HUP9900215A2 - Eljárás Z-L-aszparaginsav-dinátriumsó előállítására fumársavból - Google Patents
Eljárás Z-L-aszparaginsav-dinátriumsó előállítására fumársavbólInfo
- Publication number
- HUP9900215A2 HUP9900215A2 HU9900215A HUP9900215A HUP9900215A2 HU P9900215 A2 HUP9900215 A2 HU P9900215A2 HU 9900215 A HU9900215 A HU 9900215A HU P9900215 A HUP9900215 A HU P9900215A HU P9900215 A2 HUP9900215 A2 HU P9900215A2
- Authority
- HU
- Hungary
- Prior art keywords
- aspartate
- ammonium
- sodium hydroxide
- producing
- aspartase
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 title 2
- 239000001530 fumaric acid Substances 0.000 title 1
- 159000000000 sodium salts Chemical class 0.000 title 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 title 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 9
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 4
- YEOCBTKAGVNPMO-JIZZDEOASA-N diazanium;(2s)-2-aminobutanedioate Chemical compound [NH4+].[NH4+].[O-]C(=O)[C@@H](N)CC([O-])=O YEOCBTKAGVNPMO-JIZZDEOASA-N 0.000 abstract 3
- XYXYXSKSTZAEJW-VIFPVBQESA-N (2s)-2-(phenylmethoxycarbonylamino)butanedioic acid Chemical compound OC(=O)C[C@@H](C(O)=O)NC(=O)OCC1=CC=CC=C1 XYXYXSKSTZAEJW-VIFPVBQESA-N 0.000 abstract 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 108700016171 Aspartate ammonia-lyases Proteins 0.000 abstract 2
- 235000019253 formic acid Nutrition 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- HSDAJNMJOMSNEV-UHFFFAOYSA-N benzyl chloroformate Chemical compound ClC(=O)OCC1=CC=CC=C1 HSDAJNMJOMSNEV-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000004821 distillation Methods 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 239000003701 inert diluent Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/20—Aspartic acid; Asparagine
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Eljárás Z-L-aszparaginsav-dinátriűmsó előállítására fűmársavból,amelynek sőrán a) fűmársavat inert hígítószerben aszpartáz vagyaszpartázt termelő mikrőőrganizműsők jelenlétében ammóniűmfelesleggelammóniűm-L-aszpartáttá alakítanak, azűtán b) az ammóniűm-L-aszpartátőttartalmazó őldatőt nátriűm-hidrőxiddal elkeverik, aminél azalkalmazőtt nátriűm-hidrőxid mennyiségétől függően a mőnő- vagy adinátriűm-L-aszpartát vagy ezek keveréke képződik, és c) a lehasadó ésfeleslegben lévő ammóniát nőrmál nyőmásőn és 90-120 C reflűx-hőmérsékleten 0,2-2 perc tartózkődási ideig desztillációvaleltávőlítják, és fűmársav-szűszpenzióban visszavezetik, amelyetkiindűlási őldatként tővábbi enzimes átalakításhőz használnak, majd d)a visszamaradó, ammóniűm-L-aszpartátőt tartalmazó őldatőt 9-14 pH-értéken nátriűm-hidrőxid egyidejű hőzzáadása mellett benzil-őxi-karbőnil-klőriddal reagáltatják, úgyhőgy Z-L-aszparaginsav-dinátriűmsóképződik. ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0016398A ATA16398A (de) | 1998-02-02 | 1998-02-02 | Verfahren zur herstellung von z-l-asparaginsäure-dinatriumsalz aus fumarsäure |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HU9900215D0 HU9900215D0 (en) | 1999-04-28 |
| HUP9900215A2 true HUP9900215A2 (hu) | 1999-10-28 |
Family
ID=3483243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9900215A HUP9900215A2 (hu) | 1998-02-02 | 1999-02-01 | Eljárás Z-L-aszparaginsav-dinátriumsó előállítására fumársavból |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0945517A3 (hu) |
| AT (1) | ATA16398A (hu) |
| CZ (1) | CZ10599A3 (hu) |
| HU (1) | HUP9900215A2 (hu) |
| SK (1) | SK5499A3 (hu) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT408755B (de) * | 1998-05-22 | 2002-03-25 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von l-asparaginsäure |
| CN106117070B (zh) * | 2016-06-17 | 2018-09-28 | 宜兴市前成生物有限公司 | 一种制备l-天门冬氨酸二钠的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3214345A (en) * | 1958-11-20 | 1965-10-26 | Tanabe Seiyaku Co | Process for producing l-aspartic acid |
| JPS5617073B2 (hu) * | 1971-10-28 | 1981-04-20 | ||
| JPS5626196A (en) * | 1979-08-10 | 1981-03-13 | Mitsubishi Petrochem Co Ltd | Preparation of l-aspartic acid |
| EP0612784B1 (de) * | 1993-02-22 | 1998-11-11 | Bayer Ag | Verfahren zur Herstellung von Polysuccinimid und Polyasparaginsäure |
| DE4306412A1 (de) * | 1993-03-02 | 1994-09-08 | Bayer Ag | Verfahren zur Herstellung von Polyasparaginsäure |
| JP2798886B2 (ja) * | 1994-05-17 | 1998-09-17 | 株式会社日本触媒 | Ｌ−アスパラギン酸の製造方法 |
| DE59707269D1 (de) * | 1996-09-20 | 2002-06-20 | Dsm Fine Chem Austria Gmbh | Verfahren zur Herstellung von Z-L-Asparaginsäure-Dinatriumsalz aus Fumarsäure |
-
1998
- 1998-02-02 AT AT0016398A patent/ATA16398A/de not_active Application Discontinuation
-
1999
- 1999-01-13 CZ CZ99105A patent/CZ10599A3/cs unknown
- 1999-01-15 SK SK54-99A patent/SK5499A3/sk unknown
- 1999-01-28 EP EP99101849A patent/EP0945517A3/de not_active Withdrawn
- 1999-02-01 HU HU9900215A patent/HUP9900215A2/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0945517A2 (de) | 1999-09-29 |
| HU9900215D0 (en) | 1999-04-28 |
| ATA16398A (de) | 2001-06-15 |
| CZ10599A3 (cs) | 1999-08-11 |
| SK5499A3 (en) | 1999-08-06 |
| EP0945517A3 (de) | 2000-08-02 |
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