KR950017928A - 아세트산 유도체 - Google Patents

아세트산 유도체 Download PDF

Info

Publication number
KR950017928A
KR950017928A KR1019940032546A KR19940032546A KR950017928A KR 950017928 A KR950017928 A KR 950017928A KR 1019940032546 A KR1019940032546 A KR 1019940032546A KR 19940032546 A KR19940032546 A KR 19940032546A KR 950017928 A KR950017928 A KR 950017928A
Authority
KR
South Korea
Prior art keywords
lower alkyl
group
hydrogen
alkoxy
alkyl
Prior art date
Application number
KR1019940032546A
Other languages
English (en)
Other versions
KR100335541B1 (ko
Inventor
알리히 레오
하드바리 파울
휘르젤러 뮐러 마리안네
뮐러 마르셀
스타이너 베아트
벨러 토마스
Original Assignee
프리돌린 클라우스너, 롤란드 보러
에프. 호프만-라 롯슈 아크티엔게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 프리돌린 클라우스너, 롤란드 보러, 에프. 호프만-라 롯슈 아크티엔게젤샤프트 filed Critical 프리돌린 클라우스너, 롤란드 보러
Publication of KR950017928A publication Critical patent/KR950017928A/ko
Application granted granted Critical
Publication of KR100335541B1 publication Critical patent/KR100335541B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/04—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/10—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C07C251/16—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
    • C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/42—Y being a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02—Monothiocarbamic acids; Derivatives thereof
    • C07C333/04—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2479—Compounds containing the structure P(=X)n-N-acyl, P(=X)n-N-heteroatom, P(=X)n-N-CN (X = O, S, Se; n = 0, 1)
    • C07F9/2491—Compounds containing the structure P(=X)n-N-acyl, P(=X)n-N-heteroatom, P(=X)n-N-CN (X = O, S, Se; n = 0, 1) containing the structure P(=X)n-N-N (X = O, S, Se; n = 0, 1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

하기 일반식( I )의 아세트산 유도체는 혈소판에 유착성 단백질의 결합 및 혈소판 응집 및 세포-세포 유착에 의해 야기된 질병의 치료 또는 예방에 유용할 수 있다. 이들은 상응하는 보호된 화합물의 보호 그룹을 분리하거나 또는 사용하는 니트릴에서 시아노 그룹을 아미디노 그룹으로 전환시키므로써 제조할 수 있다.
(상기식에서, L, M, T 및 Q는 명세서에 개시한 바와 같은 의미를 갖는다.

Description

아세트산 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 하기 일반식( I )의 아세트산 유도체, 그의 수화물 또는 용매화물 및 생리학적으로 유용한 그의 염;
    I
    상기식에서, L은 하기 일반식 L1내지 L5의 그룹이고,
    L1
    L2
    L3
    L4
    L5
    이때, L그룹 및/또는 아미드 형태로 결합되지 않은 L과 M그룹사이에 존재하는 카보닐 그룹은 또한 옥심으로 존재할 수 있고, A는 하기 일반식 A1내지 A4의 그룹이고;
    A1
    A2
    A3
    A4
    [이때, E1및 E2는 수소, 저급 알킬, 하이드록시, 저급 알콕시, 저급 알콕시-저급 알킬, 카복시-저급알킬, p(O)(O-저급 알킬)2,C(O)OR1, OC(O)R1, OC(O)OR1또는 C(O)SR1이나, 단 E1및 E2중 적어도 하나는 수소이거나, 또는 E1및 E2는 이들이 결합된 질소 원자와 함께 (5,5-디메틸 또는 5-옥소)-4,5-디하이드로-1,2,4-옥사디아졸-3-일 그룹을 형성하고, R1은 저급 알콕시-저급 알킬: 저급 알킬 OH, COOH, 저급 알콕시카보닐, 저급 알카노일옥시, 저급 알케노일옥시로 치환된 저급 알킬, 임의 치환 도니 벤조일옥시로 치환된 저급 알킬 도는 저급 알길-CONH에 의해 치환된 저급 알킬: 또는 임의 치환되고 저급 알킬렌에 의해 임의 결합된 페닐; 또는 0에 의해 임의로 차단된 사이클로알킬이고, 이때 X 및 Y중 하나는 CH이고, 다른 하나는 CH, C-저급 알킬, C-저급 알콕시 또는 N이고, D는 (CH2)s또는 (CH2)1O 그룹이고, s는 1 내지 4이과, m 및 n은 0 내지 5이고, t는 0 내지 3이나, m+n은 1 내지 5이고, m+t 및 n+t는 각각 적어도 1이고, p 및 q는 0 내지 5이나, p+q는 2 내지 5이고, W1은 CH2,알킬-CH, 저급 알킬-OC(O)CH, NH, 저급 알킬-N 또는 저급 알콕시-저급 알킬-N이고, W2는 O, NH, 아실-N 또는 저급 알킬-OC(O)-N이고, G는 H 또는 α-아미노카복실산의 특징 부여 그룹이다] M은 N원자에 의해 케토 그룹에 결합된 1,4-피페리디닐렌; 또는 저급 알킬, 저급 알콕시, OCH2COOH 또는 OCH2COO 저급 알킬로 임의 치환된 1,4-페닐렌이고, Q는 O, CH2, NH, 아실-N 또는 저급 알킬 OC(0)N이고, T는 NH2, NH-저급 알킬, NH-저급 알킬(COOH 또는 COO-저급 알킬); 저급 알콕시 COOH, COO-저급 알킬, 저급 알킬-COO 또는 저급 알킬-OCOO에 의해 치환된 저급 알콕시 또는 저급 알케닐옥시; 또는 OT' 그룹이고, T'는 수소; 저급 알킬; 저급 알킬렌에 의해 임의 결합된 페닐 또는 피리딜: 또는 저급 알킬렌에 의해 임의 결합되고, O, NH 또는 NCOO-저급 알킬로 임의의 차단된 사이클로알킬이나, 단, a) L이 하기 일반식(L')의 그룹이고:
    (이때, A는 하기 일반식(A')의 그룹이고:
    E1및 E2중 하나는 수소이고, 다른 하나는 수소, 1-부톡시카보닐 또는 벤질옥시카보닐이고, X 및 Y 중 하나는 CH이고, 다른 하나는 CH 또는 N이고, W1은 NH, 저급 알킬-N 또는 저급 알콕시-저급 알킬 -N이고, G는 상기와 갈은 의미를 갖는다) M이 N원자에 의해 케토 그룹에 곁합된 1,4-피페리디닐렌이고, Q가 O인 경우, T'는 수소, 저급 알킬 및 페닐-저급 알킬이 아니고, b) L이 L11, L31또는 L41의 그룹이과 :
    (이때, A는 하기 일반식(A1)의 그룹이고,
    E1및 E2중 하나는 수소이고, 다른 하나는 수소, t-부톡시카보닐 또는 벤질옥시카보닐이고, X 및 Y중 하나는 CH이고, 다른 하나는 CH, C- 저급 알킬, C- 저급 알콕시 또는 N이고, R0및 G0는 수소 또는 저급 알킬이고, W4는 C=O 또는 C=NOH이다.) M이 저급 알킬, 저급 알콕시, OCH2COOHO 또는 CH2COOH- 저급 알킬로 임의 치환된 1,4-페닐렌이고, Q가 O, CH2, 또는 NH인 경우, T'는 수소, 저급 아킬, 페닐 및 페닐-저급 알킬이 아니다.
  2. 활성 물질로 제1항의 화합물을 함유하는, 혈소판에 유착성 단백질의 결합 및 혈소판 응집 및 세포-세포 유착에 의해 야기되는 질병의 치료 또는 예방에 유용한 약제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940032546A 1993-12-03 1994-12-02 아세트산유도체 KR100335541B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CH3609/93 1993-12-03
CH3609.93 1993-12-03
CH360993 1993-12-03
CH319894 1994-10-25
CH3198/94 1994-10-25

Publications (2)

Publication Number Publication Date
KR950017928A true KR950017928A (ko) 1995-07-20
KR100335541B1 KR100335541B1 (ko) 2003-06-11

Family

ID=25692439

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940032546A KR100335541B1 (ko) 1993-12-03 1994-12-02 아세트산유도체

Country Status (29)

Country Link
US (2) US5726185A (ko)
EP (1) EP0656348B1 (ko)
JP (1) JP2901509B2 (ko)
KR (1) KR100335541B1 (ko)
CN (1) CN1075062C (ko)
AT (1) ATE192430T1 (ko)
AU (1) AU687905B2 (ko)
BG (1) BG62399B1 (ko)
CA (1) CA2136903C (ko)
CZ (1) CZ290024B6 (ko)
DE (1) DE59409322D1 (ko)
DK (1) DK0656348T3 (ko)
ES (1) ES2147210T3 (ko)
FI (2) FI945688A (ko)
GR (1) GR3034111T3 (ko)
HU (1) HUT71332A (ko)
IL (1) IL111784A0 (ko)
IS (1) IS4237A (ko)
LV (1) LV11318B (ko)
MY (1) MY112417A (ko)
NO (1) NO302169B1 (ko)
NZ (1) NZ270020A (ko)
PT (1) PT656348E (ko)
RO (1) RO117846B1 (ko)
RU (1) RU2151768C1 (ko)
SI (1) SI0656348T1 (ko)
SK (1) SK282058B6 (ko)
TW (1) TW472042B (ko)
UA (1) UA35592C2 (ko)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0738705B1 (en) * 1994-10-07 2001-05-09 Meiji Seika Kabushiki Kaisha Gamma-diketone compound having platelet aggregation inhibiting effect
JPH08325263A (ja) * 1995-05-31 1996-12-10 Sumitomo Metal Ind Ltd 新規２−アミノ−３−フェニルプロピオン酸誘導体
US6013651A (en) * 1995-08-30 2000-01-11 G. D. Searle & Co. Meta-azacyclic amino benzoic acid compounds and derivatives thereof
US6100423A (en) * 1995-08-30 2000-08-08 G. D. Searle & Co. Amino benzenepropanoic acid compounds and derivatives thereof
ATE203234T1 (de) 1995-08-30 2001-08-15 Searle & Co Meta-guanidine, harnstoff, thioharnstoff oder azacyklische aminobenzoesäure-derivate als integrin antagonisten
JP2000506538A (ja) * 1996-03-29 2000-05-30 ジー．ディー．サール アンド カンパニー メタ―置換フェニレン誘導体
DE19622189A1 (de) * 1996-06-03 1997-12-04 Bayer Ag 3-Cyanaryl-pyrazole
EP1023295A4 (en) * 1997-02-06 2001-01-24 Merck & Co Inc PRODUCTS BY FIBRINOGEN RECEPTOR ANTAGONISTS
US6025358A (en) * 1998-06-11 2000-02-15 G. D. Searle & Co. Double prodrugs of potent GP IIb/IIIa antagonists
CZ20012320A3 (cs) 1998-12-23 2002-10-16 G. D. Searle & Co. Léčivo s obsahem inhibitoru cyklooxygenázy-2 a jednoho nebo více antineoplastických činidel pro kombinační terapii při léčení neoplasie
HU226998B1 (en) * 2000-11-23 2010-04-28 Richter Gedeon Nyrt Desloratadine hemisulphate, process for the preparation thereof and pharmaceutical compositions containing the same
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7759387B2 (en) 2003-10-08 2010-07-20 Piramal Life Sciences Limited Fibrinogen receptor antagonists and their use
EP1682537B1 (en) 2003-11-05 2012-03-28 SARcode Bioscience Inc. Modulators of cellular adhesion
DK2444079T3 (en) * 2005-05-17 2017-01-30 Sarcode Bioscience Inc Compositions and Methods for the Treatment of Eye Diseases
WO2008035359A2 (en) * 2006-06-12 2008-03-27 Cadila Healthcare Limited Oximinophenoxyalkanoic acid and phenylalkanoic acid derivatives
US20090155176A1 (en) 2007-10-19 2009-06-18 Sarcode Corporation Compositions and methods for treatment of diabetic retinopathy
WO2009128933A1 (en) * 2008-04-15 2009-10-22 Sarcode Corporation Aerosolized lfa-1 antagonists for use in localized treatment of immune related disorders
US20090258070A1 (en) * 2008-04-15 2009-10-15 John Burnier Topical LFA-1 antagonists for use in localized treatment of immune related disorders
EP2276508A4 (en) * 2008-04-15 2011-12-28 Sarcode Bioscience Inc RELEASE OF LFA-1 ANTAGONISTS AGAINST THE GAS-DARM SYSTEM
US8080562B2 (en) 2008-04-15 2011-12-20 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
WO2010011302A1 (en) * 2008-07-22 2010-01-28 Chdi, Inc. Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
US8378105B2 (en) * 2009-10-21 2013-02-19 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
AU2012300246A1 (en) 2011-08-30 2014-03-06 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
SG2014012926A (en) 2011-08-30 2014-06-27 Chdi Foundation Inc Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
KR102157608B1 (ko) 2012-07-25 2020-09-18 에스에이알코드 바이오사이언스 인코포레이티드 Lfa-1 저해제 및 그의 다형체
DE102014108210A1 (de) 2014-06-11 2015-12-17 Dietrich Gulba Rodentizid
US10258621B2 (en) 2014-07-17 2019-04-16 Chdi Foundation, Inc. Methods and compositions for treating HIV-related disorders
TW202024062A (zh) 2018-09-20 2020-07-01 日商小野藥品工業股份有限公司 ４－（｛（４ｓ）－１－（４－甲脒基苯甲醯基）－４－［４－（甲磺醯基）哌－１－基］－ｌ－脯胺醯基｝胺基）苯甲酸之新穎鹽及其新穎結晶型
CN113075343B (zh) * 2020-01-04 2024-02-23 东莞市东阳光仿制药研发有限公司 一种羟胺及其盐的检测方法
EP4070658A1 (de) 2021-04-06 2022-10-12 BIORoxx GmbH Verwendung von blutgerinnungshemmenden verbindungen als rodentizide

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5039805A (en) * 1988-12-08 1991-08-13 Hoffmann-La Roche Inc. Novel benzoic and phenylacetic acid derivatives
US5256812A (en) * 1989-01-31 1993-10-26 Hoffmann-La Roche Inc. Carboxamides and sulfonamides
US5084466A (en) * 1989-01-31 1992-01-28 Hoffmann-La Roche Inc. Novel carboxamide pyridine compounds which have useful pharmaceutical utility
US5273982A (en) * 1990-03-09 1993-12-28 Hoffmann-La Roche Inc. Acetic acid derivatives
UA39849C2 (uk) * 1991-03-26 2001-07-16 Ф.Хоффманн-Ля Рош Аг ПОХІДНІ N-АЦИЛ-<font face="Symbol">a</font>-АМІНОКИСЛОТИ АБО ЇХ ФІЗІОЛОГІЧНО ПРИЙНЯТНІ СОЛІ, ПРОСТІ АБО СКЛАДНІ ЕФІРИ, АМІДИ АБО ЇХ ГІДРАТИ ЯК ФАРМАЦЕВТИЧНО АКТИВНІ РЕЧОВИНИ
DE4213919A1 (de) * 1992-04-28 1993-11-04 Thomae Gmbh Dr K Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
WO1994015913A1 (en) * 1992-12-30 1994-07-21 Smithkline Beecham Corporation Chemical compounds
AU688756B2 (en) 1993-03-17 1998-03-19 Meiji Seika Kabushiki Kaisha Novel compound with platelet aggregation inhibitor activity
GB9313269D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Allophanic acid derivatives
CA2166075A1 (en) * 1993-06-30 1995-01-12 Yoshiharu Ikeda Novel dipiperidine derivative

Also Published As

Publication number Publication date
UA35592C2 (uk) 2001-04-16
AU687905B2 (en) 1998-03-05
JP2901509B2 (ja) 1999-06-07
DE59409322D1 (de) 2000-06-08
DK0656348T3 (da) 2000-09-11
ES2147210T3 (es) 2000-09-01
MY112417A (en) 2001-06-30
KR100335541B1 (ko) 2003-06-11
PT656348E (pt) 2000-10-31
CZ301194A3 (en) 1995-09-13
RU2151768C1 (ru) 2000-06-27
NO302169B1 (no) 1998-02-02
IS4237A (is) 1995-06-04
CN1075062C (zh) 2001-11-21
US5973188A (en) 1999-10-26
FI945688A (fi) 1995-06-04
CZ290024B6 (cs) 2002-05-15
US5726185A (en) 1998-03-10
BG99233A (en) 1995-09-29
TW472042B (en) 2002-01-11
GR3034111T3 (en) 2000-11-30
SI0656348T1 (en) 2000-08-31
LV11318A (lv) 1996-06-20
NO944650L (no) 1995-06-06
RU94042929A (ru) 1996-10-27
JPH07196592A (ja) 1995-08-01
RO117846B1 (ro) 2002-08-30
CA2136903A1 (en) 1995-06-04
FI20011980A (fi) 2001-10-11
NZ270020A (en) 1997-05-26
AU7909094A (en) 1995-06-08
BG62399B1 (bg) 1999-10-29
EP0656348A3 (de) 1995-09-06
HUT71332A (en) 1995-11-28
LV11318B (en) 1996-10-20
FI945688A0 (fi) 1994-12-02
EP0656348A2 (de) 1995-06-07
SK282058B6 (sk) 2001-10-08
CN1112104A (zh) 1995-11-22
ATE192430T1 (de) 2000-05-15
SK145894A3 (en) 1995-09-13
IL111784A0 (en) 1995-01-24
HU9403441D0 (en) 1995-02-28
NO944650D0 (no) 1994-12-02
CA2136903C (en) 2006-06-06
EP0656348B1 (de) 2000-05-03

Similar Documents

Publication Publication Date Title
KR950017928A (ko) 아세트산 유도체
AU688628B2 (en) Novel amidinonaphthyl derivative or salt thereof
AU659629B2 (en) N-acyl-alpha-amino acid derivatives
HU9300274D0 (en) Phosphonoxical as well as carbonatic derivatives of taxole and medical preparatives containing said active substance
WO2001009103A3 (en) Imidazole antiproliferative agents
KR900018098A (ko) 피리돈 카르복실산과 항균제
CA2281426A1 (en) Substituted indole compounds as anti-inflammatory and analgesic agents
EP0671390A3 (en) Antithrombotic agents
DK0659427T3 (da) 2-Phenyl-3-azoylbenzothiophener til forøgelse af thrombomodulinekspression
DE69315699D1 (de) Inhibitoren gegen die aggregation von blutplättchen
AP9701010A0 (en) Piperidineacetic acid derivatives useful as fibrinogen.
RU94039539A (ru) N,n&#39;-замещенные имидокарбонимидные диамиды, получаемые из гидроксиламинов, имеющие антимикробную и антипаразитическую активность, профилактическая композиция, композиция для снижения уровня инфекций
RU96101800A (ru) Производные амида фенилциклогексилкарбоновой кислоты, смесь их изомеров или отдельные изомеры и их соли, фармацевтическая композиция с антиартериосклеротической и антирестенозной активностью
AU2983792A (en) Diaminomethyleneamino substituted substituted phenyl thiazoles
ES8505662A1 (es) Procedimiento para la obtencion de oximeteres sustituidos por 1-azolilo
WO2002026708A1 (fr) Composes conenant de l&#39;azote et inhibiteurs de ccr3 contenant ces composes en tant que principe actif
PL338700A1 (en) Methods of reducing number of thrombocytes in blood
EP0372410A3 (en) Use of heterocyclic amides to inhibit tumor metastasis
YU49054B (sh) Derivati sirćetne kiseline, njihova primena, postupak za njihovo dobivanje i farmaceutski preparati koji sadrže ta jedinjenja
GB1384441A (en) Benzomorphan derivatives

Legal Events

Date Code Title Description
A201 Request for examination
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20060331

Year of fee payment: 5

LAPS Lapse due to unpaid annual fee