KR920701141A - 간 장해 억제제 - Google Patents

간 장해 억제제

Info

Publication number
KR920701141A
KR920701141A KR1019910701526A KR910701526A KR920701141A KR 920701141 A KR920701141 A KR 920701141A KR 1019910701526 A KR1019910701526 A KR 1019910701526A KR 910701526 A KR910701526 A KR 910701526A KR 920701141 A KR920701141 A KR 920701141A
Authority
KR
South Korea
Prior art keywords
glutathione
compound
disorder inhibitor
methyl
inhibitor according
Prior art date
Application number
KR1019910701526A
Other languages
English (en)
Other versions
KR970008108B1 (ko
Inventor
신지 오오모리
가즈미 오가따
다까히로 사까우에
Original Assignee
요시다 쇼우지
센쥬 세이야꾸 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 요시다 쇼우지, 센쥬 세이야꾸 가부시끼가이샤 filed Critical 요시다 쇼우지
Publication of KR920701141A publication Critical patent/KR920701141A/ko
Application granted granted Critical
Publication of KR970008108B1 publication Critical patent/KR970008108B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fats And Perfumes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

간 장해 억제제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (13)

  1. 하기식
    〔식중, R1,R3는 동일하거나 상이하며, 수소 또는 치환되어 있어도 좋은 저급 알킬기이고, R4는 수산기, 치환되어 있어도 좋은 저급 알콕시기 또는 치환되어 있어도 좋은 아미노기를 나타낸다. n은 0 또는 1을 나타내고, n=1일때 R2는 수소, 치환되어 있어도 좋은 저급 알킬기 또는 치환되어 있어도 좋은 페닐기를 나타낸다.〕으로 표시되는 화합물 또는 그의 염을 유효성분으로 함유하여 이루어진 간 장해 억제제.
  2. 제1항에 있어서, 화합물이 S-(2-카르복시에틸) 글루타티온인 간 장해 억제제.
  3. 제1항에 있어서, 화합물이 S-(2-메틸-2-카르복시에톡시에틸)) 글루타티온인 간 장해 억제제.
  4. 제1항에 있어서, 화합물이 S-〔(2-메틸-2-카르보에톡시히드록시)에틸〕 글루타티온인 간 장해 억제제.
  5. 제1항에 있어서, 화합물이 S-(2-메틸-2-카르바모일에틸)) 글루타티온인 간 장해 억제제.
  6. 제1항에 있어서, 화합물이 S-(2-카르보에톡시에틸) 글루타티온인 간 장해 억제제.
  7. 제1항에 있어서, 화합물이 S-(2-메틸-2-카르보벤즈옥시에틸) 글루타티온인 간 장해 억제제.
  8. 제1항에 있어서, 화합물이 S-(2-메틸-2-카르보이소부톡시에틸) 글루타티온인 간 장해 억제제.
  9. 제1항에 있어서, 화합물이 S-(2-메틸-2-카르보에톡시에틸) 글루타티온인 이소프로필 에스테르인 간 장해 억제제.
  10. 제1항에 있어서, 화합물이 S-(2-메틸-2-카르보이소부톡시에틸) 글루타티온인 이소프로필 에스테르인 간 장해 억제제.
  11. 제1항에 있어서, 화합물이 S-(1-메틸-2-카르보이소프로폭시에틸) 글루타티온인 간 장해 억제제.
  12. 제1항에 있어서, 화합물이 S-(1-메틸-2-카르보에톡시에틸) 글루타티온인 간 장해 억제제.
  13. 제1항에 있어서, 화합물이 S-(카르보이소프로폭시메틸) 글루타티온인 간 장해 억제제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910701526A 1990-04-26 1991-04-25 간 장해 억제제 KR970008108B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP90-112260 1990-04-26
JP11226090 1990-04-26
PCT/JP1991/000569 WO1991016065A1 (en) 1990-04-26 1991-04-25 Hepatic disorder inhibitor

Publications (2)

Publication Number Publication Date
KR920701141A true KR920701141A (ko) 1992-08-11
KR970008108B1 KR970008108B1 (ko) 1997-05-21

Family

ID=14582257

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1019910701527A KR970002904B1 (ko) 1990-04-26 1991-04-25 S-저급지방산 글루타티온 유도체
KR1019910701526A KR970008108B1 (ko) 1990-04-26 1991-04-25 간 장해 억제제
KR1019910701528A KR970002905B1 (ko) 1990-04-26 1991-04-26 S-저급지방산 글루타티온 유도체

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1019910701527A KR970002904B1 (ko) 1990-04-26 1991-04-25 S-저급지방산 글루타티온 유도체

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1019910701528A KR970002905B1 (ko) 1990-04-26 1991-04-26 S-저급지방산 글루타티온 유도체

Country Status (10)

Country Link
US (2) US5232913A (ko)
EP (3) EP0480060B1 (ko)
KR (3) KR970002904B1 (ko)
AT (3) ATE145919T1 (ko)
CA (2) CA2060209A1 (ko)
DE (3) DE69123428T2 (ko)
ES (3) ES2095317T3 (ko)
RU (1) RU2046798C1 (ko)
TW (1) TW203060B (ko)
WO (3) WO1991016337A1 (ko)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6030950A (en) * 1987-07-09 2000-02-29 Ohlenschlaeger; Gerhard Pharmaceutical therapeutic use of glutathione derivative
US5599903A (en) * 1992-04-03 1997-02-04 Terrapin Technologies, Inc. Glutathione analogs and paralog panels comprising glutathione mimics
US5679643A (en) * 1987-10-13 1997-10-21 Terrapin Technologies, Inc. Glutathione analogs and paralog panels comprising glutathione mimics
KR970001509B1 (ko) * 1990-02-17 1997-02-11 센쥬세이야꾸 가부시끼가이샤 글루타티온 유도체
US5786336A (en) * 1991-04-29 1998-07-28 Terrapin Technologies, Inc. Target-selective protocols based on mimics
US5955432A (en) * 1992-04-03 1999-09-21 Terrapin Technologies, Inc. Metabolic effects of certain glutathione analogs
TW225992B (ko) * 1992-07-17 1994-07-01 Senju Pharma Co
US5427425A (en) * 1994-08-05 1995-06-27 Droesch; Joaquin C. Pickup tailgate mounting assembly
ES2147162B1 (es) 1999-01-27 2001-03-16 Lacer Sa "s-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias".
US6596870B2 (en) 2000-07-13 2003-07-22 Brandeis University Asymmetric synthetic methods based on phase transfer catalysis
US7172905B2 (en) * 2001-08-07 2007-02-06 The University Of Chicago Polypeptide immobilization
EP1521961A2 (en) * 2002-07-05 2005-04-13 The University of Chicago Characterization of biochips containing self-assembled monolayers with maldi-tof-ms
US20100021398A1 (en) * 2008-01-18 2010-01-28 Skinner Keith K Compositions and methods for lightening skin and protecting skin from ultraviolet radiation with glutathione
US9017477B2 (en) * 2008-05-28 2015-04-28 Nagoya City University Process for producing colloidal crystal and colloidal crystal
JP5267096B2 (ja) * 2008-12-12 2013-08-21 住友化学株式会社 Ｎ，Ｓ−ジ−ｔｅｒｔ−ブトキシカルボニルグルタチオン蛍光誘導体及びそれを中間体として用いるグルタチオン蛍光誘導体の製造方法
US20130209366A1 (en) * 2010-08-24 2013-08-15 Oklahoma Medical Research Foundation Glutathione-Lanthionine Compounds and Methods Related Thereto
WO2014113634A1 (en) * 2013-01-17 2014-07-24 University Of Kansas Toll-like receptor 2-agonistic lipopeptides, and method of making the same

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JPS60104018A (ja) * 1983-11-11 1985-06-08 Kyowa Hakko Kogyo Co Ltd Ν−メチルホルムアミド肝毒性の軽減剤
US4879370A (en) * 1983-12-02 1989-11-07 Cornell Research Foundation, Inc. Glutathione delivery system
JPS61249997A (ja) * 1985-04-22 1986-11-07 コ−ネル・リサ−チ・フアウンデ−シヨン・インコ−ポレイテツド グルタチオンアルキルエステルおよびその用途
JPS60123497A (ja) * 1983-12-02 1985-07-02 コ−ネル・リサ−チ・フアウンデ−シヨン，インコ−ポレイテツド グルタチオン伝達系
JPS60237963A (ja) * 1984-05-02 1985-11-26 Ajinomoto Co Inc こく味調味料またはこく味の増強された食品の製造法
ATE53991T1 (de) * 1985-04-19 1990-07-15 Smithkline Beecham Corp Leukotrien-antagonisten.
JPS638337A (ja) * 1986-06-30 1988-01-14 Senjiyu Seiyaku Kk 抗血液凝固剤
US4927808A (en) * 1986-07-07 1990-05-22 Teijin Limited γ-L-glutamyl-L-cysteine ethyl ester and pharmaceutical compositions containing the same as an effective ingredient
JPS6463525A (en) * 1987-05-08 1989-03-09 Yamanouchi Pharma Co Ltd Alcoholic liver triglyceride increase-suppressing agent
DE3722647A1 (de) * 1987-07-09 1989-01-19 Gerhard Ohlenschlaeger Galenische verwendung eines tripeptids als arzneimittel
JPH02255624A (ja) * 1989-03-29 1990-10-16 Senjiyu Seiyaku Kk 血小板凝集抑制剤
US5102871A (en) * 1989-04-24 1992-04-07 Kyowa Hakko Kogyo Co., Ltd. Nutrient composition
US5093478A (en) * 1989-07-14 1992-03-03 Cornell Research Foundation, Inc. Preparing glutathione monoesters
JP2815179B2 (ja) * 1989-07-14 1998-10-27 千寿製薬株式会社 抗炎症および／または抗アレルギー剤
JP2919867B2 (ja) * 1989-09-27 1999-07-19 千寿製薬株式会社 抗腫瘍剤
JP2919870B2 (ja) * 1989-09-29 1999-07-19 千寿製薬株式会社 肝障害抑制剤
KR970001509B1 (ko) * 1990-02-17 1997-02-11 센쥬세이야꾸 가부시끼가이샤 글루타티온 유도체

Also Published As

Publication number Publication date
DE69122831T2 (de) 1997-03-27
KR920701143A (ko) 1992-08-11
EP0480061B1 (en) 1996-12-04
DE69123428D1 (de) 1997-01-16
KR920701142A (ko) 1992-08-11
DE69122466D1 (de) 1996-11-07
WO1991016337A1 (en) 1991-10-31
EP0480061A4 (en) 1993-07-21
EP0480061A1 (en) 1992-04-15
KR970008108B1 (ko) 1997-05-21
DE69122466T2 (de) 1997-03-20
US5274177A (en) 1993-12-28
KR970002904B1 (ko) 1997-03-12
WO1991016065A1 (en) 1991-10-31
DE69123428T2 (de) 1997-05-15
DE69122831D1 (de) 1996-11-28
EP0480071A1 (en) 1992-04-15
ES2092565T3 (es) 1996-12-01
ATE143670T1 (de) 1996-10-15
ATE144531T1 (de) 1996-11-15
US5232913A (en) 1993-08-03
CA2060209A1 (en) 1991-10-27
EP0480071B1 (en) 1996-10-02
ES2093098T3 (es) 1996-12-16
EP0480060B1 (en) 1996-10-23
EP0480071A4 (en) 1993-06-30
EP0480060A1 (en) 1992-04-15
EP0480060A4 (en) 1993-07-14
ES2095317T3 (es) 1997-02-16
TW203060B (ko) 1993-04-01
RU2046798C1 (ru) 1995-10-27
CA2060210A1 (en) 1991-10-27
ATE145919T1 (de) 1996-12-15
KR970002905B1 (ko) 1997-03-12
WO1991016338A1 (en) 1991-10-31

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