko) * 2012-07-10 2014-05-16 아주대학교산학협력단 인간 혈액응고인자 ⅷ 도메인 특이적 항체 및 이의 제조방법
CN104661674A (zh) 2012-07-11 2015-05-27 阿穆尼克斯运营公司 具有xten和血管性血友病因子蛋白的因子viii复合物、及其用途
WO2014018777A2 (fr) 2012-07-25 2014-01-30 Biogen Idec Ma Inc. Essai de surveillance de facteur sanguin et utilisations de celui-ci
US10391152B2 (en) 2012-10-18 2019-08-27 Bioverativ Therapeutics Inc. Methods of using a fixed dose of a clotting factor
EP3446700A1 (fr) 2012-10-30 2019-02-27 Bioverativ Therapeutics Inc. Procédé d'utilisation de polypeptide du facteur viii
DK2956477T4 (da) 2013-02-15 2024-04-15 Bioverativ Therapeutics Inc Optimeret faktor viii-gen
RS60003B1 (sr) 2013-03-15 2020-04-30 Bioverativ Therapeutics Inc Formulacije polipeptida faktora viii
TWI745671B (zh) 2013-03-15 2021-11-11 美商百歐維拉提夫治療公司 因子ix多肽調配物
DK2796145T3 (da) 2013-04-22 2018-01-29 Csl Ltd Et kovalent kompleks af von Willebrand-faktor og faktor VIII linket af en disulfidbro
SG10201913738YA (en) 2013-06-28 2020-03-30 Bioverativ Therapeutics Inc Thrombin cleavable linker with xten and its uses thereof
EP3043813B1 (fr) 2013-08-08 2021-01-13 Bioverativ Therapeutics Inc. Purification de molécules chimères du facteur viii
WO2015023891A2 (fr) 2013-08-14 2015-02-19 Biogen Idec Ma Inc. Fusions de facteur vii-xten et leurs utilisations
US10584147B2 (en) 2013-11-08 2020-03-10 Biovertiv Therapeutics Inc. Procoagulant fusion compound
WO2015085276A1 (fr) 2013-12-06 2015-06-11 Biogen Idec Ma Inc. Outils pharmacocinétiques de population et leurs utilisations
DK3091997T5 (da) 2014-01-10 2024-10-14 Bioverativ Therapeutics Inc Kimære faktor viii-proteiner og anvendelser deraf
ES2688144T3 (es) * 2014-01-20 2018-10-31 Octapharma Ag Procedimiento de fabricación de Factor VIII que tiene una relación mejorada de FVIII:C/FVIII:AG
KR102382402B1 (ko) 2014-02-04 2022-04-01 바이오젠 엠에이 인코포레이티드 번역 후 변형을 강화시키기 위한 통류 방식 양이온 교환 크로마토그래피의 용도
ES2788870T3 (es) 2014-08-04 2020-10-23 Csl Ltd Formulación de factor VIII
MA40864A (fr) 2014-10-31 2017-09-05 Biogen Ma Inc Hypotaurine, gaba, bêta-alanine et choline pour la régulation de l'accumulation de sous-produits résiduaires dans des procédés de culture de cellules mammifères
KR20170125941A (ko) 2015-03-06 2017-11-15 체에스엘 베링 리컴비넌트 퍼실리티 아게 개선된 반감기를 갖는 변형된 폰 빌레브란트 인자
DK3298036T3 (da) 2015-05-22 2022-06-07 CSL Behring Lengnau AG Fremgangsmåder til forberedelse af modificeret von Willebrand faktor
CA2986626A1 (fr) 2015-05-22 2016-12-01 Csl Behring Recombinant Facility Ag Polypeptides du facteur von willebrand tronque pour le traitement de l'hemophilie
WO2017024060A1 (fr) 2015-08-03 2017-02-09 Biogen Ma Inc. Protéines de fusion du facteur xi et leurs méthodes de production et d'utilisation
WO2017050820A1 (fr) * 2015-09-22 2017-03-30 Novo Nordisk A/S Protéines de fusion du facteur viii
CA3005565A1 (fr) 2015-11-13 2017-05-18 Baxalta Incorporated Vecteurs viraux codant pour des variants du facteur viii de recombinaison avec une expression augmentee pour la therapie genique de l'hemophilie a
SG10202106307UA (en) 2015-11-13 2021-07-29 Takeda Pharmaceuticals Co Viral vectors encoding recombinant fviii variants with increased expression for gene therapy of hemophilia a
RU2018128582A (ru) 2016-01-07 2020-02-11 Цсл Беринг Ленгнау Аг Мутированный укороченный фактор фон виллебранда
US11753461B2 (en) 2016-02-01 2023-09-12 Bioverativ Therapeutics Inc. Optimized factor VIII genes
KR102175878B1 (ko) 2016-06-24 2020-11-06 재단법인 목암생명과학연구소 Fviii 및 vwf 인자를 포함하는 키메라 단백질 및 그 용도
EP3476860A4 (fr) 2016-06-24 2020-01-22 Mogam Institute for Biomedical Research Chaîne unique recombinante fviii et son conjugué chimique
JP6351679B2 (ja) * 2016-09-30 2018-07-04 エスケー ケミカルズ カンパニー リミテッド 第viii因子とその誘導体の製造及び精製方法
CA3043397A1 (fr) 2016-11-11 2018-05-17 CSL Behring Lengnau AG Polypeptides du facteur de von willebrand tronque pour une administration extravasculaire dans le traitement ou la prophylaxie d'un trouble de la coagulation du sang
EP3538133B1 (fr) 2016-11-11 2021-02-17 CSL Behring Lengnau AG Polypeptides du facteur von willebrand tronqués pour traiter l'hémophilie
EP3548066A1 (fr) 2016-12-02 2019-10-09 Bioverativ Therapeutics Inc. Méthodes de traitement de l'arthropathie hémophilique à l'aide de facteurs de coagulation chimériques
JP2019536794A (ja) 2016-12-02 2019-12-19 バイオベラティブ セラピューティクス インコーポレイテッド 凝固因子に対する免疫寛容を誘導する方法
PL3641800T3 (pl) 2017-06-22 2024-03-18 CSL Behring Lengnau AG Modulacja immunogenności fviii przez skrócony vwf
BR112020002394A2 (pt) 2017-08-09 2020-07-28 Bioverativ Therapeutics Inc. moléculas de ácidos nucleicos e usos das mesmas
JP7110360B2 (ja) 2017-10-09 2022-08-01 テルモ ビーシーティー バイオテクノロジーズ,エルエルシー 凍結乾燥方法
TW201946929A (zh) 2018-02-01 2019-12-16 美商生物化學醫療公司 表現因子viii之慢病毒載體之使用
IL312315A (en) 2018-04-04 2024-06-01 Sigilon Therapeutics Inc Implantable particles and related methods
NZ769677A (en) 2018-05-18 2024-07-05 Bioverativ Therapeutics Inc Methods of treating hemophilia a
AU2019306194A1 (en) 2018-07-16 2021-02-04 Baxalta GmbH Gene therapy of hemophilia A using viral vectors encoding recombinant FVIII variants with increased expression
WO2020033863A1 (fr) 2018-08-09 2020-02-13 Bioverativ Therapeutics Inc. Molécules d'acide nucléique et leurs utilisations pour une thérapie génique non virale
EP3852780A1 (fr) * 2018-09-19 2021-07-28 Cell Machines, Inc. Procédés et compositions se rapportant à des complexes de coagulation améliorés comportant un facteur viii à demi-vie longue
UY38389A (es) 2018-09-27 2020-04-30 Sigilon Therapeutics Inc Dispositivos implantables para terapia celular y métodos relacionados
IL314658A (en) 2019-01-16 2024-09-01 Baxalta Inc Viral vectors encoding recombinant FVIII variants with enhanced expression for hemophilia A gene therapy
WO2020168362A1 (fr) * 2019-02-15 2020-08-20 Crispr Therapeutics Ag Édition de gène pour l'hémophilie a avec une expression de facteur viii améliorée
CA3130700A1 (fr) 2019-03-14 2020-09-17 Terumo Bct Biotechnologies, Llc Agencement de remplissage de contenant de lyophilisation, systeme et procede d'utilisation
EP3736286A1 (fr) 2019-05-09 2020-11-11 Biotest AG Molécule de facteur viii à chaîne unique
JP2022537200A (ja) 2019-06-19 2022-08-24 バイオベラティブ セラピューティクス インコーポレイテッド 血友病および低骨ミネラル密度を処置するための方法および組成物
AU2020300820A1 (en) 2019-07-04 2022-03-03 CSL Behring Lengnau AG A truncated von willebrand factor (vWF) for increasing the in vitro stability of coagulation factor VIII
WO2021094344A1 (fr) 2019-11-11 2021-05-20 CSL Behring Lengnau AG Polypeptides pour induire une tolérance au facteur viii
JP2023506171A (ja) 2019-12-12 2023-02-15 武田薬品工業株式会社 発現が上昇した組換えfviiiバリアントをコードするウイルスベクターを使用する、血友病aの遺伝子療法
JP2021156833A (ja) 2020-03-30 2021-10-07 シスメックス株式会社 血液凝固活性の測定方法
WO2022264040A1 (fr) 2021-06-14 2022-12-22 Takeda Pharmaceutical Company Limited Thérapie génique contre l'hémophilie a faisant appel à des vecteurs viraux codant pour des variants de fviii recombinés à expression accrue
WO2023028456A1 (fr) 2021-08-23 2023-03-02 Bioverativ Therapeutics Inc. Gènes de facteur viii optimisés
JP2024537797A (ja) 2021-09-30 2024-10-16 バイオベラティブ セラピューティクス インコーポレイテッド 低下した免疫原性を有する第viii因子ポリペプチドをコードする核酸
WO2024081309A1 (fr) 2022-10-11 2024-04-18 Sigilon Therapeutics, Inc. Cellules modifiées et éléments implantables pour le traitement d'une maladie

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0218712B1 (fr) 1985-04-12 1992-02-26 Genetics Institute, Inc. Nouvelles proteines procoagulantes
US5451521A (en) 1986-05-29 1995-09-19 Genetics Institute, Inc. Procoagulant proteins
US5422260A (en) 1986-05-29 1995-06-06 Genetics Institute, Inc. -Legal Affairs Human factor VIII:c muteins
US5543502A (en) 1986-06-24 1996-08-06 Novo Nordisk A/S Process for producing a coagulation active complex of factor VIII fragments
FR2619314B1 (fr) 1987-08-11 1990-06-15 Transgene Sa Analogue du facteur viii, procede de preparation et composition pharmaceutique le contenant
WO1993022336A1 (fr) * 1992-04-30 1993-11-11 Alpha Therapeutic Corporation Solubilisation et stabilisation ameliorees du complexe du facteur viii
DE69735421T2 (de) 1996-04-24 2006-10-19 The Regents Of The University Of Michigan, Ann Arbor Gegen inaktivierung resistenter faktor viii
AU1598200A (en) 1998-10-23 2000-05-15 Trustees Of The University Of Pennsylvania, The Systemic delivery of gene products via skin
CA2450125A1 (fr) 2001-06-15 2002-12-27 Andre C. Schuh Therapie genique de l'hemophilie a

Also Published As

Publication number Publication date
LUC00023I2 (fr) 2017-09-08
AU2003274766B2 (en) 2009-02-12
DK2253645T3 (en) 2016-06-27
EP1587832A1 (fr) 2005-10-26
KR20050044776A (ko) 2005-05-12
WO2004067566A1 (fr) 2004-08-12
LUC00023I1 (fr) 2017-06-21
BE2017C021I2 (fr) 2023-03-07
EP1587832B1 (fr) 2013-12-11
US20040147436A1 (en) 2004-07-29
EP2253645A2 (fr) 2010-11-24
KR100642293B1 (ko) 2006-11-03
HK1150840A1 (zh) 2012-01-13
AU2003274766A1 (en) 2004-08-23
NL300878I2 (nl) 2017-11-02
EP2253645A3 (fr) 2011-02-16
DK1587832T3 (en) 2014-02-24
ES2446041T3 (es) 2014-03-06
CA2514646C (fr) 2013-07-23
CN100404552C (zh) 2008-07-23
EP2253645B1 (fr) 2016-03-23
CN1745100A (zh) 2006-03-08
US7041635B2 (en) 2006-05-09
AU2003274766B8 (en) 2009-08-27
CA2514646A1 (fr) 2004-08-12
FR17C1024I1 (fr) 2017-09-08

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