KR920000728A - 헥사히드로아제핀 유도체, 그것들의 제법과 그것들을 함유하는 약학 조성물 - Google Patents

헥사히드로아제핀 유도체, 그것들의 제법과 그것들을 함유하는 약학 조성물 Download PDF

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KR920000728A
KR920000728A KR1019910009879A KR910009879A KR920000728A KR 920000728 A KR920000728 A KR 920000728A KR 1019910009879 A KR1019910009879 A KR 1019910009879A KR 910009879 A KR910009879 A KR 910009879A KR 920000728 A KR920000728 A KR 920000728A
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라바스트르 세르쥬
메냥 쟝-삐에르
뽈 레몽
뽕슬레 마르띤느
상뜌치 뱅상
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원본미기재
소시에떼아노님 사노피
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
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Abstract

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Description

헥사히드로아제핀 유도체, 그것들의 제법과 그것들을 함유하는 악학 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 일반식 (f)의 헥사히드로아제핀 유도체 및 그의 무기산 또는 유기산과의 염:
    식중 : -A는 -CO-CH2-, -CH (OH) -CH2- : CH2-CH2-CH2=CH- : -C≡C- 에서 선택된 기 이고; -X는 수소 또는 할로겐 이며, -Y는 시클로헥실기. 또는 X가 수소일때 페닐기 이다. )
  2. 제1항에 따르는 화합물의 약제학적으로 허용되는 부가염.
  3. 제1항에 있어서, Y가 시클로헥실기를 나타내는 화합물.
  4. cis-3-(헥사히드로아제핀-1-일)-1-(3-클로로-1-시클로헥실페닐) -4-프로펜.
  5. a)하기식 (Ⅱ)의 아세토페논에 대하여
    (식중, X 및 Y는 제1항에서 나타낸 바와 같은 의미를 갖는다. )포름알데히드 및 헥사히드로아제핀으로 축합 반응을 수행하여 A가 -CO-CH2-기를 나타내는 식(I)의 유도체를 수득하고; b)적절하다면 상기 수득된 식(I)의 화합물과 환원제를 반응시 켜 A가 -CH-(OH)-CH2-기를 나타내는 식 (I)의 화합물을 제조하고, c)적절 하다면, A가 -CH-(OH)-CH2- 기인 상기 식(I)의 화함물을 탈수하여 A가 -CH=CH-기 (트랜스)를 나타내는 식(I)의 화합물을 제조하고; d) 적절하다면, 상기 수득된 비닐렌 화합물의 수소화를 수행하여 A가 -CH2-CH2-기를 나타내는 식(I)의 화합물을 제조하고; e)마지막으로 필요하다면 적절한 무기 또는 유산기을 첨가하여 식(I)의 화합물의 부가염을 제조하는 것을 특징으로 하는, A가 -CO-CH2- ; -CH-(OH)-CH2- :트랜스-CH=CH-: -CH2-CH2-기 중에서 선택된 식(I)로표시되는 제1항에 따른 헥사히드로아제필 유도체의 제조 방법.
  6. a) 하기식 (Ⅲ)의 페닐아세틸렌 유도체에 대하여
    (식중, X 및 Y는 상기 (I)에서 나타낸 바와 같은 의미를 갖는다. )포름알데히드 및 헥사히드로아제핀으로 축합반응을 수행하여 A가 -C≡C-기를 나타내는 식 (I)의 유도체를 수득하고, 적절하다면 A가 아세틸렌기 -C≡C-기를 나타내는 식 (I)의 화합물의 발생 수소에 의한 수소화를 수행하여 A가 시스 및 트랜스 이성질체의 혼합형태인 -CH=CH- 기를 나타내는 식(I)의 화합물을 제조하거나, 지지된 금속 촉매 존재하에 수소화를 수행하여 식(I)의 비닐렌 화합물을 시스형태로 제조하고, c) 적절하다면, A가 -CH=CH- 기 또는 -C≡기를 나타내 는 식(I)의 화합물의 수소화를 수행하여 A가 -CH2-CH2- 기를 나타내는 화합물(I)을 제조하고; d)마지막으로, 필요하다면 적절한 무기 또는 유기산을 첨가하여 식(I)화합물의 부가염을 제조하는 것을 특징으로 하는,A가 -C≡C-, -CH=CH-및 -CH2CH2-기 중에서 선택된 식 (I)로 표시되는, 제1항에 따른 헥사이드로아제핀 유도체의 제조방법.
  7. 제1항 내지 제4항중 어느 한항에 따르는 화합물을 활성물질로서 함유하는 약학 조성물.
  8. 제7항에 있어서, 활성 성분이 약제학적 부형제와 조합된 약학 조성물.
  9. 제8항에 있어서, 0.5내지 1000mg의 활성성분 (I)을 함유하는 복용 단위 형태의 약학 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910009879A 1990-06-14 1991-06-14 헥사히드로아제핀 유도체, 그것들의 제법과 그것들을 함유하는 약학 조성물 KR100213531B1 (ko)

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FR90.07434 1990-06-14
FR909007434A FR2663328B1 (fr) 1990-06-14 1990-06-14 Derives d'hexahydroazepines, un procede pour leur preparation et compositions pharmaceutiques les contenant.

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FR2795724B1 (fr) * 1999-07-02 2002-12-13 Sanofi Synthelabo Nouveaux derives du benzene, un procede pour leur preparation et les compositions pharmaceutiques les contenant
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
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IE911963A1 (en) 1991-12-18
AU647481B2 (en) 1994-03-24
UA27222C2 (uk) 2000-08-15
PT97944A (pt) 1992-03-31
ES2084792T3 (es) 1996-05-16
NO180195C (no) 1997-03-05
RU2133741C1 (ru) 1999-07-27
IE74709B1 (en) 1997-07-30
CZ181891A3 (en) 1994-01-19
FR2663328B1 (fr) 1994-08-05
MY135774A (en) 2008-06-30
GR3019197T3 (en) 1996-06-30
LV10433A (lv) 1995-02-20
FI912899A0 (fi) 1991-06-14
CZ285696B6 (cs) 1999-10-13
DE69116237T2 (de) 1996-07-25
MX9203360A (es) 1992-07-01
JPH04321676A (ja) 1992-11-11
AU7843491A (en) 1991-12-19
FR2663328A1 (fr) 1991-12-20
NO912283D0 (no) 1991-06-13
US5296596A (en) 1994-03-22
ZA914572B (en) 1992-03-25
IL98479A (en) 1995-11-27
JP2620422B2 (ja) 1997-06-11
EP0461986B1 (fr) 1996-01-10
HU222490B1 (hu) 2003-07-28
HK1000598A1 (en) 1998-04-09
US5231092A (en) 1993-07-27
FI101301B1 (fi) 1998-05-29
NO180195B (no) 1996-11-25
HUT61736A (en) 1993-03-01
RU2070194C1 (ru) 1996-12-10
BR1100207A (pt) 1999-10-05
PL290675A1 (en) 1992-03-23
IL98479A0 (en) 1992-07-15
CA2044484C (en) 1998-05-26
LV10433B (en) 1995-08-20
FI912899A (fi) 1991-12-15
RU94038042A (ru) 1996-09-10
FI101301B (fi) 1998-05-29
EP0461986A1 (fr) 1991-12-18
NO912283L (no) 1991-12-16
DE69116237D1 (de) 1996-02-22
NZ238516A (en) 1993-09-27
PT97944B (pt) 1998-11-30
HU211616A9 (en) 1995-12-28
PT97944B1 (pt) 1999-05-31
PL165842B1 (pl) 1995-02-28
LT3550B (en) 1995-11-27
KR100213531B1 (ko) 1999-08-02
ATE132861T1 (de) 1996-01-15
CA2044484A1 (en) 1991-12-15
DK0461986T3 (da) 1996-05-28
LTIP704A (en) 1995-01-31

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