LU86732A1 - Derives d'indole,procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents

Derives d'indole,procede pour leur preparation et compositions pharmaceutiques les contenant Download PDF

Info

Publication number
LU86732A1
LU86732A1 LU86732A LU86732A LU86732A1 LU 86732 A1 LU86732 A1 LU 86732A1 LU 86732 A LU86732 A LU 86732A LU 86732 A LU86732 A LU 86732A LU 86732 A1 LU86732 A1 LU 86732A1
Authority
LU
Luxembourg
Prior art keywords
compound
group
general formula
formula
mixture
Prior art date
Application number
LU86732A
Other languages
English (en)
French (fr)
Inventor
Michael Dennis Dowle
Ian Harold Coates
Keith Mills
Alexander William Oxford
David Edmund Bays
Colin Frederick Webb
Colin David Eldred
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of LU86732A1 publication Critical patent/LU86732A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
LU86732A 1986-01-08 1987-01-08 Derives d'indole,procede pour leur preparation et compositions pharmaceutiques les contenant LU86732A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8600397 1986-01-08
GB868600397A GB8600397D0 (en) 1986-01-08 1986-01-08 Chemical compounds

Publications (1)

Publication Number Publication Date
LU86732A1 true LU86732A1 (fr) 1988-02-02

Family

ID=10591074

Family Applications (1)

Application Number Title Priority Date Filing Date
LU86732A LU86732A1 (fr) 1986-01-08 1987-01-08 Derives d'indole,procede pour leur preparation et compositions pharmaceutiques les contenant

Country Status (23)

Country Link
US (1) US4855314A (enExample)
EP (1) EP0240096A1 (enExample)
JP (1) JPS62228056A (enExample)
KR (1) KR870007116A (enExample)
CN (1) CN1030409A (enExample)
AU (1) AU597325B2 (enExample)
BE (1) BE1000071A4 (enExample)
CH (1) CH672637A5 (enExample)
DE (1) DE3700408A1 (enExample)
DK (1) DK8787A (enExample)
FI (1) FI870062A7 (enExample)
FR (1) FR2595351B1 (enExample)
GB (2) GB8600397D0 (enExample)
HU (1) HU198685B (enExample)
IL (1) IL81201A (enExample)
IT (1) IT1205849B (enExample)
LU (1) LU86732A1 (enExample)
NL (1) NL8700026A (enExample)
NO (1) NO870075L (enExample)
NZ (1) NZ218868A (enExample)
PH (1) PH24741A (enExample)
PT (1) PT84075B (enExample)
ZA (1) ZA87105B (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8530507D0 (en) * 1985-12-11 1986-01-22 Glaxo Group Plc Chemical compounds
GB8600398D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8724912D0 (en) 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
GB8823731D0 (en) * 1988-10-10 1988-11-16 Smith Kline French Lab Biologically active compounds
EP0636623B1 (en) * 1990-06-07 2001-08-16 AstraZeneca AB Indole derivatives as 5-HT1- like agonists
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
WO1992006973A1 (en) * 1990-10-15 1992-04-30 Pfizer Inc. Indole derivatives
CA2061520C (en) * 1991-03-27 2003-04-22 Lawrence J. Daher Delivery system for enhanced onset and increased potency
BR9206810A (pt) * 1991-11-25 1995-10-31 Pfizer Derivados de indol
TW288010B (enExample) * 1992-03-05 1996-10-11 Pfizer
RU2101283C1 (ru) * 1992-04-07 1998-01-10 Пфайзер Инк. Производные индола или их фармацевтически приемлемые соли
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
CZ282653B6 (cs) * 1992-04-10 1997-08-13 Pfizer Inc. Acylaminoindolové deriváty představující 5-HT1 agonisty, způsob jejich přípravy, farmaceutické prostředky obsahující tyto látky, jejich použití a meziprodukty postupu přípravy
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
TW251284B (enExample) * 1992-11-02 1995-07-11 Pfizer
FR2707639B1 (fr) * 1993-06-30 1995-10-13 Pf Medicament Nouveaux composés indoliques dérivés d'arylamines comme ligands sélectifs des récepteurs 5HT1D et 5HT1B.
ES2070772B1 (es) * 1993-08-09 1996-02-16 Pfizer Derivados de acilaminoindol
DK0716649T3 (da) * 1993-08-31 1999-02-08 Pfizer 5-Arylindolderivater
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
FR2749846B1 (fr) * 1996-06-17 1998-09-11 Pf Medicament Sel de methanesulfonate d'une arylpiperazine derivee de tryptamine et ses solvates pour usage pharmaceutique
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
JP2004506714A (ja) * 2000-08-21 2004-03-04 パシフィック　コーポレーション 新規チオ尿素化合物及びこれを含有する薬学的組成物
MXPA04012832A (es) * 2002-06-21 2005-05-27 Suven Life Sciences Ltd Arilsulfonil indoles novedosos que tienen afinidad por el receptor de la serotonina, utiles como agentes terapeuticos, proceso para su preparacion y composiciones farmaceuticas que los contienen.
DK1517909T3 (da) 2002-06-21 2007-02-19 Suven Life Sciences Ltd Tetracykliske arylcarbonylindoler med serotoninreceptor-affinitet til anvendelse som terpaeutiske midler, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger indeholdende dem
BR0312175A (pt) * 2002-06-21 2005-04-05 Suven Life Sciences Ltd Composto, composição farmacêutica, uso de um composto, método para o tratamento e método para reduzir a morbidez e a mortalidade associadas com o excesso de peso
BRPI0318799B8 (pt) * 2002-11-28 2021-05-25 Suven Life Sciences Ltd processo para a preparação de um composto
CN1720227A (zh) 2002-11-28 2006-01-11 苏文生命科学有限公司 N－芳基磺酰基－3－氨基烷氧基吲哚
AU2003292510B2 (en) * 2002-12-18 2009-04-23 Suven Life Sciences Limited Tetracyclic 3-substituted indoles having serotonin receptor affinity
WO2004056769A2 (en) 2002-12-20 2004-07-08 Ciba Specialty Chemicals Holding Inc. Synthesis of amines and intermediates for the synthesis thereof
BRPI0713653A2 (pt) * 2006-06-12 2012-10-23 Novartis Ag processo para a preparação de sais de n-hidróxi-3-[4-[[[2-(2-metil-1h-indol-3-il)etil]amino]metil ]fenil]-2e-2propenamida

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3472870A (en) * 1966-08-29 1969-10-14 Mead Johnson & Co Sulfonamidotryptamines
FR2334358A1 (fr) * 1975-12-12 1977-07-08 Sogeras Nouveaux medicaments derives de l'indole
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
NZ197998A (en) * 1980-08-12 1985-08-16 Glaxo Group Ltd 5-amino(methyl)-1h-indol-3-ylalkaneamines
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
HU196752B (en) * 1983-12-06 1989-01-30 Glaxo Group Ltd Process for production of medical compositions containing indole-derivatives and these compounds
GB8332434D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Production of chemical compounds
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8600398D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
GB2185020A (en) 1987-07-08
FI870062A7 (fi) 1987-07-09
GB8700382D0 (en) 1987-02-11
FR2595351A1 (fr) 1987-09-11
NO870075D0 (no) 1987-01-08
BE1000071A4 (fr) 1988-02-02
CN1030409A (zh) 1989-01-18
US4855314A (en) 1989-08-08
AU6742087A (en) 1987-07-09
PT84075B (pt) 1989-07-31
IT8747507A0 (it) 1987-01-08
AU597325B2 (en) 1990-05-31
DE3700408A1 (de) 1987-07-09
PT84075A (en) 1987-02-01
DK8787A (da) 1987-07-09
ZA87105B (en) 1987-09-30
FR2595351B1 (fr) 1990-07-13
IT1205849B (it) 1989-03-31
IL81201A (en) 1991-06-10
GB2185020B (en) 1990-05-16
GB8600397D0 (en) 1986-02-12
NO870075L (no) 1987-07-09
FI870062A0 (fi) 1987-01-08
NZ218868A (en) 1990-04-26
JPS62228056A (ja) 1987-10-06
HUT46891A (en) 1988-12-28
NL8700026A (nl) 1987-08-03
CH672637A5 (enExample) 1989-12-15
HU198685B (en) 1989-11-28
DK8787D0 (da) 1987-01-08
IL81201A0 (en) 1987-08-31
KR870007116A (ko) 1987-08-14
EP0240096A1 (en) 1987-10-07
PH24741A (en) 1990-10-01

Similar Documents

Publication Publication Date Title
LU86732A1 (fr) Derives d'indole,procede pour leur preparation et compositions pharmaceutiques les contenant
FR2530625A1 (fr) Derives d'indole, procedes pour leur preparation et compositions pharmaceutiques les contenant
EP1017693A1 (fr) Derives de carboxamidothiazoles, leur preparation, les compositions pharmaceutiques en contenant
FR2555987A1 (fr) Nouveaux derives d'indole utiles comme medicaments et intermediaires et procedes pour leur preparation
CH666026A5 (fr) Derive d'indole.
EP0984960B1 (fr) N-triazolyl-2-indolecarboxamides et leur utilisation comme agonistes de cck-a
EP1115719A2 (fr) Derives d'amidines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
CH651551A5 (fr) Derives de l'indole, leur preparation et compositions pharmaceutiques les contenant.
FR2673427A1 (fr) Derives heterocycliques diazotes n-substitues par un groupement biphenylmethyle, leur preparation, les compositions pharmaceutiques en contenant.
CA2267154A1 (fr) Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
CH667647A5 (fr) 5-alkenesulfonamides indoles.
BE1000072A4 (fr) Derives de l'indole utiles comme medicaments et procede et intermediaires pour leur preparation.
CH652394A5 (fr) Derives indoliques, leur preparation et medicaments les renfermant.
CH667454A5 (fr) Derives d'indoles.
EP1507758B1 (fr) Derives d'indole et leur utilisation en tant que ligands des recepteurs cb2
EP0620221A1 (fr) 5-Acylamino 1,2,4-thiadiazoles comme antagonistes ou agonistes de la cholécystokinine
FR2600061A1 (fr) Derives d'indole, composition pharmaceutique les contenant et procede pour leur preparation
FR2730490A1 (fr) Derives 1-(2-(vinyl-substitues))-3,4-dihydro-5h-2,3- benzodiazepine
EP0782568A1 (fr) Ethers aromatiques derives d'indoles comme "5ht1-like" ligands
LU87129A1 (fr) Nouvel acide piperazinecarboxylique,sa preparation et son utilisation comme medicament
FR2772766A1 (fr) Nouveaux composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
MC593A1 (fr) Nouveaux benzène sulfonyl-semicarbazides et leur préparation
JP4976499B2 (ja) キマーゼ阻害剤としてのビニル酸誘導体
FR2719047A1 (fr) Nouveaux dérivés de benzylamines, leur procédé de fabrication et les compositions pharmaceutiques les renfermant.
WO2000014073A1 (fr) Derives de la benzodiazepinone, procede de preparation et intermediaires de ce procede, application a titre de medicaments et compositions