IL104256A - Lyophilized pharmaceutical compositions containing anthracycline glycosides bound to polymer derivatives and their preparation - Google Patents
Lyophilized pharmaceutical compositions containing anthracycline glycosides bound to polymer derivatives and their preparationInfo
- Publication number
- IL104256A IL104256A IL10425692A IL10425692A IL104256A IL 104256 A IL104256 A IL 104256A IL 10425692 A IL10425692 A IL 10425692A IL 10425692 A IL10425692 A IL 10425692A IL 104256 A IL104256 A IL 104256A
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- polymer derivatives
- lyophilized pharmaceutical
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929200247A GB9200247D0 (en) | 1992-01-07 | 1992-01-07 | Pharmaceutical compositions containing polymer derivative-bound anthracycline glycosides and a method for their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL104256A0 IL104256A0 (en) | 1993-05-13 |
| IL104256A true IL104256A (en) | 1997-02-18 |
Family
ID=10708214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10425692A IL104256A (en) | 1992-01-07 | 1992-12-29 | Lyophilized pharmaceutical compositions containing anthracycline glycosides bound to polymer derivatives and their preparation |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6245358B1 (es) |
| EP (1) | EP0574571B1 (es) |
| JP (1) | JPH06505755A (es) |
| KR (1) | KR100290222B1 (es) |
| AT (1) | ATE179618T1 (es) |
| AU (1) | AU666513B2 (es) |
| CA (1) | CA2105466A1 (es) |
| DE (1) | DE69229109T2 (es) |
| DK (1) | DK0574571T3 (es) |
| ES (1) | ES2133380T3 (es) |
| FI (1) | FI933853A (es) |
| GB (1) | GB9200247D0 (es) |
| GR (1) | GR3030633T3 (es) |
| HU (2) | HU217806B (es) |
| IL (1) | IL104256A (es) |
| MX (1) | MX9207605A (es) |
| NZ (1) | NZ246577A (es) |
| RU (1) | RU2118171C1 (es) |
| TW (1) | TW218847B (es) |
| UA (1) | UA32522C2 (es) |
| WO (1) | WO1993013804A1 (es) |
| ZA (1) | ZA9210049B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9320781D0 (en) * | 1993-10-08 | 1993-12-01 | Erba Carlo Spa | Polymer-bound camptothecin derivatives |
| WO1998047496A2 (en) * | 1997-04-18 | 1998-10-29 | Access Pharmaceuticals, Inc. | Polymer-platinum compounds |
| US5965118A (en) * | 1997-04-18 | 1999-10-12 | Access Pharmaceuticals, Inc. | Polymer-platinum compounds |
| US7314956B2 (en) | 2001-08-08 | 2008-01-01 | Vaxim, Inc. | Multifunctional carrier for the delivery of a pharmacological agent or genetic material into a cell |
| WO2003017938A2 (en) * | 2001-08-22 | 2003-03-06 | Watson Pharmaceuticals, Inc. | Conjugates targeted to target receptors |
| US20030125268A1 (en) * | 2002-08-28 | 2003-07-03 | Rybak Mary Ellen Margaret | Farnesyl protein transferase inhibitor combinations with anti-tumor anthracycline derivatives |
| CN1703198A (zh) * | 2002-10-25 | 2005-11-30 | 辉瑞产品公司 | 呈混悬剂形式的芳基杂环活性物质的贮库制剂 |
| CN1774259B (zh) * | 2003-01-14 | 2011-12-28 | 特瓦制药工业有限公司 | 治疗系统性红斑狼疮的肽的胃肠道外制剂 |
| EP1814525A2 (en) * | 2005-05-11 | 2007-08-08 | Sicor Inc. | Stable lyophilized anthracycline glycosides |
| US20100160442A1 (en) * | 2006-07-18 | 2010-06-24 | Ossovskaya Valeria S | Formulations for cancer treatment |
| ES2395690T3 (es) * | 2007-01-16 | 2013-02-14 | Bipar Sciences, Inc. | Formulaciones para el tratamiento del cáncer |
| RU2488393C2 (ru) * | 2007-11-12 | 2013-07-27 | Новартис Аг | Жидкие композиции, включающие валсартан |
| WO2009118754A2 (en) * | 2008-03-28 | 2009-10-01 | Astron Research Limited | A process for preparing a stable lyophilized composition |
| CA2723315A1 (en) * | 2008-04-30 | 2009-11-05 | Ben-Gurion University Of The Negev Research And Development Authority | Vascular delivery systems |
| KR102239752B1 (ko) * | 2019-12-11 | 2021-04-13 | 한국과학기술연구원 | 종양 특이적 약물복합체와 항pd-l1 항체를 유효성분으로 하는 암 예방 또는 치료를 위한 병용 투여용 약학 조성물 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CS173846B1 (es) * | 1974-04-23 | 1977-03-31 | ||
| US4460560A (en) * | 1982-06-18 | 1984-07-17 | University Of Southern California | Drug delivery by polymeric carriers |
| FR2561916B1 (fr) * | 1984-03-30 | 1987-12-11 | Lafon Labor | Forme galenique pour administration orale et son procede de preparation par lyophilisation d'une emission huile dans eau |
| FR2583983B1 (fr) * | 1985-06-07 | 1988-05-27 | Centre Nat Rech Scient | Nouvelles prodrogues macromoleculaires hydrosolubles, leur preparation et leur utilisation comme medicaments notamment antitumoraux et antiparasitaires |
| GB8519452D0 (en) * | 1985-08-02 | 1985-09-11 | Erba Farmitalia | Injectable solutions |
| US4968742A (en) * | 1987-11-09 | 1990-11-06 | Miles Inc. | Preparation of ligand-polymer conjugate having a controlled number of introduced ligands |
| US5135736A (en) * | 1988-08-15 | 1992-08-04 | Neorx Corporation | Covalently-linked complexes and methods for enhanced cytotoxicity and imaging |
| US5094848A (en) * | 1989-06-30 | 1992-03-10 | Neorx Corporation | Cleavable diphosphate and amidated diphosphate linkers |
| US5079018A (en) * | 1989-08-14 | 1992-01-07 | Neophore Technologies, Inc. | Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs |
-
1992
- 1992-01-07 GB GB929200247A patent/GB9200247D0/en active Pending
- 1992-12-21 ES ES93902124T patent/ES2133380T3/es not_active Expired - Lifetime
- 1992-12-21 NZ NZ246577A patent/NZ246577A/en unknown
- 1992-12-21 WO PCT/EP1992/002968 patent/WO1993013804A1/en active IP Right Grant
- 1992-12-21 JP JP5512103A patent/JPH06505755A/ja active Pending
- 1992-12-21 DK DK93902124T patent/DK0574571T3/da active
- 1992-12-21 CA CA002105466A patent/CA2105466A1/en not_active Abandoned
- 1992-12-21 AU AU33468/93A patent/AU666513B2/en not_active Ceased
- 1992-12-21 RU RU93055778A patent/RU2118171C1/ru active
- 1992-12-21 AT AT93902124T patent/ATE179618T1/de not_active IP Right Cessation
- 1992-12-21 EP EP93902124A patent/EP0574571B1/en not_active Expired - Lifetime
- 1992-12-21 DE DE69229109T patent/DE69229109T2/de not_active Expired - Fee Related
- 1992-12-21 KR KR1019930702671A patent/KR100290222B1/ko not_active IP Right Cessation
- 1992-12-21 UA UA93003781A patent/UA32522C2/uk unknown
- 1992-12-21 HU HU9302517A patent/HU217806B/hu not_active IP Right Cessation
- 1992-12-28 US US07/997,582 patent/US6245358B1/en not_active Expired - Fee Related
- 1992-12-28 ZA ZA9210049A patent/ZA9210049B/xx unknown
- 1992-12-29 IL IL10425692A patent/IL104256A/xx not_active IP Right Cessation
- 1992-12-29 MX MX9207605A patent/MX9207605A/es not_active IP Right Cessation
- 1992-12-31 TW TW081110531A patent/TW218847B/zh active
-
1993
- 1993-09-03 FI FI933853A patent/FI933853A/fi unknown
-
1995
- 1995-06-30 HU HU95P/P00705P patent/HU211636A9/hu unknown
-
1999
- 1999-06-30 GR GR990401719T patent/GR3030633T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0574571A1 (en) | 1993-12-22 |
| DE69229109D1 (de) | 1999-06-10 |
| UA32522C2 (uk) | 2001-02-15 |
| HUT74578A (en) | 1997-01-28 |
| ATE179618T1 (de) | 1999-05-15 |
| TW218847B (es) | 1994-01-11 |
| DK0574571T3 (da) | 1999-11-01 |
| MX9207605A (es) | 1993-08-01 |
| EP0574571B1 (en) | 1999-05-06 |
| GB9200247D0 (en) | 1992-02-26 |
| HU9302517D0 (en) | 1993-12-28 |
| HU211636A9 (en) | 1995-12-28 |
| JPH06505755A (ja) | 1994-06-30 |
| WO1993013804A1 (en) | 1993-07-22 |
| FI933853A0 (fi) | 1993-09-03 |
| ZA9210049B (en) | 1993-10-06 |
| FI933853A (fi) | 1993-09-03 |
| CA2105466A1 (en) | 1993-07-08 |
| ES2133380T3 (es) | 1999-09-16 |
| NZ246577A (en) | 1996-03-26 |
| US6245358B1 (en) | 2001-06-12 |
| AU3346893A (en) | 1993-08-03 |
| AU666513B2 (en) | 1996-02-15 |
| IL104256A0 (en) | 1993-05-13 |
| GR3030633T3 (en) | 1999-10-29 |
| HU217806B (hu) | 2000-04-28 |
| DE69229109T2 (de) | 1999-08-26 |
| KR100290222B1 (ko) | 2001-09-17 |
| RU2118171C1 (ru) | 1998-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| RH | Patent void | ||
| RH1 | Patent not in force |