NO310992B1 - Diagnostisk metode for detektering av ruptur av fotale membraner og testkit som anvender denne - Google Patents
Diagnostisk metode for detektering av ruptur av fotale membraner og testkit som anvender denne Download PDFInfo
- Publication number
- NO310992B1 NO310992B1 NO19932363A NO932363A NO310992B1 NO 310992 B1 NO310992 B1 NO 310992B1 NO 19932363 A NO19932363 A NO 19932363A NO 932363 A NO932363 A NO 932363A NO 310992 B1 NO310992 B1 NO 310992B1
- Authority
- NO
- Norway
- Prior art keywords
- igfbp
- sample
- test
- concentration
- antibody
- Prior art date
Links
- 238000002405 diagnostic procedure Methods 0.000 title claims description 7
- 239000012528 membrane Substances 0.000 title description 42
- 238000003149 assay kit Methods 0.000 title description 4
- 102000004375 Insulin-like growth factor-binding protein 1 Human genes 0.000 claims description 106
- 108090000957 Insulin-like growth factor-binding protein 1 Proteins 0.000 claims description 106
- 238000012360 testing method Methods 0.000 claims description 71
- 210000004381 amniotic fluid Anatomy 0.000 claims description 42
- 150000001875 compounds Chemical class 0.000 claims description 42
- 238000000034 method Methods 0.000 claims description 29
- 239000000243 solution Substances 0.000 claims description 23
- 238000009739 binding Methods 0.000 claims description 20
- 239000003550 marker Substances 0.000 claims description 20
- 230000009870 specific binding Effects 0.000 claims description 18
- 210000002219 extraembryonic membrane Anatomy 0.000 claims description 17
- 102000004169 proteins and genes Human genes 0.000 claims description 16
- 108090000623 proteins and genes Proteins 0.000 claims description 16
- 230000027455 binding Effects 0.000 claims description 14
- 239000003153 chemical reaction reagent Substances 0.000 claims description 12
- 210000003756 cervix mucus Anatomy 0.000 claims description 10
- 238000010790 dilution Methods 0.000 claims description 9
- 239000012895 dilution Substances 0.000 claims description 9
- 239000002245 particle Substances 0.000 claims description 8
- 210000001215 vagina Anatomy 0.000 claims description 8
- 230000035945 sensitivity Effects 0.000 claims description 2
- 239000007790 solid phase Substances 0.000 claims description 2
- 239000000523 sample Substances 0.000 description 45
- 210000004379 membrane Anatomy 0.000 description 40
- 108090000790 Enzymes Proteins 0.000 description 16
- 102000004190 Enzymes Human genes 0.000 description 16
- 210000002966 serum Anatomy 0.000 description 13
- 239000000427 antigen Substances 0.000 description 12
- 102000036639 antigens Human genes 0.000 description 12
- 108091007433 antigens Proteins 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 12
- 239000008280 blood Substances 0.000 description 12
- 101001081567 Homo sapiens Insulin-like growth factor-binding protein 1 Proteins 0.000 description 8
- 102100027636 Insulin-like growth factor-binding protein 1 Human genes 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 8
- 230000008774 maternal effect Effects 0.000 description 8
- 239000000758 substrate Substances 0.000 description 8
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 7
- 108010057464 Prolactin Proteins 0.000 description 7
- 102000003946 Prolactin Human genes 0.000 description 7
- 239000004816 latex Substances 0.000 description 7
- 229920000126 latex Polymers 0.000 description 7
- 229940097325 prolactin Drugs 0.000 description 7
- 102100023635 Alpha-fetoprotein Human genes 0.000 description 6
- 102000013275 Somatomedins Human genes 0.000 description 6
- 108010026331 alpha-Fetoproteins Proteins 0.000 description 6
- 239000011324 bead Substances 0.000 description 6
- 239000000975 dye Substances 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 238000005259 measurement Methods 0.000 description 6
- 230000028327 secretion Effects 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 5
- 239000000872 buffer Substances 0.000 description 5
- 102000028416 insulin-like growth factor binding Human genes 0.000 description 5
- 108091022911 insulin-like growth factor binding Proteins 0.000 description 5
- 239000004033 plastic Substances 0.000 description 5
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 4
- 238000007865 diluting Methods 0.000 description 4
- 230000002028 premature Effects 0.000 description 4
- 230000004520 agglutination Effects 0.000 description 3
- 239000012131 assay buffer Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000001900 immune effect Effects 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 235000011330 Armoracia rusticana Nutrition 0.000 description 2
- 240000003291 Armoracia rusticana Species 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 description 2
- 208000003107 Premature Rupture Fetal Membranes Diseases 0.000 description 2
- 239000002250 absorbent Substances 0.000 description 2
- 230000002745 absorbent Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229940098773 bovine serum albumin Drugs 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000001376 precipitating effect Effects 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 238000003127 radioimmunoassay Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- ZPLCXHWYPWVJDL-UHFFFAOYSA-N 4-[(4-hydroxyphenyl)methyl]-1,3-oxazolidin-2-one Chemical compound C1=CC(O)=CC=C1CC1NC(=O)OC1 ZPLCXHWYPWVJDL-UHFFFAOYSA-N 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 description 1
- 206010056254 Intrauterine infection Diseases 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 208000001300 Perinatal Death Diseases 0.000 description 1
- 102000008217 Pregnancy Proteins Human genes 0.000 description 1
- 108010035746 Pregnancy Proteins Proteins 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 208000034713 Spontaneous Rupture Diseases 0.000 description 1
- 206010046914 Vaginal infection Diseases 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- DPKHZNPWBDQZCN-UHFFFAOYSA-N acridine orange free base Chemical compound C1=CC(N(C)C)=CC2=NC3=CC(N(C)C)=CC=C3C=C21 DPKHZNPWBDQZCN-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- OHDRQQURAXLVGJ-HLVWOLMTSA-N azane;(2e)-3-ethyl-2-[(e)-(3-ethyl-6-sulfo-1,3-benzothiazol-2-ylidene)hydrazinylidene]-1,3-benzothiazole-6-sulfonic acid Chemical compound [NH4+].[NH4+].S/1C2=CC(S([O-])(=O)=O)=CC=C2N(CC)C\1=N/N=C1/SC2=CC(S([O-])(=O)=O)=CC=C2N1CC OHDRQQURAXLVGJ-HLVWOLMTSA-N 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- DZBUGLKDJFMEHC-UHFFFAOYSA-N benzoquinolinylidene Natural products C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 description 1
- 108091008324 binding proteins Proteins 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000037029 cross reaction Effects 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 210000003785 decidua Anatomy 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000012470 diluted sample Substances 0.000 description 1
- 239000013024 dilution buffer Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000000986 disperse dye Substances 0.000 description 1
- 210000004696 endometrium Anatomy 0.000 description 1
- 210000004700 fetal blood Anatomy 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- XJCPMUIIBDVFDM-UHFFFAOYSA-M nile blue A Chemical compound [Cl-].C1=CC=C2C3=NC4=CC=C(N(CC)CC)C=C4[O+]=C3C=C(N)C2=C1 XJCPMUIIBDVFDM-UHFFFAOYSA-M 0.000 description 1
- IHRSXGONVFFQQF-SDXDJHTJSA-N nitrazine Chemical compound OS(=O)(=O)C1=CC2=CC(S(O)(=O)=O)=CC=C2C(=O)\C1=N/NC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O IHRSXGONVFFQQF-SDXDJHTJSA-N 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 230000009984 peri-natal effect Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 230000003169 placental effect Effects 0.000 description 1
- 210000005152 placental membrane Anatomy 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 230000001573 trophoblastic effect Effects 0.000 description 1
- 239000013026 undiluted sample Substances 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/36—Gynecology or obstetrics
- G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
- Y10S436/814—Pregnancy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI906469A FI86777C (fi) | 1990-12-31 | 1990-12-31 | Foerfarande foer diagnosticering av bristningen av fosterhinnorna samt reagensfoerpackning foer anvaendning daervid |
| PCT/FI1991/000413 WO1992012426A1 (en) | 1990-12-31 | 1991-12-30 | Diagnostic method for detecting the rupture of fetal membranes and test kit employing the method |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO932363D0 NO932363D0 (no) | 1993-06-28 |
| NO932363L NO932363L (no) | 1993-08-23 |
| NO310992B1 true NO310992B1 (no) | 2001-09-24 |
Family
ID=8531673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19932363A NO310992B1 (no) | 1990-12-31 | 1993-06-28 | Diagnostisk metode for detektering av ruptur av fotale membraner og testkit som anvender denne |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5554504A (ko) |
| EP (1) | EP0565541B1 (ko) |
| JP (1) | JP2592386B2 (ko) |
| KR (1) | KR0162504B1 (ko) |
| AU (1) | AU652598B2 (ko) |
| CA (1) | CA2099374C (ko) |
| DE (1) | DE69128428T2 (ko) |
| DK (1) | DK0565541T3 (ko) |
| ES (1) | ES2110487T3 (ko) |
| FI (1) | FI86777C (ko) |
| NO (1) | NO310992B1 (ko) |
| WO (1) | WO1992012426A1 (ko) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI94181C (fi) * | 1992-06-29 | 1995-07-25 | Medix Biochemica Ab Oy | Diagnostinen menetelmä synnytysajankohdan ennustamiseksi sekä siihen käytettävä reagenssipakkaus |
| CA2152676A1 (en) * | 1993-01-22 | 1994-08-04 | John C. Leavitt | Assay method to rule out rupture of membranes in women at risk for imminent delivery |
| WO1994021687A1 (en) * | 1993-03-23 | 1994-09-29 | Victor Voroteliak | A method of detecting rupture of the amniotic membranes in pregant mammals |
| US5597700A (en) * | 1994-04-28 | 1997-01-28 | California Research, Llc | Method for detecting free insulin-like growth-factor-binding protein 1 and a test device for detecting the ruptures of fetal membranes using the above method |
| US5712103A (en) * | 1995-02-13 | 1998-01-27 | Regents Of The University Of California | Diagnostic assay for the prediction of preeclampsia |
| DE29514562U1 (de) * | 1995-09-04 | 1995-11-16 | Rühl, Britta, 23623 Ahrensbök | Fruchtwasserindikator zur Selbstkontrolle über Fruchtwasserverlust |
| US5747273A (en) * | 1996-05-07 | 1998-05-05 | Diagnostic Systems Laboratories, Inc. | Immunoassay of total insulin-like growth factor binding protein-1 |
| DE19719001C2 (de) * | 1997-05-06 | 2001-05-10 | Schuetzdeller Angelika | Verfahren zum immunologisch-funktionalen Nachweis biologisch aktiver Insulin-Like Growth Factor Binding Proteine oder löslicher Insulin-Like Growth Factor - Rezeptoren im Immunoassay |
| FI981049A (fi) * | 1998-05-12 | 1999-11-13 | Medix Biochemica Ab Oy | Menetelmä ja koeväline kohdunkaulan kypsyyden arvioimiseksi IGFBP-1:n fosforyloiduilla isomuodoilla |
| US6126597A (en) * | 1998-07-22 | 2000-10-03 | Smith; Ramada S. | System for identifying premature rupture of membrane during pregnancy |
| US7790690B2 (en) | 2000-10-11 | 2010-09-07 | U.S. Department Of Veterans Affairs | Glucose sensitive regulator of insulin transcription |
| SI1535068T1 (sl) | 2002-08-13 | 2010-07-30 | N Dia Inc | Naprave in postopki za odkrivanje amnijske tekočine v vaginalnih izločkih |
| US20050131287A1 (en) * | 2003-12-16 | 2005-06-16 | Kimberly-Clark Worldwide, Inc. | Detection of premature rupture of the amniotic membrane |
| CN101010032A (zh) | 2004-07-07 | 2007-08-01 | 奥普斯特护理公司 | 监测分娩过程的方法 |
| US20060024722A1 (en) | 2004-07-30 | 2006-02-02 | Mark Fischer-Colbrie | Samples for detection of oncofetal fibronectin and uses thereof |
| JP5374682B2 (ja) * | 2008-03-24 | 2013-12-25 | 静岡県公立大学法人 | ストレス状態の評価方法及びストレス状態の評価試薬キット |
| FR2960974B1 (fr) | 2010-06-03 | 2016-12-30 | Biosynex | Procede de detection de rupture de membranes |
| US8765487B2 (en) | 2010-09-01 | 2014-07-01 | Clinical Innovations | Detection of amniotic fluid in vaginal secretions of pregnant women due to premature rupture of fetal membranes |
| US11555816B2 (en) | 2010-09-01 | 2023-01-17 | Clinical Innovations, Llc | Detection of amniotic fluid in vaginal secretions of pregnant women due to premature rupture of fetal membranes |
| US10338065B2 (en) * | 2010-09-01 | 2019-07-02 | Clinical Innovations, Llc | Detection of amniotic fluid in vaginal secretions of pregnant women due to premature rupture of fetal membranes |
| DE102010040687A1 (de) * | 2010-09-14 | 2012-03-15 | Hamilton Bonaduz Ag | Verfahren zum Herstellen von Wirkstoff-Beads |
| CN103175968A (zh) * | 2011-12-20 | 2013-06-26 | 安徽深蓝医疗科技有限公司 | 一种胎膜早破检测试剂盒及制备方法 |
| ES2761575T3 (es) | 2013-01-02 | 2020-05-20 | Qiagen Sciences Llc | Métodos para predecir el tiempo hasta el parto en una mujer embarazada |
| US10656164B2 (en) | 2016-12-22 | 2020-05-19 | Qiagen Sciences, Llc | Screening asymptomatic pregnant woman for preterm birth |
| US10935555B2 (en) | 2016-12-22 | 2021-03-02 | Qiagen Sciences, Llc | Determining candidate for induction of labor |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5096830A (en) * | 1987-11-17 | 1992-03-17 | Adeza Biomedical Corporation | Preterm labor and membrane rupture test |
| CA1337394C (en) * | 1987-11-17 | 1995-10-24 | Nelson N. H. Teng | Vaginal sample test and reagents |
| US4952517A (en) * | 1988-02-08 | 1990-08-28 | Hygeia Sciences, Inc. | Positive step immunoassay |
| US5258287A (en) * | 1988-03-22 | 1993-11-02 | Genentech, Inc. | DNA encoding and methods of production of insulin-like growth factor binding protein BP53 |
| US5037735A (en) * | 1988-06-24 | 1991-08-06 | Microgenics Corporation | Visual discrimination qualitative enzyme complementation assay |
| CA1341598C (en) * | 1988-07-15 | 2009-09-29 | Central Sydney Area Health Service | Acid-labile sub-unit (als) of insulin-like growth factor binding proteincomplex |
| US5252459A (en) * | 1988-09-23 | 1993-10-12 | Abbott Laboratories | Indicator reagents, diagnostic assays and test kits employing organic polymer latex particles |
-
1990
- 1990-12-31 FI FI906469A patent/FI86777C/fi active IP Right Grant
-
1991
- 1991-12-30 JP JP4501180A patent/JP2592386B2/ja not_active Expired - Fee Related
- 1991-12-30 DK DK92901167.4T patent/DK0565541T3/da active
- 1991-12-30 KR KR1019930701750A patent/KR0162504B1/ko not_active IP Right Cessation
- 1991-12-30 AU AU90880/91A patent/AU652598B2/en not_active Expired
- 1991-12-30 DE DE69128428T patent/DE69128428T2/de not_active Ceased
- 1991-12-30 WO PCT/FI1991/000413 patent/WO1992012426A1/en active IP Right Grant
- 1991-12-30 ES ES92901167T patent/ES2110487T3/es not_active Expired - Lifetime
- 1991-12-30 US US08/081,286 patent/US5554504A/en not_active Expired - Lifetime
- 1991-12-30 EP EP92901167A patent/EP0565541B1/en not_active Expired - Lifetime
- 1991-12-30 CA CA002099374A patent/CA2099374C/en not_active Expired - Lifetime
-
1993
- 1993-06-28 NO NO19932363A patent/NO310992B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69128428T2 (de) | 1998-07-09 |
| EP0565541A1 (en) | 1993-10-20 |
| NO932363L (no) | 1993-08-23 |
| CA2099374A1 (en) | 1992-07-01 |
| AU9088091A (en) | 1992-08-17 |
| FI86777B (fi) | 1992-06-30 |
| DK0565541T3 (da) | 1998-04-14 |
| US5554504A (en) | 1996-09-10 |
| EP0565541B1 (en) | 1997-12-10 |
| CA2099374C (en) | 2003-09-16 |
| DE69128428D1 (de) | 1998-01-22 |
| FI906469A (fi) | 1992-06-30 |
| FI906469A0 (fi) | 1990-12-31 |
| AU652598B2 (en) | 1994-09-01 |
| NO932363D0 (no) | 1993-06-28 |
| FI86777C (fi) | 1992-10-12 |
| ES2110487T3 (es) | 1998-02-16 |
| KR0162504B1 (ko) | 1999-05-01 |
| KR930703611A (ko) | 1993-11-30 |
| JPH06504841A (ja) | 1994-06-02 |
| JP2592386B2 (ja) | 1997-03-19 |
| WO1992012426A1 (en) | 1992-07-23 |
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