KR930703611A - 양막파열을 감지하는 진단방법과 이방법을 이용한 테스트키트 - Google Patents

양막파열을 감지하는 진단방법과 이방법을 이용한 테스트키트

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Publication number
KR930703611A
KR930703611A KR1019930701750A KR930701750A KR930703611A KR 930703611 A KR930703611 A KR 930703611A KR 1019930701750 A KR1019930701750 A KR 1019930701750A KR 930701750 A KR930701750 A KR 930701750A KR 930703611 A KR930703611 A KR 930703611A
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KR
South Korea
Prior art keywords
igfbp
test kit
binding
diagnostic method
detecting
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KR1019930701750A
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English (en)
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KR0162504B1 (ko
Inventor
에바-마리자 루타넨
Original Assignee
일카 코우보넨
오와이 메딕스 바이오케미카 에이비
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Application filed by 일카 코우보넨, 오와이 메딕스 바이오케미카 에이비 filed Critical 일카 코우보넨
Publication of KR930703611A publication Critical patent/KR930703611A/ko
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function
    • Y10S436/814—Pregnancy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

본 발명은 양파파열을 감지할 수 있는 신속하고 신뢰성 있는 방법과 이 방법을 실행할 수 있는 테스트키트에 관계한다. 양막파열로 인한 IGFBP-1에 특이적 결합물질을 이용하여 감지하는 것으로 구성된다.

Description

양막파열을 감지하는 진단방법과 이방법을 이용한 테스트키트
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (14)

  1. 질분비물에 있는 특정 단백질을 정량함으로써 양막파열을 감지하는 진단방법에 있어서, 감지된 단백질은 인슐린 유사성장인자 결합단백질-1, (IGFBP-1)이고 질분비물내에 있는 IGFBP-1에 특이적인 적어도 하나 이상의 IGFBP-1 결합물질을 이용하여 양막파열시 IGFBP-1을 정량하는 것을 특징으로 하는 양막파열 감지 진단방법.
  2. 제 1 항에 있어서, 테스트에 사용되는 결합물질과 질분비물내에 있는 IGFBP-1의 농도비를 조정하여, 다른 지역에 있는 IGFBP-1 의 농도가 높은 경우 양성이 되는 것을 특징으로 하는 진단방법.
  3. 제 1 항 또는 2 항에 있어서, 사용된 특이 결합물질이 IGFBP-1 에 대한 항체인 것을 특징으로 하는 진단방법.
  4. 제 3 항에 있어서, 항체가 단클론 항체인 것을 특징으로 하는 진단방법.
  5. 전술한 어느 한 항에 있어서, IGFBP-1 결합물질과 라벨된 결합물질에 기초한 시약을 이용하여, 시그날을 감지하는 것을 특징으로 하는 진단방법.
  6. 제 2, 3, 4 또는 5 항에 있어서, 테스트를 실행하기 전에 시료내에 IGFBP-1 농도를 감소시키기 위해 질분비를 시료를 희석시키는 것을 특징으로 하는 진단방법.
  7. 제 3 항에 있어서, 희석은 1:10, 적절하게는 1:20 인 것을 특징으로 하는 진단방법.
  8. 제 2, 3, 4 또는 5 항에 있어서, 라벨된 시약을 사용하고, 측정된 IGFBP-1의 농도가 충분히 높은 경우에만 시그날이 나타나는 것을 특징으로 하는 진단방법.
  9. 양박 파열을 진단하기 위한 테스트 키트에 있어서, IGFBP-1에 특이적으로 결합하는 물질이 포함된 한가지 이상의 기질을 포함하고 질분비물에서 양막파열로 인한 IGFBP-1 의 존재를 감지하는 것으로 구성된 것을 특징으로 하는 테스트키트.
  10. 제 9 항에 있어서, 결합반응을 감지하는 라벨이 추가 포함되는 것을 특징으로 하는 테스트키트.
  11. 제 10 항에 있어서, 라벨에 의해 발생되는 시그날의 강도가 양수가 있는 IGFBP-1 이 고농도일 경우에만 양성 반응이 나타나도록 조정된 것을 특징으로 하는 테스트키트.
  12. 제 9,10 또는 11항에 있어서, 시약에는 IGFBP-1에 특이적인 결합물질로써, 특히 IGFBP-1 항체, 적절하게는 단클론 항체가 포함된 것을 특징으로 하는 테스트키트.
  13. 제 10 항 또는 11항에 있어서, 결합반응을 감지하는 라벨이 다른 IGFBP-1 결합물질과 복합된 시그날 발생물질인 것을 특징으로 하는 테스트키트.
  14. 제 9 항에 있어서, 특이 결합물질에 기초한 시약은 고형상 또는 불용성 임자에 결합된 결합물질 또는 결합물질 용액으로 구성된 것을 특징으로 하는 테스트키트.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930701750A 1990-12-31 1991-12-30 양막파열을 감지하는 진단방법과 이 방법을 이용한 테스트키트 KR0162504B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI906469A FI86777C (fi) 1990-12-31 1990-12-31 Foerfarande foer diagnosticering av bristningen av fosterhinnorna samt reagensfoerpackning foer anvaendning daervid
FI906469 1990-12-31
PCT/FI1991/000413 WO1992012426A1 (en) 1990-12-31 1991-12-30 Diagnostic method for detecting the rupture of fetal membranes and test kit employing the method

Publications (2)

Publication Number Publication Date
KR930703611A true KR930703611A (ko) 1993-11-30
KR0162504B1 KR0162504B1 (ko) 1999-05-01

Family

ID=8531673

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930701750A KR0162504B1 (ko) 1990-12-31 1991-12-30 양막파열을 감지하는 진단방법과 이 방법을 이용한 테스트키트

Country Status (12)

Country Link
US (1) US5554504A (ko)
EP (1) EP0565541B1 (ko)
JP (1) JP2592386B2 (ko)
KR (1) KR0162504B1 (ko)
AU (1) AU652598B2 (ko)
CA (1) CA2099374C (ko)
DE (1) DE69128428T2 (ko)
DK (1) DK0565541T3 (ko)
ES (1) ES2110487T3 (ko)
FI (1) FI86777C (ko)
NO (1) NO310992B1 (ko)
WO (1) WO1992012426A1 (ko)

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FI94181C (fi) * 1992-06-29 1995-07-25 Medix Biochemica Ab Oy Diagnostinen menetelmä synnytysajankohdan ennustamiseksi sekä siihen käytettävä reagenssipakkaus
JP3742649B2 (ja) * 1993-01-22 2006-02-08 アデザ・バイオメデイカル・コーポレイシヨン 切迫分娩についての危険にある女性における膜の破裂を決定するための検定方法
ATE226959T1 (de) * 1993-03-23 2002-11-15 Victor Voroteliak Methode zur detektion von rissen in amniomembranen bei schwangeren säugetieren
US5597700A (en) * 1994-04-28 1997-01-28 California Research, Llc Method for detecting free insulin-like growth-factor-binding protein 1 and a test device for detecting the ruptures of fetal membranes using the above method
US5712103A (en) * 1995-02-13 1998-01-27 Regents Of The University Of California Diagnostic assay for the prediction of preeclampsia
DE29514562U1 (de) * 1995-09-04 1995-11-16 Ruehl Britta Fruchtwasserindikator zur Selbstkontrolle über Fruchtwasserverlust
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DE19719001C2 (de) * 1997-05-06 2001-05-10 Schuetzdeller Angelika Verfahren zum immunologisch-funktionalen Nachweis biologisch aktiver Insulin-Like Growth Factor Binding Proteine oder löslicher Insulin-Like Growth Factor - Rezeptoren im Immunoassay
FI981049A (fi) * 1998-05-12 1999-11-13 Medix Biochemica Ab Oy Menetelmä ja koeväline kohdunkaulan kypsyyden arvioimiseksi IGFBP-1:n fosforyloiduilla isomuodoilla
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US20050131287A1 (en) * 2003-12-16 2005-06-16 Kimberly-Clark Worldwide, Inc. Detection of premature rupture of the amniotic membrane
JP2008505695A (ja) 2004-07-07 2008-02-28 オブステケア インコーポレイテッド 出産過程の測定方法
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JP5374682B2 (ja) * 2008-03-24 2013-12-25 静岡県公立大学法人 ストレス状態の評価方法及びストレス状態の評価試薬キット
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US8765487B2 (en) 2010-09-01 2014-07-01 Clinical Innovations Detection of amniotic fluid in vaginal secretions of pregnant women due to premature rupture of fetal membranes
US10338065B2 (en) * 2010-09-01 2019-07-02 Clinical Innovations, Llc Detection of amniotic fluid in vaginal secretions of pregnant women due to premature rupture of fetal membranes
DE102010040687A1 (de) * 2010-09-14 2012-03-15 Hamilton Bonaduz Ag Verfahren zum Herstellen von Wirkstoff-Beads
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CA1337394C (en) * 1987-11-17 1995-10-24 Nelson N. H. Teng Vaginal sample test and reagents
US5096830A (en) * 1987-11-17 1992-03-17 Adeza Biomedical Corporation Preterm labor and membrane rupture test
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Also Published As

Publication number Publication date
CA2099374C (en) 2003-09-16
NO932363L (no) 1993-08-23
ES2110487T3 (es) 1998-02-16
NO932363D0 (no) 1993-06-28
US5554504A (en) 1996-09-10
KR0162504B1 (ko) 1999-05-01
WO1992012426A1 (en) 1992-07-23
EP0565541A1 (en) 1993-10-20
DE69128428D1 (de) 1998-01-22
AU9088091A (en) 1992-08-17
DE69128428T2 (de) 1998-07-09
EP0565541B1 (en) 1997-12-10
JPH06504841A (ja) 1994-06-02
FI86777B (fi) 1992-06-30
NO310992B1 (no) 2001-09-24
CA2099374A1 (en) 1992-07-01
FI906469A (fi) 1992-06-30
DK0565541T3 (da) 1998-04-14
FI86777C (fi) 1992-10-12
JP2592386B2 (ja) 1997-03-19
AU652598B2 (en) 1994-09-01
FI906469A0 (fi) 1990-12-31

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