KR940014293A - 아이오드화 아로일옥시 에스테르 - Google Patents

아이오드화 아로일옥시 에스테르 Download PDF

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Publication number
KR940014293A
KR940014293A KR1019930021260A KR930021260A KR940014293A KR 940014293 A KR940014293 A KR 940014293A KR 1019930021260 A KR1019930021260 A KR 1019930021260A KR 930021260 A KR930021260 A KR 930021260A KR 940014293 A KR940014293 A KR 940014293A
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South Korea
Prior art keywords
win
acid
alkyl
compound
aralkyl
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KR1019930021260A
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English (en)
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알. 베이컨 에드워드
제이. 다움 솔
피. 스파라 폴
Original Assignee
폴 이. 듀퐁
스터얼링 윈드롭 아이엔씨
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Publication of KR940014293A publication Critical patent/KR940014293A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/88—Carboxylic acid amides having nitrogen atoms of carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/90—Carboxylic acid amides having nitrogen atoms of carboxamide groups further acylated
    • C07C233/91—Carboxylic acid amides having nitrogen atoms of carboxamide groups further acylated with carbon atoms of the carboxamide groups bound to acyclic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)

Abstract

본 발명은 x-선 이미징 조성물 및 방법에서 조영제로 유용한 하기 구조식의 화합물을 제공한다.
식중, (Z)-COO는 아이오드화 방향족산의 잔기 ; n은 1 내지 20의 정수 ; R1는 R2는 독립적으로 수소, 알킬, 플루오로알킬, 싸이클로알킬, 아릴, 아랄킬, 알콕시 또는 아릴옥시, R3및 R4는 독립적으로 수소, 알킬, 플루오로알킬, 싸이클로알킬, 아릴, 아랄킬, 알콕시, 아릴옥시, 할로겐, 하이드록시 또는 아실아미노 ; 그리고 R5및 R6은 알킬, 싸이클로알킬, 아릴, 아랄킬, 알콕시알킬 또는 아세트아미노알킬임.

Description

아이오드화 아로일옥시 에스테르
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 하기 구조식의 화합물.
    식중, (Z)-COO는 아이오드화 방향족산의 잔기 ; n은 1 내지 20의 정수 ; R1는 R2는 독립적으로 수소, 알킬, 플루오로알킬, 싸이클로알킬, 아릴, 아랄킬, 알콕시 또는 아릴옥시, R3및 R4는 독립적으로 수소, 알킬, 플루오로알킬, 싸이클로알킬, 아릴, 아랄킬, 알콕시, 아릴옥시, 할로겐, 하이드록시 또는 아실아미노 ; 그리고 R5는 알킬, 싸이클로알킬, 아릴, 아랄킬, 알콕시알킬 또는 아세트아미노알킬임.
  2. 제 1항에 있어서, (Z)-COO가 디아트리조산, 메트리조산, 우로콘산, 아이오탈람산, 트리메스산, 아이옥사갈산, 아이옥시탈람산, 테트라아이오도테레프탈산 및 아이오디프아미드로부터 선택된 아이오드화 방향족 산의 잔기인 화합물.
  3. 제 1항에 있어서, (Z)-COO가 디아트리조산의 잔기인 화합물.
  4. 제 1항에 있어서, R1-R4=H인 화합물.
  5. 제 1항에 있어서, WIN 67722, WIN 67954, WIN 67995, WIN 68039, WIN 68061, WIN 68060, WIN 68136, WIN 68166, WIN 68767, WIN 68888, WIN 68384, WIN 68038 및 WIN 69732로 구성된 그룹에서 선택된 화합물.
  6. 제 1항의 화합물로 구성된 x-선 조영 조성물.
  7. 제 6항에 있어서, 제약학적으로 허용가능한 담체로 추가로 구성된 x-선 조영 조성물.
  8. 포유류의 신체에 조영 유효량(contrast effective amount)의 제 6항의 x-선 조영조성물을 투영하는 것으로 구성되는 의료용 x-선 진단 이미징 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930021260A 1992-12-16 1993-10-14 아이오드화 아로일옥시 에스테르 KR940014293A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/990,987 US5322679A (en) 1992-12-16 1992-12-16 Iodinated aroyloxy esters
US92-07/990,987 1992-12-16

Publications (1)

Publication Number Publication Date
KR940014293A true KR940014293A (ko) 1994-07-18

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Country Link
US (2) US5322679A (ko)
EP (1) EP0603922B1 (ko)
JP (1) JPH06199754A (ko)
KR (1) KR940014293A (ko)
AT (1) ATE155772T1 (ko)
AU (1) AU666220B2 (ko)
CA (1) CA2106413A1 (ko)
CZ (1) CZ274893A3 (ko)
DE (1) DE69312446D1 (ko)
FI (1) FI935308A (ko)
HU (1) HUT65772A (ko)
IL (1) IL107796A0 (ko)
NO (1) NO934333L (ko)
NZ (1) NZ248673A (ko)
PH (1) PH29958A (ko)
SK (1) SK142593A3 (ko)

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Also Published As

Publication number Publication date
US5322679A (en) 1994-06-21
EP0603922B1 (en) 1997-07-23
DE69312446D1 (de) 1997-09-04
NZ248673A (en) 1995-09-26
IL107796A0 (en) 1994-02-27
NO934333L (no) 1994-06-17
SK142593A3 (en) 1994-07-06
ATE155772T1 (de) 1997-08-15
US5466433A (en) 1995-11-14
AU666220B2 (en) 1996-02-01
CA2106413A1 (en) 1994-06-17
NO934333D0 (no) 1993-11-30
AU4737593A (en) 1994-06-30
JPH06199754A (ja) 1994-07-19
FI935308A (fi) 1994-06-17
PH29958A (en) 1996-09-16
CZ274893A3 (en) 1994-07-13
HUT65772A (en) 1994-07-28
FI935308A0 (fi) 1993-11-29
EP0603922A1 (en) 1994-06-29
HU9303593D0 (en) 1994-04-28

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