KR950704232A - 약리학적 활성을 가진 니트릭 에스테르들과 그들의 제조공정 - Google Patents

약리학적 활성을 가진 니트릭 에스테르들과 그들의 제조공정

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KR950704232A
KR950704232A KR1019950702136A KR19950702136A KR950704232A KR 950704232 A KR950704232 A KR 950704232A KR 1019950702136 A KR1019950702136 A KR 1019950702136A KR 19950702136 A KR19950702136 A KR 19950702136A KR 950704232 A KR950704232 A KR 950704232A
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nitrile
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바바라 아레나
피에로 델 솔다토
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베레나 라르디
니콕스 리미티드
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Abstract

일반적인 화학식(Ⅰ)의 구조를 가진 약리학적 활성을 가진 니트릭 에스테르들, 그들의 약리학적인 사용과 그들의 제조를 위한 공정.

Description

약리학적 활성을 가진 니트릭 에스테르들과 그들의 제조공정
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 다음과 같은 일반적인 화학식을 가지는 것을 특징으로 하는 니트릭 에스테르들.
    여기서, A와 B는 수소, 선형이나 가지 달린, 치환된 또는 비치환된 알킬 사슬둘중에서 선택되고, R은 다음으로 부터 선택되어진다.
    R2는 수소, 메틸, 에틸, 3 내지 12탄소 원자들의 선형이나 가지 달린, 치환되있거나 비치환된 알킬 사슬들중에서 선택되어지고, Y는 산소, NH, NR1, R1은 선형이나 가지 달린 알킬기 중에서 선택되어지고, n은 1내지 10이다.
  2. 제1항에 있어서, 상기 R은 다음과 같은 화학식을 가지는 것임을 특징으로 하는 니트릭 에스테르들.
    R2는 메틸이고, A와 B는 수소이고, Y는 산소이고, n은 4이다.
  3. 제1항에 있어서, 상기 R은 다음과 같은 화학식을 가지는 것임을 특징으로 하는 니트릭 에스테르들.
    R2는 메틸이고, A와 B는 수소이고, Y는 산소이고, n은 4이다.
  4. 제1항에 있어서, 상기 R은 다음과 같은 화학식을 가지는 것임을 특징으로 하는 니트릭 에스테르들.
    R2는 메틸이고, A와 B는 수소이고, Y는 산소이고, n은 4이다.
  5. 제1항에 있어서, 상기 R은 다음과 같은 화학식을 가지는 것임을 특징으로 하는 니트릭 에스테르들.
    R2는 메틸이고, A와 B는 수소이고, Y는 산소이고, n은 4이다.
  6. 제1항에 있어서, 상기 R은 다음과 같은 화학식을 가지는 것임을 특징으로 하는 니트릭 에스테르들.
    R2는 수소, A와 B는 수소이고, Y는 산소이고, n은 4이다.
  7. 제1항에 있어서, 상기 니트릭 에스테르들이 항-염증 시약들로서 약리학적으로 사용되는 것임을 특징으로 하는 니트릭 에스테르들.
  8. 제1항에 있어서, 상기 니트릭 에스테르들의 류마티즘 질명들, 면역성 장애, 약-중 심각한 고통상태의 처리에 사용되는 것임을 특징으로 하는 니트릭 에스테르들.
  9. 제1항에 있어서, 상기 니트릭 에스테르들은 항-혈소판 응집 시약들로서 동맥 혈전중에서 뿐만아니라, 심장수축과 뇌 국소빈혈의 처리 등, 심혈관 기관의 질병들의 치료에 사용되는 것임을 특징으로 하는 니트릭 에스테르들.
  10. 다음과 같은 일반적인 화학식을 가지는 제1항에 따른 니트릭 에스테르들을 제조하는 다음과 같은 단계들을 포함하는 것을 특징으로 하는 니트릭 에스테르 제조 공정.
    여기서, A와 B는 수소, 치환된 또는 치환되지 않은 선형이나 가지달린 알킬사슬둘중에서 선택되어지고, R은 다음으로부터 선택되어진다.
    R2는 수소, 메틸, 에틸, 3 내지 12탄소 원자들의 선형이나 가지 달린, 치환되있거나 비치환된 알킬 사슬들중에서 선택되어지고, Y는 산소, NH, NR1, R1은 선형이나 가지 달린 알킬기 중에서 선택되어지고, n은 1내지 10이다.
    -다음과 같은 일반적인 화학식을 가지는 유도체의 소디움 염의 형성
    여기서 R은 (Ⅱ), (Ⅲ), (Ⅳ), (Ⅵ), (Ⅶ), (Ⅸ), (Ⅹ), (Ⅹ, ⅩⅠ), (ⅩⅩⅩⅤ)이다.
    또는, 이실릭 크롤라이드들, 안하이드라이드로서 카르복실기로 기능화된 유도체들(ⅩⅣ)；-상기 유도체들(ⅩⅣ)의 소디움 염, 또는 상기 카르복실기로 기능화된 유도체들(ⅩⅣ)과 다음과 같은 일반적인 화학식을 가지는 조성물과의 반응시켜서 상대적인 단위체적 에스테르들 또는 상대적인 아미드들을 얻음.
    여기서, R4는 염소, 브롬 또는 R6이 수소, 선형이나 가지 달린 알킬 사슬인 NHR6로 부터 선택되어지고, A와 B는 수소, 치환되거나 비치환된 알킬 사슬로부터 선택되어지고, R3은 염소, 브롬, 요오드로부터 선택되어지고, n은 1 내지 10이다.
    -상기 단위체적에스테르들 또는 상기 아미드들과 AgNO3등과 같은 질소화 시료들을 반응시켜 유도체들(Ⅰ)의 니트릭 에스테르들을 얻음.
  11. 다음과 같은 일반적인 화학식을 가지는 제1항에 따른 니트릭 에스테르들을 제조하는 다음과 같은 단계들을 포함하는 것을 특징으로 하는 니트릭 에스테르 제조 공정.
    여기서, A와 B는 수소, 치환된 또는 치환되지 않은 선형이나 가지달린 알킬사슬둘중에서 선택되어지고, R2는 수소, 메틸, 에틸, 3 내지 12탄소 원자들의 선형이나 가지 달린, 치환되있거나 비치환된 알킬 사슬들이고, R은 다음으로부터 선택되어진다.
    Y는 산소, NH, NR1, R1은 선형이나 가지 달린 알킬기 중에서 선택되어지고, n은 1내지 10이다.
    -다음과 같은 일반적인 화학식을 가지는 유도체의 소디움 염의 형성
    여기서 R은 (Ⅱ), (Ⅲ), (Ⅳ), (Ⅵ), (Ⅶ), (Ⅸ), (Ⅹ), (Ⅹ, ⅩⅠ), (ⅩⅩⅩⅤ)이고, R2는 수소, 메틸, 에틸, 3 내지 12 탄소원자의 치환되거나 치환되지 않은 선형이나 가지 달린 알킬 사슬들이다.
    또는, 아실릭 크롤라이드들, 안하이드라이드로서 카르복실기로 기능화된 유도체들(ⅩⅣ)；
    -상기 유도체들(ⅩⅣ)의 소디움 염, 또는 상기 카르복실기로 기능화된 유도체들(ⅩⅣ)과 다음과 같은 일반적인 화학식을 가지는 조성물과의 반응시켜서 상대적인 단위체적 에스테르들 또는 상대적인 아미드들을 얻음.
    여기서, R4는 염소, 브롬 또는 R6이 수소, 선형이나 가지 달린 알킬 사슬인 NHR6로 부터 선택되어지고, A와 B는 수소, 치환되거나 비치환된 알킬 사슬로부터 선택되어지고, R3은 염소, 브롬, 요오드로부터 선택되어지고, n은 1 내지 10이다.
    -상기 단위체적 에스테르들 또는 상기 아미드들과 PBr3등과 같은 할로겐화 시료들을 반응시켜서 말단에 할로겐기가 존재하는 상기 단위체적 에스테르 또는 상기 아미드들을 얻음.
    -말단에 할로겐기가 존재하는 상기 단위체적 에스테르들 또는 상기 아미드들과 AgNO3등과 같은 질소화 시료들을 반응시켜 유도체들(Ⅰ)의 니트릭 에스테르들을 얻음.
    ※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019950702136A 1992-11-26 1993-11-15 약리학적 활성을 가진 니트릭 에스테르들과 그들의 제조공정 KR100277178B1 (ko)

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ITMI922699A IT1256450B (it) 1992-11-26 1992-11-26 Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
ITMI92A002699 1992-11-26
ITMT92A002699 1992-11-26
PCT/EP1993/003193 WO1994012463A1 (en) 1992-11-26 1993-11-15 Nitric esters having a pharmacological activity and process for their preparation

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JPH08504191A (ja) 1996-05-07
ES2103563T3 (es) 1997-09-16
ITMI922699A1 (it) 1994-05-26
EP0670825B1 (en) 1997-04-23
EP0670825A1 (en) 1995-09-13
WO1994012463A1 (en) 1994-06-09
US5621000A (en) 1997-04-15
BR9307530A (pt) 1999-05-25
RU95114376A (ru) 1997-02-20
AU676527B2 (en) 1997-03-13
CA2150229A1 (en) 1994-06-09
DE69310204T2 (de) 1997-11-20
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ATE152092T1 (de) 1997-05-15
JP3231043B2 (ja) 2001-11-19
HU215437B (hu) 2000-12-28
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