ES2133380T3 - Composiciones farmaceuticas que contienen glicosidos de antraciclina unidos a derivados polimeros, y su procedimiento de preparacion. - Google Patents
Composiciones farmaceuticas que contienen glicosidos de antraciclina unidos a derivados polimeros, y su procedimiento de preparacion.Info
- Publication number
- ES2133380T3 ES2133380T3 ES93902124T ES93902124T ES2133380T3 ES 2133380 T3 ES2133380 T3 ES 2133380T3 ES 93902124 T ES93902124 T ES 93902124T ES 93902124 T ES93902124 T ES 93902124T ES 2133380 T3 ES2133380 T3 ES 2133380T3
- Authority
- ES
- Spain
- Prior art keywords
- anthracicline
- pharmaceutical compositions
- compositions containing
- preparation procedure
- polymer derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE PRESENTA UNA COMPOSICION LIOFILIZADA QUE COMPRENDE (A) UN CONJUGADO QUE COMPRENDE UN COPOLIMERO BASADO EN METACRILAMIDO DE N-ALQUIL Y UN GLICOSIDO DE ANTRACICLINA ENLAZADO A TRAVES DE SEPARADOR PEPTIDO AL COPOLIMERO Y (B) UN AGENTE COSOLUBILIZANTE, LA COMPOSICION PUEDE CONTENER OPCIONALMENTE (C) UN MATERIAL DE RELLENO. TAMBIEN OPCIONALMENTE, UNA MOLECULA PUEDE ESTAR UNIDA AL COPOLIMERO DEL CONJUGADO POR MEDIO DE UN SEPARADOR PEPTIDO. ASIMISMO SE PRESENTA UNA SOLUCION INYECTABLE DE CONJUGADO QUE SE OBTIENE MEDIANTE LA RECONSTITUCION DE LA COMPOSICION LIOFILIZADA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929200247A GB9200247D0 (en) | 1992-01-07 | 1992-01-07 | Pharmaceutical compositions containing polymer derivative-bound anthracycline glycosides and a method for their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2133380T3 true ES2133380T3 (es) | 1999-09-16 |
Family
ID=10708214
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93902124T Expired - Lifetime ES2133380T3 (es) | 1992-01-07 | 1992-12-21 | Composiciones farmaceuticas que contienen glicosidos de antraciclina unidos a derivados polimeros, y su procedimiento de preparacion. |
Country Status (22)
Country | Link |
---|---|
US (1) | US6245358B1 (es) |
EP (1) | EP0574571B1 (es) |
JP (1) | JPH06505755A (es) |
KR (1) | KR100290222B1 (es) |
AT (1) | ATE179618T1 (es) |
AU (1) | AU666513B2 (es) |
CA (1) | CA2105466A1 (es) |
DE (1) | DE69229109T2 (es) |
DK (1) | DK0574571T3 (es) |
ES (1) | ES2133380T3 (es) |
FI (1) | FI933853A (es) |
GB (1) | GB9200247D0 (es) |
GR (1) | GR3030633T3 (es) |
HU (2) | HU217806B (es) |
IL (1) | IL104256A (es) |
MX (1) | MX9207605A (es) |
NZ (1) | NZ246577A (es) |
RU (1) | RU2118171C1 (es) |
TW (1) | TW218847B (es) |
UA (1) | UA32522C2 (es) |
WO (1) | WO1993013804A1 (es) |
ZA (1) | ZA9210049B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9320781D0 (en) * | 1993-10-08 | 1993-12-01 | Erba Carlo Spa | Polymer-bound camptothecin derivatives |
WO1998047496A2 (en) * | 1997-04-18 | 1998-10-29 | Access Pharmaceuticals, Inc. | Polymer-platinum compounds |
US5965118A (en) * | 1997-04-18 | 1999-10-12 | Access Pharmaceuticals, Inc. | Polymer-platinum compounds |
US7314956B2 (en) | 2001-08-08 | 2008-01-01 | Vaxim, Inc. | Multifunctional carrier for the delivery of a pharmacological agent or genetic material into a cell |
WO2003017938A2 (en) * | 2001-08-22 | 2003-03-06 | Watson Pharmaceuticals, Inc. | Conjugates targeted to target receptors |
US20030125268A1 (en) * | 2002-08-28 | 2003-07-03 | Rybak Mary Ellen Margaret | Farnesyl protein transferase inhibitor combinations with anti-tumor anthracycline derivatives |
EP1562546A1 (en) * | 2002-10-25 | 2005-08-17 | Pfizer Products Inc. | Depot formulations of arylheterocyclic active agents in the form of a suspension |
CN1774259B (zh) * | 2003-01-14 | 2011-12-28 | 特瓦制药工业有限公司 | 治疗系统性红斑狼疮的肽的胃肠道外制剂 |
KR20070088447A (ko) * | 2005-05-11 | 2007-08-29 | 시코르, 인크. | 안정한 동결건조된 안트라사이클린 글리코시드 |
US20100160442A1 (en) * | 2006-07-18 | 2010-06-24 | Ossovskaya Valeria S | Formulations for cancer treatment |
PL2121139T3 (pl) * | 2007-01-16 | 2013-03-29 | Bipar Sciences Inc | Formulacje do leczenia raka |
EP2222273A2 (en) * | 2007-11-12 | 2010-09-01 | Novartis AG | Liquid compositions comprising valsartan |
WO2009118754A2 (en) * | 2008-03-28 | 2009-10-01 | Astron Research Limited | A process for preparing a stable lyophilized composition |
EP2274017B1 (en) * | 2008-04-30 | 2016-04-13 | Ben Gurion University Of The Negev Research And Development Authority | E-selectin specific vascular delivery systems |
KR102239752B1 (ko) * | 2019-12-11 | 2021-04-13 | 한국과학기술연구원 | 종양 특이적 약물복합체와 항pd-l1 항체를 유효성분으로 하는 암 예방 또는 치료를 위한 병용 투여용 약학 조성물 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS173846B1 (es) * | 1974-04-23 | 1977-03-31 | ||
US4460560A (en) * | 1982-06-18 | 1984-07-17 | University Of Southern California | Drug delivery by polymeric carriers |
FR2561916B1 (fr) * | 1984-03-30 | 1987-12-11 | Lafon Labor | Forme galenique pour administration orale et son procede de preparation par lyophilisation d'une emission huile dans eau |
FR2583983B1 (fr) * | 1985-06-07 | 1988-05-27 | Centre Nat Rech Scient | Nouvelles prodrogues macromoleculaires hydrosolubles, leur preparation et leur utilisation comme medicaments notamment antitumoraux et antiparasitaires |
GB8519452D0 (en) * | 1985-08-02 | 1985-09-11 | Erba Farmitalia | Injectable solutions |
US4968742A (en) * | 1987-11-09 | 1990-11-06 | Miles Inc. | Preparation of ligand-polymer conjugate having a controlled number of introduced ligands |
US5135736A (en) * | 1988-08-15 | 1992-08-04 | Neorx Corporation | Covalently-linked complexes and methods for enhanced cytotoxicity and imaging |
US5094848A (en) * | 1989-06-30 | 1992-03-10 | Neorx Corporation | Cleavable diphosphate and amidated diphosphate linkers |
US5079018A (en) * | 1989-08-14 | 1992-01-07 | Neophore Technologies, Inc. | Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs |
-
1992
- 1992-01-07 GB GB929200247A patent/GB9200247D0/en active Pending
- 1992-12-21 AU AU33468/93A patent/AU666513B2/en not_active Ceased
- 1992-12-21 NZ NZ246577A patent/NZ246577A/en unknown
- 1992-12-21 JP JP5512103A patent/JPH06505755A/ja active Pending
- 1992-12-21 KR KR1019930702671A patent/KR100290222B1/ko not_active IP Right Cessation
- 1992-12-21 UA UA93003781A patent/UA32522C2/uk unknown
- 1992-12-21 CA CA002105466A patent/CA2105466A1/en not_active Abandoned
- 1992-12-21 AT AT93902124T patent/ATE179618T1/de not_active IP Right Cessation
- 1992-12-21 WO PCT/EP1992/002968 patent/WO1993013804A1/en active IP Right Grant
- 1992-12-21 HU HU9302517A patent/HU217806B/hu not_active IP Right Cessation
- 1992-12-21 EP EP93902124A patent/EP0574571B1/en not_active Expired - Lifetime
- 1992-12-21 ES ES93902124T patent/ES2133380T3/es not_active Expired - Lifetime
- 1992-12-21 RU RU93055778A patent/RU2118171C1/ru active
- 1992-12-21 DK DK93902124T patent/DK0574571T3/da active
- 1992-12-21 DE DE69229109T patent/DE69229109T2/de not_active Expired - Fee Related
- 1992-12-28 ZA ZA9210049A patent/ZA9210049B/xx unknown
- 1992-12-28 US US07/997,582 patent/US6245358B1/en not_active Expired - Fee Related
- 1992-12-29 IL IL10425692A patent/IL104256A/xx not_active IP Right Cessation
- 1992-12-29 MX MX9207605A patent/MX9207605A/es not_active IP Right Cessation
- 1992-12-31 TW TW081110531A patent/TW218847B/zh active
-
1993
- 1993-09-03 FI FI933853A patent/FI933853A/fi unknown
-
1995
- 1995-06-30 HU HU95P/P00705P patent/HU211636A9/hu unknown
-
1999
- 1999-06-30 GR GR990401719T patent/GR3030633T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
RU2118171C1 (ru) | 1998-08-27 |
EP0574571B1 (en) | 1999-05-06 |
HUT74578A (en) | 1997-01-28 |
MX9207605A (es) | 1993-08-01 |
DE69229109D1 (de) | 1999-06-10 |
IL104256A (en) | 1997-02-18 |
CA2105466A1 (en) | 1993-07-08 |
DE69229109T2 (de) | 1999-08-26 |
EP0574571A1 (en) | 1993-12-22 |
KR100290222B1 (ko) | 2001-09-17 |
AU666513B2 (en) | 1996-02-15 |
DK0574571T3 (da) | 1999-11-01 |
GR3030633T3 (en) | 1999-10-29 |
FI933853A0 (fi) | 1993-09-03 |
HU217806B (hu) | 2000-04-28 |
HU9302517D0 (en) | 1993-12-28 |
IL104256A0 (en) | 1993-05-13 |
UA32522C2 (uk) | 2001-02-15 |
GB9200247D0 (en) | 1992-02-26 |
JPH06505755A (ja) | 1994-06-30 |
HU211636A9 (en) | 1995-12-28 |
FI933853A (fi) | 1993-09-03 |
ZA9210049B (en) | 1993-10-06 |
ATE179618T1 (de) | 1999-05-15 |
NZ246577A (en) | 1996-03-26 |
US6245358B1 (en) | 2001-06-12 |
AU3346893A (en) | 1993-08-03 |
TW218847B (es) | 1994-01-11 |
WO1993013804A1 (en) | 1993-07-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA2A | Application withdrawn |
Effective date: 19940628 |
|
FG2A | Definitive protection |
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