DE3580293D1 - Ungesaettigte amido-substituierte cyclische aethern-verbindungen und verfahren zu ihrer herstellung. - Google Patents

Ungesaettigte amido-substituierte cyclische aethern-verbindungen und verfahren zu ihrer herstellung.

Info

Publication number
DE3580293D1
DE3580293D1 DE8585301695T DE3580293T DE3580293D1 DE 3580293 D1 DE3580293 D1 DE 3580293D1 DE 8585301695 T DE8585301695 T DE 8585301695T DE 3580293 T DE3580293 T DE 3580293T DE 3580293 D1 DE3580293 D1 DE 3580293D1
Authority
DE
Germany
Prior art keywords
aethern
unsatured
amido
compounds
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8585301695T
Other languages
English (en)
Inventor
Hiroshi Itoh
Tomio Tanaka
Atsuhiko Nitta
Hideo Kamio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Application granted granted Critical
Publication of DE3580293D1 publication Critical patent/DE3580293D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/42—Singly bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE8585301695T 1984-03-13 1985-03-12 Ungesaettigte amido-substituierte cyclische aethern-verbindungen und verfahren zu ihrer herstellung. Expired - Fee Related DE3580293D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59046532A JPS60193955A (ja) 1984-03-13 1984-03-13 環式不飽和アミド置換エ−テル化合物及びその製造方法

Publications (1)

Publication Number Publication Date
DE3580293D1 true DE3580293D1 (de) 1990-12-06

Family

ID=12749894

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585301695T Expired - Fee Related DE3580293D1 (de) 1984-03-13 1985-03-12 Ungesaettigte amido-substituierte cyclische aethern-verbindungen und verfahren zu ihrer herstellung.

Country Status (6)

Country Link
US (1) US4649219A (de)
EP (1) EP0155177B1 (de)
JP (1) JPS60193955A (de)
KR (1) KR870000958B1 (de)
CA (1) CA1244012A (de)
DE (1) DE3580293D1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100490339B1 (ko) * 2002-05-08 2005-05-17 국방과학연구소 2,2-디나이트로프로필 아크릴레이트와 2,2-디나이트로부틸아크릴레이트의 공중합체
US9745319B2 (en) 2013-03-15 2017-08-29 Araxes Pharma Llc Irreversible covalent inhibitors of the GTPase K-Ras G12C
UY35464A (es) 2013-03-15 2014-10-31 Araxes Pharma Llc Inhibidores covalentes de kras g12c.
JO3805B1 (ar) 2013-10-10 2021-01-31 Araxes Pharma Llc مثبطات كراس جي12سي
JO3556B1 (ar) 2014-09-18 2020-07-05 Araxes Pharma Llc علاجات مدمجة لمعالجة السرطان
WO2016049568A1 (en) 2014-09-25 2016-03-31 Araxes Pharma Llc Methods and compositions for inhibition of ras
WO2016049524A1 (en) 2014-09-25 2016-03-31 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
AU2016245864C1 (en) 2015-04-10 2021-09-09 Araxes Pharma Llc Substituted quinazoline compounds and methods of use thereof
US10428064B2 (en) 2015-04-15 2019-10-01 Araxes Pharma Llc Fused-tricyclic inhibitors of KRAS and methods of use thereof
US10144724B2 (en) 2015-07-22 2018-12-04 Araxes Pharma Llc Substituted quinazoline compounds and methods of use thereof
EP3133065A1 (de) 2015-08-21 2017-02-22 Merck Patent GmbH Verbindungen für optisch aktive vorrichtungen
US10858343B2 (en) 2015-09-28 2020-12-08 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
US10882847B2 (en) 2015-09-28 2021-01-05 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
WO2017058915A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
EP3356354A1 (de) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitoren von kras-g12c-mutanten proteinen
US10647703B2 (en) 2015-09-28 2020-05-12 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
WO2017058902A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
WO2017058807A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
JP2018533939A (ja) 2015-10-19 2018-11-22 アラクセス ファーマ エルエルシー Ｒａｓの阻害剤をスクリーニングするための方法
EP3377481A1 (de) 2015-11-16 2018-09-26 Araxes Pharma LLC 2-substituierte chinazolinverbindungen mit einer substituierten heterocyclischen gruppe und verfahren zur verwendung davon
WO2017100546A1 (en) 2015-12-09 2017-06-15 Araxes Pharma Llc Methods for preparation of quinazoline derivatives
CN106986789B (zh) 2016-01-20 2019-07-16 中国人民解放军军事医学科学院生物医学分析中心 对苯二酚类化合物及其制备方法与在抗肿瘤或免疫调节中的应用
US10822312B2 (en) 2016-03-30 2020-11-03 Araxes Pharma Llc Substituted quinazoline compounds and methods of use
US10646488B2 (en) 2016-07-13 2020-05-12 Araxes Pharma Llc Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
CN110036010A (zh) 2016-09-29 2019-07-19 亚瑞克西斯制药公司 Kras g12c突变蛋白的抑制剂
EP3523289A1 (de) 2016-10-07 2019-08-14 Araxes Pharma LLC Heterocyclische verbindungen als ras-inhibitoren und verfahren zur verwendung davon
CN110382482A (zh) 2017-01-26 2019-10-25 亚瑞克西斯制药公司 稠合的杂-杂二环化合物及其使用方法
WO2018140513A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer
EP3573964A1 (de) 2017-01-26 2019-12-04 Araxes Pharma LLC Benzothiophen- und benzothiazolverbindungen und verfahren zur verwendung davon
US11136308B2 (en) 2017-01-26 2021-10-05 Araxes Pharma Llc Substituted quinazoline and quinazolinone compounds and methods of use thereof
WO2018140512A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
EP3363786A1 (de) 2017-02-15 2018-08-22 Merck Patent GmbH Verbindungen für optisch aktive vorrichtungen
EP3363793A1 (de) 2017-02-15 2018-08-22 Merck Patent GmbH Hydrophobe verbindungen zur herstellung von optisch aktiven vorrichtungen
US10745385B2 (en) 2017-05-25 2020-08-18 Araxes Pharma Llc Covalent inhibitors of KRAS
US10736897B2 (en) 2017-05-25 2020-08-11 Araxes Pharma Llc Compounds and methods of use thereof for treatment of cancer
WO2018218069A1 (en) 2017-05-25 2018-11-29 Araxes Pharma Llc Quinazoline derivatives as modulators of mutant kras, hras or nras
EP4015512A1 (de) 2020-12-16 2022-06-22 AMO Ireland Optisch aktive vorrichtungen

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE8498C (de) * Graf CH. DE MONTBLANC und L. GAULARD, Chemiker, in Paris Apparate zur Bereitung der sogenannten Ammoniak-Soda
DE312689C (de) *
US2773063A (en) * 1956-12-04 Preparation of acrylamides
DE312687C (de) *
US2773899A (en) * 1953-11-24 1956-12-11 Cilag Ltd Alkenoic amides of arylethers of alkanolamines
US3037056A (en) * 1959-03-30 1962-05-29 California Research Corp Amido polyglycols
US3280189A (en) * 1961-11-17 1966-10-18 Devoe & Raynolds Co Preparation of alcohol blocked n-hydroxymethyl unsaturated acid amides
NL288928A (de) * 1962-02-14
NL293393A (de) * 1962-06-04
NL302380A (de) * 1962-12-22 1900-01-01
GB1010760A (en) * 1963-09-18 1965-11-24 Hercules Powder Co Ltd Modified polyolefines
DE1443912C3 (de) * 1964-12-08 1975-07-10 Bayer Ag, 5090 Leverkusen 3,5-Dialkyl-4-hydroxy-benzylamide der Acryl- bzw. Methacrylsäure und Verfahren zu ihrer Herstellung
US3627831A (en) * 1965-04-01 1971-12-14 Ciba Ltd Carboxylic acid amides
US3652478A (en) * 1967-10-27 1972-03-28 Mitsubishi Rayon Co Coating composition for electrodeposition coating
CH500168A (de) * 1968-04-19 1970-12-15 Basf Ag Verfahren zur Herstellung von Alkylenglykol-di(-acrylamid-N-methyl)-äthern
BE759428A (fr) * 1969-11-28 1971-04-30 Eastman Kodak Co Nouveaux composes acryliques monomeres et polymeres, utilisables en optique, et procede de preparation
US3796773A (en) * 1971-03-19 1974-03-12 Lubrizol Corp Graft polymers
US3784565A (en) * 1971-10-29 1974-01-08 Goodrich Co B F Stabilizers for chlorine-containing polymers
GB1415159A (en) * 1971-11-25 1975-11-26 Coates Bros Co Ltd Copolymers
US4233430A (en) * 1973-06-26 1980-11-11 L'oreal Anti-solar acrylamide derivative polymers, method of making the same and cosmetic compositions containing the same
US4025548A (en) * 1974-02-04 1977-05-24 The O'brien Corporation Radiation curable oligomers
US3928499A (en) * 1974-02-19 1975-12-23 Dow Chemical Co Unsaturated poly(amide-esters) and cross-linked derivatives thereof
CA1019485A (en) * 1974-06-21 1977-10-18 Sed Systems Ltd. Automatic dialing equipment
US4172933A (en) * 1975-07-16 1979-10-30 Xerox Corporation Polymers having pendant acceptor groups
US4021404A (en) * 1975-10-01 1977-05-03 The Goodyear Tire & Rubber Company Antihardeners for polymers
US4129545A (en) * 1976-01-16 1978-12-12 Mitsubishi Rayon Co., Ltd. Thermosetting acrylic copolymer usable as a powder paint and method for producing the same
US4134916A (en) * 1978-02-06 1979-01-16 Texaco Development Corp. N-polyalkoxyalkyl acrylamides or methacrylamides
US4393237A (en) * 1981-07-02 1983-07-12 Texaco Inc. Polyoxyalkylenepolyacrylamides
JPS5959495A (ja) * 1982-09-29 1984-04-05 Konishiroku Photo Ind Co Ltd 熱転写用記録紙
JPS60190746A (ja) * 1984-03-12 1985-09-28 Mitsui Toatsu Chem Inc 脂肪族ν−置換不飽和アミド化合物及びその製造方法

Also Published As

Publication number Publication date
EP0155177B1 (de) 1990-10-31
KR850006924A (ko) 1985-10-25
EP0155177A3 (en) 1987-02-04
JPS60193955A (ja) 1985-10-02
EP0155177A2 (de) 1985-09-18
CA1244012A (en) 1988-11-01
US4649219A (en) 1987-03-10
KR870000958B1 (ko) 1987-05-14
JPH0573739B2 (de) 1993-10-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee