DE69112080D1 - 2-decarboxyl-2-alkoxyalkyl-prostaglandine als augenbinnendrucksenkende mittel. - Google Patents

2-decarboxyl-2-alkoxyalkyl-prostaglandine als augenbinnendrucksenkende mittel.

Info

Publication number
DE69112080D1
DE69112080D1 DE69112080T DE69112080T DE69112080D1 DE 69112080 D1 DE69112080 D1 DE 69112080D1 DE 69112080 T DE69112080 T DE 69112080T DE 69112080 T DE69112080 T DE 69112080T DE 69112080 D1 DE69112080 D1 DE 69112080D1
Authority
DE
Germany
Prior art keywords
decarboxyl
alkoxyalkyl
carbon atoms
configuration
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69112080T
Other languages
English (en)
Other versions
DE69112080T2 (de
Inventor
Ming Chan
David Woodward
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of DE69112080D1 publication Critical patent/DE69112080D1/de
Application granted granted Critical
Publication of DE69112080T2 publication Critical patent/DE69112080T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69112080T 1990-12-06 1991-12-04 2-decarboxyl-2-alkoxyalkyl-prostaglandine als augenbinnendrucksenkende mittel. Expired - Fee Related DE69112080T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/623,234 US5139491A (en) 1990-12-06 1990-12-06 2-decarboxyl-2-alkoxyalkyl prostaglandins as ocular hypotensives
PCT/US1991/009071 WO1992010473A2 (en) 1990-12-06 1991-12-04 2-decarboxyl-2-alkoxyalkyl prostaglandins as ocular hypotensives

Publications (2)

Publication Number Publication Date
DE69112080D1 true DE69112080D1 (de) 1995-09-14
DE69112080T2 DE69112080T2 (de) 1996-01-11

Family

ID=24497288

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69112080T Expired - Fee Related DE69112080T2 (de) 1990-12-06 1991-12-04 2-decarboxyl-2-alkoxyalkyl-prostaglandine als augenbinnendrucksenkende mittel.

Country Status (12)

Country Link
US (1) US5139491A (de)
EP (1) EP0562016B1 (de)
JP (1) JP3186766B2 (de)
AT (1) ATE126211T1 (de)
AU (1) AU645647B2 (de)
BR (1) BR9107155A (de)
CA (1) CA2096945A1 (de)
DE (1) DE69112080T2 (de)
ES (1) ES2075679T3 (de)
HU (1) HUT67535A (de)
IE (1) IE914231A1 (de)
WO (1) WO1992010473A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5238961A (en) * 1990-06-14 1993-08-24 Allergan, Inc. Pgf 1-alcohols and their use as ocular hypotensives
US5288754A (en) * 1992-02-04 1994-02-22 Allergan, Inc. Polar C-1 esters of prostaglandins
US6124353A (en) * 1992-11-12 2000-09-26 Allergan Sales, Inc. Method of treating ocular hypertension with 8-epi prostaglandins
US5476872A (en) * 1993-10-18 1995-12-19 Allergan, Inc. 1,11-diesters of prostaglandin-F2α having a polar ester group at C-1
JPWO2006098292A1 (ja) * 2005-03-15 2008-08-21 小野薬品工業株式会社 眼疾患治療剤

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3069322A (en) * 1958-05-28 1962-12-18 Bergstrom Sune Pge and pgf
FR2278322A1 (fr) * 1972-12-05 1976-02-13 Ono Pharmaceutical Co Compositions contenant des prostaglandines
NL7605381A (nl) * 1975-05-26 1976-11-30 Schering Ag Werkwijze voor het bereiden van prostaanderi- vaten en werkwijze voor het bereiden van een geneesmiddel met prostaglandinewerking.
GB2048254B (en) * 1979-04-02 1983-05-25 Upjohn Co 19,20 -didehydro-19-hydroxy and 19-oxo-prostaglandin derivatives
GB8528032D0 (en) * 1985-11-13 1985-12-18 Ici Plc Ocular treatment
US4824857A (en) * 1986-05-16 1989-04-25 Yasumasa Goh Use of prostaglandin D2 -active substances
US4822820A (en) * 1986-11-24 1989-04-18 Alcon Laboratories, Inc. Use of tri-methyl PG-F2 a and derivatives in glaucoma therapy
ES2052735T3 (es) * 1987-09-18 1994-07-16 R Tech Ueno Ltd Un metodo para producir un agente hipotensor ocular.
US4994274A (en) * 1989-07-27 1991-02-19 Allergan, Inc. Intraocular pressure reducing 11,15-diacyl prostaglandins and method of using
US5011856A (en) * 1990-03-12 1991-04-30 Allergan, Inc. Use of prostaglandin F3 α as an ocular hypotensive agent
US5238961A (en) * 1990-06-14 1993-08-24 Allergan, Inc. Pgf 1-alcohols and their use as ocular hypotensives

Also Published As

Publication number Publication date
EP0562016A1 (de) 1993-09-29
HU9301348D0 (en) 1993-09-28
HUT67535A (en) 1995-04-28
ATE126211T1 (de) 1995-08-15
WO1992010473A2 (en) 1992-06-25
AU9161191A (en) 1992-07-08
BR9107155A (pt) 1993-11-16
US5139491A (en) 1992-08-18
EP0562016B1 (de) 1995-08-09
IE914231A1 (en) 1992-06-17
JPH06503346A (ja) 1994-04-14
JP3186766B2 (ja) 2001-07-11
ES2075679T3 (es) 1995-10-01
WO1992010473A3 (en) 1992-08-20
AU645647B2 (en) 1994-01-20
CA2096945A1 (en) 1992-06-07
DE69112080T2 (de) 1996-01-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee