LT5410B - 2-(chinoksalin-5-ilsulfonilamino)-benzamido junginiai kaip cck2 moduliatoriai - Google Patents

2-(chinoksalin-5-ilsulfonilamino)-benzamido junginiai kaip cck2 moduliatoriai Download PDF

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Publication number
LT5410B
LT5410B LT2006017A LT2006017A LT5410B LT 5410 B LT5410 B LT 5410B LT 2006017 A LT2006017 A LT 2006017A LT 2006017 A LT2006017 A LT 2006017A LT 5410 B LT5410 B LT 5410B
Authority
LT
Lithuania
Prior art keywords
alkyl
phenyl
quinoxaline
group
carbonyl
Prior art date
Application number
LT2006017A
Other languages
English (en)
Lithuanian (lt)
Other versions
LT2006017A (en
Inventor
Brett D. Allison
Michael D. Hack
Victor K. Phuong
Michael H. Rabinowitz
Mark D. Rosen
Original Assignee
Janssen Pharmaceutica N. V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N. V. filed Critical Janssen Pharmaceutica N. V.
Publication of LT2006017A publication Critical patent/LT2006017A/xx
Publication of LT5410B publication Critical patent/LT5410B/lt

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    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
    • C04B35/632—Organic additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Ceramic Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Materials Engineering (AREA)
  • Structural Engineering (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
LT2006017A 2003-08-08 2006-03-07 2-(chinoksalin-5-ilsulfonilamino)-benzamido junginiai kaip cck2 moduliatoriai LT5410B (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49407403P 2003-08-08 2003-08-08

Publications (2)

Publication Number Publication Date
LT2006017A LT2006017A (en) 2006-11-27
LT5410B true LT5410B (lt) 2007-03-26

Family

ID=34193199

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2006017A LT5410B (lt) 2003-08-08 2006-03-07 2-(chinoksalin-5-ilsulfonilamino)-benzamido junginiai kaip cck2 moduliatoriai

Country Status (33)

Country Link
US (3) US7288651B2 (ko)
EP (2) EP1651621B1 (ko)
JP (2) JP4818110B2 (ko)
KR (1) KR20060060007A (ko)
CN (2) CN1863782A (ko)
AR (1) AR045930A1 (ko)
AT (2) ATE353322T1 (ko)
AU (2) AU2004265311A1 (ko)
BR (1) BRPI0413449A (ko)
CA (2) CA2534887A1 (ko)
CR (1) CR8229A (ko)
CY (1) CY1106486T1 (ko)
DE (2) DE602004004663T2 (ko)
DK (2) DK1651622T3 (ko)
EA (1) EA200600203A1 (ko)
EC (1) ECSP066355A (ko)
ES (2) ES2281834T3 (ko)
HR (1) HRP20080559T3 (ko)
IL (1) IL173591A0 (ko)
IS (1) IS8280A (ko)
LT (1) LT5410B (ko)
LV (1) LV13453B (ko)
MX (2) MXPA06001550A (ko)
NO (1) NO20061122L (ko)
NZ (1) NZ545030A (ko)
PL (2) PL1651622T3 (ko)
PT (2) PT1651621E (ko)
SG (1) SG131114A1 (ko)
SI (2) SI1651622T1 (ko)
TW (1) TW200521120A (ko)
UA (1) UA84025C2 (ko)
WO (2) WO2005016897A1 (ko)
ZA (1) ZA200601946B (ko)

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DE602004004663T2 (de) * 2003-08-08 2007-11-22 Janssen Pharmaceutica N.V. Verfahren zur herstellung von 2- (chinoxalin-5-ylsulfonylamino) -benzamid-verbindungen
WO2005085188A2 (en) * 2004-03-02 2005-09-15 Compass Pharmaceuticals Llc Compounds and methods for anti-tumor therapy
JP2007533753A (ja) * 2004-04-23 2007-11-22 タケダ サン ディエゴ インコーポレイテッド インドール誘導体及びキナーゼ阻害剤としてのその使用
US7947833B2 (en) * 2004-08-04 2011-05-24 Janssen Pharmaceutica Nv Preparation of quinoxaline compounds
KR20070057252A (ko) 2004-09-24 2007-06-04 얀센 파마슈티카 엔.브이. 설폰아미드 화합물
FR2904317A1 (fr) 2006-07-27 2008-02-01 Inst Nat Sante Rech Med Analogues d'halogenobenzamides marques a titre de radiopharmaceutiques
US8592565B2 (en) * 2007-01-12 2013-11-26 The Board Of Trustees Of The Leland Stanford Junior University Preparation of azide-modified carbon surfaces for coupling to various species
US8247403B2 (en) * 2007-03-07 2012-08-21 Takeda Pharmaceutical Company Limited Benzoxazepine derivatives and use thereof
WO2008124518A1 (en) * 2007-04-03 2008-10-16 Janssen Pharmaceutica N.V. Oxo-dihydroisoindole sulfonamide compounds as modulators of the cck2 receptor
EP2131243B1 (en) * 2008-06-02 2015-07-01 ASML Netherlands B.V. Lithographic apparatus and method for calibrating a stage position
US8354557B2 (en) * 2008-06-17 2013-01-15 Concert Pharmaceuticals, Inc. Synthesis of deuterated morpholine derivatives
US20100305093A1 (en) * 2009-04-09 2010-12-02 Exelixis, Inc. Inhibitors of mTOR and Methods of Making and Using
WO2011044506A2 (en) 2009-10-09 2011-04-14 Zafgen Corporation Sulphone compounds and methods of making and using same
ES2529233T3 (es) 2010-07-09 2015-02-18 Convergence Pharmaceuticals Limited Compuestos tetrazol como bloqueadores de canales de calcio
AU2011281037B2 (en) 2010-07-22 2014-11-27 Zafgen, Inc. Tricyclic compounds and methods of making and using same
CA2825408A1 (en) 2011-01-26 2012-08-02 Zafgen, Inc. Tetrazole compounds and methods of making and using same
BR112013028666A2 (pt) 2011-05-06 2017-08-08 Zafgen Inc compostos de pirazolo sulfonamida tricícilos e métodos para fazer e usar o mesmo
WO2012154676A1 (en) 2011-05-06 2012-11-15 Zafgen Corporation Partially saturated tricyclic compounds and methods of making and using same
CA2835195A1 (en) 2011-05-06 2012-11-15 Zafgen, Inc. Tricyclic sulfonamide compounds and methods of making and using same
US20120309796A1 (en) 2011-06-06 2012-12-06 Fariborz Firooznia Benzocycloheptene acetic acids
KR20140112566A (ko) 2012-01-18 2014-09-23 자프겐 인크. 삼환식 설폰 화합물 그리고 그의 제조방법 및 그를 이용하는 방법
MX2014008706A (es) 2012-01-18 2015-03-05 Zafgen Inc Compuestos tricíclicos de sulfonamida y métodos para elaborarlos y usarlos.
US8815915B2 (en) * 2012-03-01 2014-08-26 Allergan, Inc. Benzofuran-2-sulfonamides pyridine derivatives as chemokine receptor modulators
EP2925737B1 (en) 2012-11-05 2017-06-14 Zafgen, Inc. Tricyclic compounds for use in the treatment and/or control of obesity
AU2013337282A1 (en) 2012-11-05 2015-05-21 Zafgen, Inc. Tricyclic compounds and methods of making and using same
CA2890343A1 (en) 2012-11-05 2014-05-08 Zafgen, Inc. Tricyclic compounds useful in the treatment of liver disorders
JP6361168B2 (ja) * 2013-06-17 2018-07-25 Jsr株式会社 液晶配向剤、液晶配向膜、液晶表示素子、液晶表示素子の製造方法、重合体及び化合物
CN103524386B (zh) * 2013-10-24 2016-05-18 江苏鼎龙科技有限公司 2-氨基-4-甲磺酰胺甲基苯甲酸甲酯的制备方法
EP3071206B1 (en) 2013-11-22 2021-02-17 CL Biosciences LLC Gastrin antagonists (eg yf476, netazepide) for treatment and prevention of osteoporosis
KR20170016754A (ko) * 2015-08-04 2017-02-14 씨제이헬스케어 주식회사 크로마논 유도체의 신규한 제조방법
CN106565509A (zh) * 2016-11-03 2017-04-19 江苏鼎龙科技有限公司 2‑氨基‑4‑甲氨基苯甲酸甲酯盐酸盐的制备方法
KR101894091B1 (ko) 2018-01-23 2018-08-31 씨제이헬스케어 주식회사 크로마논 유도체의 신규한 제조방법
CN108218806B (zh) * 2018-04-02 2019-03-01 上海馨远医药科技有限公司 一种n-叔丁氧羰基吗啉-3-羧酸的制备方法
CN111285806B (zh) * 2018-12-06 2022-04-15 中国医学科学院药物研究所 吡唑类化合物及其制备方法、用途和药物组合物
CN116675684B (zh) * 2023-08-02 2023-11-07 上海翰森生物医药科技有限公司 含炔基稠环类衍生物拮抗剂、其制备方法和应用

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WO1998025911A1 (fr) 1996-12-10 1998-06-18 Zeria Pharmaceutical Co., Ltd. Derives de 1,5-benzodiazepine

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KR20070057252A (ko) * 2004-09-24 2007-06-04 얀센 파마슈티카 엔.브이. 설폰아미드 화합물

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Publication number Priority date Publication date Assignee Title
WO1998025911A1 (fr) 1996-12-10 1998-06-18 Zeria Pharmaceutical Co., Ltd. Derives de 1,5-benzodiazepine

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J.H. WALSH: "Gastrointestinal Hormones", pages: 1

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Publication number Publication date
US20050038032A1 (en) 2005-02-17
ES2310294T3 (es) 2009-01-01
MXPA06001550A (es) 2006-09-04
CN1863781A (zh) 2006-11-15
PT1651622E (pt) 2007-04-30
ES2281834T3 (es) 2007-10-01
CN1863782A (zh) 2006-11-15
JP2007501841A (ja) 2007-02-01
ATE403650T1 (de) 2008-08-15
JP2007501842A (ja) 2007-02-01
DK1651622T3 (da) 2007-05-07
ATE353322T1 (de) 2007-02-15
US7304051B2 (en) 2007-12-04
WO2005016897A1 (en) 2005-02-24
TW200521120A (en) 2005-07-01
AU2004265311A1 (en) 2005-02-24
AU2004265312A1 (en) 2005-02-24
AR045930A1 (es) 2005-11-16
EA200600203A1 (ru) 2006-08-25
DE602004004663T2 (de) 2007-11-22
LV13453B (en) 2007-02-20
IS8280A (is) 2006-01-31
US20050043310A1 (en) 2005-02-24
SI1651621T1 (sl) 2008-12-31
CA2534885A1 (en) 2005-02-24
BRPI0413449A (pt) 2006-10-17
NO20061122L (no) 2006-05-04
PT1651621E (pt) 2008-09-30
ECSP066355A (es) 2006-08-30
US7288651B2 (en) 2007-10-30
CA2534885C (en) 2013-06-04
KR20060060007A (ko) 2006-06-02
SI1651622T1 (sl) 2007-06-30
EP1651621B1 (en) 2008-08-06
DE602004015614D1 (de) 2008-09-18
EP1651622A1 (en) 2006-05-03
AU2004265312B2 (en) 2010-05-20
CA2534887A1 (en) 2005-02-24
HRP20080559T3 (en) 2009-01-31
ZA200601946B (en) 2007-05-30
CY1106486T1 (el) 2012-01-25
JP4818110B2 (ja) 2011-11-16
SG131114A1 (en) 2007-04-26
WO2005016896A1 (en) 2005-02-24
DE602004004663D1 (de) 2007-03-22
PL1651622T3 (pl) 2007-07-31
CR8229A (es) 2008-09-10
US7563895B2 (en) 2009-07-21
US20080076918A1 (en) 2008-03-27
UA84025C2 (en) 2008-09-10
PL1651621T3 (pl) 2009-01-30
LT2006017A (en) 2006-11-27
DK1651621T3 (da) 2008-11-10
EP1651622B1 (en) 2007-02-07
NZ545030A (en) 2009-08-28
EP1651621A1 (en) 2006-05-03
IL173591A0 (en) 2006-07-05
MXPA06001482A (es) 2006-09-04

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