KR920006505A - 커플링된 효소반응에 의해 l-포스피노트리신을 제조하는 방법 - Google Patents

커플링된 효소반응에 의해 l-포스피노트리신을 제조하는 방법 Download PDF

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KR920006505A
KR920006505A KR1019910016748A KR910016748A KR920006505A KR 920006505 A KR920006505 A KR 920006505A KR 1019910016748 A KR1019910016748 A KR 1019910016748A KR 910016748 A KR910016748 A KR 910016748A KR 920006505 A KR920006505 A KR 920006505A
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transaminase
phosphinothricin
hmpb
glutamate
ketoglutarate
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KR1019910016748A
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KR100190203B1 (ko
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바르취 클라우스
퓰링 게르트
슐츠 아르노
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이젠브룩, 라피세
훽스트 아크티엔게젤샤프트
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/14—Glutamic acid; Glutamine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

내용 없음

Description

커플링된 효소반응에 의해 L-포스피노트리신을 제조하는 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. a)적합한 트랜스아미나제 1의 존재하에서 아스파르테이프 및 α-케토글루타르에이트를 반응시켜 옥살아세테이트 및 글루타메이트를 수득한 후, b)적합한 트랜스아미나제 2의 존재하에서 글루타메이트 및 구조식(Ⅱ)의 HMPB를 반응시켜 α-케토글루타메이트 및 L-포스피노트리신을 수득하는 반응단계를 특징으로 하는 커플링된 효소반응(여기서, 아스파르테이트대 HMPB의 몰비는 0.5 내지 1.5대 1, 바람직하게는 0.8 내지 1.2대 1, 특히 동물비이고 글루타메이트 또는 α-케토글루타르에이트는 촉매량으로 첨가한다)으로, 구조식(Ⅱ)의 4-(하이드록시메틸포스피닐)-2-옥소부티르산(HMPB)으로 부터 구조식(Ⅰ)의 L-2-아미노-4-(하이드록시메틸포스피닐)부티르산(L-포스피노트리신)을 제조하는 방법.
  2. 제1항에 있어서, 글루다메니트 또는 α-케토글루타르에이트를 HMPB에 대해 0.01 내지 1대 1, 바람직하게는 0.01 내지 0.2대 1, 특히 0.05 내지 0.2대 1의 몰비로 첨가하는 방법.
  3. 제1항 또는 제2항에 있어서, 트랜스아미나제 1이 글루타메이트/옥살아세테이트 트랜스아미나제 활성(GOT활성)을 갖는 방법.
  4. 제3항에 있어서, GOT를 돼지, 에스케리치아 콜라이 또는 바실러스, 바람직하게는 에스케리치아 콜라이 또는 바실러스로부터 수득하는 방법.
  5. 제1항 또는 제2항에 있어서, 트랜스아미나제 2가 L-포스피노트리신 트랜스아미나제 활성을 갖는 방법.
  6. 제5항 있어서, L-포스피노트리신-특이적 트랜스아미나제를 에스케리치아 콜라이로 부터 수득하는 방법.
  7. 제1항 내지 제6항중 어느 한 항에 있어서, 옥살아세테이트가 다중 하전된 양이온, 바람직하게는 Al3+, Mg2+, Zn2+, Mn2+, Fe2+또는 Fe3+의 존재하에서 피루베이틀 탈카복실화되는 방법.
  8. 제7항에 있어서, 트랜스아미나제 1 및 트래스아미나제 2가 피루베이트를 알라닌으로 전환시키지 않는 방법.
  9. 제1항 내지 제8항중 어느 한 항에 있어서, 하나 이상의 트랜지스아미나제가 고정화된 형태로 존재하는 방법.
  10. 제9항에 있어서, 고정화된 트랜스아미나제가 컬럼 반응기내에 존재하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910016748A 1990-09-27 1991-09-26 커플링된 효소반응에 의해 l-포스피노트리신을 제조하는 방법 KR100190203B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4030578.3 1990-09-27
DE4030578A DE4030578A1 (de) 1990-09-27 1990-09-27 Verfahren zur herstellung von l-phosphinothricin durch eine gekoppelte enzymatische reaktion

Publications (2)

Publication Number Publication Date
KR920006505A true KR920006505A (ko) 1992-04-27
KR100190203B1 KR100190203B1 (ko) 1999-06-01

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KR1019910016748A KR100190203B1 (ko) 1990-09-27 1991-09-26 커플링된 효소반응에 의해 l-포스피노트리신을 제조하는 방법

Country Status (6)

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US (1) US6335186B1 (ko)
EP (1) EP0477902B1 (ko)
JP (1) JP3018261B2 (ko)
KR (1) KR100190203B1 (ko)
DE (2) DE4030578A1 (ko)
DK (1) DK0477902T3 (ko)

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WO2021151737A1 (en) 2020-01-31 2021-08-05 Basf Se Herbicide combinations comprising glufosinate and flumioxazin
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BR112022014955A2 (pt) 2020-01-31 2022-09-20 Basf Se Combinação herbicida, composição, métodos para produzir uma combinação herbicida, para controlar o crescimento indesejado das plantas e/ou controlar plantas nocivas, para tratar ou proteger culturas em linha e para tratar ou proteger culturas especiais e uso de combinação herbicida
BR112022014809A2 (pt) 2020-01-31 2022-09-20 Basf Se Combinação de herbicidas, composição, métodos para produzir uma combinação de herbicidas, para controlar o crescimento de plantas indesejadas e para tratar ou proteger culturas e uso de uma combinação de herbicidas
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US20230091888A1 (en) 2020-01-31 2023-03-23 Basf Se Herbicide combinations comprising glufosinate and selected ppo inhibitors
WO2021151739A1 (en) 2020-01-31 2021-08-05 Basf Se Herbicide combinations comprising glufosinate and pyraflufen-ethyl
AU2021360993A1 (en) 2020-10-12 2023-05-18 Basf Se Herbicide combination comprising glufosinate, saflufenacil and trifludimoxazin
EP4000400A1 (en) 2020-11-17 2022-05-25 Basf Se Herbicide combination comprising glufosinate, saflufenacil and trifludimoxazin
KR20230097101A (ko) 2020-10-27 2023-06-30 바스프 에스이 살충제 마이크로에멀젼 조성물
CR20230380A (es) 2021-02-05 2023-10-12 Basf Se Composiciones herbicidas liquidas
JP2024513190A (ja) 2021-04-01 2024-03-22 ビーエーエスエフ ソシエタス・ヨーロピア Ｌ－グルホシネートを調製するための方法
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EP0477902A2 (de) 1992-04-01
US6335186B1 (en) 2002-01-01
DE4030578A1 (de) 1992-04-16
EP0477902B1 (de) 1998-02-11
EP0477902A3 (en) 1993-04-14
DK0477902T3 (da) 1998-09-23
KR100190203B1 (ko) 1999-06-01
JPH04248987A (ja) 1992-09-04
JP3018261B2 (ja) 2000-03-13
DE59108934D1 (de) 1998-03-19

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