DK2417152T3 - Fremgangsmåde til isolering af linaclotid - Google Patents
Fremgangsmåde til isolering af linaclotidInfo
- Publication number
- DK2417152T3 DK2417152T3 DK10715185.4T DK10715185T DK2417152T3 DK 2417152 T3 DK2417152 T3 DK 2417152T3 DK 10715185 T DK10715185 T DK 10715185T DK 2417152 T3 DK2417152 T3 DK 2417152T3
- Authority
- DK
- Denmark
- Prior art keywords
- linaclotide
- isolating
- isolating linaclotide
- Prior art date
Links
- KXGCNMMJRFDFNR-WDRJZQOASA-N linaclotide Chemical compound C([C@H](NC(=O)[C@@H]1CSSC[C@H]2C(=O)N[C@H]3CSSC[C@H](N)C(=O)N[C@H](C(N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N2)=O)CSSC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(N)=O)NC3=O)C(=O)N[C@H](C(NCC(=O)N1)=O)[C@H](O)C)C(O)=O)C1=CC=C(O)C=C1 KXGCNMMJRFDFNR-WDRJZQOASA-N 0.000 title 1
- 229960000812 linaclotide Drugs 0.000 title 1
- 108010024409 linaclotide Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16825909P | 2009-04-10 | 2009-04-10 | |
| PCT/EP2010/054577 WO2010115916A1 (en) | 2009-04-10 | 2010-04-07 | Process for isolating therapeutic peptide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2417152T3 true DK2417152T3 (da) | 2013-12-16 |
Family
ID=42289374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10715185.4T DK2417152T3 (da) | 2009-04-10 | 2010-04-07 | Fremgangsmåde til isolering af linaclotid |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20100261877A1 (da) |
| EP (1) | EP2417152B1 (da) |
| CN (1) | CN102482326A (da) |
| DK (1) | DK2417152T3 (da) |
| ES (1) | ES2439998T3 (da) |
| IL (1) | IL215562A0 (da) |
| WO (1) | WO2010115916A1 (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8748575B2 (en) * | 2010-06-09 | 2014-06-10 | Combimab, Inc. | Therapeutic peptides |
| EA201391254A1 (ru) * | 2011-03-01 | 2014-02-28 | Синерджи Фармасьютикалз Инк. | Способ получения агонистов гуанилатциклазы c |
| JP2016521249A (ja) * | 2012-07-12 | 2016-07-21 | フォレスト ラボラトリーズ ホールディングス リミテッド | リナクロチド組成物 |
| CN103848893B (zh) * | 2012-12-07 | 2016-08-10 | 深圳翰宇药业股份有限公司 | 一种利那洛肽的纯化方法 |
| WO2014118180A1 (en) | 2013-01-30 | 2014-08-07 | Sandoz Ag | Crystalline form of linaclotide |
| CN104231051B (zh) * | 2013-06-06 | 2020-06-26 | 深圳翰宇药业股份有限公司 | 一种利那洛肽的制备方法 |
| EP3492106B1 (en) | 2013-08-09 | 2021-02-17 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| WO2016012938A2 (en) * | 2014-07-22 | 2016-01-28 | Dr. Reddy’S Laboratories Limited | Improved process for preparation of amorphous linaclotide |
| WO2014188011A2 (en) * | 2014-09-25 | 2014-11-27 | Lonza Ltd | Method for preparation of linaclotide |
| CN110878118B (zh) * | 2018-09-06 | 2023-04-18 | 深圳翰宇药业股份有限公司 | 度拉糖肽的纯化方法与纯化试剂 |
| EP3972599B1 (en) | 2019-05-21 | 2025-10-22 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6956021B1 (en) * | 1998-08-25 | 2005-10-18 | Advanced Inhalation Research, Inc. | Stable spray-dried protein formulations |
| KR100464208B1 (ko) * | 2001-12-20 | 2005-01-03 | 엘지.필립스 엘시디 주식회사 | 액정 표시장치 및 그 구동방법 |
| SE0104462D0 (sv) * | 2001-12-29 | 2001-12-29 | Carlbiotech Ltd As | Peptide purifcation (Peptidrening) |
| US20040028747A1 (en) * | 2002-08-06 | 2004-02-12 | Tucker Christopher J. | Crystalline drug particles prepared using a controlled precipitation process |
| KR101227626B1 (ko) * | 2003-01-28 | 2013-02-01 | 아이언우드 파마슈티컬스, 인코포레이티드 | 위장병 치료 방법 및 위장병 치료용 조성물 |
| US7772188B2 (en) * | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US7371727B2 (en) | 2003-01-28 | 2008-05-13 | Microbia, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
-
2010
- 2010-04-07 CN CN2010800256056A patent/CN102482326A/zh active Pending
- 2010-04-07 DK DK10715185.4T patent/DK2417152T3/da active
- 2010-04-07 EP EP10715185.4A patent/EP2417152B1/en not_active Revoked
- 2010-04-07 WO PCT/EP2010/054577 patent/WO2010115916A1/en not_active Ceased
- 2010-04-07 ES ES10715185.4T patent/ES2439998T3/es active Active
- 2010-04-09 US US12/757,357 patent/US20100261877A1/en not_active Abandoned
-
2011
- 2011-10-05 IL IL215562A patent/IL215562A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010115916A1 (en) | 2010-10-14 |
| US20100261877A1 (en) | 2010-10-14 |
| IL215562A0 (en) | 2011-12-29 |
| EP2417152B1 (en) | 2013-10-02 |
| EP2417152A1 (en) | 2012-02-15 |
| CN102482326A (zh) | 2012-05-30 |
| ES2439998T3 (es) | 2014-01-27 |
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