DE602005007244D1 - Polysulfatierte glykoside und salze davon - Google Patents

Polysulfatierte glykoside und salze davon

Info

Publication number
DE602005007244D1
DE602005007244D1 DE602005007244T DE602005007244T DE602005007244D1 DE 602005007244 D1 DE602005007244 D1 DE 602005007244D1 DE 602005007244 T DE602005007244 T DE 602005007244T DE 602005007244 T DE602005007244 T DE 602005007244T DE 602005007244 D1 DE602005007244 D1 DE 602005007244D1
Authority
DE
Germany
Prior art keywords
glycosides
salts
polysulpated
asthma
airways
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005007244T
Other languages
English (en)
Inventor
Janos Kuszmann
Istvan Kurucz
Gabor Medgyes
Nicholas Bodor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Hungary Pharmaceutical Marketing PLC
Original Assignee
Ivax Drug Research Institute Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ivax Drug Research Institute Ltd filed Critical Ivax Drug Research Institute Ltd
Publication of DE602005007244D1 publication Critical patent/DE602005007244D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Steroid Compounds (AREA)
DE602005007244T 2004-08-05 2005-08-05 Polysulfatierte glykoside und salze davon Active DE602005007244D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59914804P 2004-08-05 2004-08-05
PCT/US2005/027877 WO2006017726A2 (en) 2004-08-05 2005-08-05 Polysulfated glycosides and salts thereof

Publications (1)

Publication Number Publication Date
DE602005007244D1 true DE602005007244D1 (de) 2008-07-10

Family

ID=35781354

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005007244T Active DE602005007244D1 (de) 2004-08-05 2005-08-05 Polysulfatierte glykoside und salze davon

Country Status (25)

Country Link
US (2) US7902158B2 (de)
EP (1) EP1778709B1 (de)
JP (1) JP5164572B2 (de)
KR (1) KR101097702B1 (de)
CN (1) CN101014607B (de)
AT (1) ATE397006T1 (de)
AU (1) AU2005271349B2 (de)
BR (1) BRPI0513095A (de)
CA (1) CA2576131C (de)
CY (1) CY1108900T1 (de)
DE (1) DE602005007244D1 (de)
DK (1) DK1778709T3 (de)
ES (1) ES2308536T3 (de)
HK (1) HK1098758A1 (de)
IL (1) IL181095A (de)
MX (1) MX2007001444A (de)
NO (1) NO20070987L (de)
NZ (1) NZ553292A (de)
PL (1) PL1778709T3 (de)
PT (1) PT1778709E (de)
RU (1) RU2413734C2 (de)
SI (1) SI1778709T1 (de)
UA (1) UA87154C2 (de)
WO (1) WO2006017726A2 (de)
ZA (1) ZA200700758B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006017726A2 (en) 2004-08-05 2006-02-16 Ivax Drug Research Institute Ltd Polysulfated glycosides and salts thereof
EP2421878B1 (de) * 2008-10-03 2017-06-14 Glycan Biosciences LLC Anionische oligosaccharidkonjugate
UA105781C2 (uk) * 2009-02-02 2014-06-25 Оцука Фармасьютікал Ко., Лтд. Низькомолекулярне полісульфатоване похідне гіалуронової кислоти і лікарський засіб, який його містить
AU2010286354A1 (en) * 2009-08-31 2012-04-19 Depomed, Inc. Gastric retentive pharmaceutical compositions for immediate and extended release of acetaminophen
WO2011068721A1 (en) 2009-12-03 2011-06-09 Opko Health, Inc. Hypersulfated disaccharide formulations
WO2012058424A1 (en) * 2010-10-29 2012-05-03 Opko Health, Inc. Hypersulfated disaccharides to treat elastase related disorders
WO2012058719A1 (en) * 2010-11-02 2012-05-10 The Universtity Of Sydney Inhalable compositions
WO2016151009A1 (en) * 2015-03-26 2016-09-29 Giuliani S.P.A. Compounds having antioxidant activity against free radicals and anti-inflammatory activity, and corresponding pharmaceutical or cosmetic compositions for skin care
WO2018035050A1 (en) 2016-08-16 2018-02-22 Opko Pharmaceuticals, Llc Pure heptasulfated disaccharides having improved oral bioavailability
JP6225321B1 (ja) 2016-08-31 2017-11-08 王子ホールディングス株式会社 ポリ硫酸ペントサンの製造方法
BR112020003908B1 (pt) 2016-08-31 2023-01-24 Oji Holdings Corporation Método para produzir um ingrediente farmacêutico ativo incluindo polissulfato de pentosano
JP6281659B1 (ja) * 2017-02-28 2018-02-21 王子ホールディングス株式会社 ポリ硫酸ペントサン、医薬組成物及び抗凝固剤
BR112019025030A2 (pt) 2017-05-31 2020-06-16 Oji Holdings Corporation Preparação umidificante tópica.
AU2018333249B2 (en) 2017-09-12 2023-03-02 Oji Holdings Corporation Pentosan polysulfate and method for producing pentosan polysulfate
MX2020006605A (es) 2017-12-20 2020-09-10 Oji Holdings Corp Polisulfato de pentosano y medicamento que contiene polisulfato de pentosano.

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021544A (en) * 1976-07-12 1977-05-03 American Cyanamid Company Complement inhibitors
DE3734815A1 (de) * 1987-10-14 1989-04-27 Luitpold Werk Chem Pharm Polyschwefelsaeureester von bis-aldonsaeureamiden und deren derivaten, verfahren zu ihrer herstellung und arzneimittel
DK505488D0 (da) * 1987-12-21 1988-09-09 Bar Shalom Daniel Middel og anvendelse af samme
US5380716A (en) 1988-12-15 1995-01-10 Glycomed, Inc. Sulfated polysaccharides as inhibitors of smooth muscle cell proliferation
IL102758A (en) 1991-08-23 1997-03-18 Akzo Nv Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them
JPH05164572A (ja) 1991-12-12 1993-06-29 Y E Data Inc エンコーダ
JP3009731B2 (ja) 1992-06-01 2000-02-14 ザ バイオメンブレイン インスティテュート オリゴ糖の還元性末端からの単糖の順次の除去およびそれらの使用
DE4408248A1 (de) * 1994-03-11 1995-09-14 Hoechst Ag Physiologisch verträgliche und physiologisch abbaubare Kohlenhydrat-Mimetika, ein Verfahren zur Herstellung und ihre Verwendung
US5783568A (en) * 1994-06-10 1998-07-21 Sugen, Inc. Methods for treating cancer and other cell proliferative diseases
JPH08109134A (ja) * 1994-10-11 1996-04-30 Sanwa Kagaku Kenkyusho Co Ltd 細胞変成抑制並びに臓器毒性軽減剤
US6153736A (en) * 1995-09-27 2000-11-28 The Liposome Company, Inc. Modified ether glyceroglycolipids
JPH09183789A (ja) 1995-10-31 1997-07-15 Sanwa Kagaku Kenkyusho Co Ltd 新規な硫酸化及び燐酸化糖誘導体、その製法及び用途
AU5706699A (en) * 1998-11-24 2000-06-13 American Home Products Corporation Benzyllactobionamides as inhibitors of smooth muscle cell proliferation
JP4913272B2 (ja) 1999-01-07 2012-04-11 生化学工業株式会社 オリゴ糖の製造方法ならびに新規オリゴ糖およびそれを含む医薬組成物
ES2258145T3 (es) * 2001-04-16 2006-08-16 Ivax Research, Inc. Disacaridos hipersulfatados y procedimientos para la utilizacion de los mismos en el tratamiento de las inflamaciones.
JP2005531611A (ja) * 2002-06-07 2005-10-20 ズートツッカー アクチェンゲゼルシャフト マンハイム／オクセンフルト ガラクトシル・イソマルト、その製造方法及び使用
WO2006017726A2 (en) 2004-08-05 2006-02-16 Ivax Drug Research Institute Ltd Polysulfated glycosides and salts thereof
US8777575B2 (en) 2008-10-16 2014-07-15 Rolls-Royce Aktiebolag Method and arrangement for propeller pitch control

Also Published As

Publication number Publication date
MX2007001444A (es) 2007-07-04
AU2005271349A1 (en) 2006-02-16
BRPI0513095A (pt) 2008-03-11
CA2576131C (en) 2012-04-24
HK1098758A1 (en) 2007-07-27
KR101097702B1 (ko) 2011-12-22
PL1778709T3 (pl) 2008-10-31
NO20070987L (no) 2007-04-11
ATE397006T1 (de) 2008-06-15
CY1108900T1 (el) 2014-07-02
NZ553292A (en) 2009-06-26
IL181095A0 (en) 2007-07-04
CN101014607A (zh) 2007-08-08
EP1778709A2 (de) 2007-05-02
ZA200700758B (en) 2008-08-27
CA2576131A1 (en) 2006-02-16
AU2005271349B2 (en) 2011-10-27
JP2008509156A (ja) 2008-03-27
RU2413734C2 (ru) 2011-03-10
CN101014607B (zh) 2014-05-14
SI1778709T1 (sl) 2008-12-31
US8987216B2 (en) 2015-03-24
PT1778709E (pt) 2008-07-24
UA87154C2 (uk) 2009-06-25
US7902158B2 (en) 2011-03-08
WO2006017726A2 (en) 2006-02-16
ES2308536T3 (es) 2008-12-01
JP5164572B2 (ja) 2013-03-21
KR20070042188A (ko) 2007-04-20
RU2007107935A (ru) 2008-09-10
WO2006017726A3 (en) 2006-04-20
DK1778709T3 (da) 2008-09-22
US20070281893A1 (en) 2007-12-06
US20110118198A1 (en) 2011-05-19
EP1778709B1 (de) 2008-05-28
IL181095A (en) 2013-07-31

Similar Documents

Publication Publication Date Title
ATE397006T1 (de) Polysulfatierte glykoside und salze davon
NO20025601D0 (no) Arylmetylaminderivater for anvendelse som tryptaseinhibitorer
GB0625648D0 (en) Compounds
ATE442349T1 (de) Diacylglycerol-acyltransferase-hemmer
EA200900613A1 (ru) Спирокетоновые ингибиторы ацетил-коа-карбоксилаз
NO20082000L (no) Pyrimidinamidforbindelser som PGDS-inhibitorer
EA200702339A1 (ru) Замещенные амидные производные в качестве ингибиторов протеинкиназы
MX2012000488A (es) Terapia de combinacion para el tratamiento de la diabetes.
HK1087702A1 (en) Arylmethylamine derivatives for use as tryptase inhibitors
HK1142062A1 (en) Oxadiazole derivatives active on sphingosine-1-phosphate (s1p)
SE0403006D0 (sv) New compounds
WO2007143557A3 (en) Compounds and methods for treating mammalian gastrointestinal parasitic infections
WO2006017752A8 (en) Sulfated oligosaccharides
WO2005112914A3 (en) Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
JP2007501270A5 (de)
WO2005023792A3 (en) Macrocyclic compounds useful as pharmaceuticals
IS7899A (is) Samverkandi samsetning sem felur í sér róflúmílast og (R.R)-formóteról
WO2006017727A3 (en) Glycosides and salts thereof
SG126014A1 (en) Treatment of asthma
WO2008022242A3 (en) Synthesis of propyl phenoxy ethers and use as delivery agents
WO2004069195A3 (en) Methods and compositions for treating inflammatory disorders of the airways
NZ622993A (en) Combination therapy for the treatment of diabetes

Legal Events

Date Code Title Description
8364 No opposition during term of opposition