LT3465B - Process for preparing deacylated 10-baccatine iii - Google Patents

Process for preparing deacylated 10-baccatine iii Download PDF

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Publication number
LT3465B
LT3465B LTIP1398A LTIP1398A LT3465B LT 3465 B LT3465 B LT 3465B LT IP1398 A LTIP1398 A LT IP1398A LT IP1398 A LTIP1398 A LT IP1398A LT 3465 B LT3465 B LT 3465B
Authority
LT
Lithuania
Prior art keywords
deacetyl
process according
baccatin iii
organic solvent
aqueous solution
Prior art date
Application number
LTIP1398A
Other languages
English (en)
Lithuanian (lt)
Inventor
Rodolphe Margraff
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of LTIP1398A publication Critical patent/LTIP1398A/xx
Publication of LT3465B publication Critical patent/LT3465B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epoxy Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
LTIP1398A 1992-10-05 1993-10-04 Process for preparing deacylated 10-baccatine iii LT3465B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9211745A FR2696462B1 (fr) 1992-10-05 1992-10-05 Procédé d'obtention de la désacétyl-10 baccatine III.

Publications (2)

Publication Number Publication Date
LTIP1398A LTIP1398A (en) 1994-11-25
LT3465B true LT3465B (en) 1995-10-25

Family

ID=9434123

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP1398A LT3465B (en) 1992-10-05 1993-10-04 Process for preparing deacylated 10-baccatine iii

Country Status (30)

Country Link
US (2) US5393896A (de)
EP (1) EP0663909B1 (de)
JP (1) JP3299753B2 (de)
KR (1) KR100301238B1 (de)
CN (1) CN1041310C (de)
AT (1) ATE147381T1 (de)
AU (1) AU680440B2 (de)
CA (2) CA2146248C (de)
CZ (2) CZ286452B6 (de)
DE (1) DE69307333T2 (de)
DK (1) DK0663909T3 (de)
EE (1) EE03124B1 (de)
ES (1) ES2095672T3 (de)
FI (1) FI109797B (de)
FR (1) FR2696462B1 (de)
GE (1) GEP19981433B (de)
GR (1) GR3022229T3 (de)
HU (1) HU225969B1 (de)
LT (1) LT3465B (de)
LV (1) LV10620B (de)
MX (1) MX9305770A (de)
NO (1) NO310414B1 (de)
NZ (1) NZ256449A (de)
PL (1) PL173993B1 (de)
RU (1) RU2108330C1 (de)
SK (1) SK280335B6 (de)
TW (1) TW404944B (de)
UA (1) UA40601C2 (de)
WO (1) WO1994007881A1 (de)
ZA (1) ZA937312B (de)

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FR2736355B1 (fr) * 1995-07-07 1997-11-07 Pf Medicament Procede d'extraction et d'isolement de la 10-desacetylbaccatine iii
US5965752A (en) * 1996-08-23 1999-10-12 Institut National De La Recherche Scientifique Preparative scale isolation and purification of taxanes
DE69812395T2 (de) 1997-08-21 2004-02-05 Florida State University, Tallahassee Verfahren zur synthese von taxanen
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Citations (7)

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Publication number Priority date Publication date Assignee Title
US4814470A (en) 1986-07-17 1989-03-21 Rhone-Poulenc Sante Taxol derivatives, their preparation and pharmaceutical compositions containing them
US4857653A (en) 1986-07-17 1989-08-15 Rhone-Poulenc Sante Process for the preparation of taxol and 10-deacetyltaxol
US4924012A (en) 1988-04-06 1990-05-08 Rhone-Poulenc Sante Process for preparing derivatives of baccatine III and of 10-deacetyl baccatine III
EP0400971A2 (de) 1989-05-31 1990-12-05 Florida State University Verfahren zur Herstellung von Taxol
EP0428376A1 (de) 1989-11-14 1991-05-22 Florida State University Methode zur Herstellung von Taxol unter Verwendung von Oxazinon
WO1992007842A1 (en) 1990-11-02 1992-05-14 University Of Florida Method for the isolation and purification of taxane derivatives
WO1992009589A1 (fr) 1990-11-23 1992-06-11 Rhone-Poulenc Rorer S.A. Procede de preparation de derives du taxane, nouveaux derives obtenus et compositions pharmaceutiques qui les contiennent

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FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US5019504A (en) * 1989-03-23 1991-05-28 The United States Of America As Represented By The Secretary Of Agriculture Production of taxol or taxol-like compounds in cell culture
US5279953A (en) * 1992-06-24 1994-01-18 Esca Genetics Corporation In vivo production of taxanes
FR2696463B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé d'obtention de la désacétyl-10 baccatine III.
FR2703049B1 (fr) * 1993-03-22 1995-04-21 Rhone Poulenc Rorer Sa Procédé de purification des taxoïdes.

Patent Citations (7)

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US4814470A (en) 1986-07-17 1989-03-21 Rhone-Poulenc Sante Taxol derivatives, their preparation and pharmaceutical compositions containing them
US4857653A (en) 1986-07-17 1989-08-15 Rhone-Poulenc Sante Process for the preparation of taxol and 10-deacetyltaxol
US4924012A (en) 1988-04-06 1990-05-08 Rhone-Poulenc Sante Process for preparing derivatives of baccatine III and of 10-deacetyl baccatine III
EP0400971A2 (de) 1989-05-31 1990-12-05 Florida State University Verfahren zur Herstellung von Taxol
EP0428376A1 (de) 1989-11-14 1991-05-22 Florida State University Methode zur Herstellung von Taxol unter Verwendung von Oxazinon
WO1992007842A1 (en) 1990-11-02 1992-05-14 University Of Florida Method for the isolation and purification of taxane derivatives
WO1992009589A1 (fr) 1990-11-23 1992-06-11 Rhone-Poulenc Rorer S.A. Procede de preparation de derives du taxane, nouveaux derives obtenus et compositions pharmaceutiques qui les contiennent

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Title
HUANG CH ET AL.: "New taxanes from Taxus brevifolia, 2.", J NAT PROD., 1986, pages 665 - 669

Also Published As

Publication number Publication date
EE03124B1 (et) 1998-10-15
EP0663909B1 (de) 1997-01-08
AU680440B2 (en) 1997-07-31
LTIP1398A (en) 1994-11-25
CN1085552A (zh) 1994-04-20
SK280335B6 (sk) 1999-12-10
DE69307333T2 (de) 1997-04-30
NO951281L (no) 1995-04-03
NO310414B1 (no) 2001-07-02
CA2146248A1 (fr) 1994-04-14
KR100301238B1 (ko) 2001-11-22
FI951590A0 (fi) 1995-04-04
GEP19981433B (en) 1998-10-30
LV10620B (en) 1995-10-20
HU9500969D0 (en) 1995-06-28
SK43195A3 (en) 1995-08-09
ES2095672T3 (es) 1997-02-16
MX9305770A (es) 1994-05-31
NO951281D0 (no) 1995-04-03
US5393896A (en) 1995-02-28
ZA937312B (en) 1994-04-25
FR2696462B1 (fr) 1994-11-25
CZ286593B6 (cs) 2000-05-17
CA2146248C (fr) 2006-12-12
ATE147381T1 (de) 1997-01-15
CA2470124A1 (fr) 1994-04-14
DK0663909T3 (de) 1997-01-27
EP0663909A1 (de) 1995-07-26
HU225969B1 (en) 2008-01-28
RU95110662A (ru) 1996-12-27
LV10620A (lv) 1995-04-20
TW404944B (en) 2000-09-11
JP3299753B2 (ja) 2002-07-08
WO1994007881A1 (fr) 1994-04-14
DE69307333D1 (de) 1997-02-20
NZ256449A (en) 1996-09-25
GR3022229T3 (en) 1997-04-30
US5736366A (en) 1998-04-07
CN1041310C (zh) 1998-12-23
FI109797B (fi) 2002-10-15
KR950703549A (ko) 1995-09-20
CA2470124C (fr) 2007-08-07
AU5115493A (en) 1994-04-26
FR2696462A1 (fr) 1994-04-08
JPH08501791A (ja) 1996-02-27
CZ84495A3 (en) 1995-09-13
FI951590L (fi) 1995-04-04
PL308243A1 (en) 1995-07-24
UA40601C2 (uk) 2001-08-15
RU2108330C1 (ru) 1998-04-10
PL173993B1 (pl) 1998-05-29
CZ286452B6 (en) 2000-04-12
HUT72678A (en) 1996-05-28

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Owner name: AVENTIS PHARMA S.A., FR

Effective date: 20041206

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Effective date: 20131004