KR970061902A - (3-알콕시페닐)마그네슘 클로라이드의 제조방법 및 용도 - Google Patents
(3-알콕시페닐)마그네슘 클로라이드의 제조방법 및 용도 Download PDFInfo
- Publication number
- KR970061902A KR970061902A KR1019970004335A KR19970004335A KR970061902A KR 970061902 A KR970061902 A KR 970061902A KR 1019970004335 A KR1019970004335 A KR 1019970004335A KR 19970004335 A KR19970004335 A KR 19970004335A KR 970061902 A KR970061902 A KR 970061902A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- alkoxyphenyl
- magnesium
- chloride
- magnesium chloride
- Prior art date
Links
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 title claims abstract 14
- 229910001629 magnesium chloride Inorganic materials 0.000 title claims abstract 7
- 238000000034 method Methods 0.000 title claims abstract 6
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 239000011777 magnesium Substances 0.000 claims 6
- 229910052749 magnesium Inorganic materials 0.000 claims 6
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- -1 magnesium halide Chemical class 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000001887 cyclopentyloxy group Chemical group C1(CCCC1)O* 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- YUKILTJWFRTXGB-UHFFFAOYSA-N 1-chloro-3-methoxybenzene Chemical compound COC1=CC=CC(Cl)=C1 YUKILTJWFRTXGB-UHFFFAOYSA-N 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical class NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- FJDYULZCGBGTRF-UHFFFAOYSA-M [Cl-].CCOC1=CC=CC([Mg+])=C1 Chemical compound [Cl-].CCOC1=CC=CC([Mg+])=C1 FJDYULZCGBGTRF-UHFFFAOYSA-M 0.000 claims 1
- 150000001299 aldehydes Chemical class 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 150000001340 alkali metals Chemical class 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 229910052744 lithium Inorganic materials 0.000 claims 1
- ZKJIBOPFTIIXPE-UHFFFAOYSA-M magnesium;methoxybenzene;chloride Chemical compound [Mg+2].[Cl-].COC1=CC=C[C-]=C1 ZKJIBOPFTIIXPE-UHFFFAOYSA-M 0.000 claims 1
- 125000006606 n-butoxy group Chemical group 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 150000001728 carbonyl compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B49/00—Grignard reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/02—Magnesium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
본 발명은 (3-알콕시페닐)마그네슘 클로라이드의 제조방법 및 특정의 카보닐 화합물과의 반응을 위한 이의 용도에 관한 것이다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (9)
- 알콕시 라디칼 중의 탄소수가 1 내지 5인 (3-알콕시페닐)콜로라이드를, 마그네슘 할라이드를 알칼리 금속으로 환원시켜 수득된 활성 마그네슘과 반응시킴으로써 알콕시 라디칼 중의 탄소수가 1 내지 5인 (3-알콕시페닐)마그네슘 클로라이드를 제조하는 방법.
- 제1항에 있어서, 활성 마그네슘이 염화마그네슘을 리튬, 나트륨 또는 칼륨으로 환원시킴으로써 수득됨을 특징으로 하는 방법.
- 제1항 또는 제2항에 있어서, 알콕시 라디칼이 메톡시, 에톡시, 프로폭시, 이소프로폭시, n-부톡시 또는 사이클로펜톡시인 (3-알콕시페닐)클로라이드를 활성 마그네슘과 반응시킴을 특징으로 하는 방법.
- 제1항 내지 제3항 중 어느 한 항에 있어서, (3-메톡시페닐)클로라이드 또는 (3-에콕시페닐)클로라이드를 활성 마그네슘과 반응시킴을 특징으로 하는 방법.
- 화학식(1)의 β-아미노알데히드 또는 β-아미노케톤 또는 화학식(2)의 알데히드 또는 케톤과의 반응을 위한, 알콕시 라디칼 중의 탄소수가 1 내지 5인 (3-알콕시페닐)마그네슘 클로라이드의 용도.상기 식에서, R1은 H 또는 C1-4알킬이고, R2는 H 또는 C1-4알킬이거나, R1과 함께하는 R2는 -(CH2)4-이거나, R3과 함께하는 R2는 C4-7사이클로알킬이거나, R4와 함께 R2는 C5-8사이클로알킬이거나, R5와 함께 R2는 5 내지 8원헤테로사이클이고, R3은 H 또는 직쇄 C1-4알킬이고, R4는 H이고, R5는 C1-3알킬이고, R|6은 C1-3알킬이고, R7과 R8은 동일하거나 상이하고 각각 H, C1-6알킬 또는 C3-6사이클로알킬이다.
- 제5항에 있어서, (3-알콕시페닐)마그네슘 클로라이드가 β-아미노알데히드 또는 β-아미노케톤과의 반응에 사용됨을 특징으로 하는 용도.
- 제5항 또는 제6항에 있어서, (3-알콕시페닐)마그네슘 클로라이드가, R1이 C1-4알킬이고, R2가 H 또는 C1-4알킬이거나, R1과 함께하는 R2가 -(CH2)4-이고 R3이 H 또는 직쇄 C1-4알킬이고, R4가 H이고, R5는 CH3이고 R6이 CH3인 화학식(1)의 β-아미노알데히드 또는 β-아미노케톤과의 반응에 사용됨을 특징으로 하는 용도.
- 제5항 내지 제7항 중 어느 한 항에 있어서, 알콕시 라디칼이 메톡시, 에톡시, 프로톡시, 이소프로톡시, n-부톡시 또는 사이클로펜톡시인 (3-알콕시페닐)마그네슘 클로라이드가 사용됨을 특징으로 하는 용도.
- 제5항 내지 제8항 중 어느 한 항에 있어서, (3-메톡시페닐)마그네슘 클로라이드 또는 (3-에톡시페닐)마그네슘 클로라이드가 사용됨을 특징으로 하는 용도.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19605778.7 | 1996-02-16 | ||
| DE19605778A DE19605778C1 (de) | 1996-02-16 | 1996-02-16 | Herstellung und Verwendung von (3-Alkoxyphenyl)magnesiumchloriden |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020050032652A Division KR100541786B1 (ko) | 1996-02-16 | 2005-04-20 | (3-알콕시페닐)마그네슘 클로라이드를 사용한 알콜의 제조방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR970061902A true KR970061902A (ko) | 1997-09-12 |
| KR100521062B1 KR100521062B1 (ko) | 2006-01-12 |
Family
ID=7785591
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019970004335A KR100521062B1 (ko) | 1996-02-16 | 1997-02-14 | (3-알콕시페닐)마그네슘클로라이드의제조방법및당해클로라이드를사용한알콜제조방법 |
| KR1020050032652A KR100541786B1 (ko) | 1996-02-16 | 2005-04-20 | (3-알콕시페닐)마그네슘 클로라이드를 사용한 알콜의 제조방법 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020050032652A KR100541786B1 (ko) | 1996-02-16 | 2005-04-20 | (3-알콕시페닐)마그네슘 클로라이드를 사용한 알콜의 제조방법 |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US5852216A (ko) |
| EP (1) | EP0790251B1 (ko) |
| JP (1) | JP3893180B2 (ko) |
| KR (2) | KR100521062B1 (ko) |
| CN (1) | CN1075075C (ko) |
| AR (1) | AR005775A1 (ko) |
| AT (1) | ATE229025T1 (ko) |
| AU (1) | AU707621B2 (ko) |
| BR (1) | BR9700208A (ko) |
| CA (1) | CA2197616C (ko) |
| CO (1) | CO4770991A1 (ko) |
| CZ (1) | CZ290270B6 (ko) |
| DE (2) | DE19605778C1 (ko) |
| DK (1) | DK0790251T3 (ko) |
| ES (1) | ES2187690T3 (ko) |
| HK (1) | HK1004812A1 (ko) |
| HU (1) | HU219060B (ko) |
| IL (1) | IL120224A (ko) |
| IN (1) | IN192277B (ko) |
| MY (1) | MY113636A (ko) |
| NO (1) | NO315943B1 (ko) |
| NZ (1) | NZ299965A (ko) |
| PE (1) | PE1098A1 (ko) |
| PL (1) | PL185309B1 (ko) |
| PT (1) | PT790251E (ko) |
| RU (1) | RU2177931C2 (ko) |
| SI (1) | SI0790251T1 (ko) |
| SK (1) | SK282190B6 (ko) |
| UA (1) | UA46740C2 (ko) |
| UY (1) | UY24460A1 (ko) |
| ZA (1) | ZA971232B (ko) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19757499A1 (de) * | 1997-12-23 | 1999-06-24 | Studiengesellschaft Kohle Mbh | Verfahren zur Synthese von Organomagnesium-Verbindungen unter Einsatz von Katalysatoren |
| US6531597B2 (en) * | 2001-02-13 | 2003-03-11 | Hoffmann-La Roche Inc. | Process for preparation of 2-phenyl acetic acid derivatives |
| EP1785412A1 (en) * | 2005-11-14 | 2007-05-16 | IPCA Laboratories Limited | Tramadol recovery process |
| US9882245B2 (en) | 2013-08-23 | 2018-01-30 | Ut-Battelle, Llc | Alkoxide-based magnesium electrolyte compositions for magnesium batteries |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2959596A (en) | 1957-11-22 | 1960-11-08 | Metal & Thermit Corp | Aryl chloride-cyclic ether grignard reagents |
| US3706809A (en) * | 1970-09-17 | 1972-12-19 | Takasago Perfumery Co Ltd | Process for preparing highly reactive organo-magnesium compounds |
| US4133824A (en) * | 1977-08-17 | 1979-01-09 | Texas Alkyls, Inc. | Organo-magnesium complexes and process for their preparation |
| JPS6072833A (ja) * | 1983-09-29 | 1985-04-24 | Hokko Chem Ind Co Ltd | 芳香族ビニル化合物の改良製造法 |
| US4731203A (en) * | 1983-11-09 | 1988-03-15 | Studiengesellschaft Kohle Mbh | Process for using finely divided highly reactive magnesium |
| US5273686A (en) * | 1987-07-11 | 1993-12-28 | Studiengesellschaft Kohle Mbh | Soluble magnesium hydrides, method of preparing them, and use thereof |
| DE307106T1 (de) | 1987-09-11 | 1989-07-13 | Hokko Chemical Industry Co. Ltd., Tokio/Tokyo | P-oder m-tert-butoxyphenethylalkohol und verfahren zu dessen herstellung. |
| JP3107920B2 (ja) | 1992-08-28 | 2000-11-13 | 花王株式会社 | 歯磨剤の製造方法 |
| US5358670A (en) * | 1993-07-02 | 1994-10-25 | Ferro Corporation | Process for preparing grignard reagents in diethylene glycol dibutyl ether |
-
1996
- 1996-02-16 DE DE19605778A patent/DE19605778C1/de not_active Expired - Fee Related
- 1996-12-18 NZ NZ299965A patent/NZ299965A/en not_active IP Right Cessation
- 1996-12-26 MY MYPI96005468A patent/MY113636A/en unknown
-
1997
- 1997-01-28 ES ES97101270T patent/ES2187690T3/es not_active Expired - Lifetime
- 1997-01-28 DK DK97101270T patent/DK0790251T3/da active
- 1997-01-28 DE DE59708849T patent/DE59708849D1/de not_active Expired - Lifetime
- 1997-01-28 PT PT97101270T patent/PT790251E/pt unknown
- 1997-01-28 SI SI9730477T patent/SI0790251T1/xx unknown
- 1997-01-28 EP EP97101270A patent/EP0790251B1/de not_active Expired - Lifetime
- 1997-01-28 AT AT97101270T patent/ATE229025T1/de active
- 1997-02-04 PE PE1997000069A patent/PE1098A1/es not_active Application Discontinuation
- 1997-02-06 BR BR9700208A patent/BR9700208A/pt not_active Application Discontinuation
- 1997-02-10 AR ARP970100524A patent/AR005775A1/es active IP Right Grant
- 1997-02-11 CO CO97006908A patent/CO4770991A1/es unknown
- 1997-02-12 CZ CZ1997430A patent/CZ290270B6/cs not_active IP Right Cessation
- 1997-02-12 SK SK202-97A patent/SK282190B6/sk not_active IP Right Cessation
- 1997-02-13 IN IN247CA1997 patent/IN192277B/en unknown
- 1997-02-13 UA UA97020620A patent/UA46740C2/uk unknown
- 1997-02-13 ZA ZA9701232A patent/ZA971232B/xx unknown
- 1997-02-14 HU HU9700441A patent/HU219060B/hu not_active IP Right Cessation
- 1997-02-14 CN CN97102454A patent/CN1075075C/zh not_active Expired - Fee Related
- 1997-02-14 KR KR1019970004335A patent/KR100521062B1/ko not_active IP Right Cessation
- 1997-02-14 IL IL12022497A patent/IL120224A/en not_active IP Right Cessation
- 1997-02-14 US US08/800,879 patent/US5852216A/en not_active Expired - Lifetime
- 1997-02-14 CA CA002197616A patent/CA2197616C/en not_active Expired - Fee Related
- 1997-02-14 NO NO19970698A patent/NO315943B1/no not_active IP Right Cessation
- 1997-02-14 JP JP03083397A patent/JP3893180B2/ja not_active Expired - Fee Related
- 1997-02-14 AU AU14715/97A patent/AU707621B2/en not_active Ceased
- 1997-02-14 RU RU97102339/04A patent/RU2177931C2/ru not_active IP Right Cessation
- 1997-02-14 UY UY24460A patent/UY24460A1/es not_active IP Right Cessation
- 1997-02-14 PL PL97318486A patent/PL185309B1/pl not_active IP Right Cessation
-
1998
- 1998-05-08 HK HK98104001A patent/HK1004812A1/xx not_active IP Right Cessation
-
2005
- 2005-04-20 KR KR1020050032652A patent/KR100541786B1/ko not_active IP Right Cessation
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