KR890005034A - 디카복실산-비스(3,5-디카바모일-2,4,6,-트리요오도아닐리드) 및 이를 함유하는 x-선 조영제 - Google Patents
디카복실산-비스(3,5-디카바모일-2,4,6,-트리요오도아닐리드) 및 이를 함유하는 x-선 조영제 Download PDFInfo
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- KR890005034A KR890005034A KR1019880011967A KR880011967A KR890005034A KR 890005034 A KR890005034 A KR 890005034A KR 1019880011967 A KR1019880011967 A KR 1019880011967A KR 880011967 A KR880011967 A KR 880011967A KR 890005034 A KR890005034 A KR 890005034A
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- South Korea
- Prior art keywords
- dihydroxy
- hydroxy
- compound
- carbamoyl
- triiodo
- Prior art date
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- 239000002872 contrast media Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 13
- -1 C 1-7 -alkoxy Chemical group 0.000 claims 9
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 4
- ROBFUDYVXSDBQM-UHFFFAOYSA-N hydroxymalonic acid Chemical compound OC(=O)C(O)C(O)=O ROBFUDYVXSDBQM-UHFFFAOYSA-N 0.000 claims 4
- 150000003018 phosphorus compounds Chemical class 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 3
- 150000003931 anilides Chemical class 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- JWTKLOUWVLRHMQ-UHFFFAOYSA-N 1-N,3-N-bis(2,3-dihydroxypropyl)-5-[[3-[3-(2,3-dihydroxypropylcarbamoyl)-5-[2,3-dihydroxypropyl(methyl)carbamoyl]-2,4,6-triiodo-N-methylanilino]-3-oxopropanoyl]-methylamino]-2,4,6-triiodo-3-N-methylbenzene-1,3-dicarboxamide Chemical compound OC(CN(C(=O)C=1C(=C(N(C(CC(=O)N(C2=C(C(=C(C(=C2I)C(NCC(CO)O)=O)I)C(N(C)CC(CO)O)=O)I)C)=O)C)C(=C(C=1I)C(NCC(CO)O)=O)I)I)C)CO JWTKLOUWVLRHMQ-UHFFFAOYSA-N 0.000 claims 1
- SGPSJPWJAOEXGM-UHFFFAOYSA-N 1-N-(2,3-dihydroxypropyl)-5-[[3-[3-(2,3-dihydroxypropylcarbamoyl)-2,4,6-triiodo-N-methyl-5-(1,3,4-trihydroxybutan-2-ylcarbamoyl)anilino]-3-oxopropanoyl]-methylamino]-2,4,6-triiodo-3-N-(1,3,4-trihydroxybutan-2-yl)benzene-1,3-dicarboxamide Chemical compound OC(CNC(=O)C=1C(=C(N(C(CC(=O)N(C2=C(C(=C(C(=C2I)C(NC(C(CO)O)CO)=O)I)C(NCC(CO)O)=O)I)C)=O)C)C(=C(C=1I)C(NC(C(CO)O)CO)=O)I)I)CO SGPSJPWJAOEXGM-UHFFFAOYSA-N 0.000 claims 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 1
- VLDSMCHWNWDAKQ-UHFFFAOYSA-N 2-methoxypropanedioic acid Chemical compound COC(C(O)=O)C(O)=O VLDSMCHWNWDAKQ-UHFFFAOYSA-N 0.000 claims 1
- UFRIFFBNKZYPII-UHFFFAOYSA-N 3-N-(2,3-dihydroxypropyl)-5-[[3-[3-[2,3-dihydroxypropyl(methyl)carbamoyl]-5-(2-hydroxyethylcarbamoyl)-2,4,6-triiodo-N-methylanilino]-3-oxopropanoyl]-methylamino]-1-N-(2-hydroxyethyl)-2,4,6-triiodo-3-N-methylbenzene-1,3-dicarboxamide Chemical compound OC(CN(C(=O)C=1C(=C(N(C(CC(=O)N(C2=C(C(=C(C(=C2I)C(NCCO)=O)I)C(N(C)CC(CO)O)=O)I)C)=O)C)C(=C(C=1I)C(NCCO)=O)I)I)C)CO UFRIFFBNKZYPII-UHFFFAOYSA-N 0.000 claims 1
- GTGSYPNDDOFQAH-UHFFFAOYSA-N 3-n-(2,3-dihydroxypropyl)-5-[2,3-dihydroxypropyl-[3-[n-(2,3-dihydroxypropyl)-3-(2,3-dihydroxypropylcarbamoyl)-5-(2-hydroxyethylcarbamoyl)-2,4,6-triiodoanilino]-2-hydroxy-3-oxopropanoyl]amino]-1-n-(2-hydroxyethyl)-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound OCC(O)CNC(=O)C1=C(I)C(C(=O)NCCO)=C(I)C(N(CC(O)CO)C(=O)C(O)C(=O)N(CC(O)CO)C=2C(=C(C(=O)NCC(O)CO)C(I)=C(C(=O)NCCO)C=2I)I)=C1I GTGSYPNDDOFQAH-UHFFFAOYSA-N 0.000 claims 1
- XOYUURPLLKWWHE-UHFFFAOYSA-N 5-[[3-[3-[bis(2-hydroxyethyl)carbamoyl]-5-(2,3-dihydroxypropylcarbamoyl)-2,4,6-triiodo-N-methylanilino]-3-oxopropanoyl]-methylamino]-1-N-(2,3-dihydroxypropyl)-3-N,3-N-bis(2-hydroxyethyl)-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound OC(CNC(=O)C=1C(=C(N(C(CC(=O)N(C2=C(C(=C(C(=C2I)C(N(CCO)CCO)=O)I)C(NCC(CO)O)=O)I)C)=O)C)C(=C(C=1I)C(N(CCO)CCO)=O)I)I)CO XOYUURPLLKWWHE-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Paints Or Removers (AREA)
- Polyurethanes Or Polyureas (AREA)
- Polyesters Or Polycarbonates (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polyamides (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (14)
- 하기 일반식(I)의 디카복실산-비스(3,5-디카바모일-2,4,6-트리요오도아닐리드).상기식에서, 아미드라디칼 -CONR1R2및 -CONR3R4는 서로 상이하며, R1은 수소, C1-4-알킬 또는 R2이고, 여기서, R1및 R2는 동일하거나 상이하며, R2는 모노하이드록시- 또는 폴리하이드록시-C2-8알킬이며, R3은 수소, C1-4-알킬 또는 R4이고, 여기서, R3및 R4는 동일하거나 상이하며, R4는 모노하이드록시-또는 폴리하이드록시-C2-8-알킬이며, R5는 수소, C1-4-알킬, 또는 모노하이드록시- 또는 폴리하이드록시-C1-4-알킬이고, X는 임의로 1 내지 6개의 하이드록시, C1-7-알콕시, 벤질옥시, 하이드록시벤질옥시 또는 하이드록시-C1-7-알콕시그룹에 의해 치환되고/되거나 1 내지 3개의 산소원자에 의해 차단되는 C1-6-알킬렌이다.
- 제1항에 있어서, X가 -CH2-인 화합물.
- 제1항에 있어서, X가또는인 화합물.
- 제1항에 있어서, X가 직쇄인 화합물.
- 제1항에 있어서, R1이 H 또는 CH3인 화합물.
- 제1항에 있어서, R2가, -CH2CH2OH 또는인 화합물.
- 제1항에 있어서, R3이 H 또는 -CH2CH2OH인 화합물.
- 제1항에 있어서, R4가-CH2CH2OH 또는인 화합물.
- 제1항에 있어서, R5가 -CH3, -CH2CH2-OH 또는인 화합물.
- 제1항에 있어서, 말론산 비스[3-(2,3-디하이드록시-N-메틸-프로필카바모일)-5-(2,3-디하이드록시-프로필카바모일)-2,4,6-트리요오도-N-메틸아닐리드], 말론산 비스{3-(2,3-디하이드록시-프로필카바모일)-5-[비스(2-하이드록시에틸)-카바모일]-2,4,6-트리요오도-N-메틸아닐리드}, 말론산 비스{3-(2,3-디하이드록시-프로필카바모일)-5-[(1RS,2SR)-2,3-디하이드록시-1-하이드록시메틸프로필-카바모일]-2,4,6-트리요오도-N-메틸아닐리드}, 말론산비스[3-(2,3-하이드록시-N-메틸-에틸-카바모일)-5-(2,3-디하이드록시-프로필카바모일)-2,4,6-트리요오도-N-(2-하이드록시-에틸)아닐리드], 말론산비스[3-(2,3-디하이드록시-N-메틸-프로필-카바모일)-5-(2-하이드록시-에틸-카바모일)-2,4,6-트리요오도-N-메틸아닐리드], 말론산비스{3-(2,3-디하이드록시-플필카바모일)-5-(2-하이드록시에틸-카바모일)-2,4,6-트리요오도-N-(2,3-디하이드록시-프로필)아닐리드}, 하이드록시말론산 비스[3-(2,3-디하이드록시-프로필카바모일)-5-(2-하이드록시-에틸-카바모일)-2,4,6-트리요오도-N-(2,3-디하이드록시-프로필)아닐리드], 하이드록시말론산 비스[3-(2-하이드록시-1-하이드록시메틸에틸-카바모일)-5-(2,3-하이드록시-프로필-카바모일)-2,4,6-트리요오도-N-메틸아닐리드], 메톡시말론산 비스[3-(2-하이드록시-1-하이드록시메틸에틸-카바모일)-5-(2,3-하이드록시-프로필-카바모일)-2,4,6-트리요오도-N-메틸아닐리드], 2,3-디하이드록시 숙산 비스[3-(2,3-디하이드록시-프로필카바모일)-5-(2-하이드록시-에틸카바모일)-2,4,6-트리요오도-N-(2-하이드록시에틸)아닐리드], 및 하이드록시말론산 비스-{3-(2,3-디하이드록시-N-메틸-프로필카바모일)-5-(2,3-디하이드록시-프로필카바모일)-2,4,6-트리요오도-N-메틸아닐리드]중에서 선택되는 화합물.
- 제1항의 화합물의 유효량 및 약제학적으로 허용되는 부형제를 함유함을 특징으로 하는 약젝학적 조성물.
- 제10하의 화합물의 유효량 및 약제학적으로 허용되는 부형제를 함유함을 특징으로 하는 약제학적 조성물.
- 제1항의 화합물의 유효량을 투여함을 특징으로 하여, 환자의 X-선 조영을 수행하는 방법.
- 제10항의 화합물의 유효량을 투여함을 특징으로 하여 환자의 X-선 조영을 수행하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP3731542.0 | 1987-09-17 | ||
DE19873731542 DE3731542A1 (de) | 1987-09-17 | 1987-09-17 | Neue dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6-triiod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel |
Publications (2)
Publication Number | Publication Date |
---|---|
KR890005034A true KR890005034A (ko) | 1989-05-11 |
KR0139061B1 KR0139061B1 (ko) | 1998-05-01 |
Family
ID=6336386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880011967A KR0139061B1 (ko) | 1987-09-17 | 1988-09-16 | 디카복실산-비스-(3,5-디카바모일-2,4,6-트리요오드아닐리드) 및 이를 함유하는 x-선 조영제 |
Country Status (15)
Country | Link |
---|---|
US (1) | US5073362A (ko) |
EP (1) | EP0308364B1 (ko) |
JP (1) | JP2569144B2 (ko) |
KR (1) | KR0139061B1 (ko) |
AT (1) | ATE97126T1 (ko) |
AU (1) | AU616203B2 (ko) |
CA (1) | CA1333911C (ko) |
DE (2) | DE3731542A1 (ko) |
DK (1) | DK514788A (ko) |
ES (1) | ES2059557T3 (ko) |
FI (1) | FI93208C (ko) |
IE (1) | IE62460B1 (ko) |
NO (1) | NO175857C (ko) |
PT (1) | PT88537B (ko) |
ZA (1) | ZA886939B (ko) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6929967B2 (en) | 2001-12-27 | 2005-08-16 | Lg. Philips Lcd Co., Ltd. | Method of forming pattern |
KR101012646B1 (ko) * | 2010-04-01 | 2011-02-09 | 대우조선해양 주식회사 | 공기 공동 선박 |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3739098A1 (de) * | 1987-11-16 | 1989-05-24 | Schering Ag | Neue substituierte dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6- trijod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel |
EP0410974A4 (en) * | 1988-03-01 | 1991-09-11 | Mallinckrodt, Inc. | Nonionic x-ray contrast agents, compositions and methods |
IL94718A (en) * | 1989-07-05 | 1994-10-21 | Schering Ag | Non-ionic carboxamide contrast agent and method of preparation |
US5191120A (en) * | 1989-12-13 | 1993-03-02 | Mallinckrodt Medical, Inc. | Process for preparing nonionic X-ray contrast agents |
US5075502A (en) * | 1989-12-13 | 1991-12-24 | Mallinckrodt, Inc. | Nonionic x-ray contrast agents, compositions and methods |
IT1245853B (it) * | 1990-11-16 | 1994-10-25 | Bracco Spa | 1,3-bis(3-(mono o poliidrossi)acilamino-5-(mono o poliidrossi-alchil) aminocarbonil-2,4,6-triiodo-benzoil-amino)-idrossi- o idrossi-alchil- propani, loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono |
FR2673180B1 (fr) * | 1991-02-25 | 1994-03-04 | Guerbet Sa | Nouveaux composes non ioniques poly-iodes, procede de preparation, produit de contraste les contenant. |
ES2037605B1 (es) * | 1991-11-18 | 1994-02-01 | Invest Justesa Imagen S A Cent | Metodo para preparar nuevos agentes yodados no ionicos de constraste a los rayos x. |
FR2695125B1 (fr) * | 1992-08-25 | 1994-12-23 | Guerbet Sa | Nouveaux composés poly-iodés, procédé de préparation, produit de contraste les contenant. |
WO1994022810A1 (es) * | 1993-04-01 | 1994-10-13 | Centro Investigacion Justesa Imagen, S.A. | Nuevos dimeros iodados no ionicos como agentes de contraste a los rayos x, metodo para su preparacion y composiciones galenicas que los contienen |
US5611342A (en) * | 1994-02-15 | 1997-03-18 | Molecular Biosystems, Inc. | Method of computer tomography imaging the gastrointestinal tract and surrounding upper abdominal tissues and organs using an orally administered low density contrast medium |
WO1995026331A1 (es) * | 1994-03-25 | 1995-10-05 | Centro Investigacion Justesa Imagen, S.A. | Nuevos dimeros iodados no ionicos como agentes de contraste a los rayos x, metodo para su preparacion y composiciones farmaceuticas que los contienen |
SE520688C2 (sv) | 2000-04-11 | 2003-08-12 | Bone Support Ab | Ett injicerbart ersättningsmaterial för benmineral |
SE517168C2 (sv) | 2000-07-17 | 2002-04-23 | Bone Support Ab | En komposition för ett injicerbart ersättningsmaterial för benmineral |
SE522098C2 (sv) | 2001-12-20 | 2004-01-13 | Bone Support Ab | Ett nytt benmineralsubstitut |
DE60220949T2 (de) | 2001-12-20 | 2008-03-06 | Bone Support Ab | Neuer knochenmineralien-ersatzstoff |
SE0300620D0 (sv) | 2003-03-05 | 2003-03-05 | Bone Support Ab | A new bone substitute composition |
SE0302983D0 (sv) | 2003-11-11 | 2003-11-11 | Bone Support Ab | Anordning för att förse spongiöst ben med benersättnings- och/eller benförstärkningsmaterial och förfarande i samband därmed |
SE527528C2 (sv) | 2004-06-22 | 2006-04-04 | Bone Support Ab | Anordning för framställning av härdbar massa samt användning av anordningen |
WO2006055959A2 (en) * | 2004-11-19 | 2006-05-26 | Bioquanta Corp. | Pf4 pharmacophores and their uses |
AU2007297012B2 (en) * | 2006-09-13 | 2011-12-22 | Sanofi-Aventis | Tartrate derivatives for use as coagulation factor IXa inhibitors |
US9180137B2 (en) | 2010-02-09 | 2015-11-10 | Bone Support Ab | Preparation of bone cement compositions |
WO2012136813A2 (en) | 2011-04-07 | 2012-10-11 | Universitetet I Oslo | Agents for medical radar diagnosis |
PL2958603T3 (pl) | 2013-02-20 | 2018-10-31 | Bone Support Ab | Ulepszone zestalanie utwardzalnego materiału zastępczego kości |
US10610366B2 (en) | 2015-01-29 | 2020-04-07 | Theracell, Inc. | Demineralized bone fiber composition for use in minimally invasive surgery |
US10639157B2 (en) | 2017-03-14 | 2020-05-05 | Theracell, Inc. | Demineralized bone fiber composition for use in minimally invasive surgery |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2628517C2 (de) * | 1976-06-23 | 1985-02-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel |
CH626873A5 (ko) * | 1977-03-28 | 1981-12-15 | Bracco Ind Chimica Spa | |
DE2909439A1 (de) * | 1979-03-08 | 1980-09-18 | Schering Ag | Neue nichtionische roentgenkontrastmittel |
DK273280A (da) * | 1979-06-28 | 1980-12-29 | Schering Ag | Trijoderede 5-aminoisophthalsyrederivater |
IT1207226B (it) * | 1979-08-09 | 1989-05-17 | Bracco Ind Chimica Spa | Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono. |
US4341756A (en) * | 1980-01-31 | 1982-07-27 | The Regents Of The University Of California | Novel amino-dioxepane intermediates for the synthesis of new non-ionic contrast media |
NO161560C (no) * | 1980-04-17 | 1989-09-06 | Univ California | Symmetriske trijodisoftaldiamid-derivater og roentgenkontrastmidler inneholdende disse. |
DE3038853A1 (de) * | 1980-10-10 | 1982-05-27 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii) |
EP0108638B1 (en) * | 1982-11-08 | 1986-07-16 | NYEGAARD & CO. A/S | X-ray contrast agents |
DE3739098A1 (de) * | 1987-11-16 | 1989-05-24 | Schering Ag | Neue substituierte dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6- trijod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel |
-
1987
- 1987-09-17 DE DE19873731542 patent/DE3731542A1/de not_active Withdrawn
-
1988
- 1988-09-14 CA CA000577366A patent/CA1333911C/en not_active Expired - Fee Related
- 1988-09-14 JP JP63228903A patent/JP2569144B2/ja not_active Expired - Lifetime
- 1988-09-15 ES ES88730215T patent/ES2059557T3/es not_active Expired - Lifetime
- 1988-09-15 EP EP88730215A patent/EP0308364B1/de not_active Expired - Lifetime
- 1988-09-15 AT AT88730215T patent/ATE97126T1/de not_active IP Right Cessation
- 1988-09-15 DK DK514788A patent/DK514788A/da not_active Application Discontinuation
- 1988-09-15 DE DE88730215T patent/DE3885557D1/de not_active Expired - Lifetime
- 1988-09-16 AU AU22251/88A patent/AU616203B2/en not_active Ceased
- 1988-09-16 FI FI884271A patent/FI93208C/fi not_active IP Right Cessation
- 1988-09-16 ZA ZA886939A patent/ZA886939B/xx unknown
- 1988-09-16 KR KR1019880011967A patent/KR0139061B1/ko not_active IP Right Cessation
- 1988-09-16 NO NO884127A patent/NO175857C/no unknown
- 1988-09-16 IE IE280888A patent/IE62460B1/en not_active IP Right Cessation
- 1988-09-16 PT PT88537A patent/PT88537B/pt not_active IP Right Cessation
-
1990
- 1990-07-16 US US07/554,948 patent/US5073362A/en not_active Expired - Fee Related
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6929967B2 (en) | 2001-12-27 | 2005-08-16 | Lg. Philips Lcd Co., Ltd. | Method of forming pattern |
KR101012646B1 (ko) * | 2010-04-01 | 2011-02-09 | 대우조선해양 주식회사 | 공기 공동 선박 |
Also Published As
Publication number | Publication date |
---|---|
US5073362A (en) | 1991-12-17 |
CA1333911C (en) | 1995-01-10 |
IE882808L (en) | 1989-03-17 |
ZA886939B (en) | 1989-06-28 |
NO175857B (ko) | 1994-09-12 |
NO175857C (no) | 1994-12-21 |
AU616203B2 (en) | 1991-10-24 |
DE3885557D1 (de) | 1993-12-16 |
DK514788D0 (da) | 1988-09-15 |
DE3731542A1 (de) | 1989-03-30 |
EP0308364B1 (de) | 1993-11-10 |
NO884127D0 (no) | 1988-09-16 |
JP2569144B2 (ja) | 1997-01-08 |
NO884127L (no) | 1989-03-20 |
AU2225188A (en) | 1989-04-13 |
FI884271A (fi) | 1989-03-18 |
JPH0196160A (ja) | 1989-04-14 |
IE62460B1 (en) | 1995-02-08 |
ATE97126T1 (de) | 1993-11-15 |
EP0308364A3 (de) | 1991-01-30 |
PT88537B (pt) | 1992-11-30 |
PT88537A (pt) | 1988-10-01 |
ES2059557T3 (es) | 1994-11-16 |
DK514788A (da) | 1989-03-18 |
FI884271A0 (fi) | 1988-09-16 |
EP0308364A2 (de) | 1989-03-22 |
FI93208B (fi) | 1994-11-30 |
FI93208C (fi) | 1995-03-10 |
KR0139061B1 (ko) | 1998-05-01 |
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