KR930004673B1 - 치환된 이미다졸의 제조방법 - Google Patents

치환된 이미다졸의 제조방법 Download PDF

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Publication number
KR930004673B1
KR930004673B1 KR1019850008704A KR850008704A KR930004673B1 KR 930004673 B1 KR930004673 B1 KR 930004673B1 KR 1019850008704 A KR1019850008704 A KR 1019850008704A KR 850008704 A KR850008704 A KR 850008704A KR 930004673 B1 KR930004673 B1 KR 930004673B1
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KR
South Korea
Prior art keywords
compound
och
dihydro
formula
inden
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019850008704A
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English (en)
Korean (ko)
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KR860004028A (ko
Inventor
요하네스 카르야라이넨 아르토
에이나리 피르타넨 라이모
레에나 카르야라이넨 아르야
오이바 안테로 쿠르케라 카우코
Original Assignee
파르모스-이티마오이
하이키 오얀페래, 하칸 코트카
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Publication of KR860004028A publication Critical patent/KR860004028A/ko
Application granted granted Critical
Publication of KR930004673B1 publication Critical patent/KR930004673B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Lubricants (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Epoxy Resins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Dental Preparations (AREA)
  • Golf Clubs (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
KR1019850008704A 1984-11-23 1985-11-21 치환된 이미다졸의 제조방법 Expired - Fee Related KR930004673B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB08429578A GB2167408B (en) 1984-11-23 1984-11-23 Substituted imidazole derivatives and their preparation and use
GB8429578 1984-11-23

Publications (2)

Publication Number Publication Date
KR860004028A KR860004028A (ko) 1986-06-16
KR930004673B1 true KR930004673B1 (ko) 1993-06-03

Family

ID=10570140

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850008704A Expired - Fee Related KR930004673B1 (ko) 1984-11-23 1985-11-21 치환된 이미다졸의 제조방법

Country Status (26)

Country Link
US (1) US4689339A (enExample)
EP (2) EP0310745B1 (enExample)
JP (1) JPH064597B2 (enExample)
KR (1) KR930004673B1 (enExample)
AT (2) ATE85050T1 (enExample)
AU (2) AU586839B2 (enExample)
BG (1) BG60762B2 (enExample)
CA (1) CA1268770C (enExample)
DD (1) DD258230A1 (enExample)
DE (2) DE3587045T2 (enExample)
DK (2) DK164903C (enExample)
ES (2) ES8704462A1 (enExample)
FI (1) FI80264C (enExample)
GB (1) GB2167408B (enExample)
GR (1) GR852817B (enExample)
HK (1) HK3592A (enExample)
HU (1) HU195189B (enExample)
IE (1) IE58165B1 (enExample)
IL (1) IL77111A (enExample)
NO (1) NO166585C (enExample)
NZ (1) NZ214258A (enExample)
PH (1) PH22016A (enExample)
PT (1) PT81542B (enExample)
SG (1) SG106891G (enExample)
SU (1) SU1424736A3 (enExample)
ZA (1) ZA858942B (enExample)

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US4891431A (en) * 1986-01-28 1990-01-02 Mitsui Petrochemical Industries, Ltd. Process for preparing 2-unsubstituted imidazoles
FI862039A0 (fi) * 1986-05-15 1986-05-15 Farmos Oy Nytt foerfarande foer framstaellning av 4(5)-substituerade imidazolderivat.
FI81092C (fi) * 1986-05-15 1990-09-10 Farmos Oy Foerfarande foer framstaellning av terapeutiskt aktiva 4(5)-(2,3-dihydro-1h-inden-2-yl)-imidazolderivat.
JP2576493B2 (ja) * 1987-03-20 1997-01-29 アイシン精機株式会社 原稿読取り装置に用いられる原稿トレ−
FR2621327B1 (fr) * 1987-10-06 1990-01-05 Commissariat Energie Atomique Procede de production et d'extraction de polysaccharides a partir d'une culture de porphyridium cruentum et dispositif pour la mise en oeuvre du procede
GB2225782A (en) * 1988-12-09 1990-06-13 Farmos Group Limited Imidazole derivatives useful for treatment of diabetes
GB8903437D0 (en) * 1989-02-15 1989-04-05 Erba Carlo Spa Imidazolyl derivatives of 3,4-dihydro-2h-1-benzothiopyran
CA1321751C (en) * 1989-02-21 1993-08-31 Eugene C. Crichlow Mechanism mediating ruminal stasis in ruminal lactic acidosis
DK344489D0 (da) * 1989-07-12 1989-07-12 Novo Nordisk As Substituerede 2-imidazoliner og fremstilling og anvendelse deraf
GB2244431A (en) * 1990-05-31 1991-12-04 Farmos Oy Treatment of age related memory impairment and other cognitive disorders
GB2256135B (en) 1991-05-31 1995-01-18 Orion Yhtymae Oy Transdermal administration of 4-substituted imidazoles
US5541211A (en) * 1991-06-18 1996-07-30 Orion-Yhtyma Oy Administration of atipamezole to elicit a yohimbine-like alpha-adrenoreceptor antagonistic noradrenergic transmission
CZ287406B6 (cs) * 1991-11-05 2000-11-15 Smithkline Beecham Corporation Indanové a indenové deriváty, způsob jejich výroby a farmaceutické prostředky s jejich obsahem
GB9127050D0 (en) * 1991-12-20 1992-02-19 Orion Yhtymae Oy Substituted imidazole derivatives and their preparation and use
GB9127430D0 (en) * 1991-12-27 1992-02-19 Scras Benzofuranylimidazole derivatives
GB9312669D0 (en) 1993-06-18 1993-08-04 Orion Yhtymae Oy New opticla isomers
GB9425211D0 (en) * 1994-12-14 1995-02-15 Ucb Sa Substituted 1H-imidazoles
FR2733983B1 (fr) * 1995-05-10 1997-08-01 Pf Medicament Procede de preparation d'un derive d'acide benzofurane carboxylque optiquement pur et son utilisation pour preparer l'efaroxan
GB9520150D0 (en) * 1995-10-03 1995-12-06 Orion Yhtymae Oy New imidazole derivatives
FR2754709B1 (fr) 1996-10-23 1999-03-05 Sanofi Sa Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition
EP0986530A1 (en) * 1997-06-05 2000-03-22 Venantius Limited Indane compounds and their pharmaceutical use
AU3378399A (en) * 1998-04-02 1999-10-25 Ortho-Mcneil Pharmaceutical, Inc. 4-thionaphthyl-1h-imidazoles with alpha-2-adrenergic activity
FR2784989B1 (fr) * 1998-09-10 2002-09-27 Fabre Pierre Sante Derive d'ester d'acide 2-ethyl-2,3-dihydrobenzofurane- carboxylique, procede de preparation et utilisation pour la preparation de derives de l'efaroxan
WO2000042023A1 (en) * 1999-01-18 2000-07-20 Novo Nordisk A/S Substituted imidazoles, their preparation and use
US6388090B2 (en) * 2000-01-14 2002-05-14 Orion Corporation Imidazole derivatives
US6593324B2 (en) 2000-03-01 2003-07-15 Orion Corporation Dervatives of quinoline as alpha-2 antagonists
PT1280779E (pt) * 2000-05-08 2005-11-30 Orion Corp Novos indanilimidazois policiclicos com actividade adrenergica alfa2
US6503894B1 (en) 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
US6543389B2 (en) 2001-06-26 2003-04-08 Pfizer Inc. Insecticidal pet collar
EA008537B1 (ru) 2002-04-03 2007-06-29 Орион Корпорейшн Полициклические соединения как эффективные антагонисты альфа2-адренорецептора
US8188126B2 (en) 2002-05-16 2012-05-29 Pierre Fabre Medicament Imidazolic compounds and use thereof as alpha-2 adrenergic receptors
FI116292B (fi) * 2003-01-08 2005-10-31 Juvantia Pharma Ltd Oy Menetelmä substituoitujen imidatsolijohdannaisten valmistamiseksi ja menetelmässä käytettäviä välituotteita
WO2005041950A1 (en) * 2003-11-04 2005-05-12 Akzo Nobel N.V. Ectoparasiticidal formulations of spinosyns and azole pesticides
FI20050657A0 (fi) * 2005-06-17 2005-06-17 Orion Corp Atipametsolin kiteytysmenetelmä
CN101287470B (zh) 2005-10-12 2012-10-17 优尼麦德药物股份有限公司 改良的睾酮凝胶及使用方法
US7592461B2 (en) * 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
ATE459251T1 (de) * 2006-08-08 2010-03-15 Intervet Int Bv Zusammensetzung für verstärkte antiparasitische wirksamkeit
TWI457122B (zh) 2007-07-20 2014-10-21 Orion Corp 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3-二氫苯並[1,4]戴奧辛-2-基甲基衍生物
CL2008003553A1 (es) * 2007-12-05 2009-11-27 Grindeks Jsc Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso
JP6446054B2 (ja) 2013-11-05 2018-12-26 スリーエム・イノベイティブ・プロパティーズ・カンパニー ゴマ油ベースの注射製剤
AR104882A1 (es) 2015-06-05 2017-08-23 Orion Corp DERIVADOS DE 2-(1-HETEROARILPIPERAZIN-4-IL)METIL-1,4-BENZODIOXANO COMO ANTAGONISTAS DE a2C
EP3370718B1 (en) * 2015-11-05 2021-01-27 University Of Louisville Research Foundation, Inc. Local and regional anesthesia and analgesia
CN109415355A (zh) 2016-06-29 2019-03-01 奥赖恩公司 苯并二噁烷衍生物及其药物用途
AU2019411230B2 (en) 2018-12-21 2025-04-17 Société des Produits Nestlé S.A. Nutritional composition for inducing a feeling of satiety, a better sleep and/or limiting nocturnal awaking in infants or young children
CN111978254A (zh) * 2019-05-22 2020-11-24 南京康德祥医药科技有限公司 一种阿替美唑盐酸盐的制备工艺
CN111925330A (zh) * 2020-09-07 2020-11-13 上海阿达玛斯试剂有限公司 一种阿替美唑的制备方法
LU103072B1 (en) 2023-02-15 2024-08-19 Univ Ljubljani N,N-DIALKYL-4-(2-ETHYLINDAN-2-YL)-lH-IMIDAZOLE-l-CARBOXAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISEASES
EP4658639A1 (en) 2023-02-01 2025-12-10 Univerza V Ljubljani N,n-dialkyl-4-(2-ethylindan-2-yl)-1h-imidazole-1-carboxamides and related compounds for treatment of neurodegenerative diseases
CN117186010A (zh) * 2023-08-15 2023-12-08 厦门欧瑞捷生物科技有限公司 一种盐酸阿替美唑的合成方法

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DE2933962A1 (de) * 1979-08-22 1981-03-26 Hoechst Ag, 65929 Frankfurt Verfahren zur herstellung von 4,5-dichlor-imidazolen.
IL62122A0 (en) * 1980-03-04 1981-03-31 Erba Farmitalia N-imidazolyl derivatives of 1-chroman,their preparation and pharmaceutical compositions containing them
US4302469A (en) * 1980-09-10 1981-11-24 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antidepressants
ZW13782A1 (en) * 1981-07-28 1982-10-06 Reckitt & Colmann Prod Ltd Imidazoline derivatives
ES523609A0 (es) * 1982-07-05 1985-03-01 Erba Farmitalia Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos.
FR2539415B1 (fr) * 1983-01-14 1985-09-13 Adir Derives de la d-2 imidazoline, leur preparation et leur application en therapeutique
FR2542738A1 (fr) * 1983-03-18 1984-09-21 Synthelabo Indanyl-2 d2-imidazoline, procede pour la preparer, et compositions pharmaceutiques qui la contiennent

Also Published As

Publication number Publication date
HUT38913A (en) 1986-07-28
AU586839B2 (en) 1989-07-27
ES8704462A1 (es) 1987-04-01
FI854335A7 (fi) 1986-05-24
DK58292A (da) 1992-05-04
FI80264C (fi) 1990-05-10
ES557268A0 (es) 1987-12-16
BG60762B2 (bg) 1996-02-29
PT81542B (pt) 1988-03-03
US4689339A (en) 1987-08-25
JPH064597B2 (ja) 1994-01-19
HU195189B (en) 1988-04-28
IL77111A0 (en) 1986-04-29
JPS61143366A (ja) 1986-07-01
NO166585C (no) 1991-08-21
NZ214258A (en) 1989-02-24
FI80264B (fi) 1990-01-31
ES8801248A1 (es) 1987-12-16
GB2167408A (en) 1986-05-29
IE852929L (en) 1986-05-23
ES549178A0 (es) 1987-04-01
AU5008385A (en) 1986-05-29
CA1266669A1 (en) 1990-03-13
NO854671L (no) 1986-05-26
PH22016A (en) 1988-05-13
SU1424736A3 (ru) 1988-09-15
CA1268770C (en) 1990-05-08
DK540485D0 (da) 1985-11-22
DK164903B (da) 1992-09-07
EP0183492A1 (en) 1986-06-04
DK164903C (da) 1993-01-25
FI854335A0 (fi) 1985-11-05
ATE85050T1 (de) 1993-02-15
DE3587045T2 (de) 1993-06-03
EP0310745A3 (en) 1989-10-11
GB8429578D0 (en) 1985-01-03
GR852817B (enExample) 1986-03-21
DK540485A (da) 1986-05-24
IE58165B1 (en) 1993-07-28
NO166585B (no) 1991-05-06
DE3574252D1 (en) 1989-12-21
HK3592A (en) 1992-01-17
EP0183492B1 (en) 1989-11-15
ATE47997T1 (de) 1989-12-15
EP0310745A2 (en) 1989-04-12
DE3587045D1 (de) 1993-03-11
DD258230A1 (de) 1988-07-13
ZA858942B (en) 1986-08-27
AU3332989A (en) 1989-08-10
SG106891G (en) 1992-02-14
GB2167408B (en) 1988-05-25
KR860004028A (ko) 1986-06-16
PT81542A (en) 1985-12-01
EP0310745B1 (en) 1993-01-27
IL77111A (en) 1989-09-28
DK58292D0 (da) 1992-05-04

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