LU92200I2 - Linaclotide et toute forme thérapeutique équivalente de celuici, protégé par le brevet de base, y compris des sels pharmaceutiquement acceptables - Google Patents
Linaclotide et toute forme thérapeutique équivalente de celuici, protégé par le brevet de base, y compris des sels pharmaceutiquement acceptablesInfo
- Publication number
- LU92200I2 LU92200I2 LU92200C LU92200C LU92200I2 LU 92200 I2 LU92200 I2 LU 92200I2 LU 92200 C LU92200 C LU 92200C LU 92200 C LU92200 C LU 92200C LU 92200 I2 LU92200 I2 LU 92200I2
- Authority
- LU
- Luxembourg
- Prior art keywords
- disorders
- constipation
- conditions
- dyspepsia
- linaclotide
- Prior art date
Links
- KXGCNMMJRFDFNR-WDRJZQOASA-N linaclotide Chemical compound C([C@H](NC(=O)[C@@H]1CSSC[C@H]2C(=O)N[C@H]3CSSC[C@H](N)C(=O)N[C@H](C(N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N2)=O)CSSC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(N)=O)NC3=O)C(=O)N[C@H](C(NCC(=O)N1)=O)[C@H](O)C)C(O)=O)C1=CC=C(O)C=C1 KXGCNMMJRFDFNR-WDRJZQOASA-N 0.000 title 1
- 229960000812 linaclotide Drugs 0.000 title 1
- 108010024409 linaclotide Proteins 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 206010010774 Constipation Diseases 0.000 abstract 4
- 201000006549 dyspepsia Diseases 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 208000035475 disorder Diseases 0.000 abstract 3
- 102100034605 Atrial natriuretic peptide receptor 3 Human genes 0.000 abstract 2
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 2
- 101000924488 Homo sapiens Atrial natriuretic peptide receptor 3 Proteins 0.000 abstract 2
- 208000021302 gastroesophageal reflux disease Diseases 0.000 abstract 2
- 206010009900 Colitis ulcerative Diseases 0.000 abstract 1
- 201000005078 Colonic Pseudo-Obstruction Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 206010017943 Gastrointestinal conditions Diseases 0.000 abstract 1
- 208000017228 Gastrointestinal motility disease Diseases 0.000 abstract 1
- 206010021518 Impaired gastric emptying Diseases 0.000 abstract 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 201000006704 Ulcerative Colitis Diseases 0.000 abstract 1
- 208000014797 chronic intestinal pseudoobstruction Diseases 0.000 abstract 1
- 208000001288 gastroparesis Diseases 0.000 abstract 1
- 208000024798 heartburn Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002981 neuropathic effect Effects 0.000 abstract 1
- 229940127240 opiate Drugs 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
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-
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- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Nutrition Science (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44309803P | 2003-01-28 | 2003-01-28 | |
| US47128803P | 2003-05-15 | 2003-05-15 | |
| US51946003P | 2003-11-12 | 2003-11-12 | |
| PCT/US2004/002390 WO2004069165A2 (fr) | 2003-01-28 | 2004-01-28 | Procedes et compositions pour le traitement de troubles gastro-intestinaux |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LU92200I1 LU92200I1 (fr) | 2020-06-02 |
| LU92200I2 true LU92200I2 (fr) | 2024-03-21 |
Family
ID=32854294
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU92200C LU92200I2 (fr) | 2003-01-28 | 2013-05-22 | Linaclotide et toute forme thérapeutique équivalente de celuici, protégé par le brevet de base, y compris des sels pharmaceutiquement acceptables |
| LU92201C LU92201I2 (fr) | 2003-01-28 | 2013-05-22 | Linaclotide et toute forme thérapeutique équivalente de celuici, protégé par le brevet de base, y compris des sels pharmaceutiquement acceptables |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU92201C LU92201I2 (fr) | 2003-01-28 | 2013-05-22 | Linaclotide et toute forme thérapeutique équivalente de celuici, protégé par le brevet de base, y compris des sels pharmaceutiquement acceptables |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US20040266989A1 (fr) |
| EP (3) | EP2246360B1 (fr) |
| JP (3) | JP4584911B2 (fr) |
| KR (2) | KR101227626B1 (fr) |
| CN (2) | CN101787073B (fr) |
| AT (2) | ATE365174T1 (fr) |
| AU (2) | AU2004210161B2 (fr) |
| BE (1) | BE2013C032I2 (fr) |
| BR (2) | BRPI0407071B8 (fr) |
| CA (1) | CA2514507C (fr) |
| CY (5) | CY1110905T1 (fr) |
| DE (2) | DE602004028678D1 (fr) |
| DK (3) | DK1911763T3 (fr) |
| ES (3) | ES2285417T3 (fr) |
| FR (2) | FR13C0029I2 (fr) |
| HK (1) | HK1078768A1 (fr) |
| HU (1) | HUS1300022I1 (fr) |
| IL (2) | IL169863A (fr) |
| LT (1) | LTC1594517I2 (fr) |
| LU (2) | LU92200I2 (fr) |
| MX (1) | MXPA05008097A (fr) |
| NL (1) | NL300593I2 (fr) |
| NO (2) | NO334112B1 (fr) |
| NZ (2) | NZ570134A (fr) |
| PT (3) | PT1911763E (fr) |
| RU (2) | RU2353383C2 (fr) |
| SG (2) | SG168407A1 (fr) |
| SI (3) | SI1594517T1 (fr) |
| WO (1) | WO2004069165A2 (fr) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2622468T3 (es) | 2001-03-29 | 2017-07-06 | Synergy Pharmaceuticals, Inc. | Agonistas del receptor de guanilato ciclasa para el tratamiento de inflamación tisular y carcinogénesis |
| US7371727B2 (en) | 2003-01-28 | 2008-05-13 | Microbia, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US7304036B2 (en) | 2003-01-28 | 2007-12-04 | Microbia, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US20060281682A1 (en) * | 2003-01-28 | 2006-12-14 | Currie Mark G | Methods and compositions for the treatment of gastrointestinal disorders |
| SI1594517T1 (sl) * | 2003-01-28 | 2007-10-31 | Microbia Inc | Sestavki za zdravljenje gastrointestinalnih motenj |
| US7772188B2 (en) * | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| CA2529307C (fr) | 2003-06-13 | 2013-12-24 | Microbia, Inc. | Methodes et compositions pour le traitement de troubles gastro-intestinaux |
| US7494979B2 (en) * | 2003-06-13 | 2009-02-24 | Ironwood Pharmaceuticals, Inc. | Method for treating congestive heart failure and other disorders |
| WO2005115412A2 (fr) * | 2004-05-25 | 2005-12-08 | University Of Georgia Research Foundation, Inc. | Compositions et procedes de modulation d'une reponse immunitaire |
| JPWO2006046746A1 (ja) * | 2004-10-26 | 2008-05-22 | 味の素株式会社 | 内臓痛予防・治療剤 |
| CA2619650A1 (fr) * | 2005-08-19 | 2007-02-22 | Microbia, Inc. | Compositions et methodes de traitement de troubles gastro-intestinaux |
| EP3586846A1 (fr) | 2005-09-29 | 2020-01-01 | Ipsen Pharma | Composition pour l'utilisation dans le traitement de la dysmotilité gastrointestinale |
| EP1996218A4 (fr) * | 2006-02-24 | 2012-07-11 | Ironwood Pharmaceuticals Inc | Méthodes et compositions servant au traitement de troubles gastro-intestinaux |
| US8779090B2 (en) | 2007-02-26 | 2014-07-15 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of heart failure and other disorders |
| WO2008137318A1 (fr) * | 2007-05-04 | 2008-11-13 | Ironwood Pharmaceuticals, Inc. | Compositions et procédés de traitement de troubles associés à la rétention de sel ou de fluide |
| US8969514B2 (en) * | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| EA020466B1 (ru) | 2007-06-04 | 2014-11-28 | Синерджи Фармасьютикалз Инк. | Агонисты гуанилатциклазы, пригодные для лечения желудочно-кишечных нарушений, воспаления, рака и других заболеваний |
| WO2009149278A1 (fr) | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonistes de guanylate cyclase utiles dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles |
| CA2726917C (fr) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles |
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