ES2094278T3 - Procedimiento para la preparacion enzimatica de acidos 7-amino-cefalosporanicos. - Google Patents

Procedimiento para la preparacion enzimatica de acidos 7-amino-cefalosporanicos.

Info

Publication number
ES2094278T3
ES2094278T3 ES92202159T ES92202159T ES2094278T3 ES 2094278 T3 ES2094278 T3 ES 2094278T3 ES 92202159 T ES92202159 T ES 92202159T ES 92202159 T ES92202159 T ES 92202159T ES 2094278 T3 ES2094278 T3 ES 2094278T3
Authority
ES
Spain
Prior art keywords
amino
procedure
enzymatic preparation
cephalosporanic acids
acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92202159T
Other languages
English (en)
Inventor
Ezio Battistel
Pietro Cesti
Giuliana Franzosi
Der Goes Wilhelmus Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ministero dell Universita e della Ricerca Scientifica e Tecnologica (MURST)
Original Assignee
Ministero dell Universita e della Ricerca Scientifica e Tecnologica (MURST)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ministero dell Universita e della Ricerca Scientifica e Tecnologica (MURST) filed Critical Ministero dell Universita e della Ricerca Scientifica e Tecnologica (MURST)
Application granted granted Critical
Publication of ES2094278T3 publication Critical patent/ES2094278T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/025—Achromobacter
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y10S435/834—Bacillus cereus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/874—Pseudomonas

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

SE OBTIENEN ACIDOS DE FORMULA SOMETIENDO A CONVERSION ENCIMATICA COMPUESTOS CON LA SIGUIENTE FORMULA: DONDE R REPRESENTA H, OH, O-CO-R", SIENDO R" UN RADICAL ALQUIL CON 1 A 4 ATOMOS DE CARBONO, R1 REPRESENTA UN GRUPO CARBOXILICO. LA REACCION SE LLEVA A CABO EN PRESENCIA DE UN MICROORGANISMO ELEGIDO DE LOS GENEROS PSEUDOMONAS, BACILLUS, ACHROMOBACTER, O EN PRESENCIA DE LA ENCIMA, YA SEA LIBRE O INMOVILIZADA, DERIVADA DE ELLOS.
ES92202159T 1991-07-24 1992-07-15 Procedimiento para la preparacion enzimatica de acidos 7-amino-cefalosporanicos. Expired - Lifetime ES2094278T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI912039A IT1250698B (it) 1991-07-24 1991-07-24 Processo per la preparazione enzimatica di acidi 7-ammino-cefalosporanici.

Publications (1)

Publication Number Publication Date
ES2094278T3 true ES2094278T3 (es) 1997-01-16

Family

ID=11360414

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92202159T Expired - Lifetime ES2094278T3 (es) 1991-07-24 1992-07-15 Procedimiento para la preparacion enzimatica de acidos 7-amino-cefalosporanicos.

Country Status (10)

Country Link
US (1) US5332663A (es)
EP (1) EP0525861B1 (es)
JP (1) JP3195058B2 (es)
AT (1) ATE144794T1 (es)
CA (1) CA2074032A1 (es)
DE (1) DE69214891T2 (es)
DK (1) DK0525861T3 (es)
ES (1) ES2094278T3 (es)
GR (1) GR3022044T3 (es)
IT (1) IT1250698B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100345994B1 (ko) * 1994-06-22 2002-12-16 제일제당주식회사 7-아미노세팔로스포란산의효소적제조방법
US5766871A (en) * 1996-11-27 1998-06-16 Food Industry Research And Development Institute Screening and characterization of glutaryl-7-aminocephalosporanic acid acylase
DE19924632B4 (de) 1999-05-28 2006-04-13 Sanofi-Aventis Deutschland Gmbh Verfahren zur Verzögerung der Desaktivierung von Glutarylamidase während einer Enzymkatalyse
DE60115267T2 (de) 2000-09-22 2006-08-17 Bristol-Myers Squibb Co. Glutaryl-cephalosporin-amidase aus pseudomonas diminuta bs-203

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1357977A (fr) * 1963-05-20 1964-04-10 Merck & Co Inc Procédé de production d'acide 7-aminocéphalosphalosporanique par voie enzymatique
CH475284A (de) * 1963-11-19 1969-07-15 Ciba Geigy Verfahren zur Herstellung von Desacetyl-7-amino-cephalosporansäure
US3239394A (en) * 1964-06-15 1966-03-08 Merck & Co Inc Process for producing 7-amino-cephalosporanic acid
CH590292A5 (es) * 1973-12-20 1977-07-29 Ciba Geigy Ag
DK158316C (da) * 1974-01-23 1990-10-08 Toyo Jozo Kk Fremgangsmaade til fremstilling af 3-substituerede 7-amino-3-cephem-4-carboxylsyrederivater
JPS5619999B2 (es) * 1974-02-07 1981-05-11
NO155547C (no) * 1979-02-10 1987-04-15 Kyowa Hakko Kogyo Kk Optisk aktive cefalosporin-analoge og salter derav samt fremgangsmaate for deres fremstilling.
JPS5671092A (en) * 1979-11-14 1981-06-13 Kyowa Hakko Kogyo Co Ltd Optical active cephalosporin analogous derivative
JPS6121097A (ja) * 1984-07-10 1986-01-29 Asahi Chem Ind Co Ltd ７−アミノセフアロスポラン酸及びその誘導体の製造法
DE3881531D1 (de) * 1987-01-17 1993-07-15 Hoechst Ag Verwendung von gamma-glutamyl-transpeptidase.
EP0322032A3 (en) * 1987-12-21 1991-01-30 Merck & Co. Inc. One-step enzymatic conversion of cephalosporin c and derivatives to 7-aminocephalosporanic acid and derivatives
US5104800A (en) * 1989-06-27 1992-04-14 Merck & Co., Inc. One-step cephalosporin c amidase enzyme
CA2040707C (en) * 1990-04-27 2002-07-09 Kenji Mitsushima Cephalosporin acetylhydrolase gene and protein encoded by said gene
JPH088877B2 (ja) * 1990-06-19 1996-01-31 塩野義製薬株式会社 デアセチル―７―アミノセファロスポラン酸の製造法
JPH04104792A (ja) * 1990-08-22 1992-04-07 Asahi Chem Ind Co Ltd 新規アクレモニウム・クリソゲナム
GB9019724D0 (en) * 1990-09-10 1990-10-24 Fujisawa Pharmaceutical Co Cephalosporin c acylase
IT1252308B (it) * 1990-12-21 1995-06-08 Antibioticos Spa Procedimento enzimatico per la produzione di acido 7- amminocefalosporanico e derivati

Also Published As

Publication number Publication date
US5332663A (en) 1994-07-26
DE69214891T2 (de) 1997-05-15
ITMI912039A1 (it) 1993-01-25
EP0525861B1 (en) 1996-10-30
DK0525861T3 (da) 1997-03-17
CA2074032A1 (en) 1993-01-25
ATE144794T1 (de) 1996-11-15
JPH05211889A (ja) 1993-08-24
ITMI912039A0 (it) 1991-07-24
IT1250698B (it) 1995-04-21
GR3022044T3 (en) 1997-03-31
DE69214891D1 (de) 1996-12-05
EP0525861A1 (en) 1993-02-03
JP3195058B2 (ja) 2001-08-06

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