KR850006924A - 불포화된 고리형 아미도-치환된 에테르 화합물의 제조방법 - Google Patents

불포화된 고리형 아미도-치환된 에테르 화합물의 제조방법 Download PDF

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KR850006924A
KR850006924A KR1019850001614A KR850001614A KR850006924A KR 850006924 A KR850006924 A KR 850006924A KR 1019850001614 A KR1019850001614 A KR 1019850001614A KR 850001614 A KR850001614 A KR 850001614A KR 850006924 A KR850006924 A KR 850006924A
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hydrogen atom
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히로시(외 3) 이또
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오꾸 미쓰오
미쓰이도오 아쓰가가꾸 가부시끼 가이샤
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00Preparation of carboxylic acid amides
    • C07C231/08Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/64Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40Radicals substituted by oxygen atoms
    • C07D307/42Singly bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

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Description

불포화된 고리형 아미도-치환된 에테르 화합물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 비양자성 극성 용매 증에서 강염기의 존재하에 다음 일반식(Ⅱ)로 표시되는 고리형 할로겐-치환된 에테르 화합물과 다음 일반식(Ⅲ)으로 표시되는 불포하된 아미드 화합물을 반응시킴을 특징으로 하는 다음 일반식(Ⅰ)로 표시되는 불포화된 고리형 아미드-치환된 에테르화합물의 제조방법.
    상기식에서, R1및 R1′은 각각 고리형기이고; Z는 C1∼C5를 갖는 알킬렌기, C2∼C5를 갖는 알케닐렌기, 일반식(식중, r은 1∼50의 정수이고; x는 1∼5의 정수이다)로 표시되는 옥시알킬렌기 또는 일반식(식중, y,z는 1∼5의 정수이다)로 표시되는 아미노 알킬렌기이고; A 및 A′은 각각 할로겐원자, 히드록실기, 옥소기, 시아노기, 니트로기, 메르캅토기, 슬포기 또는 그의 염, C1∼C20을 갖는 알킬기, C2∼C15를 갖는 알케닐기, C1∼C20을 갖는 할로알킬기, 일반식또는 -R″′〔식증, R′R″은 각각 수소원자, 저금알킬기 또는 일반식(식중, n은 4∼20의 정수이고, R3는 수소원자 또는 메틸기이다)로 표시되는-불포화된 아미도 폴리메틸렌기 이고; R″′은 저급 알킬렌기이다〕로 표시되는 아미노 또는 아미노알킬기, 일반식 R0-,RCO- 또는 RCOO-(식중 R은 C1∼C20알킬기, C2∼C15알케닐기 또는 아릴기이다)로 표시되는 기, 일반식 COOR4(식중 R4는 수소원자, 알칼리금속원자, C1∼C20알킬기 C2∼C15알케닐기, 아릴기 또는 일반식 (식중 p는 4∼20의 정수이고, R5는 수소원자 또는 메틸 기이다)로 표시되는-불포화된 아미도폴리메틸렌기를 나타내고; B는 산소원자, 카르브닐기, 티오기, 슬포닐기, 아조기, C1∼C5알킬렌기 또는 C2∼C5알케닐렌기 나타내고; R2는 수소원자 또는 메틸기를 나타내고, 1 및 1′은 각각 0∼5의 정수이고 (A) ALC (A′)1′은 각각 상기 A 및 A′에서 정의한 기 및 원자의 기로부터 선택되고, 같거나 또는 다를수 있는 기 또는 0∼5원자의 결합을 의미하고; m은 4∼20의 정수이고; α,α',β및 β′은 모두가 동시에 0이 아니라는 조건하에 0∼4의 정수일 수 있고; q는 0 또는 1이다.
    상기식에서, R1,R1′,Z,A,A',B,q,m,1,1′α,α',β 및 β′은 상기에 정의한 바와 같고,X는 할로겐 원자를 나타낸다.
    상기식에서 R2는 상기에 정의한 바와 같다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850001614A 1984-03-13 1985-03-13 불포화된 고리형 아미도-치환된 에테르 화합물의 제조방법 KR870000958B1 (ko)

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JP59046532A JPS60193955A (ja) 1984-03-13 1984-03-13 環式不飽和アミド置換エ−テル化合物及びその製造方法
JP46532/84 1984-03-13

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KR870000958B1 KR870000958B1 (ko) 1987-05-14

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US (1) US4649219A (ko)
EP (1) EP0155177B1 (ko)
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CA (1) CA1244012A (ko)
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Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100490339B1 (ko) * 2002-05-08 2005-05-17 국방과학연구소 2,2-디나이트로프로필 아크릴레이트와 2,2-디나이트로부틸아크릴레이트의 공중합체
US9745319B2 (en) 2013-03-15 2017-08-29 Araxes Pharma Llc Irreversible covalent inhibitors of the GTPase K-Ras G12C
US9227978B2 (en) 2013-03-15 2016-01-05 Araxes Pharma Llc Covalent inhibitors of Kras G12C
TWI659021B (zh) 2013-10-10 2019-05-11 亞瑞克西斯製藥公司 Kras g12c之抑制劑
JO3556B1 (ar) 2014-09-18 2020-07-05 Araxes Pharma Llc علاجات مدمجة لمعالجة السرطان
US10011600B2 (en) 2014-09-25 2018-07-03 Araxes Pharma Llc Methods and compositions for inhibition of Ras
US9862701B2 (en) 2014-09-25 2018-01-09 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
EP3280708B1 (en) 2015-04-10 2021-09-01 Araxes Pharma LLC Substituted quinazoline compounds and methods of use thereof
MX2017013275A (es) 2015-04-15 2018-01-26 Araxes Pharma Llc Inhibidores triciclicos fusionados de kras y metodos de uso de los mismos.
US10144724B2 (en) 2015-07-22 2018-12-04 Araxes Pharma Llc Substituted quinazoline compounds and methods of use thereof
EP3133065A1 (en) 2015-08-21 2017-02-22 Merck Patent GmbH Compounds for optically active devices
WO2017058915A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
EP3356359B1 (en) 2015-09-28 2021-10-20 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
WO2017058805A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
WO2017058768A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
US10875842B2 (en) 2015-09-28 2020-12-29 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
US10858343B2 (en) 2015-09-28 2020-12-08 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
WO2017058902A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
WO2017070256A2 (en) 2015-10-19 2017-04-27 Araxes Pharma Llc Method for screening inhibitors of ras
CA3005089A1 (en) 2015-11-16 2017-05-26 Araxes Pharma Llc 2-substituted quinazoline compounds comprising a substituted heterocyclic group and methods of use thereof
WO2017100546A1 (en) 2015-12-09 2017-06-15 Araxes Pharma Llc Methods for preparation of quinazoline derivatives
CN106986789B (zh) 2016-01-20 2019-07-16 中国人民解放军军事医学科学院生物医学分析中心 对苯二酚类化合物及其制备方法与在抗肿瘤或免疫调节中的应用
WO2017172979A1 (en) 2016-03-30 2017-10-05 Araxes Pharma Llc Substituted quinazoline compounds and methods of use
US10646488B2 (en) 2016-07-13 2020-05-12 Araxes Pharma Llc Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
WO2018064510A1 (en) 2016-09-29 2018-04-05 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
US10377743B2 (en) 2016-10-07 2019-08-13 Araxes Pharma Llc Inhibitors of RAS and methods of use thereof
EP3573970A1 (en) 2017-01-26 2019-12-04 Araxes Pharma LLC 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
US11358959B2 (en) 2017-01-26 2022-06-14 Araxes Pharma Llc Benzothiophene and benzothiazole compounds and methods of use thereof
EP3573967A1 (en) 2017-01-26 2019-12-04 Araxes Pharma LLC Fused hetero-hetero bicyclic compounds and methods of use thereof
US11274093B2 (en) 2017-01-26 2022-03-15 Araxes Pharma Llc Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
US11279689B2 (en) 2017-01-26 2022-03-22 Araxes Pharma Llc 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer
EP3363786A1 (en) 2017-02-15 2018-08-22 Merck Patent GmbH Compounds for optically active devices
EP3363793A1 (en) 2017-02-15 2018-08-22 Merck Patent GmbH Hydrophobic compounds for optically active devices
BR112019024674A2 (pt) 2017-05-25 2020-06-16 Araxes Pharma Llc Inibidores covalentes da kras
US11639346B2 (en) 2017-05-25 2023-05-02 Araxes Pharma Llc Quinazoline derivatives as modulators of mutant KRAS, HRAS or NRAS
JP2020521741A (ja) 2017-05-25 2020-07-27 アラクセス ファーマ エルエルシー がんの処置のための化合物およびその使用の方法
EP4015512A1 (en) * 2020-12-16 2022-06-22 AMO Ireland Optically active devices

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2773063A (en) * 1956-12-04 Preparation of acrylamides
DE312689C (ko) *
DE312687C (ko) *
DE8498C (de) * Graf CH. DE MONTBLANC und L. GAULARD, Chemiker, in Paris Apparate zur Bereitung der sogenannten Ammoniak-Soda
US2773899A (en) * 1953-11-24 1956-12-11 Cilag Ltd Alkenoic amides of arylethers of alkanolamines
US3037056A (en) * 1959-03-30 1962-05-29 California Research Corp Amido polyglycols
US3280189A (en) * 1961-11-17 1966-10-18 Devoe & Raynolds Co Preparation of alcohol blocked n-hydroxymethyl unsaturated acid amides
NL137061C (ko) * 1962-02-14
NL293393A (ko) * 1962-06-04
NL302380A (ko) * 1962-12-22 1900-01-01
GB1010760A (en) * 1963-09-18 1965-11-24 Hercules Powder Co Ltd Modified polyolefines
DE1443912C3 (de) * 1964-12-08 1975-07-10 Bayer Ag, 5090 Leverkusen 3,5-Dialkyl-4-hydroxy-benzylamide der Acryl- bzw. Methacrylsäure und Verfahren zu ihrer Herstellung
US3627831A (en) * 1965-04-01 1971-12-14 Ciba Ltd Carboxylic acid amides
US3652478A (en) * 1967-10-27 1972-03-28 Mitsubishi Rayon Co Coating composition for electrodeposition coating
CH500168A (de) * 1968-04-19 1970-12-15 Basf Ag Verfahren zur Herstellung von Alkylenglykol-di(-acrylamid-N-methyl)-äthern
BE759428A (fr) * 1969-11-28 1971-04-30 Eastman Kodak Co Nouveaux composes acryliques monomeres et polymeres, utilisables en optique, et procede de preparation
US3796773A (en) * 1971-03-19 1974-03-12 Lubrizol Corp Graft polymers
US3784565A (en) * 1971-10-29 1974-01-08 Goodrich Co B F Stabilizers for chlorine-containing polymers
GB1415159A (en) * 1971-11-25 1975-11-26 Coates Bros Co Ltd Copolymers
US4233430A (en) * 1973-06-26 1980-11-11 L'oreal Anti-solar acrylamide derivative polymers, method of making the same and cosmetic compositions containing the same
US4025548A (en) * 1974-02-04 1977-05-24 The O'brien Corporation Radiation curable oligomers
US3928499A (en) * 1974-02-19 1975-12-23 Dow Chemical Co Unsaturated poly(amide-esters) and cross-linked derivatives thereof
CA1019485A (en) * 1974-06-21 1977-10-18 Sed Systems Ltd. Automatic dialing equipment
US4172933A (en) * 1975-07-16 1979-10-30 Xerox Corporation Polymers having pendant acceptor groups
US4021404A (en) * 1975-10-01 1977-05-03 The Goodyear Tire & Rubber Company Antihardeners for polymers
US4129545A (en) * 1976-01-16 1978-12-12 Mitsubishi Rayon Co., Ltd. Thermosetting acrylic copolymer usable as a powder paint and method for producing the same
US4134916A (en) * 1978-02-06 1979-01-16 Texaco Development Corp. N-polyalkoxyalkyl acrylamides or methacrylamides
US4393237A (en) * 1981-07-02 1983-07-12 Texaco Inc. Polyoxyalkylenepolyacrylamides
JPS5959495A (ja) * 1982-09-29 1984-04-05 Konishiroku Photo Ind Co Ltd 熱転写用記録紙
JPS60190746A (ja) * 1984-03-12 1985-09-28 Mitsui Toatsu Chem Inc 脂肪族ν−置換不飽和アミド化合物及びその製造方法

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KR870000958B1 (ko) 1987-05-14
JPH0573739B2 (ko) 1993-10-15
DE3580293D1 (de) 1990-12-06
EP0155177A3 (en) 1987-02-04
CA1244012A (en) 1988-11-01
JPS60193955A (ja) 1985-10-02
EP0155177B1 (en) 1990-10-31
US4649219A (en) 1987-03-10
EP0155177A2 (en) 1985-09-18

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