BRPI0606283A2 - formulações de antagonista de receptor de leucotrieno/corticosteróide em nanopartìcula - Google Patents
formulações de antagonista de receptor de leucotrieno/corticosteróide em nanopartìculaInfo
- Publication number
- BRPI0606283A2 BRPI0606283A2 BRPI0606283-0A BRPI0606283A BRPI0606283A2 BR PI0606283 A2 BRPI0606283 A2 BR PI0606283A2 BR PI0606283 A BRPI0606283 A BR PI0606283A BR PI0606283 A2 BRPI0606283 A2 BR PI0606283A2
- Authority
- BR
- Brazil
- Prior art keywords
- receptor antagonist
- leukotriene receptor
- corticosteroid
- formulations
- adult
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 7
- 239000003199 leukotriene receptor blocking agent Substances 0.000 title abstract 4
- 239000003246 corticosteroid Substances 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 title abstract 3
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 abstract 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 abstract 1
- 208000036284 Rhinitis seasonal Diseases 0.000 abstract 1
- 102000007451 Steroid Receptors Human genes 0.000 abstract 1
- 208000002205 allergic conjunctivitis Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 208000024998 atopic conjunctivitis Diseases 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 108091008723 corticosteroid receptors Proteins 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 231100000304 hepatotoxicity Toxicity 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 230000007056 liver toxicity Effects 0.000 abstract 1
- 239000002105 nanoparticle Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 208000017022 seasonal allergic rhinitis Diseases 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Abstract
FORMULAçõES DE ANTAGONISTA DE RECEPTOR DE LEUCOTRIENO/CORTICOSTERóIDE EM NANOPARTìCULA. A presente invenção refere-se a composições em nanopartícula, que compreende um corticosterólde e um antagonista de receptor de leucotrieno são descritas. As composições são úteis na profilaxia e tratamentocrónico de asma em pacientes adultos e pediátricos e para o alívio de conjuntivite alérgica, sintomas de rinite alérgica sazonal em pacientes adultos e pediátricos. Combinação de um antagonista de receptor de leucotrieno com um corticosteróide em faixas de tamanho de partícula de menos do que 2000 nm em uma formulação única resulta em eficácia aperfeiçoada. Ainda, a obediência do paciente é aumentada uma vez que apenas uma forma de dosagem é necessária. Ainda, administração local do antagonista de receptor de leucotrieno resulta em menos toxidez do fígado uma vez que o fígado será exposto a quantidades menores de fármaco do que acontece seguindo administração oral. As composições de fármaco de acordo com a invenção podem ser formuladas em formulações para inalação, nasais ou oculares.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66233905P | 2005-03-16 | 2005-03-16 | |
PCT/US2006/009837 WO2006099591A1 (en) | 2005-03-16 | 2006-03-16 | Nanoparticulate leukotriene receptor antagonist/corticosteroid formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0606283A2 true BRPI0606283A2 (pt) | 2009-06-09 |
Family
ID=36615692
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0606283-0A BRPI0606283A2 (pt) | 2005-03-16 | 2006-03-16 | formulações de antagonista de receptor de leucotrieno/corticosteróide em nanopartìcula |
Country Status (14)
Country | Link |
---|---|
US (1) | US20070065374A1 (pt) |
EP (1) | EP1863450A1 (pt) |
JP (1) | JP2008533174A (pt) |
KR (1) | KR20070118258A (pt) |
CN (1) | CN101175480A (pt) |
AU (1) | AU2006225117A1 (pt) |
BR (1) | BRPI0606283A2 (pt) |
CA (1) | CA2601179A1 (pt) |
EA (1) | EA200701987A1 (pt) |
IL (1) | IL185951A0 (pt) |
MX (1) | MX2007011502A (pt) |
NO (1) | NO20075291L (pt) |
WO (1) | WO2006099591A1 (pt) |
ZA (1) | ZA200708456B (pt) |
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US8324192B2 (en) | 2005-11-12 | 2012-12-04 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
US8679545B2 (en) | 2005-11-12 | 2014-03-25 | The Regents Of The University Of California | Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract |
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WO2008008733A2 (en) * | 2006-07-10 | 2008-01-17 | Elan Pharma International Ltd. | Nanoparticulate sorafenib formulations |
US20080213181A1 (en) * | 2006-12-21 | 2008-09-04 | Bristol-Myers Squibb Pharma Company | Preparation of Paramagnetic Nanoparticles Conjugated to Leukotriene B4 (LTB4) Receptor Antagonists, and Their Use as MRI Contrast Agents for the Detection of Infection and Inflammation |
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-
2006
- 2006-03-16 CA CA002601179A patent/CA2601179A1/en not_active Abandoned
- 2006-03-16 BR BRPI0606283-0A patent/BRPI0606283A2/pt not_active IP Right Cessation
- 2006-03-16 AU AU2006225117A patent/AU2006225117A1/en not_active Abandoned
- 2006-03-16 EA EA200701987A patent/EA200701987A1/ru unknown
- 2006-03-16 US US11/376,553 patent/US20070065374A1/en not_active Abandoned
- 2006-03-16 JP JP2008502115A patent/JP2008533174A/ja not_active Withdrawn
- 2006-03-16 MX MX2007011502A patent/MX2007011502A/es not_active Application Discontinuation
- 2006-03-16 KR KR1020077023439A patent/KR20070118258A/ko not_active Application Discontinuation
- 2006-03-16 EP EP06738842A patent/EP1863450A1/en not_active Withdrawn
- 2006-03-16 CN CNA2006800170773A patent/CN101175480A/zh active Pending
- 2006-03-16 WO PCT/US2006/009837 patent/WO2006099591A1/en active Application Filing
-
2007
- 2007-09-16 IL IL185951A patent/IL185951A0/en unknown
- 2007-10-03 ZA ZA200708456A patent/ZA200708456B/xx unknown
- 2007-10-16 NO NO20075291A patent/NO20075291L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1863450A1 (en) | 2007-12-12 |
NO20075291L (no) | 2007-11-21 |
CN101175480A (zh) | 2008-05-07 |
JP2008533174A (ja) | 2008-08-21 |
WO2006099591A1 (en) | 2006-09-21 |
KR20070118258A (ko) | 2007-12-14 |
US20070065374A1 (en) | 2007-03-22 |
ZA200708456B (en) | 2009-05-27 |
IL185951A0 (en) | 2008-01-06 |
CA2601179A1 (en) | 2006-09-21 |
MX2007011502A (es) | 2007-12-07 |
EA200701987A1 (ru) | 2008-02-28 |
AU2006225117A1 (en) | 2006-09-21 |
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