NZ218868A - 3-(2-aminoethyl)indole derivatives, pharmaceutical compsositions thereof and intermediates - Google Patents

3-(2-aminoethyl)indole derivatives, pharmaceutical compsositions thereof and intermediates

Info

Publication number
NZ218868A
NZ218868A NZ218868A NZ21886887A NZ218868A NZ 218868 A NZ218868 A NZ 218868A NZ 218868 A NZ218868 A NZ 218868A NZ 21886887 A NZ21886887 A NZ 21886887A NZ 218868 A NZ218868 A NZ 218868A
Authority
NZ
New Zealand
Prior art keywords
compsositions
aminoethyl
intermediates
pharmaceutical
indole derivatives
Prior art date
Application number
NZ218868A
Other languages
English (en)
Inventor
Alexander William Oxford
Ian Harold Coates
David Edmund Bays
Colin Frederick Webb
Michael Dennis Dowle
Keith Mills
Colin David Eldred
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of NZ218868A publication Critical patent/NZ218868A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NZ218868A 1986-01-08 1987-01-08 3-(2-aminoethyl)indole derivatives, pharmaceutical compsositions thereof and intermediates NZ218868A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868600397A GB8600397D0 (en) 1986-01-08 1986-01-08 Chemical compounds

Publications (1)

Publication Number Publication Date
NZ218868A true NZ218868A (en) 1990-04-26

Family

ID=10591074

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ218868A NZ218868A (en) 1986-01-08 1987-01-08 3-(2-aminoethyl)indole derivatives, pharmaceutical compsositions thereof and intermediates

Country Status (23)

Country Link
US (1) US4855314A (enExample)
EP (1) EP0240096A1 (enExample)
JP (1) JPS62228056A (enExample)
KR (1) KR870007116A (enExample)
CN (1) CN1030409A (enExample)
AU (1) AU597325B2 (enExample)
BE (1) BE1000071A4 (enExample)
CH (1) CH672637A5 (enExample)
DE (1) DE3700408A1 (enExample)
DK (1) DK8787A (enExample)
FI (1) FI870062A7 (enExample)
FR (1) FR2595351B1 (enExample)
GB (2) GB8600397D0 (enExample)
HU (1) HU198685B (enExample)
IL (1) IL81201A (enExample)
IT (1) IT1205849B (enExample)
LU (1) LU86732A1 (enExample)
NL (1) NL8700026A (enExample)
NO (1) NO870075L (enExample)
NZ (1) NZ218868A (enExample)
PH (1) PH24741A (enExample)
PT (1) PT84075B (enExample)
ZA (1) ZA87105B (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8530507D0 (en) * 1985-12-11 1986-01-22 Glaxo Group Plc Chemical compounds
GB8600398D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8724912D0 (en) 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
GB8823731D0 (en) * 1988-10-10 1988-11-16 Smith Kline French Lab Biologically active compounds
CZ288351B6 (en) * 1990-06-07 2001-05-16 Astrazeneca Ab Nitrogenous heterocyclic compound, process of its preparation and use as well as a medicament containing thereof
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
HU225055B1 (en) * 1990-10-15 2006-05-29 Pfizer Indole derivatives, their intermediates, process for production them and pharmaceutical compositions containing the compounds
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
CA2061520C (en) * 1991-03-27 2003-04-22 Lawrence J. Daher Delivery system for enhanced onset and increased potency
CA2124206C (en) * 1991-11-25 2001-02-27 John Eugene Macor Indole derivatives
TW288010B (enExample) * 1992-03-05 1996-10-11 Pfizer
AU670579B2 (en) 1992-04-07 1996-07-25 Pfizer Inc. Indole derivatives as 5-HT1 agonists
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
EP0635015B1 (en) * 1992-04-10 1997-01-29 Pfizer Inc. Acylaminoindole derivatives as 5-ht1 agonists
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
TW251284B (enExample) * 1992-11-02 1995-07-11 Pfizer
FR2707639B1 (fr) * 1993-06-30 1995-10-13 Pf Medicament Nouveaux composés indoliques dérivés d'arylamines comme ligands sélectifs des récepteurs 5HT1D et 5HT1B.
ES2070772B1 (es) * 1993-08-09 1996-02-16 Pfizer Derivados de acilaminoindol
AU686654B2 (en) * 1993-08-31 1998-02-12 Pfizer Inc. 5-arylindole derivatives
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
FR2749846B1 (fr) * 1996-06-17 1998-09-11 Pf Medicament Sel de methanesulfonate d'une arylpiperazine derivee de tryptamine et ses solvates pour usage pharmaceutique
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
EP1311478B1 (en) * 2000-08-21 2006-06-07 Pacific Corporation Novel (thio)urea compounds and the pharmaceutical compositions containing the same
SI1517909T1 (sl) 2002-06-21 2007-06-30 Suven Life Sciences Ltd Novi tetraciklični arilkarbonil indoli, ki imajo afiniteto za serotoninski receptor, uporabni kot terapevtska sredstva, postopek za njihovo pripravo in farmacevtski sestavki, ki jih vsebujejo
ES2297216T3 (es) * 2002-06-21 2008-05-01 Suven Life Sciences Limited Indoles tetraciclicos arilsulfonil que tienen afinidad con el receptor de la serotonina.
BR0312175A (pt) * 2002-06-21 2005-04-05 Suven Life Sciences Ltd Composto, composição farmacêutica, uso de um composto, método para o tratamento e método para reduzir a morbidez e a mortalidade associadas com o excesso de peso
US7507835B2 (en) 2002-11-28 2009-03-24 Suven Life Sciences Ltd. N-arylsulfonyl-3-aminoalkoxyindoles
ATE401307T1 (de) * 2002-11-28 2008-08-15 Suven Life Sciences Ltd N-arylsulfonyl-2-substituierte indole mit affinität zum serotonin rezeptor, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen
JP4571507B2 (ja) * 2002-12-18 2010-10-27 スベン ライフ サイエンシズ リミティド セロトニン受容体親和性を有する四環系３−置換インドール
CA2508290C (en) * 2002-12-20 2017-02-28 Ciba Specialty Chemicals Holding Inc. Synthesis of amines and intermediates for the synthesis thereof
AU2007257882B2 (en) 2006-06-12 2011-09-08 Secura Bio Inc. Process for making salts of N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3472870A (en) * 1966-08-29 1969-10-14 Mead Johnson & Co Sulfonamidotryptamines
FR2334358A1 (fr) * 1975-12-12 1977-07-08 Sogeras Nouveaux medicaments derives de l'indole
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
DK157995C (da) * 1980-08-12 1990-08-06 Glaxo Group Ltd Analogifremgangsmaade til fremstilling af indolderivater
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8332435D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8332434D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Production of chemical compounds
GB8600398D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
IT1205849B (it) 1989-03-31
GB8600397D0 (en) 1986-02-12
PH24741A (en) 1990-10-01
EP0240096A1 (en) 1987-10-07
NO870075D0 (no) 1987-01-08
GB2185020A (en) 1987-07-08
US4855314A (en) 1989-08-08
KR870007116A (ko) 1987-08-14
IL81201A0 (en) 1987-08-31
CN1030409A (zh) 1989-01-18
IT8747507A0 (it) 1987-01-08
FR2595351A1 (fr) 1987-09-11
GB8700382D0 (en) 1987-02-11
FR2595351B1 (fr) 1990-07-13
JPS62228056A (ja) 1987-10-06
DE3700408A1 (de) 1987-07-09
PT84075A (en) 1987-02-01
ZA87105B (en) 1987-09-30
NL8700026A (nl) 1987-08-03
IL81201A (en) 1991-06-10
FI870062A0 (fi) 1987-01-08
CH672637A5 (enExample) 1989-12-15
GB2185020B (en) 1990-05-16
PT84075B (pt) 1989-07-31
HU198685B (en) 1989-11-28
HUT46891A (en) 1988-12-28
LU86732A1 (fr) 1988-02-02
FI870062A7 (fi) 1987-07-09
NO870075L (no) 1987-07-09
DK8787A (da) 1987-07-09
DK8787D0 (da) 1987-01-08
AU597325B2 (en) 1990-05-31
AU6742087A (en) 1987-07-09
BE1000071A4 (fr) 1988-02-02

Similar Documents

Publication Publication Date Title
AU6762687A (en) N,s and o-substituted indole derivatives
ZA901602B (en) Novel benzimidazole and azabenzimidazole derivatives,preparation intermediates and pharmaceuticals
GB2185020B (en) Indole derivatives
NZ218823A (en) Indole derivatives and pharmaceutical compositions thereof
NO892083D0 (no) Fremgangsmaate for fremstilling av arylmetylenyl-derivaterav tiazolidinoner, imidazolidinoner og oksazolidinoner.
IL86877A0 (en) Indole derivatives,their preparation and pharmaceutical compositions containing them
ZA872999B (en) Thienopyrimidine-2,4-dione derivatives and intermediates thereof
AU5650890A (en) Indole derivatives and medicine
EP0429341A3 (en) Heterocyclic derivatives, their preparation and pharmaceuticals containing them
IL75122A (en) 3-methyl-5-(tetrahydro-6-oxopyridazin-3-yl)indoline derivatives,their preparation and use
NZ219624A (en) Indole derivatives and pharmaceutical compositions
AU6556186A (en) 3-(pyrazolio-methyl)-cephem derivatives
NZ217580A (en) Tetrahydro-2-heterocyclyl alkyl-pyrido(4,3-b)indole derivatives and pharmaceutical compositions
NZ221052A (en) Cephalosporin derivatives, pharmaceutical compositions and intermediates
GB2186874B (en) Indole derivatives
NO893826D0 (no) Fremgangsmaate for fremstilling av 2'-halomethyliden, 2'-ethenyliden og 2'-ethenyladenosinderivater.
NZ218754A (en) 3-(2-aminoethyl)indole derivatives, intermediates thereof and pharmaceutical compositions thereof
AU8181187A (en) Lactam derivatives and preparation thereof
NZ218855A (en) 3-aminoglycosyl-21-amino-14,21-epoxy-24-norcholanic acid lactam derivatives and pharmaceutical compositions
NZ221633A (en) Heterocyclic sulphonamides, intermediates therefor and pharmaceutical compositions
AU6791790A (en) 5-(2-methyl-4,4,4-trifluorobutyl-carbamoyl)indole derivatives
GB2191488B (en) Indole derivatives
EP0211698A3 (en) (dihydro-4,5-1h-imidazolyl-2)-2-dihydro-2,3-indole derivatives, their preparation and their use as medicaments
IL81546A (en) N-(alpha-(4-diphenylalkyl-piperazin-1-ylmethyl))-purine-ethanol derivatives,their production and pharmaceutical compositions containing them
GB8925896D0 (en) Indole derivatives,their preparation and use as medicament