CN1030141C - 4’-去甲基表鬼臼脂素葡萄糖苷-4’-磷酸酯的制备方法 - Google Patents
4’-去甲基表鬼臼脂素葡萄糖苷-4’-磷酸酯的制备方法 Download PDFInfo
- Publication number
- CN1030141C CN1030141C CN92102890A CN92102890A CN1030141C CN 1030141 C CN1030141 C CN 1030141C CN 92102890 A CN92102890 A CN 92102890A CN 92102890 A CN92102890 A CN 92102890A CN 1030141 C CN1030141 C CN 1030141C
- Authority
- CN
- China
- Prior art keywords
- protecting group
- compound
- formula
- phosphate
- benzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US834,954 | 1991-02-20 | ||
| US69398191A | 1991-04-29 | 1991-04-29 | |
| US07/693,981 | 1991-04-29 | ||
| US693,981 | 1991-04-29 | ||
| US83495492A | 1992-02-20 | 1992-02-20 | |
| US07/834,954 | 1992-02-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1066268A CN1066268A (zh) | 1992-11-18 |
| CN1030141C true CN1030141C (zh) | 1995-10-25 |
Family
ID=27105281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN92102890A Expired - Fee Related CN1030141C (zh) | 1991-04-29 | 1992-04-21 | 4’-去甲基表鬼臼脂素葡萄糖苷-4’-磷酸酯的制备方法 |
Country Status (16)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3061476B2 (ja) * | 1992-04-24 | 2000-07-10 | 日本化薬株式会社 | エトポシド燐酸エステルの製造法 |
| US5459248A (en) * | 1993-11-04 | 1995-10-17 | Bristol-Myers Squibb Company | Process of preparing etoposide phosphate and etoposide |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6032799A (ja) * | 1983-07-29 | 1985-02-19 | Microbial Chem Res Found | 新規４′−デメチル−４−エピポドフィロトキシン誘導体 |
| US4904768A (en) * | 1987-08-04 | 1990-02-27 | Bristol-Myers Company | Epipodophyllotoxin glucoside 4'-phosphate derivatives |
| US4958010A (en) * | 1988-02-16 | 1990-09-18 | Bristol-Myers Company | Epipodophyllotoxin glucoside lactam derivatives |
| DE3913326A1 (de) * | 1989-04-22 | 1990-11-08 | Behringwerke Ag | Verfahren zur herstellung von etoposiden |
| US5036055A (en) * | 1989-06-07 | 1991-07-30 | Bristol-Myers Company | Acylated derivatives of etoposide |
| US5034380A (en) * | 1989-11-20 | 1991-07-23 | Bristol-Myers Squibb Company | Alkoxymethylidene epipodophyllotoxin glucosides |
-
1992
- 1992-03-07 TW TW081101737A patent/TW260671B/zh active
- 1992-03-09 CA CA002062510A patent/CA2062510A1/en not_active Abandoned
- 1992-03-10 IL IL10118892A patent/IL101188A/en not_active IP Right Cessation
- 1992-03-16 AU AU12886/92A patent/AU653788B2/en not_active Ceased
- 1992-03-19 NZ NZ24205992A patent/NZ242059A/en unknown
- 1992-04-08 NO NO921363A patent/NO178826C/no unknown
- 1992-04-10 KR KR1019920006008A patent/KR920019812A/ko not_active Abandoned
- 1992-04-14 JP JP4137449A patent/JPH05178880A/ja active Pending
- 1992-04-16 EP EP92106655A patent/EP0511563A1/en not_active Ceased
- 1992-04-20 MY MYPI92000666A patent/MY131083A/en unknown
- 1992-04-21 CN CN92102890A patent/CN1030141C/zh not_active Expired - Fee Related
- 1992-04-21 FI FI921756A patent/FI921756A7/fi not_active Application Discontinuation
- 1992-04-22 HU HU939300731A patent/HUT63428A/hu unknown
- 1992-04-22 IE IE128592A patent/IE921285A1/en not_active Application Discontinuation
- 1992-04-22 HU HU9300730A patent/HUT63431A/hu unknown
- 1992-04-22 HU HU9201341A patent/HUT65255A/hu unknown
- 1992-04-29 CZ CS921310A patent/CZ131092A3/cs unknown
- 1992-04-29 SK SK1310-92A patent/SK131092A3/sk unknown
-
1994
- 1994-08-09 AU AU68981/94A patent/AU658343B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU6898194A (en) | 1994-10-06 |
| HU9300730D0 (en) | 1993-05-28 |
| NO178826C (no) | 1996-06-12 |
| EP0511563A1 (en) | 1992-11-04 |
| FI921756L (fi) | 1992-10-30 |
| IL101188A0 (en) | 1992-11-15 |
| MY131083A (en) | 2007-07-31 |
| CA2062510A1 (en) | 1992-10-30 |
| IL101188A (en) | 1995-12-08 |
| NO178826B (no) | 1996-03-04 |
| NO921363L (no) | 1992-10-30 |
| HU9201341D0 (en) | 1992-07-28 |
| NZ242059A (en) | 1994-07-26 |
| HUT63428A (en) | 1993-08-30 |
| JPH05178880A (ja) | 1993-07-20 |
| FI921756A0 (fi) | 1992-04-21 |
| NO921363D0 (no) | 1992-04-08 |
| CZ131092A3 (en) | 1993-01-13 |
| HUT65255A (en) | 1994-05-02 |
| FI921756A7 (fi) | 1992-10-30 |
| SK131092A3 (en) | 1995-09-13 |
| AU658343B2 (en) | 1995-04-06 |
| HUT63431A (en) | 1993-08-30 |
| KR920019812A (ko) | 1992-11-20 |
| AU1288692A (en) | 1992-11-05 |
| IE921285A1 (en) | 1992-11-04 |
| TW260671B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1995-10-21 |
| CN1066268A (zh) | 1992-11-18 |
| AU653788B2 (en) | 1994-10-13 |
| HU9300731D0 (en) | 1993-05-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |