ES2056930T3 - Inhibidores de la renina que contienen fluor. - Google Patents

Inhibidores de la renina que contienen fluor.

Info

Publication number
ES2056930T3
ES2056930T3 ES88305846T ES88305846T ES2056930T3 ES 2056930 T3 ES2056930 T3 ES 2056930T3 ES 88305846 T ES88305846 T ES 88305846T ES 88305846 T ES88305846 T ES 88305846T ES 2056930 T3 ES2056930 T3 ES 2056930T3
Authority
ES
Spain
Prior art keywords
fluorine containing
inhibitors
renine
renine inhibitors
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88305846T
Other languages
English (en)
Inventor
Dennis Jay Hoover
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Application granted granted Critical
Publication of ES2056930T3 publication Critical patent/ES2056930T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

INHIBIDORES DE RENINA, UTILES COMO ANTIHIPERTENSIVOS DE FORMULA (I), O UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES, DONDE X ES O O NH; R1 ES UN GRUPO ALQUILO QUE TIENE 1-6 ATOMOS DE CARBONO, IMIDAZOL-4-ILMETILO O METILTIOMETILO; Y ES =CH-OH O =C=O; Y R2 ES CF2CONHCH3 O EL GRUPO DE FORMULA: (FIG. A).
ES88305846T 1987-07-01 1988-06-24 Inhibidores de la renina que contienen fluor. Expired - Lifetime ES2056930T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6898987A 1987-07-01 1987-07-01

Publications (1)

Publication Number Publication Date
ES2056930T3 true ES2056930T3 (es) 1994-10-16

Family

ID=22085994

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88305846T Expired - Lifetime ES2056930T3 (es) 1987-07-01 1988-06-24 Inhibidores de la renina que contienen fluor.

Country Status (9)

Country Link
EP (1) EP0297815B1 (es)
JP (1) JPH0757759B2 (es)
AT (1) ATE109157T1 (es)
CA (1) CA1322075C (es)
DE (1) DE3850818T2 (es)
DK (1) DK362688A (es)
ES (1) ES2056930T3 (es)
FI (1) FI883134A7 (es)
PT (1) PT87867B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8619182D0 (en) * 1986-08-06 1986-09-17 Sandoz Ltd Peptides & derivatives
EP0369391A3 (en) * 1988-11-15 1991-09-25 Boehringer Ingelheim Pharmaceuticals Inc. N-substituted amides
DE4126485A1 (de) * 1991-08-10 1993-02-11 Bayer Ag Trifluormethyl-haltige pseudopeptide
JP2005259307A (ja) * 2004-03-15 2005-09-22 Sony Corp 光ピックアップ及びディスクドライブ装置
WO2007060891A2 (ja) 2005-11-24 2007-05-31 Asahi Kasei Chemicals Corp メタクリル樹脂及びその製造方法
MY155971A (en) 2009-10-22 2015-12-30 Asahi Kasei Chemicals Corp Methacrylic resin, molded body thereof, and method for producing methacrylic resin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986006379A1 (en) * 1985-04-19 1986-11-06 The Upjohn Company Dihalo-statine substituted renin inhibitors
DE3538749A1 (de) * 1985-10-31 1987-05-07 Merck Patent Gmbh Peptide

Also Published As

Publication number Publication date
DK362688D0 (da) 1988-06-30
DE3850818T2 (de) 1994-11-17
FI883134L (fi) 1989-01-02
JPH0757759B2 (ja) 1995-06-21
PT87867A (pt) 1989-06-30
DK362688A (da) 1989-02-14
EP0297815A2 (en) 1989-01-04
EP0297815B1 (en) 1994-07-27
ATE109157T1 (de) 1994-08-15
FI883134A0 (fi) 1988-06-30
DE3850818D1 (de) 1994-09-01
PT87867B (pt) 1995-05-04
EP0297815A3 (en) 1990-06-06
FI883134A7 (fi) 1989-01-02
CA1322075C (en) 1993-09-07
JPS6422865A (en) 1989-01-25

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