CY1108900T1 - Πολυθειωμενα γλυκοζιδια και αλατα αυτων - Google Patents

Πολυθειωμενα γλυκοζιδια και αλατα αυτων

Info

Publication number
CY1108900T1
CY1108900T1 CY20081100899T CY081100899T CY1108900T1 CY 1108900 T1 CY1108900 T1 CY 1108900T1 CY 20081100899 T CY20081100899 T CY 20081100899T CY 081100899 T CY081100899 T CY 081100899T CY 1108900 T1 CY1108900 T1 CY 1108900T1
Authority
CY
Cyprus
Prior art keywords
salts
polyphylened
glucose
asthma
airways
Prior art date
Application number
CY20081100899T
Other languages
English (en)
Inventor
Janos Kuszmann
Istvan Kurucz
Gabor Medgyes
Nicholas Bodor
Original Assignee
Ivax Drug Research Institute Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ivax Drug Research Institute Ltd filed Critical Ivax Drug Research Institute Ltd
Publication of CY1108900T1 publication Critical patent/CY1108900T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Steroid Compounds (AREA)

Abstract

Η εφεύρεση αφορά πολυθειωμένα γλυκοζίδια του τύπου (I), τα φαρμακευτικώς αποδεκτά άλατα αυτών, καθώς επίσης τις φαρμακευτικές συνθέσεις που περιέχουν αυτές τις ενώσεις ως δραστικά συστατικά. Περαιτέρω η εφεύρεση παρέχει μέθοδο αποτροπής, θεραπείας ή ανακούφισης των συμπτωμάτων οξειών και χρόνιων φλεγμονωδών διαταραχών των αεροδών θηλαστικών, συμπεριλαμβανομένου άσθματος και σχετικών με άσθμα παθολογιών.
CY20081100899T 2004-08-05 2008-08-25 Πολυθειωμενα γλυκοζιδια και αλατα αυτων CY1108900T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59914804P 2004-08-05 2004-08-05
EP05783149A EP1778709B1 (en) 2004-08-05 2005-08-05 Polysulfated glycosides and salts thereof

Publications (1)

Publication Number Publication Date
CY1108900T1 true CY1108900T1 (el) 2014-07-02

Family

ID=35781354

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081100899T CY1108900T1 (el) 2004-08-05 2008-08-25 Πολυθειωμενα γλυκοζιδια και αλατα αυτων

Country Status (25)

Country Link
US (2) US7902158B2 (el)
EP (1) EP1778709B1 (el)
JP (1) JP5164572B2 (el)
KR (1) KR101097702B1 (el)
CN (1) CN101014607B (el)
AT (1) ATE397006T1 (el)
AU (1) AU2005271349B2 (el)
BR (1) BRPI0513095A (el)
CA (1) CA2576131C (el)
CY (1) CY1108900T1 (el)
DE (1) DE602005007244D1 (el)
DK (1) DK1778709T3 (el)
ES (1) ES2308536T3 (el)
HK (1) HK1098758A1 (el)
IL (1) IL181095A (el)
MX (1) MX2007001444A (el)
NO (1) NO20070987L (el)
NZ (1) NZ553292A (el)
PL (1) PL1778709T3 (el)
PT (1) PT1778709E (el)
RU (1) RU2413734C2 (el)
SI (1) SI1778709T1 (el)
UA (1) UA87154C2 (el)
WO (1) WO2006017726A2 (el)
ZA (1) ZA200700758B (el)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2413734C2 (ru) 2004-08-05 2011-03-10 Ивакс Драг Рисерч Инститьют Лтд Полисульфатированные гликозиды и их соли
CN102256990B (zh) * 2008-10-03 2014-09-24 聚糖生物科学有限责任公司 阴离子寡糖轭合物
KR101678429B1 (ko) * 2009-02-02 2016-11-22 오츠카 세이야쿠 가부시키가이샤 저분자량 다황산화 히알루론산 유도체 및 이를 함유하는 의약
RU2012112552A (ru) * 2009-08-31 2013-10-10 Дипомед, Инк. Удерживаемые в желудке фармацевтические композиции для немедленного и продленного высвобождения ацетаминофена
CN102711463B (zh) 2009-12-03 2015-05-13 Opko健康公司 超硫酸化双糖制剂
RU2013116520A (ru) * 2010-10-29 2014-12-10 Опко Хелс, Инк. Гиперсульфатированные дисахариды для лечения нарушений, связанных с эластазой
WO2012058719A1 (en) * 2010-11-02 2012-05-10 The Universtity Of Sydney Inhalable compositions
PL3274347T3 (pl) * 2015-03-26 2021-02-08 Giuliani S.P.A. Związki o aktywności przeciwutleniającej względem wolnych rodników i o aktywności przeciwzapalnej oraz odpowiednie kompozycje farmaceutyczne do pielęgnacji skóry
EP3500583A1 (en) 2016-08-16 2019-06-26 OPKO Pharmaceuticals, LLC Pure heptasulfated disaccharides having improved oral bioavailability
JP6225321B1 (ja) 2016-08-31 2017-11-08 王子ホールディングス株式会社 ポリ硫酸ペントサンの製造方法
MX2020002288A (es) 2016-08-31 2020-07-14 Oji Holdings Corp Metodo de produccion para xilooligosacarido acido y xilooligosacarido acido.
JP6281659B1 (ja) 2017-02-28 2018-02-21 王子ホールディングス株式会社 ポリ硫酸ペントサン、医薬組成物及び抗凝固剤
BR112019025030A2 (pt) 2017-05-31 2020-06-16 Oji Holdings Corporation Preparação umidificante tópica.
AU2018333249B2 (en) 2017-09-12 2023-03-02 Oji Holdings Corporation Pentosan polysulfate and method for producing pentosan polysulfate
KR102533822B1 (ko) 2017-12-20 2023-05-17 오지 홀딩스 가부시키가이샤 폴리황산펜토산 및 폴리황산펜토산을 포함하는 의약

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US5380716A (en) * 1988-12-15 1995-01-10 Glycomed, Inc. Sulfated polysaccharides as inhibitors of smooth muscle cell proliferation
IL102758A (en) 1991-08-23 1997-03-18 Akzo Nv Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them
JPH05164572A (ja) 1991-12-12 1993-06-29 Y E Data Inc エンコーダ
CA2136070C (en) * 1992-06-01 1997-06-03 Brad K. Bendiak Sequential removal of monosaccharides from the reducing end of oligosaccharides and uses thereof
DE4408248A1 (de) * 1994-03-11 1995-09-14 Hoechst Ag Physiologisch verträgliche und physiologisch abbaubare Kohlenhydrat-Mimetika, ein Verfahren zur Herstellung und ihre Verwendung
US5783568A (en) * 1994-06-10 1998-07-21 Sugen, Inc. Methods for treating cancer and other cell proliferative diseases
JPH08109134A (ja) * 1994-10-11 1996-04-30 Sanwa Kagaku Kenkyusho Co Ltd 細胞変成抑制並びに臓器毒性軽減剤
US6153736A (en) * 1995-09-27 2000-11-28 The Liposome Company, Inc. Modified ether glyceroglycolipids
JPH09183789A (ja) 1995-10-31 1997-07-15 Sanwa Kagaku Kenkyusho Co Ltd 新規な硫酸化及び燐酸化糖誘導体、その製法及び用途
AU5706699A (en) * 1998-11-24 2000-06-13 American Home Products Corporation Benzyllactobionamides as inhibitors of smooth muscle cell proliferation
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PT1381620E (pt) * 2001-04-16 2006-06-30 Ivax Research Inc Dissacaridos hipersulfatados e metodos de utilizacao dos mesmos para o tratamento de inflamacoes
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Also Published As

Publication number Publication date
WO2006017726A2 (en) 2006-02-16
ES2308536T3 (es) 2008-12-01
CA2576131A1 (en) 2006-02-16
WO2006017726A3 (en) 2006-04-20
US20070281893A1 (en) 2007-12-06
AU2005271349A1 (en) 2006-02-16
IL181095A0 (en) 2007-07-04
BRPI0513095A (pt) 2008-03-11
ZA200700758B (en) 2008-08-27
EP1778709A2 (en) 2007-05-02
HK1098758A1 (en) 2007-07-27
JP2008509156A (ja) 2008-03-27
US7902158B2 (en) 2011-03-08
IL181095A (en) 2013-07-31
US8987216B2 (en) 2015-03-24
AU2005271349B2 (en) 2011-10-27
DK1778709T3 (da) 2008-09-22
EP1778709B1 (en) 2008-05-28
PL1778709T3 (pl) 2008-10-31
NO20070987L (no) 2007-04-11
DE602005007244D1 (de) 2008-07-10
MX2007001444A (es) 2007-07-04
RU2007107935A (ru) 2008-09-10
SI1778709T1 (sl) 2008-12-31
ATE397006T1 (de) 2008-06-15
KR20070042188A (ko) 2007-04-20
CA2576131C (en) 2012-04-24
UA87154C2 (uk) 2009-06-25
CN101014607A (zh) 2007-08-08
RU2413734C2 (ru) 2011-03-10
US20110118198A1 (en) 2011-05-19
KR101097702B1 (ko) 2011-12-22
PT1778709E (pt) 2008-07-24
NZ553292A (en) 2009-06-26
CN101014607B (zh) 2014-05-14
JP5164572B2 (ja) 2013-03-21

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