KR940014278A - 아이오드화 아로일옥시 카복사미드 - Google Patents

아이오드화 아로일옥시 카복사미드 Download PDF

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KR940014278A
KR940014278A KR1019930021154A KR930021154A KR940014278A KR 940014278 A KR940014278 A KR 940014278A KR 1019930021154 A KR1019930021154 A KR 1019930021154A KR 930021154 A KR930021154 A KR 930021154A KR 940014278 A KR940014278 A KR 940014278A
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bis
acid
triiodobenzoate
oxoethyl
acetylamino
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KR1019930021154A
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KR100300358B1 (ko
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알. 베이컨 에드워드
제이. 다움 솔
알. 일리그 칼
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폴 이. 듀퐁
스터얼링 윈드롭 아이엔씨.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

본 발명은 X-선 이미징 조성물 및 방법에서 조영제로 유용한 한기 구조식의 화합물을 제공한다.
식중,는 아이오드화 방향족산의 잔기 ; n은 0 내지 20의 정수 ; R1및 R2는 독립적으로 소수, 알킬, 플루오로알킬, 싸이클로알킬, 아릴, 아랄킬, 알콜시 또는 아릴옥시 ; R3및 R4는 독립적으로 R1및 R2에 대해 정의된 바와같은 치환체, 할로겐, 하이드록시 또는 아실아미도 ; 그리고 R5및 R6은 독립적으로 수소, 알킬, 싸이클로알킬, 아릴, 아랄킬, 알콕시, 알칵시알킬 또는 아세트아미도알킬 ; 또는 R5및 R6는 이들이 부착되어 있는 질소원자와 함께, 4 내지 7원 질소함유 고리를 나타냄.

Description

아이오드화 아로일옥시 카복사미드
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 하기 구조식의 화합물.
    식중,는 아이오드화 방향족산의 잔기 ; n은 0 내지 20의 정수 ; R1및 R2는 독립적으로 소수, 알킬, 플루오로알킬, 싸이클로알킬, 아릴, 아랄킬, 알콜시 또는 아릴옥시 ; R3및 R4는 독립적으로 R1및 R2에 대해 정의된 바와같은 치환체, 할로겐, 하이드록시 또는 아실아미도 ; 그리고 R5및 R6은 독립적으로 수소, 알킬, 싸이클로알킬, 아릴, 아랄킬, 알콕시, 알칵시알킬 또는 아세트아미도알킬 ; 또는 R5및 R6는 이들이 부착되어 있는 질소원자와 함께, 4 내지 7원 질소함유 고리를 나타냄.
  2. 제 1 항에 있어서,가 디아트리조산, 메트리조산, 우로콘산, 아이오탈람산, 트리메스산, 아이옥사갈산, 아이옥시탈람산, 테트라아이오도테레프탈산 및 아이오디프아미드로부터 선택된 아이오드화 방향족 산의 잔기인 화합물.
  3. 제 1 항에 있어서,가 디아트리조산의 잔기인 화합물.
  4. 제 1 항에 있어서, n=0,R1=H 및 R2=H인 화합물.
  5. 제 1 항에 있어서, 2-아미노-2-옥소에틸 3,5-비스(아세틸아미노)-2, 4, 6-트리아이오도벤조에이트, 2-에틸아미노-2-옥소에틸 3,5-비스(아세틸아미노)2, 4, 6-트리아이오도벤조에이트, 2-디에틸아미노-2-옥소메틸, 3,5-비스(아세틸아미노)-2, 4, 6-트리아이오도벤조에이트, 2-디부틸아미노-2-옥소에틸 3,5-비스(아세틸아미노)-2, 4, 6-트리아이오도벤조에이트, 2-디이소프로필아미노-2-옥소에틸 3,5-비스(아세틸아미노)-2, 4, 6-트리아이오도벤조에이트, 2-디에틸아미노-2-옥소에틸 3,5-비스(디아세틸아미노)-2, 4, 6-트리아이오도벤조에이트, 2-비스(2-하드록시에틸)아미노-2-옥소에틸 3,5-비스(아세틸아미노)-2, 4, 6-트리아이오도벤조에이트, 2-디에틸아미노-2-옥소에틸 3,5-비스(디아세틸아미노)-2, 4, 6-트리아이오도벤조에이트, 그리고 2-비스(2-아세톡시에틸)아미노2-옥소에틸 3,5-비스(디아세틸아미노)-2, 4, 6-트리아이오도도벤조에이트로 구성된 그룹에서 선택된 화합물.
  6. 제 1 항의 화합물로 구성관 x-선 조영 조성물.
  7. 제 6 항에 있어서, 제약학적으로 허용가능한 담체로 추가로 구성된 x-선 조용 조성물.
  8. 포유류의 신체에 조영 유효량(contrast effective amount)의 제 6 항의 x-선 조영조성물을 투여하는 것으로 구성되는 의료용 x-선 진단 이미징 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930021154A 1992-12-08 1993-10-13 아이오드화아로일옥시카복사미드 KR100300358B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/986,646 US5260478A (en) 1992-12-08 1992-12-08 Iodinated aroyloxy carboxamides
US92-07/986,646 1992-12-08

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KR940014278A true KR940014278A (ko) 1994-07-18
KR100300358B1 KR100300358B1 (ko) 2001-10-22

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US (1) US5260478A (ko)
EP (1) EP0601616A1 (ko)
JP (1) JPH06228067A (ko)
KR (1) KR100300358B1 (ko)
AU (1) AU662442B2 (ko)
CA (1) CA2107597A1 (ko)
CZ (1) CZ235593A3 (ko)
FI (1) FI935362A (ko)
HU (1) HUT65744A (ko)
IL (1) IL107054A (ko)
MX (1) MX9305805A (ko)
MY (1) MY109203A (ko)
NO (1) NO933467L (ko)
NZ (1) NZ248651A (ko)
PH (1) PH30156A (ko)
SK (1) SK120393A3 (ko)
TW (1) TW253881B (ko)

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US5488133A (en) * 1994-03-10 1996-01-30 Eastman Kodak Company Iodinated aroyloxy ketones
US5716642A (en) * 1995-01-10 1998-02-10 Nano Systems L.L.C. Microprecipitation of nanoparticulate pharmaceutical agents using surface active material derived from similar pharmaceutical agents
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UA72189C2 (uk) 1997-11-17 2005-02-15 Янссен Фармацевтика Н.В. Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот
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US7198795B2 (en) 2000-09-21 2007-04-03 Elan Pharma International Ltd. In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions
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US11297981B2 (en) 2010-12-21 2022-04-12 Sanandan Sudhir Multifunctional food processor
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AU662442B2 (en) 1995-08-31
HU9303475D0 (en) 1994-04-28
IL107054A (en) 1997-09-30
NO933467L (no) 1994-06-09
HUT65744A (en) 1994-07-28
SK120393A3 (en) 1994-06-08
IL107054A0 (en) 1993-12-28
NZ248651A (en) 1994-08-26
PH30156A (en) 1997-01-21
KR100300358B1 (ko) 2001-10-22
TW253881B (ko) 1995-08-11
US5260478A (en) 1993-11-09
EP0601616A1 (en) 1994-06-15
FI935362A (fi) 1994-06-09
AU4732493A (en) 1994-06-23
MY109203A (en) 1996-12-31
MX9305805A (es) 1994-06-30
JPH06228067A (ja) 1994-08-16
CA2107597A1 (en) 1994-06-09
NO933467D0 (no) 1993-09-28
CZ235593A3 (en) 1994-07-13
FI935362A0 (fi) 1993-11-30

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