LT3550B - Process for the preparation of hexahydroazepines derivatives - Google Patents
Process for the preparation of hexahydroazepines derivatives Download PDFInfo
- Publication number
- LT3550B LT3550B LTIP704A LTIP704A LT3550B LT 3550 B LT3550 B LT 3550B LT IP704 A LTIP704 A LT IP704A LT IP704 A LTIP704 A LT IP704A LT 3550 B LT3550 B LT 3550B
- Authority
- LT
- Lithuania
- Prior art keywords
- formula
- compound
- group
- give
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Control Of Transmission Device (AREA)
- Data Exchanges In Wide-Area Networks (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR909007434A FR2663328B1 (fr) | 1990-06-14 | 1990-06-14 | Derives d'hexahydroazepines, un procede pour leur preparation et compositions pharmaceutiques les contenant. |
Publications (2)
Publication Number | Publication Date |
---|---|
LTIP704A LTIP704A (en) | 1995-01-31 |
LT3550B true LT3550B (en) | 1995-11-27 |
Family
ID=9397608
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTIP704A LT3550B (en) | 1990-06-14 | 1993-06-23 | Process for the preparation of hexahydroazepines derivatives |
Country Status (30)
Country | Link |
---|---|
US (2) | US5231092A (ru) |
EP (1) | EP0461986B1 (ru) |
JP (1) | JP2620422B2 (ru) |
KR (1) | KR100213531B1 (ru) |
AT (1) | ATE132861T1 (ru) |
AU (1) | AU647481B2 (ru) |
BR (1) | BR1100207A (ru) |
CA (1) | CA2044484C (ru) |
CZ (1) | CZ285696B6 (ru) |
DE (1) | DE69116237T2 (ru) |
DK (1) | DK0461986T3 (ru) |
ES (1) | ES2084792T3 (ru) |
FI (1) | FI101301B (ru) |
FR (1) | FR2663328B1 (ru) |
GR (1) | GR3019197T3 (ru) |
HK (1) | HK1000598A1 (ru) |
HU (2) | HU222490B1 (ru) |
IE (1) | IE74709B1 (ru) |
IL (1) | IL98479A (ru) |
LT (1) | LT3550B (ru) |
LV (1) | LV10433B (ru) |
MX (1) | MX9203360A (ru) |
MY (1) | MY135774A (ru) |
NO (1) | NO180195C (ru) |
NZ (1) | NZ238516A (ru) |
PL (1) | PL165842B1 (ru) |
PT (1) | PT97944B1 (ru) |
RU (2) | RU2070194C1 (ru) |
UA (1) | UA27222C2 (ru) |
ZA (1) | ZA914572B (ru) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2751645B1 (fr) * | 1996-07-29 | 1998-12-24 | Sanofi Sa | Amines pour la fabrication de medicaments destines a empecher la proliferation de cellules tumorales |
US6005102A (en) * | 1997-10-15 | 1999-12-21 | American Home Products Corporation | Aryloxy-alkyl-dialkylamines |
FR2794742B1 (fr) | 1999-06-11 | 2005-06-03 | Sanofi Synthelabo | Nouveaux derives du benzene, un procede pour leur preparation et les compositions pharmaceutiques les contenant |
FR2795724B1 (fr) * | 1999-07-02 | 2002-12-13 | Sanofi Synthelabo | Nouveaux derives du benzene, un procede pour leur preparation et les compositions pharmaceutiques les contenant |
WO2007047978A2 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
EP2026813A2 (en) | 2006-05-09 | 2009-02-25 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
JP2009536669A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス,インコーポレイティド | アンジオテンシン調節による神経新生 |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
JP5632279B2 (ja) | 2007-05-30 | 2014-11-26 | アイエヌディー−スイフト ラボラトリーズ リミテッド | 塩酸イバブラジンの調製方法及びポリモルフ |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US20230364033A1 (en) | 2020-09-17 | 2023-11-16 | Meletios Therapeutics | Compounds for treating virus infections |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2249659A1 (ru) | 1973-11-02 | 1975-05-30 | Clin Midy | |
US4709094A (en) | 1986-07-10 | 1987-11-24 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Sigma brain receptor ligands and their use |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2881165A (en) * | 1956-06-29 | 1959-04-07 | Nl Combinatie Chem Ind | alpha-alpha-diphenyl-gamma-hexamethyleneiminobutyramide |
DE1545561A1 (de) * | 1965-08-23 | 1969-12-11 | Acraf | Verfahren zur Herstellung von pharmakologisch aktiven N,N-disubstituierten 1-Aryl-3-aminopropinen |
US4104383A (en) * | 1973-11-02 | 1978-08-01 | C M Industries | Derivatives of phenylpropenylamine |
DE3019497A1 (de) * | 1980-05-22 | 1981-11-26 | Bayer Ag, 5090 Leverkusen | Aminopropiophenon-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide |
AU4261285A (en) * | 1984-06-01 | 1985-12-05 | Tokyo Tanabe Company Limited | 1-propanone derivatives |
DE3508398A1 (de) * | 1985-03-08 | 1986-11-06 | Hoechst Ag, 6230 Frankfurt | Fungizide mittel auf der basis von 3-(hetero)-arylpropylaminen sowie neue (hetero)-aryl-propylamine und verfahren zu ihrer herstellung |
-
1990
- 1990-06-14 FR FR909007434A patent/FR2663328B1/fr not_active Expired - Fee Related
-
1991
- 1991-06-10 IE IE196391A patent/IE74709B1/en not_active IP Right Cessation
- 1991-06-11 ES ES91401531T patent/ES2084792T3/es not_active Expired - Lifetime
- 1991-06-11 AT AT91401531T patent/ATE132861T1/de not_active IP Right Cessation
- 1991-06-11 DE DE69116237T patent/DE69116237T2/de not_active Expired - Fee Related
- 1991-06-11 DK DK91401531.8T patent/DK0461986T3/da active
- 1991-06-11 EP EP91401531A patent/EP0461986B1/fr not_active Expired - Lifetime
- 1991-06-12 NZ NZ238516A patent/NZ238516A/xx not_active IP Right Cessation
- 1991-06-12 PT PT97944A patent/PT97944B1/pt not_active IP Right Cessation
- 1991-06-13 NO NO912283A patent/NO180195C/no unknown
- 1991-06-13 CZ CS911818A patent/CZ285696B6/cs not_active IP Right Cessation
- 1991-06-13 US US07/714,832 patent/US5231092A/en not_active Expired - Lifetime
- 1991-06-13 IL IL9847991A patent/IL98479A/en not_active IP Right Cessation
- 1991-06-13 RU SU4895622/04A patent/RU2070194C1/ru not_active IP Right Cessation
- 1991-06-13 CA CA002044484A patent/CA2044484C/en not_active Expired - Fee Related
- 1991-06-13 UA UA4895622A patent/UA27222C2/ru unknown
- 1991-06-13 RU RU94038042/04A patent/RU2133741C1/ru not_active IP Right Cessation
- 1991-06-14 FI FI912899A patent/FI101301B/fi active IP Right Grant
- 1991-06-14 HU HU9101983A patent/HU222490B1/hu active IP Right Grant
- 1991-06-14 KR KR1019910009879A patent/KR100213531B1/ko not_active IP Right Cessation
- 1991-06-14 ZA ZA914572A patent/ZA914572B/xx unknown
- 1991-06-14 JP JP3143212A patent/JP2620422B2/ja not_active Expired - Fee Related
- 1991-06-14 AU AU78434/91A patent/AU647481B2/en not_active Ceased
- 1991-06-14 PL PL91290675A patent/PL165842B1/pl not_active IP Right Cessation
- 1991-06-14 MY MYPI91001068A patent/MY135774A/en unknown
-
1992
- 1992-06-25 MX MX9203360A patent/MX9203360A/es unknown
-
1993
- 1993-02-25 LV LVP-93-141A patent/LV10433B/en unknown
- 1993-04-14 US US08/045,722 patent/US5296596A/en not_active Expired - Lifetime
- 1993-06-23 LT LTIP704A patent/LT3550B/lt not_active IP Right Cessation
-
1995
- 1995-06-30 HU HU95P/P00617P patent/HU211616A9/hu unknown
-
1996
- 1996-03-05 GR GR960400601T patent/GR3019197T3/el unknown
-
1997
- 1997-04-02 BR BR1100207-7A patent/BR1100207A/pt active IP Right Grant
- 1997-11-10 HK HK97102148A patent/HK1000598A1/xx not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2249659A1 (ru) | 1973-11-02 | 1975-05-30 | Clin Midy | |
US4709094A (en) | 1986-07-10 | 1987-11-24 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Sigma brain receptor ligands and their use |
Non-Patent Citations (8)
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PD9A | Change of patent owner |
Free format text: SANOFI,32-34 RUE MARBEUF, 75008 PARIS,FR,19970918 |
|
PC9A | Transfer of patents |
Free format text: SANOFI-SYNTHELABO, 174 AVENUE DE FRANCE, 75013 PARIS,FR, 0000515, |
|
PD9A | Change of patent owner |
Owner name: SANOFI-AVENTIS, FR Effective date: 20041213 |
|
MM9A | Lapsed patents |
Effective date: 20090623 |