KR890005034A - 디카복실산-비스(3,5-디카바모일-2,4,6,-트리요오도아닐리드) 및 이를 함유하는 x-선 조영제 - Google Patents

디카복실산-비스(3,5-디카바모일-2,4,6,-트리요오도아닐리드) 및 이를 함유하는 x-선 조영제 Download PDF

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KR890005034A
KR890005034A KR1019880011967A KR880011967A KR890005034A KR 890005034 A KR890005034 A KR 890005034A KR 1019880011967 A KR1019880011967 A KR 1019880011967A KR 880011967 A KR880011967 A KR 880011967A KR 890005034 A KR890005034 A KR 890005034A
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dihydroxy
hydroxy
compound
carbamoyl
triiodo
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KR1019880011967A
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KR0139061B1 (ko
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블라츠 키빅쯔 페터
스펙크 울리흐
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원본미기재
쉐링 아크티엔게젤샤프트
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Paints Or Removers (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polyamides (AREA)

Abstract

내용 없음

Description

디카복실산-비스(3,5-디카바모일-2,4,6-트리요오도아닐리드) 및 이를 함유하는 X-선 조영제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (14)

  1. 하기 일반식(I)의 디카복실산-비스(3,5-디카바모일-2,4,6-트리요오도아닐리드).
    상기식에서, 아미드라디칼 -CONR1R2및 -CONR3R4는 서로 상이하며, R1은 수소, C1-4-알킬 또는 R2이고, 여기서, R1및 R2는 동일하거나 상이하며, R2는 모노하이드록시- 또는 폴리하이드록시-C2-8알킬이며, R3은 수소, C1-4-알킬 또는 R4이고, 여기서, R3및 R4는 동일하거나 상이하며, R4는 모노하이드록시-또는 폴리하이드록시-C2-8-알킬이며, R5는 수소, C1-4-알킬, 또는 모노하이드록시- 또는 폴리하이드록시-C1-4-알킬이고, X는 임의로 1 내지 6개의 하이드록시, C1-7-알콕시, 벤질옥시, 하이드록시벤질옥시 또는 하이드록시-C1-7-알콕시그룹에 의해 치환되고/되거나 1 내지 3개의 산소원자에 의해 차단되는 C1-6-알킬렌이다.
  2. 제1항에 있어서, X가 -CH2-인 화합물.
  3. 제1항에 있어서, X가또는인 화합물.
  4. 제1항에 있어서, X가 직쇄인 화합물.
  5. 제1항에 있어서, R1이 H 또는 CH3인 화합물.
  6. 제1항에 있어서, R2가, -CH2CH2OH 또는인 화합물.
  7. 제1항에 있어서, R3이 H 또는 -CH2CH2OH인 화합물.
  8. 제1항에 있어서, R4가-CH2CH2OH 또는인 화합물.
  9. 제1항에 있어서, R5가 -CH3, -CH2CH2-OH 또는인 화합물.
  10. 제1항에 있어서, 말론산 비스[3-(2,3-디하이드록시-N-메틸-프로필카바모일)-5-(2,3-디하이드록시-프로필카바모일)-2,4,6-트리요오도-N-메틸아닐리드], 말론산 비스{3-(2,3-디하이드록시-프로필카바모일)-5-[비스(2-하이드록시에틸)-카바모일]-2,4,6-트리요오도-N-메틸아닐리드}, 말론산 비스{3-(2,3-디하이드록시-프로필카바모일)-5-[(1RS,2SR)-2,3-디하이드록시-1-하이드록시메틸프로필-카바모일]-2,4,6-트리요오도-N-메틸아닐리드}, 말론산비스[3-(2,3-하이드록시-N-메틸-에틸-카바모일)-5-(2,3-디하이드록시-프로필카바모일)-2,4,6-트리요오도-N-(2-하이드록시-에틸)아닐리드], 말론산비스[3-(2,3-디하이드록시-N-메틸-프로필-카바모일)-5-(2-하이드록시-에틸-카바모일)-2,4,6-트리요오도-N-메틸아닐리드], 말론산비스{3-(2,3-디하이드록시-플필카바모일)-5-(2-하이드록시에틸-카바모일)-2,4,6-트리요오도-N-(2,3-디하이드록시-프로필)아닐리드}, 하이드록시말론산 비스[3-(2,3-디하이드록시-프로필카바모일)-5-(2-하이드록시-에틸-카바모일)-2,4,6-트리요오도-N-(2,3-디하이드록시-프로필)아닐리드], 하이드록시말론산 비스[3-(2-하이드록시-1-하이드록시메틸에틸-카바모일)-5-(2,3-하이드록시-프로필-카바모일)-2,4,6-트리요오도-N-메틸아닐리드], 메톡시말론산 비스[3-(2-하이드록시-1-하이드록시메틸에틸-카바모일)-5-(2,3-하이드록시-프로필-카바모일)-2,4,6-트리요오도-N-메틸아닐리드], 2,3-디하이드록시 숙산 비스[3-(2,3-디하이드록시-프로필카바모일)-5-(2-하이드록시-에틸카바모일)-2,4,6-트리요오도-N-(2-하이드록시에틸)아닐리드], 및 하이드록시말론산 비스-{3-(2,3-디하이드록시-N-메틸-프로필카바모일)-5-(2,3-디하이드록시-프로필카바모일)-2,4,6-트리요오도-N-메틸아닐리드]중에서 선택되는 화합물.
  11. 제1항의 화합물의 유효량 및 약제학적으로 허용되는 부형제를 함유함을 특징으로 하는 약젝학적 조성물.
  12. 제10하의 화합물의 유효량 및 약제학적으로 허용되는 부형제를 함유함을 특징으로 하는 약제학적 조성물.
  13. 제1항의 화합물의 유효량을 투여함을 특징으로 하여, 환자의 X-선 조영을 수행하는 방법.
  14. 제10항의 화합물의 유효량을 투여함을 특징으로 하여 환자의 X-선 조영을 수행하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880011967A 1987-09-17 1988-09-16 디카복실산-비스-(3,5-디카바모일-2,4,6-트리요오드아닐리드) 및 이를 함유하는 x-선 조영제 KR0139061B1 (ko)

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DEP3731542.0 1987-09-17
DE19873731542 DE3731542A1 (de) 1987-09-17 1987-09-17 Neue dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6-triiod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel

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KR890005034A true KR890005034A (ko) 1989-05-11
KR0139061B1 KR0139061B1 (ko) 1998-05-01

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US (1) US5073362A (ko)
EP (1) EP0308364B1 (ko)
JP (1) JP2569144B2 (ko)
KR (1) KR0139061B1 (ko)
AT (1) ATE97126T1 (ko)
AU (1) AU616203B2 (ko)
CA (1) CA1333911C (ko)
DE (2) DE3731542A1 (ko)
DK (1) DK514788A (ko)
ES (1) ES2059557T3 (ko)
FI (1) FI93208C (ko)
IE (1) IE62460B1 (ko)
NO (1) NO175857C (ko)
PT (1) PT88537B (ko)
ZA (1) ZA886939B (ko)

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KR101012646B1 (ko) * 2010-04-01 2011-02-09 대우조선해양 주식회사 공기 공동 선박

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DE60220949T2 (de) 2001-12-20 2008-03-06 Bone Support Ab Neuer knochenmineralien-ersatzstoff
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WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6929967B2 (en) 2001-12-27 2005-08-16 Lg. Philips Lcd Co., Ltd. Method of forming pattern
KR101012646B1 (ko) * 2010-04-01 2011-02-09 대우조선해양 주식회사 공기 공동 선박

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US5073362A (en) 1991-12-17
CA1333911C (en) 1995-01-10
IE882808L (en) 1989-03-17
ZA886939B (en) 1989-06-28
NO175857B (ko) 1994-09-12
NO175857C (no) 1994-12-21
AU616203B2 (en) 1991-10-24
DE3885557D1 (de) 1993-12-16
DK514788D0 (da) 1988-09-15
DE3731542A1 (de) 1989-03-30
EP0308364B1 (de) 1993-11-10
NO884127D0 (no) 1988-09-16
JP2569144B2 (ja) 1997-01-08
NO884127L (no) 1989-03-20
AU2225188A (en) 1989-04-13
FI884271A (fi) 1989-03-18
JPH0196160A (ja) 1989-04-14
IE62460B1 (en) 1995-02-08
ATE97126T1 (de) 1993-11-15
EP0308364A3 (de) 1991-01-30
PT88537B (pt) 1992-11-30
PT88537A (pt) 1988-10-01
ES2059557T3 (es) 1994-11-16
DK514788A (da) 1989-03-18
FI884271A0 (fi) 1988-09-16
EP0308364A2 (de) 1989-03-22
FI93208B (fi) 1994-11-30
FI93208C (fi) 1995-03-10
KR0139061B1 (ko) 1998-05-01

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