KR920019812A - 4'-데메틸에피포도필로톡신 글루코사이드 4'- 포스페이트의 제조방법 - Google Patents

4'-데메틸에피포도필로톡신 글루코사이드 4'- 포스페이트의 제조방법 Download PDF

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Publication number
KR920019812A
KR920019812A KR1019920006008A KR920006008A KR920019812A KR 920019812 A KR920019812 A KR 920019812A KR 1019920006008 A KR1019920006008 A KR 1019920006008A KR 920006008 A KR920006008 A KR 920006008A KR 920019812 A KR920019812 A KR 920019812A
Authority
KR
South Korea
Prior art keywords
protecting group
compound
benzyl
phenyl
lewis acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
KR1019920006008A
Other languages
English (en)
Korean (ko)
Inventor
지. 솔니어 마크
캐도우 존 에프
알. 랭글리 데이비드
민 툰 민
Original Assignee
도미닉 엠. 메짜펠
브리스톨-마이어즈 스퀴브 컴페니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 도미닉 엠. 메짜펠, 브리스톨-마이어즈 스퀴브 컴페니 filed Critical 도미닉 엠. 메짜펠
Publication of KR920019812A publication Critical patent/KR920019812A/ko
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1019920006008A 1991-04-29 1992-04-10 4'-데메틸에피포도필로톡신 글루코사이드 4'- 포스페이트의 제조방법 Abandoned KR920019812A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US69398191A 1991-04-29 1991-04-29
US693,981 1991-04-29
US83495492A 1992-02-20 1992-02-20
US834954 1992-02-20

Publications (1)

Publication Number Publication Date
KR920019812A true KR920019812A (ko) 1992-11-20

Family

ID=27105281

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920006008A Abandoned KR920019812A (ko) 1991-04-29 1992-04-10 4'-데메틸에피포도필로톡신 글루코사이드 4'- 포스페이트의 제조방법

Country Status (16)

Country Link
EP (1) EP0511563A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH05178880A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR920019812A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1030141C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (2) AU653788B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2062510A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CZ (1) CZ131092A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI921756A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (3) HUT63428A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE921285A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL101188A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MY (1) MY131083A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO178826C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ242059A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SK (1) SK131092A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW260671B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6032799A (ja) * 1983-07-29 1985-02-19 Microbial Chem Res Found 新規４′−デメチル−４−エピポドフィロトキシン誘導体
US4904768A (en) * 1987-08-04 1990-02-27 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-phosphate derivatives
US4958010A (en) * 1988-02-16 1990-09-18 Bristol-Myers Company Epipodophyllotoxin glucoside lactam derivatives
DE3913326A1 (de) * 1989-04-22 1990-11-08 Behringwerke Ag Verfahren zur herstellung von etoposiden
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides

Also Published As

Publication number Publication date
AU6898194A (en) 1994-10-06
HU9300730D0 (en) 1993-05-28
NO178826C (no) 1996-06-12
EP0511563A1 (en) 1992-11-04
FI921756L (fi) 1992-10-30
IL101188A0 (en) 1992-11-15
MY131083A (en) 2007-07-31
CA2062510A1 (en) 1992-10-30
IL101188A (en) 1995-12-08
NO178826B (no) 1996-03-04
NO921363L (no) 1992-10-30
HU9201341D0 (en) 1992-07-28
NZ242059A (en) 1994-07-26
HUT63428A (en) 1993-08-30
JPH05178880A (ja) 1993-07-20
FI921756A0 (fi) 1992-04-21
CN1030141C (zh) 1995-10-25
NO921363D0 (no) 1992-04-08
CZ131092A3 (en) 1993-01-13
HUT65255A (en) 1994-05-02
FI921756A7 (fi) 1992-10-30
SK131092A3 (en) 1995-09-13
AU658343B2 (en) 1995-04-06
HUT63431A (en) 1993-08-30
AU1288692A (en) 1992-11-05
IE921285A1 (en) 1992-11-04
TW260671B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1995-10-21
CN1066268A (zh) 1992-11-18
AU653788B2 (en) 1994-10-13
HU9300731D0 (en) 1993-05-28

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Legal Events

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PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19920410

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19950517

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19920410

Comment text: Patent Application

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 19980228

NORF Unpaid initial registration fee
PC1904 Unpaid initial registration fee