AR035827A1 - Disacaridos hipersulfatados - Google Patents

Disacaridos hipersulfatados

Info

Publication number
AR035827A1
AR035827A1 ARP020101380A ARP020101380A AR035827A1 AR 035827 A1 AR035827 A1 AR 035827A1 AR P020101380 A ARP020101380 A AR P020101380A AR P020101380 A ARP020101380 A AR P020101380A AR 035827 A1 AR035827 A1 AR 035827A1
Authority
AR
Argentina
Prior art keywords
group
independently
members
hypersulphated
disablets
Prior art date
Application number
ARP020101380A
Other languages
English (en)
Inventor
Tahir Ahmed
Gregory A Smith
Original Assignee
Ivax Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ivax Research Inc filed Critical Ivax Research Inc
Publication of AR035827A1 publication Critical patent/AR035827A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Polymers & Plastics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Disacáridos hipersulfatados, que tienen estructura (1), en el cual R1, R2, R3, R4, R5 y R6 son SO3-; PO3-o H; y R1, R2, R3, R4, R5, y R6 son cada uno independientemente ya sea SO3- o PO3-; por lo menos cinco integrantes del grupo constituido por R1, R2, R3, R4, R5, y R6 son cada uno independientemente ya sea SO3- o PO3-; o por lo menos cuatro integrantes del grupo constituido por R1, R2, R3, R4, R5 y R6 son cada uno independientemente ya sea SO3- o PO3-; o a) por lo menos tres integrantes del grupo constituido por R1, R2, R3, R4, R5 y R6 son cada uno independientemente ya sea SO3- o PO3-; o b) por los menos dos integrantes del grupo constituido por R1, R2, R3, R4, R5 y R6 son cada uno independientemente ya sea SO3- o PO3-; o c) con la condición que, si: (i) R3 y R4 son ambos SO3- entonces por lo menos un integrante del grupo constituido por R1, R2, R5 y R6 es SO3-o PO3-; o (ii) R3, R4, R5 son SO3- entonces por lo menos un integrante del grupo constituido por R1, R2, y R6 es SO3-, o PO3-; o (iii) R1 y R4 son ambos SO3- y R3 no es SO3-, entonces por lo menos un integrante del grupo constituido por R2, R5 y R6 es SO3-; o PO3-. Estos compuestos son útiles para tratar inflamaciones, en particular, inflamaciones pulmonares, incluyendo asma y patologías relacionadas con el asma, como la alergia.
ARP020101380A 2001-04-16 2002-04-16 Disacaridos hipersulfatados AR035827A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28479001P 2001-04-16 2001-04-16

Publications (1)

Publication Number Publication Date
AR035827A1 true AR035827A1 (es) 2004-07-14

Family

ID=23091543

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020101380A AR035827A1 (es) 2001-04-16 2002-04-16 Disacaridos hipersulfatados

Country Status (13)

Country Link
US (1) US7056898B2 (es)
EP (1) EP1381620B1 (es)
JP (1) JP2005510453A (es)
KR (1) KR20040008157A (es)
AR (1) AR035827A1 (es)
AT (1) ATE321064T1 (es)
CA (1) CA2444761A1 (es)
DE (1) DE60210070T2 (es)
DK (1) DK1381620T3 (es)
ES (1) ES2258145T3 (es)
NZ (1) NZ529036A (es)
PT (1) PT1381620E (es)
WO (1) WO2002083700A2 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005075490A2 (en) * 2004-02-03 2005-08-18 Ivax Corporation Synthesis of polysulfated uronic acid glycosides
EP1731131A1 (en) * 2004-03-29 2006-12-13 Kringle Pharma Inc. Hgf production accelerator containing heparin-like oligosaccharide
WO2006017727A2 (en) * 2004-08-05 2006-02-16 Ivax Corporation Glycosides and salts thereof
WO2006017726A2 (en) * 2004-08-05 2006-02-16 Ivax Drug Research Institute Ltd Polysulfated glycosides and salts thereof
EP2506711B1 (en) * 2009-12-03 2019-04-03 OPKO Health, Inc. Hypersulfated disaccharide formulations
JP2014500863A (ja) * 2010-10-29 2014-01-16 オプコ ヘルス インコーポレイテッド エラスターゼ関連障害を治療するための高硫酸化二糖
JP5871500B2 (ja) * 2011-06-20 2016-03-01 公益財団法人先端医療振興財団 α−Ｋｌｏｔｈｏ／ＦＧＦ２３複合体形成阻害化合物
WO2018035050A1 (en) 2016-08-16 2018-02-22 Opko Pharmaceuticals, Llc Pure heptasulfated disaccharides having improved oral bioavailability

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL85145A (en) 1987-01-23 1994-08-26 Univ Australian Anti-metastatic pharmacological or veterinary preparations containing modified herpin with reduced anticoagulant activity
US5827886A (en) * 1997-05-07 1998-10-27 Thione International, Inc. Composition for relief of arthritis-induced symptoms

Also Published As

Publication number Publication date
PT1381620E (pt) 2006-06-30
NZ529036A (en) 2005-11-25
JP2005510453A (ja) 2005-04-21
US20030087875A1 (en) 2003-05-08
WO2002083700A3 (en) 2003-04-17
US7056898B2 (en) 2006-06-06
EP1381620A2 (en) 2004-01-21
DE60210070T2 (de) 2006-12-07
WO2002083700A2 (en) 2002-10-24
WO2002083700B1 (en) 2003-09-18
DE60210070D1 (de) 2006-05-11
EP1381620B1 (en) 2006-03-22
ATE321064T1 (de) 2006-04-15
DK1381620T3 (da) 2006-06-26
KR20040008157A (ko) 2004-01-28
ES2258145T3 (es) 2006-08-16
CA2444761A1 (en) 2002-10-24

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