KR920014481A - 의료용 화상형성에 유용한 x-선 콘트라스트 조성물 - Google Patents

의료용 화상형성에 유용한 x-선 콘트라스트 조성물 Download PDF

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KR920014481A
KR920014481A KR1019920001076A KR920001076A KR920014481A KR 920014481 A KR920014481 A KR 920014481A KR 1019920001076 A KR1019920001076 A KR 1019920001076A KR 920001076 A KR920001076 A KR 920001076A KR 920014481 A KR920014481 A KR 920014481A
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composition
ray contrast
contrast agent
particle size
ethyl
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KR1019920001076A
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쥐. 리비씨드지 게리
알. 쿠퍼 유겐
엘. 멕킨타이어 조오지
마이클 쇼우 제이.
씨. 컨디 케테드
에프. 비숍 존
에이. 체카이 데이빗
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원본미기재
스터링 윈쓰롭 아이엔씨.
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Priority claimed from US07/647,105 external-priority patent/US5145684A/en
Application filed by 원본미기재, 스터링 윈쓰롭 아이엔씨. filed Critical 원본미기재
Publication of KR920014481A publication Critical patent/KR920014481A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476—Particles, beads, capsules, spheres
    • A61K49/0485—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A61K49/049—Surface-modified nanoparticles, e.g. immune-nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414—Particles, beads, capsules or spheres
    • A61K49/0423—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414—Particles, beads, capsules or spheres
    • A61K49/0423—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A61K49/0428—Surface-modified nanoparticles, e.g. immuno-nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

의료용 화상형성에 유용한 X-선 콘트라스트 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (16)

  1. 평균 유효 입자크기가 400nm 미만이 되도록 유지하기 충분한 양만큼의 표면 변형제가 표면위에 흡착되어있는 비-방사성 결정형 유기 X-선 콘트라스트제와 의약용으로 적당한 이의 담체로 구성된 미립자로 이루어진 X-선 콘트라스트 조성물.
  2. 제1항에 있어서, 상기 입자의 유효 입자크기가 300nm 미만인 조성물.
  3. 제1항에 있어서, 상기 입자의 유효 입자크기가 200nm 미만인 조성물.
  4. 제1항에 있어서, 상기 입자의 유효 입자크기가 100nm 미만인 조성물.
  5. 제1항부터 제4항까지중 어느 한 항에 있어서, 상기 X-선 콘트라스트제가 요오드화된 방향족 화합물인 조성물.
  6. 제1항부터 제5항까지중 어느 한 항에 있어서, 상기 X-선 콘트라스트제가 디아트리조산, 메트리조산, 아이오탈라민산 및 트리메신산으로 구성된 그룹에서부터 선택된 요오드화된 방향족산의 에스테르 또는 아미드인 조성물.
  7. 제1항부터 제7항까지중 어느 한 항에 있어서, X-선 콘트라스트제가 에틸-3,5-디아세토아미도-2,4,6-트리아이오도벤조에이트, 에틸(3,5-비스(아세틸아미노)-2,4,6-트리아이오도벤조일옥시)아세테이트 또는 에틸-2-(3,5-비스(아세틸아미노)-2,4,6-트리아이오도벤조일옥시)부티레이트인 조성물.
  8. 제1항부터 제7항까지중 어느 한 항에 있어서, 상기 담체가 수성 액체인 조성물.
  9. 제1항부터 제8항까지중 어느 한 항에 있어서, 상기 입자가 10-25wt%의 양으로 존재하는 조성물.
  10. 제1항부터 제9항까지중 어느 한 항에 있어서, 상기 표면변형제가 에틸렌디아민에 산화 프로필렌과 산화에틸렌을 연속적으로 부가하여 만든 4 기능 블럭 공중합체인 조성물.
  11. 제1항부터 제9항까지중 어느 한 항에 있어서, 상기 표면변형제의 일반식이 다음과 같은 조성물.
    식중, L은
    L'은 화학결합 -O-, -S-, -NH-, -CONH- 또는 -SO2NH-; R은 소수성의 치환되었거나 그렇지 않은 알킬, 치환되었거나 그렇지않은 시클로알킬, 또는 치환되었거나 그렇지않은 아릴 그룹; 각각의 R1과 R2는 서로 무관하게 수소 또는 C1-4알킬그룹; 각각의 a와 b는 a와 b의 합이 3보다 크지않다는 조건을 만족한다면 서로 무관하게 0 또는 1-3의 정수; 각각의 x와 y는 서로 무관하게 3-7의 정수.
  12. 에틸렌디아민에 산화에틸렌과 산화프로필렌을 연속적으로 부가하여 만든 4 기능 블럭 공중합체가 표면위에 흡착되어 있는 결정형 에틸-3,5-디아세트아미도-2,4,6-트리아이오도벤조에이트로 구성된 미립자로 이루어진 제1항의 조성물.
  13. 에틸렌디아민에 산화에틸렌과 산화프로필렌을 연속적으로 부가하여 만든 4 기능 블럭 공중합체가 표면위에 흡착되어 있는 디아트리조산의 에틸 글리코레이트 에스테르의 결정으로 구성된 미립자로 이루어진 제1항의 조성물.
  14. 에틸렌디아민에 산화에틸렌과 산화프로필렌을 연속적으로 부가하여 만든 4 기능 블럭 공중합체가 표면위에 흡착되어 있는 결정형 에틸-2-(3,5-비스(아세틸아미노)-2,4,6-트리아이오도벤조일옥시)부티레이트로 구성된 미립자로 이루어진 제1항의 조성물.
  15. 콘트라스트를 만들기에 충분한 양만큼의 제1-14항중 어느 한 항의 조성물을 시험하려고 하는 대상의 몸체에 주입하는 것으로 구성된 의료용 X-선 진단 화상형성 방법.
  16. 분쇄용기에 비-방사성 유기 X-선 콘트라스트제, 액상 매질, 평균 입자크기가 3mm 미만인 딱딱한 분쇄용 매질 및 임의의 표면 변형제를 넣고; 상기한 콘트라스트제를 습식 분쇄한뒤 분쇄하는 동안 표면 변형제가 없었다면 상기 액상 매질을 표면 변형제와 혼합하여 평균 입자크기가 약 400nm 미만인 미립자를 만든 다음; 상기 분쇄 용기 및 매질에서 상기 미립자를 분리해내는 단계를 포함하는 X-선 콘트라스트 조성물의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920001076A 1991-01-25 1992-01-25 의료용 화상형성에 유용한 x-선 콘트라스트 조성물 KR920014481A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/647,105 US5145684A (en) 1991-01-25 1991-01-25 Surface modified drug nanoparticles
US91/647,105 1991-01-25
US81026191A 1991-12-19 1991-12-19
US91/810,261 1991-12-19

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KR920014481A true KR920014481A (ko) 1992-08-25

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US (2) US5318767A (ko)
EP (1) EP0498482B1 (ko)
JP (1) JPH04317053A (ko)
KR (1) KR920014481A (ko)
AT (1) ATE184202T1 (ko)
AU (1) AU642066B2 (ko)
CA (1) CA2059431A1 (ko)
DE (1) DE69229925T2 (ko)
DK (1) DK0498482T3 (ko)
ES (1) ES2139586T3 (ko)
FI (1) FI920322A (ko)
GR (1) GR3032059T3 (ko)
HU (1) HU208497B (ko)
IE (1) IE920218A1 (ko)
IL (1) IL100755A (ko)
MX (1) MX9200292A (ko)
MY (1) MY109075A (ko)
NO (1) NO920333L (ko)
NZ (1) NZ241361A (ko)
PH (1) PH30756A (ko)
RU (1) RU2074002C1 (ko)
TW (1) TW199101B (ko)

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RU2074002C1 (ru) 1997-02-27
MY109075A (en) 1996-11-30
AU1014592A (en) 1992-07-30
CA2059431A1 (en) 1992-07-26
TW199101B (ko) 1993-02-01
EP0498482A3 (en) 1993-03-03
FI920322A (fi) 1992-07-26
HU9200227D0 (en) 1992-04-28
DK0498482T3 (da) 2000-03-27
DE69229925D1 (de) 1999-10-14
EP0498482A2 (en) 1992-08-12
IE920218A1 (en) 1992-07-29
NO920333D0 (no) 1992-01-24
ATE184202T1 (de) 1999-09-15
HUT60635A (en) 1992-10-28
IL100755A (en) 1995-12-08
JPH04317053A (ja) 1992-11-09
DE69229925T2 (de) 2000-02-17
FI920322A0 (fi) 1992-01-24
PH30756A (en) 1997-10-17
IL100755A0 (en) 1992-09-06
EP0498482B1 (en) 1999-09-08
NZ241361A (en) 1993-06-25
AU642066B2 (en) 1993-10-07
GR3032059T3 (en) 2000-03-31
US5451393A (en) 1995-09-19
NO920333L (no) 1992-07-27
HU208497B (en) 1993-11-29
MX9200292A (es) 1992-10-01
US5318767A (en) 1994-06-07
ES2139586T3 (es) 2000-02-16

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