KR950704232A - 약리학적 활성을 가진 니트릭 에스테르들과 그들의 제조공정 - Google Patents
약리학적 활성을 가진 니트릭 에스테르들과 그들의 제조공정Info
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- KR950704232A KR950704232A KR1019950702136A KR19950702136A KR950704232A KR 950704232 A KR950704232 A KR 950704232A KR 1019950702136 A KR1019950702136 A KR 1019950702136A KR 19950702136 A KR19950702136 A KR 19950702136A KR 950704232 A KR950704232 A KR 950704232A
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- hydrogen
- esters
- nitrile
- linear
- derivatives
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- -1 Nitrile esters Chemical class 0.000 title claims abstract 16
- 238000004519 manufacturing process Methods 0.000 title claims 3
- 230000000144 pharmacologic effect Effects 0.000 title abstract 3
- 239000001257 hydrogen Substances 0.000 claims 17
- 229910052739 hydrogen Inorganic materials 0.000 claims 17
- 150000002431 hydrogen Chemical class 0.000 claims 17
- 125000000217 alkyl group Chemical group 0.000 claims 14
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 8
- 150000002148 esters Chemical class 0.000 claims 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
- 239000001301 oxygen Substances 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 8
- 150000001408 amides Chemical class 0.000 claims 6
- 239000000126 substance Substances 0.000 claims 5
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 4
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 4
- 229910052794 bromium Inorganic materials 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 229910052801 chlorine Inorganic materials 0.000 claims 4
- 239000000460 chlorine Substances 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 159000000000 sodium salts Chemical class 0.000 claims 3
- 101710134784 Agnoprotein Proteins 0.000 claims 2
- 150000008064 anhydrides Chemical class 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 2
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 2
- 201000006474 Brain Ischemia Diseases 0.000 claims 1
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- TUZZXCDXAYXWKW-UHFFFAOYSA-N [ClH]1[C-]=CC=C1 Chemical class [ClH]1[C-]=CC=C1 TUZZXCDXAYXWKW-UHFFFAOYSA-N 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 230000000702 anti-platelet effect Effects 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 claims 1
- 206010008118 cerebral infarction Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 230000010247 heart contraction Effects 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 238000005121 nitriding Methods 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 claims 1
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/80—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms having carbon atoms of carboxamide groups and keto groups bound to the same carbon atom, e.g. acetoacetamides
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
- C07C203/02—Esters of nitric acid
- C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
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- C07—ORGANIC CHEMISTRY
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- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/21—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
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- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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Abstract
일반적인 화학식(Ⅰ)의 구조를 가진 약리학적 활성을 가진 니트릭 에스테르들, 그들의 약리학적인 사용과 그들의 제조를 위한 공정.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (11)
- 다음과 같은 일반적인 화학식을 가지는 것을 특징으로 하는 니트릭 에스테르들.여기서, A와 B는 수소, 선형이나 가지 달린, 치환된 또는 비치환된 알킬 사슬둘중에서 선택되고, R은 다음으로 부터 선택되어진다.R2는 수소, 메틸, 에틸, 3 내지 12탄소 원자들의 선형이나 가지 달린, 치환되있거나 비치환된 알킬 사슬들중에서 선택되어지고, Y는 산소, NH, NR1, R1은 선형이나 가지 달린 알킬기 중에서 선택되어지고, n은 1내지 10이다.
- 제1항에 있어서, 상기 R은 다음과 같은 화학식을 가지는 것임을 특징으로 하는 니트릭 에스테르들.R2는 메틸이고, A와 B는 수소이고, Y는 산소이고, n은 4이다.
- 제1항에 있어서, 상기 R은 다음과 같은 화학식을 가지는 것임을 특징으로 하는 니트릭 에스테르들.R2는 메틸이고, A와 B는 수소이고, Y는 산소이고, n은 4이다.
- 제1항에 있어서, 상기 R은 다음과 같은 화학식을 가지는 것임을 특징으로 하는 니트릭 에스테르들.R2는 메틸이고, A와 B는 수소이고, Y는 산소이고, n은 4이다.
- 제1항에 있어서, 상기 R은 다음과 같은 화학식을 가지는 것임을 특징으로 하는 니트릭 에스테르들.R2는 메틸이고, A와 B는 수소이고, Y는 산소이고, n은 4이다.
- 제1항에 있어서, 상기 R은 다음과 같은 화학식을 가지는 것임을 특징으로 하는 니트릭 에스테르들.R2는 수소, A와 B는 수소이고, Y는 산소이고, n은 4이다.
- 제1항에 있어서, 상기 니트릭 에스테르들이 항-염증 시약들로서 약리학적으로 사용되는 것임을 특징으로 하는 니트릭 에스테르들.
- 제1항에 있어서, 상기 니트릭 에스테르들의 류마티즘 질명들, 면역성 장애, 약-중 심각한 고통상태의 처리에 사용되는 것임을 특징으로 하는 니트릭 에스테르들.
- 제1항에 있어서, 상기 니트릭 에스테르들은 항-혈소판 응집 시약들로서 동맥 혈전중에서 뿐만아니라, 심장수축과 뇌 국소빈혈의 처리 등, 심혈관 기관의 질병들의 치료에 사용되는 것임을 특징으로 하는 니트릭 에스테르들.
- 다음과 같은 일반적인 화학식을 가지는 제1항에 따른 니트릭 에스테르들을 제조하는 다음과 같은 단계들을 포함하는 것을 특징으로 하는 니트릭 에스테르 제조 공정.여기서, A와 B는 수소, 치환된 또는 치환되지 않은 선형이나 가지달린 알킬사슬둘중에서 선택되어지고, R은 다음으로부터 선택되어진다.R2는 수소, 메틸, 에틸, 3 내지 12탄소 원자들의 선형이나 가지 달린, 치환되있거나 비치환된 알킬 사슬들중에서 선택되어지고, Y는 산소, NH, NR1, R1은 선형이나 가지 달린 알킬기 중에서 선택되어지고, n은 1내지 10이다.-다음과 같은 일반적인 화학식을 가지는 유도체의 소디움 염의 형성여기서 R은 (Ⅱ), (Ⅲ), (Ⅳ), (Ⅵ), (Ⅶ), (Ⅸ), (Ⅹ), (Ⅹ, ⅩⅠ), (ⅩⅩⅩⅤ)이다.또는, 이실릭 크롤라이드들, 안하이드라이드로서 카르복실기로 기능화된 유도체들(ⅩⅣ);-상기 유도체들(ⅩⅣ)의 소디움 염, 또는 상기 카르복실기로 기능화된 유도체들(ⅩⅣ)과 다음과 같은 일반적인 화학식을 가지는 조성물과의 반응시켜서 상대적인 단위체적 에스테르들 또는 상대적인 아미드들을 얻음.여기서, R4는 염소, 브롬 또는 R6이 수소, 선형이나 가지 달린 알킬 사슬인 NHR6로 부터 선택되어지고, A와 B는 수소, 치환되거나 비치환된 알킬 사슬로부터 선택되어지고, R3은 염소, 브롬, 요오드로부터 선택되어지고, n은 1 내지 10이다.-상기 단위체적에스테르들 또는 상기 아미드들과 AgNO3등과 같은 질소화 시료들을 반응시켜 유도체들(Ⅰ)의 니트릭 에스테르들을 얻음.
- 다음과 같은 일반적인 화학식을 가지는 제1항에 따른 니트릭 에스테르들을 제조하는 다음과 같은 단계들을 포함하는 것을 특징으로 하는 니트릭 에스테르 제조 공정.여기서, A와 B는 수소, 치환된 또는 치환되지 않은 선형이나 가지달린 알킬사슬둘중에서 선택되어지고, R2는 수소, 메틸, 에틸, 3 내지 12탄소 원자들의 선형이나 가지 달린, 치환되있거나 비치환된 알킬 사슬들이고, R은 다음으로부터 선택되어진다.Y는 산소, NH, NR1, R1은 선형이나 가지 달린 알킬기 중에서 선택되어지고, n은 1내지 10이다.-다음과 같은 일반적인 화학식을 가지는 유도체의 소디움 염의 형성여기서 R은 (Ⅱ), (Ⅲ), (Ⅳ), (Ⅵ), (Ⅶ), (Ⅸ), (Ⅹ), (Ⅹ, ⅩⅠ), (ⅩⅩⅩⅤ)이고, R2는 수소, 메틸, 에틸, 3 내지 12 탄소원자의 치환되거나 치환되지 않은 선형이나 가지 달린 알킬 사슬들이다.또는, 아실릭 크롤라이드들, 안하이드라이드로서 카르복실기로 기능화된 유도체들(ⅩⅣ);-상기 유도체들(ⅩⅣ)의 소디움 염, 또는 상기 카르복실기로 기능화된 유도체들(ⅩⅣ)과 다음과 같은 일반적인 화학식을 가지는 조성물과의 반응시켜서 상대적인 단위체적 에스테르들 또는 상대적인 아미드들을 얻음.여기서, R4는 염소, 브롬 또는 R6이 수소, 선형이나 가지 달린 알킬 사슬인 NHR6로 부터 선택되어지고, A와 B는 수소, 치환되거나 비치환된 알킬 사슬로부터 선택되어지고, R3은 염소, 브롬, 요오드로부터 선택되어지고, n은 1 내지 10이다.-상기 단위체적 에스테르들 또는 상기 아미드들과 PBr3등과 같은 할로겐화 시료들을 반응시켜서 말단에 할로겐기가 존재하는 상기 단위체적 에스테르 또는 상기 아미드들을 얻음.-말단에 할로겐기가 존재하는 상기 단위체적 에스테르들 또는 상기 아미드들과 AgNO3등과 같은 질소화 시료들을 반응시켜 유도체들(Ⅰ)의 니트릭 에스테르들을 얻음.※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
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Application Number | Priority Date | Filing Date | Title |
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ITMI92A002699 | 1992-11-26 | ||
ITMT92A002699 | 1992-11-26 | ||
ITMI922699A IT1256450B (it) | 1992-11-26 | 1992-11-26 | Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione |
PCT/EP1993/003193 WO1994012463A1 (en) | 1992-11-26 | 1993-11-15 | Nitric esters having a pharmacological activity and process for their preparation |
Publications (2)
Publication Number | Publication Date |
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KR950704232A true KR950704232A (ko) | 1995-11-17 |
KR100277178B1 KR100277178B1 (ko) | 2001-01-15 |
Family
ID=11364352
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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KR1019950702136A KR100277178B1 (ko) | 1992-11-26 | 1993-11-15 | 약리학적 활성을 가진 니트릭 에스테르들과 그들의 제조공정 |
Country Status (16)
Country | Link |
---|---|
US (1) | US5621000A (ko) |
EP (1) | EP0670825B1 (ko) |
JP (1) | JP3231043B2 (ko) |
KR (1) | KR100277178B1 (ko) |
AT (1) | ATE152092T1 (ko) |
AU (1) | AU676527B2 (ko) |
BR (1) | BR9307530A (ko) |
CA (1) | CA2150229C (ko) |
DE (1) | DE69310204T2 (ko) |
DK (1) | DK0670825T3 (ko) |
ES (1) | ES2103563T3 (ko) |
GR (1) | GR3024018T3 (ko) |
HU (1) | HU215437B (ko) |
IT (1) | IT1256450B (ko) |
RU (1) | RU2127723C1 (ko) |
WO (1) | WO1994012463A1 (ko) |
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US4585877A (en) * | 1985-05-06 | 1986-04-29 | American Home Products Corporation | Process for preparing 1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)-indole-1-acetic acid, etodolac |
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IT1243367B (it) * | 1990-07-26 | 1994-06-10 | Italfarmaco Spa | Derivati acidi benzoici sostituiti ad attivita' cardiovascolare |
-
1992
- 1992-11-26 IT ITMI922699A patent/IT1256450B/it active IP Right Grant
-
1993
- 1993-11-15 US US08/446,624 patent/US5621000A/en not_active Expired - Lifetime
- 1993-11-15 AT AT94901797T patent/ATE152092T1/de active
- 1993-11-15 AU AU56241/94A patent/AU676527B2/en not_active Ceased
- 1993-11-15 ES ES94901797T patent/ES2103563T3/es not_active Expired - Lifetime
- 1993-11-15 BR BR9307530A patent/BR9307530A/pt not_active Application Discontinuation
- 1993-11-15 JP JP51270194A patent/JP3231043B2/ja not_active Expired - Fee Related
- 1993-11-15 CA CA002150229A patent/CA2150229C/en not_active Expired - Fee Related
- 1993-11-15 DE DE69310204T patent/DE69310204T2/de not_active Expired - Lifetime
- 1993-11-15 EP EP94901797A patent/EP0670825B1/en not_active Expired - Lifetime
- 1993-11-15 DK DK94901797.4T patent/DK0670825T3/da active
- 1993-11-15 WO PCT/EP1993/003193 patent/WO1994012463A1/en active IP Right Grant
- 1993-11-15 KR KR1019950702136A patent/KR100277178B1/ko not_active IP Right Cessation
- 1993-11-15 HU HU9501531A patent/HU215437B/hu not_active IP Right Cessation
- 1993-11-15 RU RU95114376A patent/RU2127723C1/ru not_active IP Right Cessation
-
1997
- 1997-07-08 GR GR970401673T patent/GR3024018T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU5624194A (en) | 1994-06-22 |
RU95114376A (ru) | 1997-02-20 |
ATE152092T1 (de) | 1997-05-15 |
IT1256450B (it) | 1995-12-05 |
ES2103563T3 (es) | 1997-09-16 |
JP3231043B2 (ja) | 2001-11-19 |
ITMI922699A0 (it) | 1992-11-26 |
AU676527B2 (en) | 1997-03-13 |
JPH08504191A (ja) | 1996-05-07 |
HU9501531D0 (en) | 1995-07-28 |
HUT73773A (en) | 1996-09-30 |
EP0670825B1 (en) | 1997-04-23 |
CA2150229C (en) | 2005-06-14 |
ITMI922699A1 (it) | 1994-05-26 |
US5621000A (en) | 1997-04-15 |
DE69310204D1 (de) | 1997-05-28 |
RU2127723C1 (ru) | 1999-03-20 |
WO1994012463A1 (en) | 1994-06-09 |
DE69310204T2 (de) | 1997-11-20 |
KR100277178B1 (ko) | 2001-01-15 |
EP0670825A1 (en) | 1995-09-13 |
HU215437B (hu) | 2000-12-28 |
GR3024018T3 (en) | 1997-10-31 |
CA2150229A1 (en) | 1994-06-09 |
BR9307530A (pt) | 1999-05-25 |
DK0670825T3 (da) | 1997-10-13 |
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