ES2100522T3 - Compuesto de piridincarboximidamida y su utilizacion. - Google Patents

Compuesto de piridincarboximidamida y su utilizacion.

Info

Publication number
ES2100522T3
ES2100522T3 ES93902543T ES93902543T ES2100522T3 ES 2100522 T3 ES2100522 T3 ES 2100522T3 ES 93902543 T ES93902543 T ES 93902543T ES 93902543 T ES93902543 T ES 93902543T ES 2100522 T3 ES2100522 T3 ES 2100522T3
Authority
ES
Spain
Prior art keywords
piridincarboximidamida
compound
effect
bisalkylsulfonylamino
nitroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93902543T
Other languages
English (en)
Inventor
Hideki Okawara
Tatsuo Nakajima
Nobuyuki Ogawa
Tomoko Kashiwabara
Soichiro Kaneta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kirin Brewery Co Ltd
Original Assignee
Kirin Brewery Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kirin Brewery Co Ltd filed Critical Kirin Brewery Co Ltd
Application granted granted Critical
Publication of ES2100522T3 publication Critical patent/ES2100522T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE DESCRIBE UNA PIRIDINECARBOXIMIDAMIDA CON LA FORMULA GENERAL (I), QUE TIENE UN EFECTO VASODILATADOR (EFECTO HIPOTENSIVO O ANTIANGINAL), O SU SAL CON ADICION DE ACIDO, DONDE UN R1 Y R2 REPRESENTA HIDROGENO Y EL OTRO REPRESENTA ALQUILO, HIDROXIALQUILO, CARBOXI, AMINO, ACILAMINO, ALQUILAMINO, DIALQUILAMINO, ARALQUILAMINO, ALQUILSULFONAMIDO, BISALQUISULFONILAMINO O HIDROXI; Y R3 REPRESENTA NITROXI, 2-CLOROFENILO O FENILO.
ES93902543T 1992-01-28 1993-01-28 Compuesto de piridincarboximidamida y su utilizacion. Expired - Lifetime ES2100522T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP1334292 1992-01-28
JP6622192 1992-03-24
JP32576092 1992-12-04

Publications (1)

Publication Number Publication Date
ES2100522T3 true ES2100522T3 (es) 1997-06-16

Family

ID=27280214

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93902543T Expired - Lifetime ES2100522T3 (es) 1992-01-28 1993-01-28 Compuesto de piridincarboximidamida y su utilizacion.

Country Status (18)

Country Link
US (1) US5508293A (es)
EP (1) EP0634400B1 (es)
JP (1) JP2648395B2 (es)
KR (1) KR100249755B1 (es)
CN (1) CN1043760C (es)
AT (1) ATE151073T1 (es)
AU (1) AU674839B2 (es)
CA (1) CA2129013C (es)
DE (1) DE69309454T2 (es)
DK (1) DK0634400T3 (es)
ES (1) ES2100522T3 (es)
FI (1) FI105399B (es)
HK (1) HK1000094A1 (es)
HU (1) HU218487B (es)
MX (1) MX9300433A (es)
NO (1) NO302070B1 (es)
TW (1) TW232009B (es)
WO (1) WO1993015057A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6075024A (en) 1991-11-27 2000-06-13 Sepracor Inc. Methods for treating infection using optically pure (S)-lomefloxacin
WO1997000239A1 (fr) * 1995-06-14 1997-01-03 Sankyo Company, Limited Medicament contre l'angine contenant un derive nitroxy comme ingredient actif
WO1998035673A1 (fr) * 1997-02-14 1998-08-20 Kirin Beer Kabushiki Kaisha Medicaments utilises dans la decongestion du flux sanguin peripherique
US20040229781A1 (en) * 2000-05-10 2004-11-18 Marks Andrew Robert Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias
US7393652B2 (en) * 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US20060293266A1 (en) * 2000-05-10 2006-12-28 The Trustees Of Columbia Phosphodiesterase 4D in the ryanodine receptor complex protects against heart failure
US20040048780A1 (en) * 2000-05-10 2004-03-11 The Trustees Of Columbia University In The City Of New York Method for treating and preventing cardiac arrhythmia
US6489125B1 (en) * 2000-05-10 2002-12-03 The Trustees Of Columbia University In The City Of New York Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor
US7879840B2 (en) * 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7718644B2 (en) * 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
JP2003321329A (ja) * 2002-04-25 2003-11-11 Kirin Brewery Co Ltd 育毛剤
US7544678B2 (en) * 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
JP2007525165A (ja) 2003-03-07 2007-09-06 トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク タイプ１ライアノジン受容体に基づく方法
US8710045B2 (en) * 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
US7704990B2 (en) * 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
TW200908984A (en) 2007-08-07 2009-03-01 Piramal Life Sciences Ltd Pyridyl derivatives, their preparation and use
EP3088390A1 (en) 2015-04-30 2016-11-02 Bayer CropScience AG Catalytic hydrogenation of substituted cyanopyridines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI95244C (fi) * 1988-12-27 1996-01-10 Kirin Brewery Analogiamenetelmä valmistaa lääkeaineina käyttökelpoisia uusia karboksimidiamidijohdannaisia tai niiden farmaseuttisesti sopivia happoadditiosuoloja
JPH0662567B2 (ja) * 1988-12-27 1994-08-17 麒麟麦酒株式会社 ピリジンカルボキシイミダミド誘導体、その製造中間体、製造法および用途
JP2846070B2 (ja) * 1989-11-29 1999-01-13 麒麟麦酒株式会社 カルボキシイミダミド誘導体

Also Published As

Publication number Publication date
DK0634400T3 (da) 1997-04-28
EP0634400A1 (en) 1995-01-18
MX9300433A (es) 1994-07-29
EP0634400A4 (en) 1995-06-14
FI105399B (fi) 2000-08-15
HUT70506A (en) 1995-10-30
AU674839B2 (en) 1997-01-16
DE69309454T2 (de) 1997-08-14
TW232009B (es) 1994-10-11
DE69309454D1 (de) 1997-05-07
CA2129013A1 (en) 1993-07-29
HK1000094A1 (en) 1997-11-21
HU9402218D0 (en) 1994-09-28
US5508293A (en) 1996-04-16
WO1993015057A1 (en) 1993-08-05
NO942740D0 (no) 1994-07-22
AU3367793A (en) 1993-09-01
KR950700255A (ko) 1995-01-16
FI943508A0 (fi) 1994-07-26
JP2648395B2 (ja) 1997-08-27
CA2129013C (en) 2001-08-14
NO302070B1 (no) 1998-01-19
HU218487B (hu) 2000-09-28
CN1043760C (zh) 1999-06-23
ATE151073T1 (de) 1997-04-15
KR100249755B1 (ko) 2000-04-01
NO942740L (no) 1994-09-27
FI943508A (fi) 1994-09-22
EP0634400B1 (en) 1997-04-02
CN1077949A (zh) 1993-11-03

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