DK0464844T3 - Bis(4-(2,6-dialkyl)phenol)silanderivater som antiatherosclerotiske midler og som antioxidanter - Google Patents

Bis(4-(2,6-dialkyl)phenol)silanderivater som antiatherosclerotiske midler og som antioxidanter

Info

Publication number
DK0464844T3
DK0464844T3 DK91111220.9T DK91111220T DK0464844T3 DK 0464844 T3 DK0464844 T3 DK 0464844T3 DK 91111220 T DK91111220 T DK 91111220T DK 0464844 T3 DK0464844 T3 DK 0464844T3
Authority
DK
Denmark
Prior art keywords
phenol
bis
dialkyl
antioxidants
silane derivatives
Prior art date
Application number
DK91111220.9T
Other languages
Danish (da)
English (en)
Inventor
Roger A Parker
Simon Jen Tan Mao
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Application granted granted Critical
Publication of DK0464844T3 publication Critical patent/DK0464844T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K15/00—Anti-oxidant compositions; Compositions inhibiting chemical change
    • C09K15/04—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds
    • C09K15/32—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing two or more of boron, silicon, phosphorus, selenium, tellurium or a metal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Materials Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Fats And Perfumes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK91111220.9T 1990-07-05 1991-07-05 Bis(4-(2,6-dialkyl)phenol)silanderivater som antiatherosclerotiske midler og som antioxidanter DK0464844T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54805190A 1990-07-05 1990-07-05
US69668491A 1991-05-07 1991-05-07

Publications (1)

Publication Number Publication Date
DK0464844T3 true DK0464844T3 (da) 1996-01-29

Family

ID=27068750

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91111220.9T DK0464844T3 (da) 1990-07-05 1991-07-05 Bis(4-(2,6-dialkyl)phenol)silanderivater som antiatherosclerotiske midler og som antioxidanter

Country Status (20)

Country Link
US (1) US5281738A (ko)
EP (1) EP0464844B1 (ko)
JP (1) JP2963557B2 (ko)
KR (1) KR0186006B1 (ko)
CN (1) CN1029614C (ko)
AT (1) ATE132154T1 (ko)
AU (1) AU639807B2 (ko)
CA (1) CA2046050C (ko)
DE (1) DE69115771T2 (ko)
DK (1) DK0464844T3 (ko)
ES (1) ES2084062T3 (ko)
FI (1) FI101704B1 (ko)
GR (1) GR3018926T3 (ko)
HU (1) HU210695B (ko)
IE (1) IE72155B1 (ko)
IL (1) IL98711A (ko)
NO (1) NO179914C (ko)
NZ (1) NZ238807A (ko)
PT (1) PT98219B (ko)
TW (1) TW213919B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2707989B1 (fr) * 1993-07-22 1995-10-13 Pf Medicament Nouveaux dérivés de benzylamines silylées, leurs sels, leurs procédés de fabrication et les compositions pharmaceutiques les renfermant.
US5677291A (en) * 1993-12-10 1997-10-14 Hoechst Marion Roussel, Inc. Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
WO1995015760A1 (en) * 1993-12-10 1995-06-15 Merrell Pharmaceuticals Inc. Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
US5449679A (en) * 1994-07-29 1995-09-12 Leonard; Robert J. Process and products for reducing biological fluid levels of a lipid soluble waste
US5608095A (en) * 1996-04-30 1997-03-04 Hoechst Marion Roussel, Inc. Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
US5795876A (en) * 1996-04-30 1998-08-18 Hoechst Marion Rousssel, Inc. Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2, 6-di-alkyl-4-silyl-phenols
US6114572A (en) * 1996-11-20 2000-09-05 Hoechst Marion Roussel, Inc. Substituted phenols and thiophenols useful as antioxidant agents
US6121463A (en) * 1997-06-24 2000-09-19 Hoechst Marion Roussel, Inc. Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
AUPO787897A0 (en) * 1997-07-14 1997-08-07 Cardiac Crc Nominees Pty Limited Silicon-containing chain extenders
US9000472B2 (en) * 2011-12-30 2015-04-07 Dow Corning Corporation Optical assembly and method of forming an optical assembly
CN104817581B (zh) * 2015-05-07 2018-01-02 衢州学院 一种含硅二元酚及其制备方法
EP4110787A1 (en) * 2020-02-24 2023-01-04 Dow Global Technologies LLC Non-cryogenic synthesis of heteroatom-bridge precursors of metal-ligand complex catalysts

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3506674A (en) * 1967-07-03 1970-04-14 Gen Electric Certain pyridyl thio ether silanes
US3853776A (en) * 1972-09-29 1974-12-10 Monsanto Co Low pour point fluids and blends containing same
US3801617A (en) * 1973-07-24 1974-04-02 Nasa Thiophenyl ether disiloxanes and trisiloxanes useful as lubricant fluids
AR208203A1 (es) * 1974-09-10 1976-12-09 Cortial Proceso para la preparacion de acido p-trialquilsilil benzoico y derivados del mismo
JPS61263988A (ja) * 1985-05-16 1986-11-21 Shionogi & Co Ltd シリル置換エ−テル類および殺虫・殺ダニ剤
US4636573A (en) * 1985-09-09 1987-01-13 Pastor Stephen D Hindered silicon ester stabilizers
US4804653A (en) * 1986-05-02 1989-02-14 Uniroyal Chemical Company, Inc. Thiomethyl-substituted organosilane compounds and their use as pesticides
US4783495A (en) * 1987-11-20 1988-11-08 Ciba-Geigy Corporation (Hydroxyphenyl) silane stabilizers
US5155250A (en) * 1990-07-05 1992-10-13 Merrell Dow Pharmaceuticals Inc. 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents
DE4031001A1 (de) * 1990-10-01 1992-04-02 Hoechst Ag Verfahren zur herstellung von 4-ethoxyphenyl-3-arylpropyl-(dimethyl)silanen

Also Published As

Publication number Publication date
HUT58748A (en) 1992-03-30
AU8011491A (en) 1992-01-09
JP2963557B2 (ja) 1999-10-18
NO912629D0 (no) 1991-07-04
KR0186006B1 (ko) 1999-05-15
CA2046050C (en) 2001-09-18
FI101704B (fi) 1998-08-14
NO179914B (no) 1996-09-30
IE72155B1 (en) 1997-03-26
AU639807B2 (en) 1993-08-05
IL98711A0 (en) 1992-07-15
EP0464844A1 (en) 1992-01-08
HU912271D0 (en) 1991-12-30
NO179914C (no) 1997-01-08
DE69115771D1 (de) 1996-02-08
EP0464844B1 (en) 1995-12-27
ES2084062T3 (es) 1996-05-01
CN1029614C (zh) 1995-08-30
HU210695B (en) 1995-06-28
IL98711A (en) 1996-07-23
NO912629L (no) 1992-01-06
CA2046050A1 (en) 1992-01-06
TW213919B (ko) 1993-10-01
CN1057842A (zh) 1992-01-15
PT98219B (pt) 1998-12-31
DE69115771T2 (de) 1996-06-05
ATE132154T1 (de) 1996-01-15
US5281738A (en) 1994-01-25
JPH04230394A (ja) 1992-08-19
GR3018926T3 (en) 1996-05-31
KR920002616A (ko) 1992-02-28
IE912341A1 (en) 1992-01-15
FI101704B1 (fi) 1998-08-14
PT98219A (pt) 1992-05-29
FI913253A0 (fi) 1991-07-04
NZ238807A (en) 1994-03-25
FI913253A (fi) 1992-01-06

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