KR920002616A - 아테롬성 동맥경화증 치료제로서의 비스[4-(2,6-디-알킬)페놀]실란 유도체 - Google Patents

아테롬성 동맥경화증 치료제로서의 비스[4-(2,6-디-알킬)페놀]실란 유도체 Download PDF

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KR920002616A
KR920002616A KR1019910011223A KR910011223A KR920002616A KR 920002616 A KR920002616 A KR 920002616A KR 1019910011223 A KR1019910011223 A KR 1019910011223A KR 910011223 A KR910011223 A KR 910011223A KR 920002616 A KR920002616 A KR 920002616A
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South Korea
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bis
compound
phenol
reacting
formula
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KR1019910011223A
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KR0186006B1 (ko
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앨런 파커 로저
젠 탄 마오 사이몬
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개리 디. 스트리트
메렐 다우 파마슈티칼즈 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K15/00—Anti-oxidant compositions; Compositions inhibiting chemical change
    • C09K15/04—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds
    • C09K15/32—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing two or more of boron, silicon, phosphorus, selenium, tellurium or a metal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te

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  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

아테롬성 동맥경화증 치료제로서의 비스[4-(2,6-디-알킬)페놀]실란 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (24)

  1. 하기 일반식(Ⅰ)의 화합물 :
  3. 상기식에서, R1,R2,R3및R4는 각각 독립적으로 C1-6알킬그룹이고; Z는 티오, 옥시 또는 메틸렌그룹이며; A는 C1-4알킬렌그룹이다.
  4. 제1항에 있어서, R1및 R2가 3급-부틸인 화합물.
  5. 제2항에 있어서, A가 메틸렌인 화합물.
  6. 제3항에 있어서, Z가 티오인 화합물.
  7. 제3항에 있어서, Z가 옥시인 화합물.
  8. 제3항에 있어서, Z가 메틸렌인 화합물.
  9. 제1항에 있어서, 4,4'-〔(디메틸실릴렌)비스(메틸렌티오)〕-비스〔2,6-디-3급-부틸〕페놀인 화합물.
  10. 제1항에 있어서, 4,4'-〔(디메틸실릴렌)비스(메틸렌티오)〕-비스〔2,6-디메틸〕페놀인 화합물.
  11. 제1항에 있어서, 4,4'-〔(디메틸실릴렌)디-2,1-에탄디일〕비스〔2,6-디메틸〕페놀인 화합물.
  12. 제1항에 있어서, 4,4'-〔(디메틸실릴렌)디-2,1-에탄디일〕비스〔2,6-디에틸〕페놀인 화합물.
  13. 아테롬성 동맥경화증 치료적 유효량의 제1항에 따른 화합물을 이를 필요로 하는 환자에게 투여하여 아테롬성 동맥경화증 환자의 아테롬성 동맥경화증 진행을 억제하는 방법.
  14. 산화방지적 유효량의 제1항에 따른 화합물을 이를 필요로 하는 환자에 투여하여 상기 환자에게서의 LDL지질과산화를 억제하는 방법.
  15. 하기 일반식(2)의 화합물을 적합한 비양자성 용매중에서 비-친핵성 염기 및 적절한 비스-할로알킬렌실란 0.5당량과 반응시켜 하기 일반식(1a)의 화합물을 제조하는 방법 :
  17. 상기식에서, R1,R2,R3및R4는 각각 독립적으로 C1-6알킬 그룹이고; Z'는 티오 또는 옥시그룹이며; A는 C1-4알킬렌 그룹이다.
  18. (a)적절한 비스-할로알킬실란을 적합한 비양자성 용매중에서 마그네슘 금속과 반응시켜 비스(마그네슘 할로겐화물)염을 형성시키고; (b)비스(마그네슘 할로겐화물)염을 적절한 3,5-디알킬-4-하이드록시-벤즈알데하이드 2당량과 반응시켜 상응하는 디올을 형성시키며; (c)디올을 환원시키는 단계들을 포함하여 하기 일반식(1b)의 화합물을 제조하는 방법 :
  20. 상기식에서, R1,R2,R3및R4는 각각 독립적으로 C1-6알킬그룹이고; A는 C1-6알킬렌 그룹이다.
  21. (a)적절한 비스-할로알킬실란을 적합한 비양자성 용매중에서 마그네슘 금속과 반응시켜 비스(마그네슘 할로겐화물)염을 형성시키고; (b)비스(마그네슘 할로겐화물)염을 적절한 3,5-디알킬-4-하이드록시-벤질할라이드 2당량과 반응시키는 단계들을 포함하여 하기 일반식(1b)의 화합물을 제조하는 방법 :
  23. 상기식에서, R1,R2,R3및R4는 각각 독립적으로 C1-6알킬그룹이고; A는 C1-4알킬렌 그룹이다.
  24. ※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
KR1019910011223A 1990-07-05 1991-07-03 비스(4-(2,6-디-알킬)페놀)실란 유도체, 이의 제조방법 및 이를 포함하는 약제학적 조성물 KR0186006B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US54805190A 1990-07-05 1990-07-05
US548,051 1990-07-05
US07/548,051 1990-07-05
US69668491A 1991-05-07 1991-05-07
US696684 1991-05-07
US696,684 1991-05-07

Publications (2)

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KR920002616A true KR920002616A (ko) 1992-02-28
KR0186006B1 KR0186006B1 (ko) 1999-05-15

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KR1019910011223A KR0186006B1 (ko) 1990-07-05 1991-07-03 비스(4-(2,6-디-알킬)페놀)실란 유도체, 이의 제조방법 및 이를 포함하는 약제학적 조성물

Country Status (20)

Country Link
US (1) US5281738A (ko)
EP (1) EP0464844B1 (ko)
JP (1) JP2963557B2 (ko)
KR (1) KR0186006B1 (ko)
CN (1) CN1029614C (ko)
AT (1) ATE132154T1 (ko)
AU (1) AU639807B2 (ko)
CA (1) CA2046050C (ko)
DE (1) DE69115771T2 (ko)
DK (1) DK0464844T3 (ko)
ES (1) ES2084062T3 (ko)
FI (1) FI101704B (ko)
GR (1) GR3018926T3 (ko)
HU (1) HU210695B (ko)
IE (1) IE72155B1 (ko)
IL (1) IL98711A (ko)
NO (1) NO179914C (ko)
NZ (1) NZ238807A (ko)
PT (1) PT98219B (ko)
TW (1) TW213919B (ko)

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US5677291A (en) * 1993-12-10 1997-10-14 Hoechst Marion Roussel, Inc. Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
AU681731B2 (en) * 1993-12-10 1997-09-04 Aventis Inc. Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
US5449679A (en) * 1994-07-29 1995-09-12 Leonard; Robert J. Process and products for reducing biological fluid levels of a lipid soluble waste
US5608095A (en) * 1996-04-30 1997-03-04 Hoechst Marion Roussel, Inc. Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
US5795876A (en) * 1996-04-30 1998-08-18 Hoechst Marion Rousssel, Inc. Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2, 6-di-alkyl-4-silyl-phenols
US6114572A (en) * 1996-11-20 2000-09-05 Hoechst Marion Roussel, Inc. Substituted phenols and thiophenols useful as antioxidant agents
US6121463A (en) * 1997-06-24 2000-09-19 Hoechst Marion Roussel, Inc. Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
AUPO787897A0 (en) * 1997-07-14 1997-08-07 Cardiac Crc Nominees Pty Limited Silicon-containing chain extenders
US9000472B2 (en) * 2011-12-30 2015-04-07 Dow Corning Corporation Optical assembly and method of forming an optical assembly
CN104817581B (zh) * 2015-05-07 2018-01-02 衢州学院 一种含硅二元酚及其制备方法
JP2023516912A (ja) * 2020-02-24 2023-04-21 ダウ グローバル テクノロジーズ エルエルシー 金属－配位子錯体触媒のヘテロ原子架橋前駆体の非極低温合成

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Also Published As

Publication number Publication date
CN1029614C (zh) 1995-08-30
IE72155B1 (en) 1997-03-26
IL98711A0 (en) 1992-07-15
HU210695B (en) 1995-06-28
IL98711A (en) 1996-07-23
ATE132154T1 (de) 1996-01-15
JP2963557B2 (ja) 1999-10-18
DE69115771T2 (de) 1996-06-05
NO912629L (no) 1992-01-06
CN1057842A (zh) 1992-01-15
CA2046050C (en) 2001-09-18
TW213919B (ko) 1993-10-01
EP0464844B1 (en) 1995-12-27
ES2084062T3 (es) 1996-05-01
NZ238807A (en) 1994-03-25
PT98219A (pt) 1992-05-29
NO179914C (no) 1997-01-08
AU8011491A (en) 1992-01-09
FI101704B1 (fi) 1998-08-14
HU912271D0 (en) 1991-12-30
JPH04230394A (ja) 1992-08-19
GR3018926T3 (en) 1996-05-31
FI101704B (fi) 1998-08-14
FI913253A (fi) 1992-01-06
US5281738A (en) 1994-01-25
PT98219B (pt) 1998-12-31
KR0186006B1 (ko) 1999-05-15
AU639807B2 (en) 1993-08-05
FI913253A0 (fi) 1991-07-04
NO912629D0 (no) 1991-07-04
NO179914B (no) 1996-09-30
EP0464844A1 (en) 1992-01-08
IE912341A1 (en) 1992-01-15
CA2046050A1 (en) 1992-01-06
DK0464844T3 (da) 1996-01-29
HUT58748A (en) 1992-03-30
DE69115771D1 (de) 1996-02-08

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