KR920700601A - 피부투과 증진제 조성물 - Google Patents
피부투과 증진제 조성물Info
- Publication number
- KR920700601A KR920700601A KR1019910701172A KR910701172A KR920700601A KR 920700601 A KR920700601 A KR 920700601A KR 1019910701172 A KR1019910701172 A KR 1019910701172A KR 910701172 A KR910701172 A KR 910701172A KR 920700601 A KR920700601 A KR 920700601A
- Authority
- KR
- South Korea
- Prior art keywords
- pharmacologically active
- composition
- active substance
- ether
- diethylene glycol
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Amplifiers (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 실시예 6에서 얻어지는 조성물의 적정 비율화 상태의 결과를 나타내는 표시도이다.
Claims (11)
- 다음으로 구성되는 약물학적 활성물질의 경피전달에 유용한 조성물 (a) 치료학적 유효량을 갖는 최소한 하나 이상의 약물학적 활성물질; 및 (b) 상기 최소한 하나 이상의 약물학적 활성물질의 경피침투를 증진시키는 유효량의 투과정진제조성물; 이 증진제조성물은 디에틸렌글리콜모노에틸에테르, 디에틸렌글리콜모노메틸에테르, 및 이들의 혼합물로 구성되는 군에서 선택된 에테르성분과 구조식[CH3(CH2)m COO]nR (여기서 m은 8 내지 16범위의 정수, n은 1 또는 2 및 R은 하나 또는 둘의 히드록실기로 치환되거나 또는 무치환 저금알킬(C1-C3) 잔기이다.)로 주어지는 에스테르 성분으로 구성되는 조성물.
- 제1항에 있어서, n이 10인 조성물.
- 제1항 또는 제2항에 있어서, 에테르성분이 디에틸렌글리콜모노에틸에테르인 조성물.
- 제1항에 있어서, 에테르성분은 디에틸렌글리콜모노에틸에테르이고, 에스테르 성분은 프로필렌 글리콜 모노로레이트, 이거나 또는 프로필렌 글리콜 디로 레이트와 프로필렌 글리콜 모노로레이트 같이 쓰는 조성물.
- 제1항에 있어서, 최소한 하나 이상의 약물학적 활성물질이 스테로이드인 조성물.
- 제1항에 있어서, 최소한 하나 이상의 약물학적 활성물질이 프로게스토겐, 에스트로겐 또는 이들의 혼합물로 구성되는 조성물.
- 제6항에 있어서, 프로게스토겐은 노르에틴드론 또는 노르에틴드론 아세테이트이고, 에스트로겐은 에스트라디올인 조성물.
- 다음으로 구성되는 최소한 하나 이상의 약물학적 활성물질의 경피투여용 시스템. (a) 최소한 하나 이상의 약물학적 활성물질의 공급처; (b) 디에틸렌글리콜모노에틸에테르, 디에틸렌글리콜모노메틸에테르, 및 그들의 혼합물로 구성되는 군에서 선택된 에테르성분과, 구조식[CH3(CH2)m COO]nR (여기서 m은 8 내지 16범위의 정수, n은 1 또는 2 및 R은 하나 또는 두개의 히드록실기로 치환 또는 무치환 저급알킬(C1-C3) 잔기이다.)로 주어지는 에스테르 성분으로 이루어지는 투과증진제조성물의공급처; 및 (c0 활성물질과 증진제의 조성물이 피부에 전달되는 상태로 시스템을 유지시키는 장치.
- 제8항에 있어서, n이 10인 조성물.
- 제8항에 있어서, 에테르성분은 디에틸렌글리콜모노에틸에테르이고 에스테르 성분은 프로필렌 글리콜 모노로레이트 이거나 또는 프로필렌 글리콜 디로레이트와 프로필렌 글리콜 모노노레이트를 같은 쓰는 시스템.
- 제9항에 있어서, 최소한 하나 이상의 약물학적 활성물질이 스테로이드인 시스템.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US327,312 | 1989-03-22 | ||
US327312 | 1989-03-22 | ||
US07/327,312 US4973468A (en) | 1989-03-22 | 1989-03-22 | Skin permeation enhancer compositions |
PCT/US1990/001469 WO1990011064A1 (en) | 1989-03-22 | 1990-03-19 | Skin permeation enhancer compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
KR920700601A true KR920700601A (ko) | 1992-08-10 |
KR950010324B1 KR950010324B1 (ko) | 1995-09-14 |
Family
ID=23276050
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019910701172A KR950010324B1 (ko) | 1989-03-22 | 1990-03-19 | 피부투과증진제조성물 |
Country Status (12)
Country | Link |
---|---|
US (1) | US4973468A (ko) |
EP (1) | EP0464150B1 (ko) |
JP (1) | JP2550441B2 (ko) |
KR (1) | KR950010324B1 (ko) |
AT (1) | ATE156995T1 (ko) |
AU (1) | AU629331B2 (ko) |
CA (1) | CA2012875C (ko) |
DE (1) | DE69031309T2 (ko) |
DK (1) | DK0464150T3 (ko) |
ES (1) | ES2106029T3 (ko) |
FI (1) | FI914391A0 (ko) |
WO (1) | WO1990011064A1 (ko) |
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-
1990
- 1990-03-19 KR KR1019910701172A patent/KR950010324B1/ko not_active IP Right Cessation
- 1990-03-19 ES ES90905963T patent/ES2106029T3/es not_active Expired - Lifetime
- 1990-03-19 JP JP2505844A patent/JP2550441B2/ja not_active Expired - Lifetime
- 1990-03-19 DE DE69031309T patent/DE69031309T2/de not_active Expired - Lifetime
- 1990-03-19 AU AU54174/90A patent/AU629331B2/en not_active Ceased
- 1990-03-19 WO PCT/US1990/001469 patent/WO1990011064A1/en active IP Right Grant
- 1990-03-19 AT AT90905963T patent/ATE156995T1/de not_active IP Right Cessation
- 1990-03-19 DK DK90905963.6T patent/DK0464150T3/da active
- 1990-03-19 EP EP90905963A patent/EP0464150B1/en not_active Expired - Lifetime
- 1990-03-22 CA CA002012875A patent/CA2012875C/en not_active Expired - Fee Related
-
1991
- 1991-09-18 FI FI914391A patent/FI914391A0/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
DE69031309T2 (de) | 1998-01-08 |
ATE156995T1 (de) | 1997-09-15 |
JPH04505157A (ja) | 1992-09-10 |
FI914391A0 (fi) | 1991-09-18 |
ES2106029T3 (es) | 1997-11-01 |
JP2550441B2 (ja) | 1996-11-06 |
AU5417490A (en) | 1990-10-22 |
DE69031309D1 (de) | 1997-09-25 |
WO1990011064A1 (en) | 1990-10-04 |
US4973468A (en) | 1990-11-27 |
CA2012875A1 (en) | 1990-09-22 |
DK0464150T3 (da) | 1997-09-15 |
EP0464150B1 (en) | 1997-08-20 |
EP0464150A4 (en) | 1993-04-14 |
KR950010324B1 (ko) | 1995-09-14 |
EP0464150A1 (en) | 1992-01-08 |
AU629331B2 (en) | 1992-10-01 |
CA2012875C (en) | 1995-12-05 |
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