KR920701143A - S-저급지방산 글루타티온 유도체 - Google Patents

S-저급지방산 글루타티온 유도체

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Publication number
KR920701143A
KR920701143A KR1019910701528A KR910701528A KR920701143A KR 920701143 A KR920701143 A KR 920701143A KR 1019910701528 A KR1019910701528 A KR 1019910701528A KR 910701528 A KR910701528 A KR 910701528A KR 920701143 A KR920701143 A KR 920701143A
Authority
KR
South Korea
Prior art keywords
compound
glutathione
lower alkyl
formula
methyl
Prior art date
Application number
KR1019910701528A
Other languages
English (en)
Other versions
KR970002905B1 (ko
Inventor
신지 오오모리
가즈미 오가따
다까히로 사까우에
Original Assignee
요시다 쇼우지
센쥬 세이야꾸 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 요시다 쇼우지, 센쥬 세이야꾸 가부시끼가이샤 filed Critical 요시다 쇼우지
Publication of KR920701143A publication Critical patent/KR920701143A/ko
Application granted granted Critical
Publication of KR970002905B1 publication Critical patent/KR970002905B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fats And Perfumes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

S-저급지방산 글루타티온 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 하기식
    〔식중, R1은 치환되어 있어도 좋은 저급알킬기, R2는 수소를 나타낸다. R3는 수소 또는 치환되어 있어도 좋은 저급알킬기, R4는 수산기 또는 치환되어 있어도 좋은 저급알콕시기를 나타낸다. 단, n은 1을 나타낸다.〕으로 나타내어지는 화합물 또는 그의 염.
  2. 제1항에 있어서, 화합물이 S-(2-메틸-2-카르보에톡시에틸) 글루타티온 이소프로필 에스테르인 화합물.
  3. 제1항에 있어서, 화합물이 S-(2-메틸-2-카르보소부톡시에틸) 글루타티온 이소프로필 에스테르인 화합물.
  4. 글루타티온 또는 그의 에스테르와, 일반식
    R2-A-COOH (Ⅱ)
    〔R2는 수소를 나타내고, A는 식(식중, R3는 수소 또는 SH기와 반응하지 않는 치환기를 가지고 있어도 좋은 저급 알킬기를 나타낸다.) 또는 식(식중, X는 할로겐원자를, R3는 상기 의미와 동일한 의미를 갖는다.)으로 나타내어지는 2가의 기를 나타낸다.〕으로 표시되는 유기 모노카르복실산 또는 그의 에스테르를 반응시키고, 필요에 따라 얻어진 반응생성물을 에스테르화 하는 것을 특징으로 하는 제1항 기재의 화합물의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910701528A 1990-04-26 1991-04-26 S-저급지방산 글루타티온 유도체 KR970002905B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP90-112260 1990-04-26
JP11226090 1990-04-26
PCT/JP1991/000581 WO1991016338A1 (en) 1990-04-26 1991-04-26 S-(lower fatty acid)-substituted glutathione derivative

Publications (2)

Publication Number Publication Date
KR920701143A true KR920701143A (ko) 1992-08-11
KR970002905B1 KR970002905B1 (ko) 1997-03-12

Family

ID=14582257

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1019910701527A KR970002904B1 (ko) 1990-04-26 1991-04-25 S-저급지방산 글루타티온 유도체
KR1019910701526A KR970008108B1 (ko) 1990-04-26 1991-04-25 간 장해 억제제
KR1019910701528A KR970002905B1 (ko) 1990-04-26 1991-04-26 S-저급지방산 글루타티온 유도체

Family Applications Before (2)

Application Number Title Priority Date Filing Date
KR1019910701527A KR970002904B1 (ko) 1990-04-26 1991-04-25 S-저급지방산 글루타티온 유도체
KR1019910701526A KR970008108B1 (ko) 1990-04-26 1991-04-25 간 장해 억제제

Country Status (10)

Country Link
US (2) US5232913A (ko)
EP (3) EP0480060B1 (ko)
KR (3) KR970002904B1 (ko)
AT (3) ATE145919T1 (ko)
CA (2) CA2060209A1 (ko)
DE (3) DE69123428T2 (ko)
ES (3) ES2093098T3 (ko)
RU (1) RU2046798C1 (ko)
TW (1) TW203060B (ko)
WO (3) WO1991016065A1 (ko)

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US6030950A (en) * 1987-07-09 2000-02-29 Ohlenschlaeger; Gerhard Pharmaceutical therapeutic use of glutathione derivative
US5599903A (en) * 1992-04-03 1997-02-04 Terrapin Technologies, Inc. Glutathione analogs and paralog panels comprising glutathione mimics
US5679643A (en) * 1987-10-13 1997-10-21 Terrapin Technologies, Inc. Glutathione analogs and paralog panels comprising glutathione mimics
EP0469156B1 (en) * 1990-02-17 1996-10-23 Senju Pharmaceutical Co., Ltd. Glutathione derivative
US5786336A (en) * 1991-04-29 1998-07-28 Terrapin Technologies, Inc. Target-selective protocols based on mimics
US5955432A (en) * 1992-04-03 1999-09-21 Terrapin Technologies, Inc. Metabolic effects of certain glutathione analogs
TW225992B (ko) * 1992-07-17 1994-07-01 Senju Pharma Co
US5427425A (en) * 1994-08-05 1995-06-27 Droesch; Joaquin C. Pickup tailgate mounting assembly
ES2147162B1 (es) 1999-01-27 2001-03-16 Lacer Sa "s-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias".
US6596870B2 (en) 2000-07-13 2003-07-22 Brandeis University Asymmetric synthetic methods based on phase transfer catalysis
US7172905B2 (en) 2001-08-07 2007-02-06 The University Of Chicago Polypeptide immobilization
EP2500729A1 (en) * 2002-07-05 2012-09-19 The University of Chicago Characterization of biochips containing self-assembled monolayers
US20100021398A1 (en) * 2008-01-18 2010-01-28 Skinner Keith K Compositions and methods for lightening skin and protecting skin from ultraviolet radiation with glutathione
EP2295137B1 (en) * 2008-05-28 2012-06-06 Nagoya City University Process for producing colloidal crystal
JP5267096B2 (ja) * 2008-12-12 2013-08-21 住友化学株式会社 Ｎ，Ｓ−ジ−ｔｅｒｔ−ブトキシカルボニルグルタチオン蛍光誘導体及びそれを中間体として用いるグルタチオン蛍光誘導体の製造方法
US20130209366A1 (en) * 2010-08-24 2013-08-15 Oklahoma Medical Research Foundation Glutathione-Lanthionine Compounds and Methods Related Thereto
WO2014113634A1 (en) * 2013-01-17 2014-07-24 University Of Kansas Toll-like receptor 2-agonistic lipopeptides, and method of making the same

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60104018A (ja) * 1983-11-11 1985-06-08 Kyowa Hakko Kogyo Co Ltd Ν−メチルホルムアミド肝毒性の軽減剤
JPS60123497A (ja) * 1983-12-02 1985-07-02 コ−ネル・リサ−チ・フアウンデ−シヨン，インコ−ポレイテツド グルタチオン伝達系
JPS61249997A (ja) * 1985-04-22 1986-11-07 コ−ネル・リサ−チ・フアウンデ−シヨン・インコ−ポレイテツド グルタチオンアルキルエステルおよびその用途
US4879370A (en) * 1983-12-02 1989-11-07 Cornell Research Foundation, Inc. Glutathione delivery system
JPS60237963A (ja) * 1984-05-02 1985-11-26 Ajinomoto Co Inc こく味調味料またはこく味の増強された食品の製造法
EP0202759B1 (en) * 1985-04-19 1990-06-20 Smithkline Beecham Corporation Leukotriene antagonists
JPS638337A (ja) * 1986-06-30 1988-01-14 Senjiyu Seiyaku Kk 抗血液凝固剤
US4927808A (en) * 1986-07-07 1990-05-22 Teijin Limited γ-L-glutamyl-L-cysteine ethyl ester and pharmaceutical compositions containing the same as an effective ingredient
JPS6463525A (en) * 1987-05-08 1989-03-09 Yamanouchi Pharma Co Ltd Alcoholic liver triglyceride increase-suppressing agent
DE3722647A1 (de) * 1987-07-09 1989-01-19 Gerhard Ohlenschlaeger Galenische verwendung eines tripeptids als arzneimittel
JPH02255624A (ja) * 1989-03-29 1990-10-16 Senjiyu Seiyaku Kk 血小板凝集抑制剤
US5102871A (en) * 1989-04-24 1992-04-07 Kyowa Hakko Kogyo Co., Ltd. Nutrient composition
JP2815179B2 (ja) * 1989-07-14 1998-10-27 千寿製薬株式会社 抗炎症および／または抗アレルギー剤
US5093478A (en) * 1989-07-14 1992-03-03 Cornell Research Foundation, Inc. Preparing glutathione monoesters
JP2919867B2 (ja) * 1989-09-27 1999-07-19 千寿製薬株式会社 抗腫瘍剤
JP2919870B2 (ja) * 1989-09-29 1999-07-19 千寿製薬株式会社 肝障害抑制剤
EP0469156B1 (en) * 1990-02-17 1996-10-23 Senju Pharmaceutical Co., Ltd. Glutathione derivative

Also Published As

Publication number Publication date
EP0480060A1 (en) 1992-04-15
DE69122466D1 (de) 1996-11-07
DE69122466T2 (de) 1997-03-20
EP0480060B1 (en) 1996-10-23
WO1991016337A1 (en) 1991-10-31
DE69123428D1 (de) 1997-01-16
ES2093098T3 (es) 1996-12-16
DE69123428T2 (de) 1997-05-15
KR970002904B1 (ko) 1997-03-12
KR920701141A (ko) 1992-08-11
US5232913A (en) 1993-08-03
ATE143670T1 (de) 1996-10-15
EP0480071A1 (en) 1992-04-15
TW203060B (ko) 1993-04-01
WO1991016338A1 (en) 1991-10-31
WO1991016065A1 (en) 1991-10-31
CA2060209A1 (en) 1991-10-27
ES2095317T3 (es) 1997-02-16
DE69122831D1 (de) 1996-11-28
ATE144531T1 (de) 1996-11-15
RU2046798C1 (ru) 1995-10-27
KR920701142A (ko) 1992-08-11
ATE145919T1 (de) 1996-12-15
KR970008108B1 (ko) 1997-05-21
EP0480060A4 (en) 1993-07-14
EP0480061A4 (en) 1993-07-21
EP0480061A1 (en) 1992-04-15
EP0480061B1 (en) 1996-12-04
US5274177A (en) 1993-12-28
KR970002905B1 (ko) 1997-03-12
EP0480071B1 (en) 1996-10-02
ES2092565T3 (es) 1996-12-01
DE69122831T2 (de) 1997-03-27
EP0480071A4 (en) 1993-06-30
CA2060210A1 (en) 1991-10-27

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