GB2185020B - Indole derivatives - Google Patents

Indole derivatives

Info

Publication number
GB2185020B
GB2185020B GB8700382A GB8700382A GB2185020B GB 2185020 B GB2185020 B GB 2185020B GB 8700382 A GB8700382 A GB 8700382A GB 8700382 A GB8700382 A GB 8700382A GB 2185020 B GB2185020 B GB 2185020B
Authority
GB
United Kingdom
Prior art keywords
indole derivatives
indole
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB8700382A
Other versions
GB8700382D0 (en
GB2185020A (en
Inventor
Keith Mills
Colin David Eldred
Alexander William Oxford
Michael Dennis Dowle
Ian Harold Coates
David Edmund Bays
Colin Frederick Webb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of GB8700382D0 publication Critical patent/GB8700382D0/en
Publication of GB2185020A publication Critical patent/GB2185020A/en
Application granted granted Critical
Publication of GB2185020B publication Critical patent/GB2185020B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
GB8700382A 1986-01-08 1987-01-08 Indole derivatives Expired - Fee Related GB2185020B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868600397A GB8600397D0 (en) 1986-01-08 1986-01-08 Chemical compounds

Publications (3)

Publication Number Publication Date
GB8700382D0 GB8700382D0 (en) 1987-02-11
GB2185020A GB2185020A (en) 1987-07-08
GB2185020B true GB2185020B (en) 1990-05-16

Family

ID=10591074

Family Applications (2)

Application Number Title Priority Date Filing Date
GB868600397A Pending GB8600397D0 (en) 1986-01-08 1986-01-08 Chemical compounds
GB8700382A Expired - Fee Related GB2185020B (en) 1986-01-08 1987-01-08 Indole derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB868600397A Pending GB8600397D0 (en) 1986-01-08 1986-01-08 Chemical compounds

Country Status (23)

Country Link
US (1) US4855314A (en)
EP (1) EP0240096A1 (en)
JP (1) JPS62228056A (en)
KR (1) KR870007116A (en)
CN (1) CN1030409A (en)
AU (1) AU597325B2 (en)
BE (1) BE1000071A4 (en)
CH (1) CH672637A5 (en)
DE (1) DE3700408A1 (en)
DK (1) DK8787A (en)
FI (1) FI870062A (en)
FR (1) FR2595351B1 (en)
GB (2) GB8600397D0 (en)
HU (1) HU198685B (en)
IL (1) IL81201A (en)
IT (1) IT1205849B (en)
LU (1) LU86732A1 (en)
NL (1) NL8700026A (en)
NO (1) NO870075L (en)
NZ (1) NZ218868A (en)
PH (1) PH24741A (en)
PT (1) PT84075B (en)
ZA (1) ZA87105B (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8530507D0 (en) * 1985-12-11 1986-01-22 Glaxo Group Plc Chemical compounds
GB8600398D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8724912D0 (en) 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
GB8823731D0 (en) * 1988-10-10 1988-11-16 Smith Kline French Lab Biologically active compounds
SK281621B6 (en) * 1990-06-07 2001-05-10 Astrazeneca Ab Therapeutic heterocyclic compounds
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
DE9190141U1 (en) * 1990-10-15 1993-07-15 Pfizer, Inc., New York, N.Y., Us
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
CA2061520C (en) * 1991-03-27 2003-04-22 Lawrence J. Daher Delivery system for enhanced onset and increased potency
US5639752A (en) * 1991-11-25 1997-06-17 Pfizer Inc Indole derivatives
TW288010B (en) * 1992-03-05 1996-10-11 Pfizer
US5747501A (en) 1992-04-07 1998-05-05 Pfizer, Inc. Indole derivatives
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
WO1993021180A1 (en) * 1992-04-10 1993-10-28 Pfizer Inc. Acylaminoindole derivatives as 5-ht1 agonists
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
TW251284B (en) * 1992-11-02 1995-07-11 Pfizer
FR2707639B1 (en) * 1993-06-30 1995-10-13 Pf Medicament New indole compounds derived from arylamines as selective ligands for the 5HT1D and 5HT1B receptors.
ES2070772B1 (en) * 1993-08-09 1996-02-16 Pfizer DERIVATIVES OF ACILAMINOINDOL
BR9407402A (en) * 1993-08-31 1996-11-05 Pfizer Derivatives of 5-arylindole
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
FR2749846B1 (en) * 1996-06-17 1998-09-11 Pf Medicament METHANESULFONATE SALT OF ARYLPIPERAZINE DERIVED FROM TRYPTAMINE AND ITS SOLVATES FOR PHARMACEUTICAL USE
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
DE60120421T2 (en) * 2000-08-21 2006-12-28 Pacific Corp. NEW (THIO) UREA CONNECTIONS AND MEDICINAL COMPOSITIONS CONTAINING THEM
JP4455992B2 (en) * 2002-06-21 2010-04-21 スベン ライフ サイエンシズ リミティド Arylalkyl indoles having serotonin receptor affinity useful as therapeutic agents, methods for their production, and pharmaceutical compositions containing them
CN1665815A (en) 2002-06-21 2005-09-07 苏文生命科学有限公司 Novel tetracyclo-aryl-carbonyl indoles used as therapeutical agents with 5-hydroxy-tryptamine receptor affinity, their preparation process and pharmaceutical compounds containing same
DK1523486T3 (en) * 2002-06-21 2008-03-03 Suven Life Sciences Ltd Tetracyclic arylsulfonyl indoles with serotonin receptor affinity
JP4559230B2 (en) * 2002-11-28 2010-10-06 スベン ライフ サイエンシズ リミティド Novel N-arylsulfonyl-3-substituted indoles having affinity for serotonin receptors, methods for their preparation, and pharmaceutical compositions containing them
PT1567492E (en) 2002-11-28 2013-07-22 Suven Life Sciences Ltd N-arylsulfonyl-3-aminoalkoxyindoles
BRPI0316895C1 (en) * 2002-12-18 2021-05-25 Suven Life Sciences Ltd compound, process for preparing the compound, pharmaceutical composition and use of the compound
CA2508290C (en) 2002-12-20 2017-02-28 Ciba Specialty Chemicals Holding Inc. Synthesis of amines and intermediates for the synthesis thereof
BRPI0713653A2 (en) 2006-06-12 2012-10-23 Novartis Ag Process for the preparation of n-hydroxy-3- [4 - [[[2- (2-methyl-1h-indol-3-yl) ethyl] amino] methyl] phenyl] -2e-2propenamide salts

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2081717A (en) * 1980-08-12 1982-02-24 Glaxo Group Ltd Hereocyclic compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3472870A (en) * 1966-08-29 1969-10-14 Mead Johnson & Co Sulfonamidotryptamines
FR2334358A1 (en) * 1975-12-12 1977-07-08 Sogeras NEW DRUGS DERIVED FROM INDOLE
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
SE454777B (en) * 1980-08-12 1988-05-30 Glaxo Group Ltd 5-SUBSTITUTED 3-AMINOALKYL-1H INDOLES, PROCEDURES FOR THE PREPARATION OF THESE AND A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF MIGREN
GB8332434D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Production of chemical compounds
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
HU196752B (en) * 1983-12-06 1989-01-30 Glaxo Group Ltd Process for production of medical compositions containing indole-derivatives and these compounds
GB8600398D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2081717A (en) * 1980-08-12 1982-02-24 Glaxo Group Ltd Hereocyclic compounds

Also Published As

Publication number Publication date
AU6742087A (en) 1987-07-09
LU86732A1 (en) 1988-02-02
HU198685B (en) 1989-11-28
EP0240096A1 (en) 1987-10-07
CN1030409A (en) 1989-01-18
KR870007116A (en) 1987-08-14
PT84075A (en) 1987-02-01
DE3700408A1 (en) 1987-07-09
HUT46891A (en) 1988-12-28
FR2595351B1 (en) 1990-07-13
BE1000071A4 (en) 1988-02-02
GB8700382D0 (en) 1987-02-11
NO870075L (en) 1987-07-09
CH672637A5 (en) 1989-12-15
NO870075D0 (en) 1987-01-08
AU597325B2 (en) 1990-05-31
NZ218868A (en) 1990-04-26
IT8747507A0 (en) 1987-01-08
PT84075B (en) 1989-07-31
IT1205849B (en) 1989-03-31
FR2595351A1 (en) 1987-09-11
DK8787D0 (en) 1987-01-08
IL81201A0 (en) 1987-08-31
GB2185020A (en) 1987-07-08
FI870062A (en) 1987-07-09
GB8600397D0 (en) 1986-02-12
JPS62228056A (en) 1987-10-06
US4855314A (en) 1989-08-08
DK8787A (en) 1987-07-09
ZA87105B (en) 1987-09-30
NL8700026A (en) 1987-08-03
FI870062A0 (en) 1987-01-08
PH24741A (en) 1990-10-01
IL81201A (en) 1991-06-10

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19940108