LU79891A1 - Procede de culture de virus - Google Patents
Procede de culture de virus Download PDFInfo
- Publication number
- LU79891A1 LU79891A1 LU79891A LU79891A LU79891A1 LU 79891 A1 LU79891 A1 LU 79891A1 LU 79891 A LU79891 A LU 79891A LU 79891 A LU79891 A LU 79891A LU 79891 A1 LU79891 A1 LU 79891A1
- Authority
- LU
- Luxembourg
- Prior art keywords
- culture
- virus
- carried out
- fermenter
- cells
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title claims description 18
- 238000000034 method Methods 0.000 title claims description 17
- 239000000835 fiber Substances 0.000 claims description 24
- 239000000725 suspension Substances 0.000 claims description 22
- 102000008186 Collagen Human genes 0.000 claims description 14
- 108010035532 Collagen Proteins 0.000 claims description 14
- 229920001436 collagen Polymers 0.000 claims description 14
- 238000003756 stirring Methods 0.000 claims description 10
- 239000006228 supernatant Substances 0.000 claims description 10
- 235000015097 nutrients Nutrition 0.000 claims description 9
- 241000711798 Rabies lyssavirus Species 0.000 claims description 7
- 230000006978 adaptation Effects 0.000 claims description 3
- 238000012136 culture method Methods 0.000 claims description 2
- 101100245379 Arabidopsis thaliana PBF1 gene Proteins 0.000 claims 1
- 238000010899 nucleation Methods 0.000 claims 1
- 238000009331 sowing Methods 0.000 claims 1
- 238000005273 aeration Methods 0.000 description 11
- 230000003612 virological effect Effects 0.000 description 8
- 238000013019 agitation Methods 0.000 description 6
- 108090000631 Trypsin Proteins 0.000 description 4
- 102000004142 Trypsin Human genes 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 230000000050 nutritive effect Effects 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000012588 trypsin Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 206010037742 Rabies Diseases 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical compound O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229960000380 propiolactone Drugs 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 108010059712 Pronase Proteins 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000002528 anti-freeze Effects 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 229940077731 carbohydrate nutrients Drugs 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 238000010908 decantation Methods 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- AIUDWMLXCFRVDR-UHFFFAOYSA-N dimethyl 2-(3-ethyl-3-methylpentyl)propanedioate Chemical class CCC(C)(CC)CCC(C(=O)OC)C(=O)OC AIUDWMLXCFRVDR-UHFFFAOYSA-N 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 229960005030 other vaccine in atc Drugs 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 229940066779 peptones Drugs 0.000 description 1
- 229960003127 rabies vaccine Drugs 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/205—Rhabdoviridae, e.g. rabies virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2531/00—Microcarriers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20111—Lyssavirus, e.g. rabies virus
- C12N2760/20151—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7720115 | 1977-06-30 | ||
| FR7720115A FR2396083A1 (fr) | 1977-06-30 | 1977-06-30 | Procede de culture de virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU79891A1 true LU79891A1 (fr) | 1980-01-22 |
Family
ID=9192781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU79891A LU79891A1 (fr) | 1977-06-30 | 1978-06-29 | Procede de culture de virus |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4169761A (it) |
| AR (1) | AR216331A1 (it) |
| BE (1) | BE868573A (it) |
| DE (1) | DE2828073C2 (it) |
| DK (1) | DK147889C (it) |
| FR (1) | FR2396083A1 (it) |
| GB (1) | GB1604003A (it) |
| IE (1) | IE47060B1 (it) |
| IT (1) | IT1097352B (it) |
| LU (1) | LU79891A1 (it) |
| NL (1) | NL7806899A (it) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE456164B (sv) * | 1980-08-20 | 1988-09-12 | Kjell Nilsson | Forfarande for immobilisering, odling och efterfoljande frigoring av animala celler samt mikroberare av gelatin med absorberade animala celler |
| JPS5832876B2 (ja) * | 1981-03-27 | 1983-07-15 | 呉羽化学工業株式会社 | 組織培養基材 |
| JPS5928472A (ja) * | 1982-08-09 | 1984-02-15 | Koken:Kk | 細胞培養用基質およびこの基質を用いた細胞培養・分離法 |
| US4560655A (en) * | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| SE454518B (sv) * | 1984-05-21 | 1988-05-09 | Statens Bakteriologiska Lab | Forfarande for odling av diploida celler i nervaro av cellulosafibrer |
| US4748121A (en) * | 1984-11-30 | 1988-05-31 | Ppg Industries, Inc. | Porous glass fibers with immobilized biochemically active material |
| US4861714A (en) * | 1985-04-04 | 1989-08-29 | Verax Corporation | Weighted collagen microsponge for immobilizing bioactive material |
| US5100783A (en) * | 1985-05-10 | 1992-03-31 | Verax Corporation | Weighted microsponge for immobilizing bioactive material |
| DE3526809A1 (de) * | 1985-07-26 | 1987-04-02 | Behringwerke Ag | Tollwut-lebendimpfstoff |
| EP0513803A2 (en) * | 1991-05-17 | 1992-11-19 | Japan Vilene Company, Ltd. | Carrier for immobilization of animal cells, process for manufacture thereof, and methods for cultivation |
-
1977
- 1977-06-30 FR FR7720115A patent/FR2396083A1/fr active Granted
-
1978
- 1978-05-30 GB GB24289/78A patent/GB1604003A/en not_active Expired
- 1978-06-23 US US05/918,962 patent/US4169761A/en not_active Expired - Lifetime
- 1978-06-27 IT IT25037/78A patent/IT1097352B/it active
- 1978-06-27 DE DE2828073A patent/DE2828073C2/de not_active Expired
- 1978-06-27 NL NL7806899A patent/NL7806899A/xx not_active Application Discontinuation
- 1978-06-27 DK DK289378A patent/DK147889C/da active
- 1978-06-29 AR AR272761A patent/AR216331A1/es active
- 1978-06-29 LU LU79891A patent/LU79891A1/fr unknown
- 1978-06-29 IE IE1315/78A patent/IE47060B1/en unknown
- 1978-06-29 BE BE188933A patent/BE868573A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2396083A1 (fr) | 1979-01-26 |
| GB1604003A (en) | 1981-12-02 |
| DK289378A (da) | 1978-12-31 |
| US4169761A (en) | 1979-10-02 |
| DK147889B (da) | 1985-01-02 |
| IT7825037A0 (it) | 1978-06-27 |
| IT1097352B (it) | 1985-08-31 |
| BE868573A (fr) | 1978-12-29 |
| NL7806899A (nl) | 1979-01-03 |
| FR2396083B1 (it) | 1980-03-07 |
| DK147889C (da) | 1985-06-10 |
| DE2828073C2 (de) | 1983-05-05 |
| AR216331A1 (es) | 1979-12-14 |
| IE47060B1 (en) | 1983-12-14 |
| IE781315L (en) | 1978-12-30 |
| DE2828073A1 (de) | 1979-01-11 |
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