LT4879B - Pirazolino dariniai, jų gavimas ir jų panaudojimas vaistams - Google Patents

Pirazolino dariniai, jų gavimas ir jų panaudojimas vaistams Download PDF

Info

Publication number
LT4879B
LT4879B LT2000108A LT2000108A LT4879B LT 4879 B LT4879 B LT 4879B LT 2000108 A LT2000108 A LT 2000108A LT 2000108 A LT2000108 A LT 2000108A LT 4879 B LT4879 B LT 4879B
Authority
LT
Lithuania
Prior art keywords
dihydro
pyrazole
trifluoromethyl
aminosulfonylphenyl
methylsulfonylphenyl
Prior art date
Application number
LT2000108A
Other languages
English (en)
Lithuanian (lt)
Other versions
LT2000108A (en
Inventor
Maria Rosa Cuberes-Altisent
Juana Maria Berrocal-Romero
Maria Montserrat Contijoch-Llobet
Jordi Frigola-Constansa
Original Assignee
Laboratorios Del Dr. Esteve,S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Del Dr. Esteve,S.A. filed Critical Laboratorios Del Dr. Esteve,S.A.
Publication of LT2000108A publication Critical patent/LT2000108A/xx
Publication of LT4879B publication Critical patent/LT4879B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
LT2000108A 1998-05-29 2000-11-28 Pirazolino dariniai, jų gavimas ir jų panaudojimas vaistams LT4879B (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009801129A ES2137138B1 (es) 1998-05-29 1998-05-29 Derivados de pirazolinas, su preparacion y su aplicacion como medicamentos.

Publications (2)

Publication Number Publication Date
LT2000108A LT2000108A (en) 2001-09-25
LT4879B true LT4879B (lt) 2002-01-25

Family

ID=8303969

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2000108A LT4879B (lt) 1998-05-29 2000-11-28 Pirazolino dariniai, jų gavimas ir jų panaudojimas vaistams

Country Status (32)

Country Link
US (2) USRE38963E1 (zh)
EP (1) EP1083171B1 (zh)
JP (1) JP4633928B2 (zh)
KR (1) KR100603666B1 (zh)
CN (1) CN1189459C (zh)
AR (1) AR018402A1 (zh)
AT (1) ATE265437T1 (zh)
AU (1) AU752001B2 (zh)
BG (1) BG64950B1 (zh)
BR (1) BR9910801A (zh)
CA (1) CA2333475C (zh)
CO (1) CO5031241A1 (zh)
CU (1) CU22995A3 (zh)
CZ (1) CZ298391B6 (zh)
DE (1) DE69916828T2 (zh)
DK (1) DK1083171T3 (zh)
ES (2) ES2137138B1 (zh)
GE (1) GEP20043237B (zh)
HU (1) HUP0102102A3 (zh)
IS (1) IS2040B (zh)
LT (1) LT4879B (zh)
LV (1) LV12632B (zh)
NO (1) NO316600B1 (zh)
NZ (1) NZ508990A (zh)
PL (1) PL344412A1 (zh)
PT (1) PT1083171E (zh)
RU (1) RU2233272C2 (zh)
SI (1) SI20580B (zh)
SK (1) SK285550B6 (zh)
TW (1) TW572898B (zh)
WO (1) WO1999062884A1 (zh)
ZA (1) ZA200007638B (zh)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU771668C (en) * 1999-06-16 2005-08-11 Temple University - Of The Commonwealth System Of Higher Education 1-(4-sulfamylaryl)-3-substituted-5-aryl-2-pyrazolines as inhibitors of cyclooxygenase-2
ES2174757B1 (es) * 2001-04-06 2003-11-01 Esteve Labor Dr Empleo de derivados de firazolinas en la elaboracion de un medicamentopara la prevencion y/o el tratamiento de enfermedades proliferativas celulares.
US20030105144A1 (en) 2001-04-17 2003-06-05 Ping Gao Stabilized oral pharmaceutical composition
US6878729B2 (en) 2001-05-04 2005-04-12 The Procter & Gamble Company Medicinal uses of dihydropyrazoles
ES2183720B1 (es) 2001-06-18 2004-01-16 Esteve Labor Dr Procedimiento para la preparacion de derivados de 1,5-diaril-3-trifluorometil-delta2-pirazolinas racemicas y enantiomericamente puras.
CA2519189C (en) 2003-05-07 2012-07-17 Osteologix A/S Water-soluble strontium salts for use in treatment of cartilage and/or bone conditions
ES2238923B1 (es) * 2004-02-16 2006-11-01 Laboratorios Del Dr. Esteve, S.A. Nuevos derivados pirazolinicos sustituidos.
US7998996B2 (en) * 2004-02-17 2011-08-16 Laboratorios Del Dr. Esteve S.A. Substituted pyrazoline compounds for reducing triglycerides in blood
ES2257929B1 (es) * 2004-07-16 2007-05-01 Laboratorios Del Dr. Esteve, S.A. Derivados de pirazolina, procedimiento para su obtencion y utilizacion de los mismos como agentes terapeuticos.
ES2278503B1 (es) * 2005-06-27 2008-06-16 Laboratorios Del Dr. Esteve, S.A. Epoxidacion de cetonas alfa, beta - insaturadas.
WO2007009710A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds: methods for their preparation
EP1849784A1 (en) * 2006-04-26 2007-10-31 Laboratorios Del Dr. Esteve, S.A. Indoline-substituted pyrazoline compounds, their preparation and use as medicaments
WO2007009692A1 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A Use of substituted pyrazoline compounds for the treatment of food disorders, including obesity or metabolic syndrome in patients with developed diabetes
EP1743892A1 (en) * 2005-07-15 2007-01-17 Laboratorios del Dr. Esteve S.A. Substituted pyrazoline compounds, their preparation and use as medicaments
WO2007009699A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A Use of substituted pyrazoline compounds and their derivatives for the treatment of cannabinoid system-associated diseases
ES2326724B1 (es) * 2005-07-15 2010-05-11 Laboratorios Del Dr. Esteve, S.A. Nuevas formulaciones de compuestos de pirazolina sustituidos.
WO2007009702A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds, having predetermined stereochemistry, for reducing triglycerides in blood
EP1749526A1 (en) * 2005-07-15 2007-02-07 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazoline compounds for the treatment of food disorders, including obesity or metabolic syndrome in patients with developed diabetes
ES2330993B1 (es) * 2005-07-15 2010-07-06 Laboratorios Del Dr. Esteve, S.A. Combinacion de antagonista del receptor de cannabinoides de tipo pirazolina y estatina.
EP1743642A1 (en) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazoline compounds and their derivatives for the treatment of cannabinoid system-associated diseases
ES2326725B1 (es) * 2005-07-15 2010-05-11 Laboratorios Del Dr. Esteve, S.A. Uso de compuestos de pirazolina sustituidos para el tratamiento de trastornos alimentarios, que incluyen la obesidad o el sindrome metabolico en pacientes con diabetes desarrollada.
ES2316306B1 (es) * 2005-07-15 2009-11-23 Laboratorios Del Dr. Esteve, S.A. Combinacion de un compuesto de pirazolina sustituido y un farmaco utilizado en trastornos relacionados con los alimentos.
EP1743643A1 (en) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. New formulations of substituted pyrazoline compounds
ES2334967B1 (es) * 2005-07-15 2010-10-21 Laboratorios Del Dr. Esteve, S.A. Compuestos de pirazolina sustituidos, con una estereoquimica predeterminada, para la reduccion de trigliceridos en sangre.
WO2007009683A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr.Esteve, S.A. Pharmaceutical formulations of substituted pyrazoline compounds
EP1743638A1 (en) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Pharmaceutical formulations of substituted pyrazoline compounds
EP1760078A1 (en) * 2005-07-15 2007-03-07 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds; methods for their preparation
EP1743636A1 (en) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Combination of a substituted pyrazoline compound and a drug used in food-related disorders
EP1757587A1 (en) * 2005-07-15 2007-02-28 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds, their preparation and use as medicaments
EP1745781A1 (en) * 2005-07-15 2007-01-24 Laboratorios Del Dr. Esteve, S.A. Combination of pyrazoline type cannabinoid receptor antagonist and statin
AR061623A1 (es) * 2006-06-26 2008-09-10 Novartis Ag Derivados de acido fenilacetico
US20100111858A1 (en) * 2007-01-19 2010-05-06 Howard Carol P Diangostic and Therapeutic Cyclooxygenase-2 Binding Ligands
EP3009137A1 (en) * 2014-10-16 2016-04-20 Ecuphar N.V. Pyrazoline-derived compound and its use in a weekly dosage regime against inflammation and pain derived from degenerative joint disease in mammals
EP4029502A1 (en) 2021-01-15 2022-07-20 Ecuphar N.V. Pyrazoline-derived compound (enflicoxib) for use in the prevention and/or treatment of pain and inflammation associated to surgery in mammals
IL305573A (en) 2021-03-15 2023-10-01 Saul Yedgar Hyaluronic acid conjugated with dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment or suppression of inflammatory diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2060660B (en) * 1979-10-18 1983-11-23 Bostik Ltd Adhesives containing pyrazoline activators
JPS5818363A (ja) * 1981-07-13 1983-02-02 アメリカン・サイアナミド・カンパニ− 複素環式置換アミノピラゾリン類およびその薬としての用途
DE3765782D1 (de) * 1987-01-05 1990-11-29 Du Pont Pyrazolin mit insektizidischer aktivitaet.
RU2169143C2 (ru) * 1995-05-25 2001-06-20 Джи. Ди. Сирл Энд Ко. Способ получения 3-галогеналкил-1н-пиразолов
GB9520584D0 (en) * 1995-10-09 1995-12-13 Fujisawa Pharmaceutical Co Pyrazole derivatives,processes for preparation thereof and pharmaceutical composition comprising the same

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
FLOWER RJ, VANE JR: "Inhibition of prostaglandin biosynthesis.", BIOCHEM PHARM, 1974
PICOT D ET AL.: "The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1", NATURE., 1994, pages 243 - 249
SIROIS J, RICHARDS JS.: "Purification and characterization of a novel, distinct isoform of prostaglandin endoperoxide synthase induced by human chorionic gonadotropin in granulosa cells of rat preovulatory follicles.", J. BIOL. CHEM., pages 6382 - 6388
VANE J R.: "Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs", NATURE NEW BIOL., 1971, pages 232 - 235
VANE JR, BOTTING RM.: "New insights into the mode of action of anti-inflammatory drugs.", INFLAMM RES., 1995, pages 1 - 10
W. WILKERSON ET AL.: "Antiinflammatory 4,5-Diarylpyrroles: Synthesis and QSAR", J. MED. CHEM., 1994, pages 988 - 998, XP002920002, DOI: doi:10.1021/jm00033a017

Also Published As

Publication number Publication date
SI20580B (sl) 2007-10-31
JP2002516908A (ja) 2002-06-11
ES2137138B1 (es) 2000-09-16
ES2137138A1 (es) 1999-12-01
CZ298391B6 (cs) 2007-09-19
HUP0102102A2 (hu) 2002-03-28
SI20580A (sl) 2001-12-31
ZA200007638B (en) 2001-11-13
KR20010052437A (ko) 2001-06-25
ES2221382T3 (es) 2004-12-16
BG105005A (en) 2001-08-31
NO20006029L (no) 2001-01-26
CO5031241A1 (es) 2001-04-27
KR100603666B1 (ko) 2006-07-24
ATE265437T1 (de) 2004-05-15
BG64950B1 (bg) 2006-10-31
BR9910801A (pt) 2001-11-27
EP1083171A1 (en) 2001-03-14
AU3932999A (en) 1999-12-20
AR018402A1 (es) 2001-11-14
NZ508990A (en) 2002-12-20
DE69916828T2 (de) 2005-04-14
NO20006029D0 (no) 2000-11-28
EP1083171B1 (en) 2004-04-28
PT1083171E (pt) 2004-09-30
SK18072000A3 (sk) 2001-07-10
SK285550B6 (sk) 2007-03-01
LV12632B (en) 2001-07-20
CU22995A3 (es) 2004-10-12
LT2000108A (en) 2001-09-25
US6353117B1 (en) 2002-03-05
DK1083171T3 (da) 2004-08-09
NO316600B1 (no) 2004-03-01
CA2333475C (en) 2009-12-08
DE69916828D1 (de) 2004-06-03
RU2233272C2 (ru) 2004-07-27
IS5736A (is) 2000-11-28
GEP20043237B (en) 2004-05-25
AU752001B2 (en) 2002-09-05
LV12632A (lv) 2001-03-20
CN1307566A (zh) 2001-08-08
PL344412A1 (en) 2001-11-05
WO1999062884A1 (es) 1999-12-09
CZ20004418A3 (en) 2001-06-13
CN1189459C (zh) 2005-02-16
USRE38963E1 (en) 2006-01-31
CA2333475A1 (en) 1999-12-09
JP4633928B2 (ja) 2011-02-16
IS2040B (is) 2005-08-15
TW572898B (en) 2004-01-21
HUP0102102A3 (en) 2002-06-28

Similar Documents

Publication Publication Date Title
LT4879B (lt) Pirazolino dariniai, jų gavimas ir jų panaudojimas vaistams
DE69422306T2 (de) Substituierte pyrazolyl-benzolsulfonamide zur behandlung von entzündungen
US5434178A (en) 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation
US5510496A (en) Substituted pyrazolyl benzenesulfonamides
TWI449696B (zh) 以５員雜環為主之ｐ３８激酶抑制劑
JP3490716B2 (ja) 炎症治療用３，４−置換ピラゾール
JPH09505828A (ja) 炎症治療用１，５−ジフェニルピラゾール化合物
JPH09505829A (ja) 炎症および炎症関連障害を処置するための１，４，５−トリフェニルピラゾリル化合物
JP2007528362A (ja) 置換アリールアルカン酸誘導体及びその用途
Tsuji et al. Studies on anti-inflammatory agents. IV. Synthesis and pharmacological properties of 1, 5-diarylpyrazoles and related derivatives
KR19990063989A (ko) 염증 치료용의 1,3,5-삼치환된 피라졸 화합물
EA022799B1 (ru) Пиразолилзамещенные производные угольной кислоты в качестве модуляторов рецептора простациклина (pgi2), применимые для лечения связанных с ним нарушений
MXPA00011839A (en) Pyrazoline derivatives, their preparation and application as medicaments
ES2337005B1 (es) Compuestos de pirazolina azepan o azocansustituidos, su preparacion ysu uso como medicamentos.
ES2325569B1 (es) Compuestos de pirazolina cicloalcanosustituidos, su preparacion y su uso como medicamentos.

Legal Events

Date Code Title Description
MM9A Lapsed patents

Effective date: 20080527